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Chen Ling · SciRah

Researcher profile · Semantic Scholar

Chen Ling

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Chen Ling — researcher profile on SciRah

h-index: 23
Works: 46
Citations: 1,382

Most-cited papers

High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.
D. Markusic, R. Herzog, G. Aslanidi, Brad E. Hoffman +9 more
2010Molecular Therapy137 citations Open access
Semantic Scholar
Lignin nanotubes as vehicles for gene delivery into human cells.
E. Ten, Chen Ling, Yuan Wang, A. Srivastava +2 more
2014Biomacromolecules106 citations
Semantic Scholar
Human Hepatocyte Growth Factor Receptor Is a Cellular Coreceptor for Adeno-Associated Virus Serotype 3
Chen Ling, Yuan Lu, J. Kalsi, G. Jayandharan +9 more
2010Human Gene Therapy103 citations Open access
Semantic Scholar
mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
Lin-Qing Miao, Liu Yang, Hao-Liang Huang, Fei-Si Liang +2 more
2016eLife99 citations Open access
Semantic Scholar
Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?
G. Aslanidi, A. Rivers, Luis Ortiz, Liu-Jiang Song +6 more
2013PLoS ONE99 citations Open access
Semantic Scholar
Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo
Liu-Jiang Song, M. Kauss, E. Kopin, M. Chandra +17 more
2013Cytotherapy80 citations Open access
Semantic Scholar
Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Shaoyong Li, Chen Ling, L. Zhong, Mengxin Li +10 more
2015Molecular Therapy79 citations Open access
Semantic Scholar
High-Efficiency Transduction of Fibroblasts and Mesenchymal Stem Cells by Tyrosine-Mutant AAV2 Vectors for Their Potential Use in Cellular Therapy
Mengxin Li, G. Jayandharan, Bao-Zheng Li, Chen Ling +3 more
2010Human Gene Therapy70 citations Open access
Semantic Scholar
The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload-mediated hepatic inflammation.
Min Li, Yu-Xiao Tang, Lusha Wu, Feng-Feng Mo +6 more
2017Blood51 citations Open access
Semantic Scholar
Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell‐based cancer immunotherapy
Jheel Pandya, Luis Ortiz, Chen Ling, A. Rivers +1 more
2014Immunology and Cell Biology50 citations
Semantic Scholar
High-efficiency Transduction of Human Monocyte-derived Dendritic Cells by Capsid-modified Recombinant AAV2 Vectors
G. Aslanidi, A. Rivers, Luis Ortiz, L. Govindasamy +5 more
2012Vaccine46 citations Open access
Semantic Scholar
High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing
Chen Ling, Kanit Bhukhai, Zifei Yin, M. Tan +4 more
2016Scientific Reports40 citations Open access
Semantic Scholar
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors
Jin-Song Wei, Gai Ran, Xin Wang, Ning Jiang +4 more
2019Journal of Biological Chemistry33 citations Open access
Semantic Scholar
Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo
Bao-Zheng Li, Wen-Qin Ma, Chen Ling, K. van Vliet +4 more
2015Human Gene Therapy Methods33 citations Open access
Semantic Scholar
Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
Yu-Xiao Tang, Dong-Yao Wang, Xiaowen Niu, Hui-Wen Wu +9 more
2020Free Radical Biology & Medicine31 citations
Semantic Scholar
Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors
Chen Ling, Zifei Yin, Jun Li, Daniel Zhang +2 more
2016Molecular Therapy: Methods & Clinical Development30 citations Open access
Semantic Scholar
Development of novel AAV serotype 6 based vectors with selective tropism for human cancer cells
Rana Sayroo, Diego Nolasco, Zifei Yin, Yanerys Colon-Cortes +3 more
2015Gene Therapy30 citations
Semantic Scholar
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing
Hua Yang, Keyun Qing, G. Keeler, L. Yin +7 more
2020Molecular Therapy: Nucleic Acids27 citations Open access
Semantic Scholar
Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B
Harrison C. Brown, C. Doering, Roland W. Herzog, Chen Ling +4 more
2020Human Gene Therapy27 citations Open access
Semantic Scholar
Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors
Gai Ran, Xiao Chen, Yi-lin Xie, Qingyun Zheng +8 more
2020Molecular Therapy: Methods & Clinical Development25 citations Open access
Semantic Scholar
TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer
John S. S. Butterfield, Moanaro Biswas, Jamie L. Shirley, Sandeep R. P. Kumar +4 more
2019Human Gene Therapy Methods25 citations Open access
Semantic Scholar
Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses
Chen Ling, Bao-Zheng Li, Wen-Qin Ma, A. Srivastava
2016Human Gene Therapy Methods25 citations Open access
Semantic Scholar
AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo
L. Yin, G. Keeler, Yuanhui Zhang, Brad E. Hoffman +3 more
2020Gene Therapy24 citations Open access
Semantic Scholar
Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo
Qingyun Zheng, Tian-Yi Wang, Xiang-Ying Zhu, Xia Tian +7 more
2021Molecular Therapy: Methods & Clinical Development19 citations Open access
Semantic Scholar
The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.
Yi-lin Xie, Ji-Yao Wang, Yun He, Xiao-min Yu +4 more
2022Journal of Integrative Medicine16 citations
Semantic Scholar
Negative Autoregulation of Epstein-Barr Virus (EBV) Replicative Gene Expression by EBV SM Protein
D. Verma, Chen Ling, E. Johannsen, T. Nagaraja +1 more
2009Journal of Virology15 citations Open access
Semantic Scholar
The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy.
Gai Ran, Xi-Ling Feng, Yi-lin Xie, Qingfang Zheng +6 more
2021Journal of Integrative Medicine11 citations
Semantic Scholar
A Simple Method to Increase the Transduction Efficiency of Single-Stranded Adeno-Associated Virus Vectors In Vitro and In Vivo
Wen-Qin Ma, Bao-Zheng Li, Chen Ling, G. Jayandharan +2 more
2011Human Gene Therapy11 citations Open access
Semantic Scholar
Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
Jun-Mei Zhou, Xiaowei Sun, Lu Yang, Liqun Wang +7 more
2020The FASEB Journal10 citations Open access
Semantic Scholar
Reprogramming immune response with capsid-optimized AAV6 vectors for immunotherapy of cancer
M. Pandya, K. Britt, Brad E. Hoffman, Chen Ling +1 more
2015Journal of immunotherapy10 citations Open access
Semantic Scholar
Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein
Fan Jia, Li Li, Haizhou Liu, Pei Lv +4 more
2021Molecular Brain7 citations Open access
Semantic Scholar
Enhanced transgene expression from single-stranded AAV vectors in human cells in vitro and in murine hepatocytes in vivo
Yuan Lu, Chen Ling, Jakob Shoti, Huan Yang +4 more
2024Molecular Therapy: Nucleic Acids6 citations Open access
Semantic Scholar
Chinese Medicine Protein and Peptide in Gene and Cell Therapy.
Yiping Feng, Zifei Yin, Daniel Zhang, A. Srivastava +1 more
2019Current protein and peptide science5 citations
Semantic Scholar
Author response: mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
Lin-Qing Miao, Liu Yang, Hao-Liang Huang, Fei-Si Liang +2 more
20162 citations Open access
Semantic Scholar
Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin
Lawrence J. Tartaglia, A. Bennett, Alexander S. Plattner, N. Muzyczka +3 more
2013Protein Expression and Purification2 citations Open access
Semantic Scholar
AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo
L. Yin, G. Keeler, Yuanhui Zhang, Brad E. Hoffman +3 more
2020Gene Therapy1 citations Open access
Semantic Scholar
Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein
Fan Jia, Li Li, Haizhou Liu, Pei Lv +4 more
2021Molecular Brain0 citations Open access
Semantic Scholar
Hepatocyte-specific HNF4α/miR-122 pathway contributes to the iron-overload mediated hepatic inflammation Short title: Role of HNF4α/miR-122 pathway during iron-overload Authors:
Min Li, Yu-Xiao Tang, Lusha Wu, Feng-Feng Mo +6 more
20170 citations
Semantic Scholar
271. Strategies Based on NexGen AAV2 to Improve AKT3-Induced CNS Axon Regeneration In Vivo
Yang Hu, Lin-Qing Miao, Liu Yang, Hao-Liang Huang +2 more
20160 citations Open access
Semantic Scholar
10. High-Efficiency Transduction of Primary Human CD34+ Hematopoietic Stem/Progenitor Cells by AAV6 Serotype Vectors: Strategies for Overcoming Donor Variation and Implications in Genome Editing
Zifei Yin, Kanit Bukhai, G. Aslanidi, Chen Ling +5 more
20160 citations Open access
Semantic Scholar
723. AAV Mediated Cancer Targeting: Systemic Trafficking to Tumor Is More Important Than Vector Tumor Cell Interaction
Yuan Lu, Damien Marsic, Chen Ling, Maria V. Guijario +8 more
20160 citations Open access
Semantic Scholar
91. Development of Optimized [“Opt”] AAV Vectors by Combining Capsid-Modified NextGen and Genome-Modified GenX AAV Vectors for High-Efficiency Transduction at Further Reduced Doses
Chen Ling, Bao-Zheng Li, Wen-Qin Ma, G. Aslanidi +1 more
20160 citations Open access
Semantic Scholar
220. AAV-Mediated miR122 Overexpression Rescues Hepatic Inflammatory Response Induced by Acute Iron-Overload
Min Li, Yu-Xiao Tang, Lusha Wu, Feng-Feng Mo +5 more
20160 citations Open access
Semantic Scholar
548. Recombinant AAV3 Serotype Vectors Generated by Using AAV3 ITRs and AAV3 Rep Proteins Efficiently Transduce Human Liver Cancer Cell Lines In Vitro and Human Liver Tumors in a Murine Xenograft Model In Vivo
Chen Ling, Zifei Yin, Jun Li, Daniel Zhang +2 more
20160 citations Open access
Semantic Scholar
550. Primary Human CD34+ Hematopoietic Stem/Progenitor Cell (HSPC) Transduction By AAV6 Serotype Vectors: Strategies for Overcoming the Donor-Variation
Zifei Yin, G. Aslanidi, Chen Ling, Yuanhui Zhang +4 more
20150 citations Open access
Semantic Scholar
221. The Utilization of Capsid-Optimized Adeno-Associated Virus (AAV) Vectors for Cancer Immunotherapy
M. Pandya, K. Britt, Chen Ling, Brad E. Hoffman +1 more
20150 citations Open access
Semantic Scholar

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