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E. Cheadle · SciRah

Researcher profile · Semantic Scholar

E. Cheadle

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E. Cheadle — researcher profile on SciRah

h-index: 26
Works: 68
Citations: 3,712

Most-cited papers

Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade.
S. Dovedi, Amy L. Adlard, G. Lipowska-Bhalla, Conor McKenna +10 more
2014Cancer Research1,198 citations Open access
Semantic Scholar
Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade
S. Dovedi, E. Cheadle, A. Popple, Edmund Poon +10 more
2017Clinical Cancer Research343 citations Open access
Semantic Scholar
The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors: Evaluation of Four Different scFvs and Antigens
R. Guest, Robert E. Hawkins, N. Kirillova, E. Cheadle +9 more
2005Journal of immunotherapy331 citations
Semantic Scholar
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies.
W. Alduaij, A. Ivanov, J. Honeychurch, E. Cheadle +9 more
2011Blood310 citations Open access
Semantic Scholar
CD19 CAR T Cells Expressing IL-12 Eradicate Lymphoma in Fully Lymphoreplete Mice through Induction of Host Immunity
G. Kueberuwa, Milena Kalaitsidou, E. Cheadle, R. Hawkins +1 more
2017Molecular Therapy: Oncolytics149 citations Open access
Semantic Scholar
Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway.
J. Honeychurch, W. Alduaij, Mahsa Azizyan, E. Cheadle +5 more
2012Blood133 citations Open access
Semantic Scholar
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity
M. Cazaux, C. Grandjean, Fabrice Lemaître, Z. Garcia +6 more
2019Journal of Experimental Medicine130 citations Open access
Semantic Scholar
CAR T cells: driving the road from the laboratory to the clinic
E. Cheadle, H. Gornall, V. Baldan, V. Hanson +2 more
2014Immunological Reviews118 citations
Semantic Scholar
Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations
Madyson Colton, E. Cheadle, J. Honeychurch, T. Illidge
2020Radiation Oncology81 citations Open access
Semantic Scholar
Natural Expression of the CD19 Antigen Impacts the Long-Term Engraftment but Not Antitumor Activity of CD19-Specific Engineered T Cells
E. Cheadle, R. Hawkins, H. Batha, A. O'Neill +2 more
2010Journal of Immunology77 citations Open access
Semantic Scholar
A recombinant E. coli vaccine to promote MHC class I-dependent antigen presentation: application to cancer immunotherapy
K. Radford, Darren E. Higgins, S. Pasquini, E. Cheadle +4 more
2002Gene Therapy71 citations Open access
Semantic Scholar
Eotaxin-2 and Colorectal Cancer: A Potential Target for Immune Therapy
E. Cheadle, K. Riyad, D. Subar, D. Rothwell +5 more
2007Clinical Cancer Research65 citations
Semantic Scholar
Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer
G. Owens, V. Sheard, Milena Kalaitsidou, D. Blount +6 more
2017Journal of immunotherapy60 citations Open access
Semantic Scholar
Immuno-regulatory antibodies for the treatment of cancer
J. Honeychurch, E. Cheadle, S. Dovedi, T. Illidge
2015Expert Opinion on Biological Therapy52 citations
Semantic Scholar
Antitumor efficacy of radiation plus immunotherapy depends upon dendritic cell activation of effector CDS+ T cells
S. Dovedi, G. Lipowska-Bhalla, S. Beers, E. Cheadle +4 more
2016Cancer immunology research51 citations Open access
Semantic Scholar
Differential Role of Th1 and Th2 Cytokines in Autotoxicity Driven by CD19-Specific Second-Generation Chimeric Antigen Receptor T Cells in a Mouse Model
E. Cheadle, V. Sheard, D. Rothwell, J. Bridgeman +5 more
2014Journal of Immunology46 citations Open access
Semantic Scholar
Chimeric antigen receptors for T-cell based therapy.
E. Cheadle, V. Sheard, A. Hombach, M. Chmielewski +7 more
2012Methods in molecular biology41 citations
Semantic Scholar
Closely Related Mycobacterial Strains Demonstrate Contrasting Levels of Efficacy as Antitumor Vaccines and Are Processed for Major Histocompatibility Complex Class I Presentation by Multiple Routes in Dendritic Cells
E. Cheadle, D. O'Donnell, P. Selby, A. M. Jackson
2005Infection and Immunity37 citations Open access
Semantic Scholar
A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells
E. Cheadle, G. Lipowska-Bhalla, S. Dovedi, E. Fagnano +3 more
2017Leukemia36 citations Open access
Semantic Scholar
Eradication of Established B-cell Lymphoma by CD19-specific Murine T Cells is Dependent on Host Lymphopenic Environment and Can be Mediated by CD4+ and CD8+ T Cells
E. Cheadle, R. Hawkins, H. Batha, D. Rothwell +2 more
2009Journal of immunotherapy36 citations
Semantic Scholar
Mycobacterium bovis bacillus Calmette–Guérin‐infected dendritic cells potently activate autologous T cells via a B7 and interleukin‐12‐dependent mechanism
E. Cheadle, P. Selby, A. M. Jackson
2003Immunology34 citations
Semantic Scholar
Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy
S. Dovedi, Amy L. Adlard, Yosuke Ota, M. Murata +13 more
2016OncoTarget30 citations Open access
Semantic Scholar
Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial
R. Guest, N. Kirillova, S. Mowbray, H. Gornall +10 more
2014Cancer Immunology and Immunotherapy28 citations Open access
Semantic Scholar
The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B‐cell lymphoma
E. Cheadle, D. Gilham, Robert E. Hawkins
2008British Journal of Haematology28 citations Open access
Semantic Scholar
Ex vivo expanded tumour-infiltrating lymphocytes from ovarian cancer patients release anti-tumour cytokines in response to autologous primary ovarian cancer cells
G. Owens, M. Price, E. Cheadle, R. Hawkins +2 more
2018Cancer Immunology and Immunotherapy27 citations Open access
Semantic Scholar
Killing of non‐Hodgkin lymphoma cells by autologous CD19 engineered T cells
E. Cheadle, D. Gilham, F. Thistlethwaite, J. Radford +1 more
2005British Journal of Haematology27 citations
Semantic Scholar
Bugs as drugs for cancer
E. Cheadle, A. M. Jackson
2002Immunology26 citations
Semantic Scholar
Pretreatment Lymphocyte Count Predicts Benefit From Concurrent Chemotherapy With Radiotherapy in Oropharyngeal Cancer
J. Price, H. Mistry, G. Betts, E. Cheadle +12 more
2022Journal of Clinical Oncology24 citations Open access
Semantic Scholar
Update on obinutuzumab in the treatment of B-cell malignancies
T. Illidge, E. Cheadle, C. Donaghy, J. Honeychurch
2014Expert Opinion on Biological Therapy22 citations
Semantic Scholar
The induction of immunogenic cell death by type II anti‐CD20 monoclonal antibodies has mechanistic differences compared with type I rituximab
E. Cheadle, L. Sidon, S. Dovedi, M. Melis +3 more
2013British Journal of Haematology22 citations Open access
Semantic Scholar
Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1
Debayan Mukherjee, E. Romano, R. Walshaw, L. Zeef +11 more
2023Oncoimmunology16 citations Open access
Semantic Scholar
Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response
Shuhui Cheng, E. Cheadle, T. Illidge
2020Cancers14 citations Open access
Semantic Scholar
MT-103 Micromet/MedImmune.
E. Cheadle
2006Current opinion in molecular therapeutics (Print)13 citations
Semantic Scholar
Radiation Therapy Induces an Adaptive Upregulation of PD-L1 on Tumor Cells Which May Limit the Efficacy of the Anti-Tumor Immune Response But Can Be Circumvented by Anti-PD-L1
T. Illidge, G. Lipowska-Bhalla, E. Cheadle, J. Honeychurch +5 more
201412 citations
Semantic Scholar
Erratum: A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells
E. Cheadle, G. Lipowska-Bhalla, S. Dovedi, E. Fagnano +3 more
2017Leukemia6 citations Open access
Semantic Scholar
Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies
E. Fagnano, Swati Pendharkar, Madyson Colton, Philip N. Jones +7 more
2023Frontiers in Cell and Developmental Biology4 citations Open access
Semantic Scholar
Improving therapeutic activity of anti-CD20 antibody therapy through immunomodulation in lymphoid malignancies
G. Lipowska-Bhalla, E. Fagnano, T. Illidge, E. Cheadle
2016Leukemia and Lymphoma4 citations
Semantic Scholar
The anti-tumor immune response generated by radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade
S. Dovedi, Amy L. Adlard, G. Lipowska-Bhalla, Conor McKenna +10 more
2014Journal of Immunotherapy for Cancer4 citations Open access
Semantic Scholar
New opportunities for anti-CD20 monoclonal antibody to give a direct punch to the tumor
T. Illidge, E. Cheadle, J. Honeychurch
2014Leukemia and Lymphoma3 citations Open access
Semantic Scholar
Longitudinal plasma nano-proteomics reveals acute systemic responses to radiotherapy and predictive biomarkers of late toxicity
H. Abumanhal-Masarweh, Salam A. Assi, Xinming Liu, C. Guerrero Quiles +8 more
2026Communications Medicine2 citations Open access
Semantic Scholar
Abstract 5034: The antitumor immune response generated by radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade
S. Dovedi, G. Lipowska-Bhalla, E. Cheadle, Edmund Poon +5 more
20142 citations
Semantic Scholar
Toward personalized immunotherapy for non-Hodgkin lymphoma: targeting the idiotypic immunoglobulin.
A. Armstrong, E. Cheadle, R. Hawkins
2005BioDrugs2 citations
Semantic Scholar
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Nabina Pun, Urszula M. Cytlak, Dave Lee, Rita G Domingues +10 more
2025Mucosal Immunology1 citations Open access
Semantic Scholar
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
Nabina Pun, Urszula M. Cytlak, Dave Lee, Rita G Domingues +8 more
2024bioRxiv1 citations Open access
Semantic Scholar
Improving CEA-targeted CAR-T cell therapy for solid tumours.
W. Zheng, G. Kueberuwa, E. Cheadle, A. Armstrong +1 more
20181 citations
Semantic Scholar
Antibody-Induced Non-Apoptotic Cell Death in Human Lymphoma and Leukemia Cells Is Mediated Through NADPH Oxidase-Derived Reactive Oxygen Species
J. Honeychurch, W. Alduaij, E. Cheadle, Mahsa Azizyan +5 more
20111 citations
Semantic Scholar
The second cellular therapy of cancer symposium, 27–29 March 2009, Milan, Italy
J. Bridgeman, D. Gilham, R. Hawkins, E. Cheadle
2010Cancer Immunology and Immunotherapy1 citations Open access
Semantic Scholar
The Tumour Immune Microenvironment as a Predictor of the Response to Neoadjuvant Therapy in Rectal Cancer
Sreya Wadud, E. Cheadle, P. A. Sutton
2026Cancers0 citations Open access
Semantic Scholar
Investigating the Immune Effects of Radiotherapy in Non-Small Cell Lung Cancer—Results of the PD-RAD Study
Shuhui Cheng, T. Kordbacheh, Antonia Banyard, A. Chaturvedi +7 more
2026Oncology Research0 citations Open access
Semantic Scholar
LY11 Proposal for a UK prospective trial evaluating the outcomes of low-dose radiotherapy in cutaneous B-cell and T-cell lymphomas
Christina Hague, Andrew Brocklehurst, A. Chaturvedi, E. Cheadle +5 more
2026British Journal of Dermatology0 citations
Semantic Scholar

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J. Honeychurch×20
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J. Honeychurch — researcher profile on SciRah
T. Illidge×19
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D. Gilham×14
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S. Dovedi×12
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R. Hawkins — researcher profile on SciRah

G. Lipowska-Bhalla×7

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R. Stewart — researcher profile on SciRah

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T. Illidge — researcher profile on SciRah

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W. Alduaij — researcher profile on SciRah