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J. Plescia · SciRah

Researcher profile · Semantic Scholar

J. Plescia

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J. Plescia — researcher profile on SciRah

h-index: 36
Works: 56
Citations: 11K

Most-cited papers

Control of apoptosis and mitotic spindle checkpoint by survivin
Feng-Zhi Li, G. Ambrosini, E. Chu, J. Plescia +3 more
1998Nature2,002 citations
Semantic Scholar
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
Daniel S. O'Connor, D. Grossman, J. Plescia, Feng-Zhi Li +5 more
2000Proceedings of the National Academy of Sciences of the United States of America686 citations Open access
Semantic Scholar
Pleiotropic cell-division defects and apoptosis induced by interference with survivin function
Feng-Zhi Li, E. J. Ackermann, C. Bennett, Annette L. Rothermel +5 more
1999Nature Cell Biology621 citations
Semantic Scholar
Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor.
L. A. Miles, Carol M. Dahlberg, J. Plescia, Jordi Félez +2 more
1991Biochemistry576 citations
Semantic Scholar
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.
B. Kang, J. Plescia, T. Dohi, J. Rosa +2 more
2007Cell461 citations Open access
Semantic Scholar
The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type
Edward E Plow, D. Freaney, J. Plescia, L. A. Miles
1986Journal of Cell Biology452 citations Open access
Semantic Scholar
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
T. Dohi, Elena Beltrami, N. Wall, J. Plescia +1 more
2004Journal of Clinical Investigation421 citations Open access
Semantic Scholar
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway.
L. Languino, J. Plescia, A. Duperray, A. A. Brian +3 more
1993Cell376 citations
Semantic Scholar
Survivin and molecular pathogenesis of colorectal cancer.
P. J. Kim, J. Plescia, H. Clevers, E. Fearon +1 more
2003The Lancet349 citations
Semantic Scholar
Rational design of shepherdin, a novel anticancer agent.
J. Plescia, Whitney Salz, Fang Xia, M. Pennati +9 more
2005Cancer Cell337 citations Open access
Semantic Scholar
Regulation of survivin function by Hsp90
P. Fortugno, Elena Beltrami, J. Plescia, J. Fontana +4 more
2003Proceedings of the National Academy of Sciences of the United States of America335 citations Open access
Semantic Scholar
Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function.
P. Fortugno, N. Wall, A. Giodini, Daniel S. O'Connor +5 more
2002Journal of Cell Science330 citations
Semantic Scholar
Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
N. Wall, Daniel S. O'Connor, J. Plescia, Y. Pommier +1 more
2003Cancer Research275 citations
Semantic Scholar
Urine detection of survivin and diagnosis of bladder cancer.
Shannon D. Smith, Marcia A. Wheeler, J. Plescia, J. Colberg +2 more
2001Journal of the American Medical Association (JAMA)250 citations
Semantic Scholar
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.
B. Kang, J. Plescia, Ho-Young Song, M. Meli +5 more
2009Journal of Clinical Investigation224 citations Open access
Semantic Scholar
Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.
O. Blanc-Brude, M. Mesri, N. Wall, J. Plescia +2 more
2003Clinical Cancer Research220 citations
Semantic Scholar
A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18).
D. C. Altieri, Francisca R. Agbanyo, J. Plescia, M. H. Ginsberg +2 more
1990Journal of Biological Chemistry197 citations Open access
Semantic Scholar
Running title : Fibronectin – mediated regulation of survivin expression 1 Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor alpha-Induced Apoptosis via the AKT / Survivin Pathway
M. Fornaro, J. Plescia, S. Chheang, G. Tallini +3 more
2003171 citations
Semantic Scholar
The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion.
D. C. Altieri, J. Plescia, E. F. Plow
1993Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells.
M. Siegelin, T. Dohi, C. Raskett, G. Orlowski +5 more
2011Journal of Clinical Investigation161 citations Open access
Semantic Scholar
Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain.
Lu-Bing Zhou, D. Lee, J. Plescia, C.-Y. Lau +1 more
1994Journal of Biological Chemistry148 citations
Semantic Scholar
Molecular Identification of a Novel Fibrinogen Binding Site on the First Domain of ICAM-1 Regulating Leukocyte-Endothelium Bridging*
A. Duperray, L. Languino, J. Plescia, A. Mcdowall +4 more
1997Journal of Biological Chemistry146 citations Open access
Semantic Scholar
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
I. Leav, J. Plescia, H. Goel, Jing Li +4 more
2010American Journal of Pathology138 citations Open access
Semantic Scholar
Acute Ablation of Survivin Uncovers p53-dependent Mitotic Checkpoint Functions and Control of Mitochondrial Apoptosis*
Elena Beltrami, J. Plescia, John C. Wilkinson, C. Duckett +1 more
2004Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells.
L. A. Miles, Eugene G. Levin, J. Plescia, D. Collen +1 more
1988Blood130 citations
Semantic Scholar
A functional Notch–survivin gene signature in basal breast cancer
Connie W. Lee, K. Simin, Qin Liu, J. Plescia +4 more
2008Breast Cancer Research127 citations Open access
Semantic Scholar
Survivin does not inhibit caspase-3 activity.
Damon P. Banks, J. Plescia, Dario C. Altieri, Jun Chen +3 more
2000Blood121 citations
Semantic Scholar
Structural Recognition of a Novel Fibrinogen Chain Sequence (117133) by Intercellular Adhesion Molecule-1 Mediates Leukocyte-Endothelium Interaction (*)
D. Altieri, A. Duperray, J. Plescia, G. B. Thornton +1 more
1995Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Interleukin-11 Up-Regulates Survivin Expression in Endothelial Cells through a Signal Transducer and Activator of Transcription-3 Pathway
K. Mahboubi, Feng-Zhi Li, J. Plescia, N. Kirkiles-Smith +6 more
2001Laboratory Investigation118 citations Open access
Semantic Scholar
PRECLINICAL CHARACTERIZATION OF MITOCHONDRIA-TARGETED SMALL MOLECULE Hsp90 INHIBITORS, GAMITRINIBS, IN ADVANCED PROSTATE CANCER
B. Kang, M. Siegelin, J. Plescia, C. Raskett +6 more
2010Clinical Cancer Research95 citations Open access
Semantic Scholar
Activation of Mac-1 (CD11b/CD18)-bound factor X by released cathepsin G defines an alternative pathway of leucocyte initiation of coagulation.
J. Plescia, D. C. Altieri
1996Biochemical Journal95 citations Open access
Semantic Scholar
A survivin gene signature predicts aggressive tumor behavior.
Whitney Salz, D. Eisenberg, J. Plescia, D. Garlick +4 more
2005Cancer Research92 citations Open access
Semantic Scholar
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.
B. Gyurkocza, J. Plescia, C. Raskett, D. Garlick +6 more
2006Journal of the National Cancer Institute91 citations Open access
Semantic Scholar
Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead.
M. Meli, M. Pennati, M. Curto, M. Daidone +5 more
2006Journal of Medicinal Chemistry89 citations
Semantic Scholar
Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing
M. Guha, J. Plescia, I. Leav, Jing Li +2 more
2009Cancer Research72 citations Open access
Semantic Scholar
GLOBAL TARGETING OF SUBCELLULAR Hsp90 NETWORKS FOR THERAPY OF GLIOBLASTOMA*
M. Siegelin, J. Plescia, C. Raskett, C. Gilbert +2 more
2010Molecular Cancer Therapeutics43 citations Open access
Semantic Scholar
Activation-dependent Exposure of the Inter-EGF Sequence Leu83-Leu88 in Factor Xa Mediates Ligand Binding to Effector Cell Protease Receptor-1*
G. Ambrosini, J. Plescia, K. Chu, K. High +1 more
1997Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Dual Regulation of Ligand Binding by CD11b I Domain
M. Mesri, J. Plescia, D. Altieri
1998Journal of Biological Chemistry33 citations Open access
Semantic Scholar
IL-11 Protects Human Microvascular Endothelium from Alloinjury In Vivo by Induction of Survivin Expression1
N. Kirkiles-Smith, K. Mahboubi, J. Plescia, J. McNiff +4 more
2004Journal of Immunology29 citations Open access
Semantic Scholar
Molecular Identification of the Cross-reacting Epitope on αMβ2 Integrin I Domain Recognized by Anti-αIIbβ3 Monoclonal Antibody 7E3 and Its Involvement in Leukocyte Adherence*
J. Plescia, M. Conte, G. Vanmeter, G. Ambrosini +1 more
1998Journal of Biological Chemistry29 citations Open access
Semantic Scholar
A survivin gene signature predicts aggressive tumor
Whitney Salz, D. Eisenberg, J. Plescia
200527 citations
Semantic Scholar
IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression.
N. Kirkiles-Smith, K. Mahboubi, J. Plescia, J. McNiff +4 more
2004Journal of Immunology27 citations
Semantic Scholar
Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo.
Andrew W. Hoel, Peng Yu, K. Nguyen, Xin X. Sui +3 more
2012American Journal of Pathology13 citations Open access
Semantic Scholar
In Silico-Experimental Approach for Drug Design: the Binding Mode of Peptidic and Non Peptidic Inhibitors to Hsp90 N-Terminal Domain
S. Tomaselli, M. Meli, J. Plescia, L. Zetta +3 more
2010Chemical Biology and Drug Design12 citations Open access
Semantic Scholar
αMβ2 (CD11b/CD18, Mac‐1) integrin activation by a unique monoclonal antibody to αM I domain that is divalent cation‐sensitive
Randal P. Orchekowski, J. Plescia, D. C. Altieri, M. Bajt
2000Journal of Leukocyte Biology10 citations
Semantic Scholar
Neutrophil Secretion During Blood Coagulation: Evidence for a Prekallikrein Independent Pathway
E. Plow, J. Plescia
1988Thrombosis and Haemostasis9 citations Open access
Semantic Scholar
Molecular identification of the cross-reacting epitope on alphaM beta2 integrin I domain recognized by anti-alphaIIb beta3 monoclonal antibody 7E3 and its involvement in leukocyte adherence.
J. Plescia, M. Conte, G. Vanmeter, G. Ambrosini +1 more
1998Journal of Biological Chemistry6 citations
Semantic Scholar
AlphaMbeta2 (CD11b/CD18, Mac-1) integrin activation by a unique monoclonal antibody to alphaM I domain that is divalent cation-sensitive.
R. Orchekowski, J. Plescia, D. Altieri, M. Bajt
2000Journal of Leukocyte Biology5 citations
Semantic Scholar
Antileukemic Activity of Shepherdin, a Novel Targeted Inhibitor of the Survivin-Hsp90 Complex.
B. Gyurkocza, J. Plescia, M. Toke, D. Greiner +3 more
20052 citations
Semantic Scholar
Control of apoptosis andmitotic spindle checkpoint bysurvivin
Feng-Zhi Li, G. Ambrosini, E. Chu, J. Plescia +3 more
1 citations
Semantic Scholar

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