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M. Chmielewski · SciRah

Researcher profile · Semantic Scholar

M. Chmielewski

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M. Chmielewski — researcher profile on SciRah

h-index: 30
Works: 52
Citations: 4,888

Most-cited papers

TRUCKs: the fourth generation of CARs
M. Chmielewski, H. Abken
2015Expert Opinion on Biological Therapy670 citations
Semantic Scholar
IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression.
M. Chmielewski, Caroline Kopecky, A. Hombach, H. Abken
2011Cancer Research522 citations Open access
Semantic Scholar
Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
M. Chmielewski, A. Hombach, H. Abken
2014Immunological Reviews353 citations
Semantic Scholar
CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors.
M. Chmielewski, H. Abken
2017Cell Reports350 citations Open access
Semantic Scholar
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.
K. Krebs, Nina Böttinger, Li-Rung Huang, M. Chmielewski +11 more
2013Gastroenterology223 citations Open access
Semantic Scholar
OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4+ T cells
A. Hombach, Johannes Heiders, Marcel Foppe, M. Chmielewski +1 more
2012Oncoimmunology206 citations Open access
Semantic Scholar
Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity
M. Ligtenberg, D. Mougiakakos, Madhura Mukhopadhyay, Kristina Witt +5 more
2016Journal of Immunology203 citations Open access
Semantic Scholar
Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas
Anna Kruschinski, A. Moosmann, I. Poschke, H. Norell +6 more
2008Proceedings of the National Academy of Sciences of the United States of America199 citations Open access
Semantic Scholar
T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity1
M. Chmielewski, A. Hombach, C. Heuser, G. Adams +1 more
2004Journal of Immunology186 citations Open access
Semantic Scholar
T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.
F. Bohne, M. Chmielewski, G. Ebert, K. Wiegmann +6 more
2008Gastroenterology175 citations Open access
Semantic Scholar
Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells
M. Chmielewski, A. Hombach, H. Abken
2013Frontiers in Immunology158 citations Open access
Semantic Scholar
TRUCKS, the fourth‐generation CAR T cells: Current developments and clinical translation
M. Chmielewski, H. Abken
2020Advances in Cell and Gene Therapy150 citations Open access
Semantic Scholar
T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice.
M. Chmielewski, O. Hahn, G. Rappl, Michael D. Nowak +3 more
2012Gastroenterology143 citations
Semantic Scholar
CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation.
D. Kofler, M. Chmielewski, G. Rappl, A. Hombach +5 more
2011Molecular Therapy139 citations Open access
Semantic Scholar
CAR T cells transform to trucks: chimeric antigen receptor–redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer
M. Chmielewski, H. Abken
2012Cancer Immunology and Immunotherapy127 citations
Semantic Scholar
Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma
Jelena Skuljec, M. Chmielewski, C. Happle, A. Habener +3 more
2017Frontiers in Immunology106 citations Open access
Semantic Scholar
Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice.
A. Maliar, Charlotte Servais, T. Waks, M. Chmielewski +4 more
2012Gastroenterology97 citations Open access
Semantic Scholar
Intra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors
André Kunert, M. Chmielewski, R. Wijers, C. Berrevoets +2 more
2017Oncoimmunology92 citations Open access
Semantic Scholar
Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNγ.
A. Textor, J. Listopad, Lara Le Wührmann, C. Perez +5 more
2014Cancer Research82 citations Open access
Semantic Scholar
Superior Therapeutic Index in Lymphoma Therapy: CD30(+) CD34(+) Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
A. Hombach, Andre Görgens, M. Chmielewski, Florian Murke +3 more
2016Molecular Therapy64 citations Open access
Semantic Scholar
CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack
M. Chmielewski, A. Hombach, H. Abken
2011Gene Therapy60 citations Open access
Semantic Scholar
Review: Sustainable Clinical Development of CAR-T Cells – Switching From Viral Transduction Towards CRISPR-Cas Gene Editing
D. Wagner, U. Koehl, M. Chmielewski, C. Scheid +1 more
2022Frontiers in Immunology53 citations Open access
Semantic Scholar
Adoptive Immunotherapy with Redirected T Cells Produces CCR7− Cells That Are Trapped in the Periphery and Benefit from Combined CD28-OX40 Costimulation
A. Hombach, M. Chmielewski, G. Rappl, H. Abken
2013Human Gene Therapy53 citations
Semantic Scholar
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
M. Bunse, J. Pfeilschifter, Julia Bluhm, Maria Zschummel +10 more
2021Nature Communications52 citations Open access
Semantic Scholar
CAR T Cells with Enhanced Sensitivity to B Cell Maturation Antigen for the Targeting of B Cell Non-Hodgkin's Lymphoma and Multiple Myeloma.
Julia Bluhm, E. Kieback, Stephen F. Marino, F. Oden +6 more
2018Molecular Therapy52 citations Open access
Semantic Scholar
IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors
A. Hombach, Markus Barden, L. Hannappel, M. Chmielewski +3 more
2021Molecular Therapy50 citations Open access
Semantic Scholar
Regulatory CAR-T cells in autoimmune diseases: Progress and current challenges
T. Riet, M. Chmielewski
2022Frontiers in Immunology47 citations Open access
Semantic Scholar
Selective bispecific T cell recruiting antibody and antitumor activity of adoptive T cell transfer.
S. Kobold, J. Steffen, M. Chaloupka, S. Grassmann +14 more
2015Journal of the National Cancer Institute44 citations Open access
Semantic Scholar
Chimeric antigen receptors for T-cell based therapy.
E. Cheadle, V. Sheard, A. Hombach, M. Chmielewski +7 more
2012Methods in molecular biology41 citations
Semantic Scholar
Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response
Ivan Grskovic, A. Kutsch, C. Frie, G. Groma +13 more
2012Journal of Bone and Mineral Research36 citations
Semantic Scholar
Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.
S. Oberbeck, A. Schrader, K. Warner, Dennis Jungherz +41 more
2020Blood29 citations Open access
Semantic Scholar
Superior Therapeutic Index in Lymphoma Therapy: CD30+ CD34+ Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
A. Hombach, Andre Görgens, M. Chmielewski, Florian Murke +3 more
2016Molecular Therapy29 citations Open access
Semantic Scholar
T cells redirected by a CD3ζ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term
M. Chmielewski, G. Rappl, A. Hombach, H. Abken
2012Gene Therapy29 citations Open access
Semantic Scholar
An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL
Lars Fabian Prinz, T. Riet, Daniel Felix Neureuther, Simon Lennartz +21 more
2024Cell Reports Medicine18 citations Open access
Semantic Scholar
FimH-based display of functional eukaryotic proteins on bacteria surfaces
M. Chmielewski, J. Kuehle, Danuta Chrobok, N. Riet +2 more
2019Scientific Reports13 citations Open access
Semantic Scholar
Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies
R. Flümann, Julie Hansen, Benedikt W. Pelzer, P. Nieper +32 more
2022Blood Cancer Discovery12 citations Open access
Semantic Scholar
Depletion of Collagen IX Alpha1 Impairs Myeloid Cell Function
K. Probst, Jacek Stermann, Inga von Bomhard, J. Etich +11 more
2018Stem Cells11 citations Open access
Semantic Scholar
[97] T CELLS REDIRECTED AGAINST HEPATITIS B VIRUS SURFACE PROTEINS ELIMINATE INFECTED HEPATOCYTES
F. Bonne, M. Chmielewski, G. Ebert, A. Schulze +4 more
200711 citations Open access
Semantic Scholar
TRUCKs with IL‐18 payload: Toward shaping the immune landscape for a more efficacious CAR T‐cell therapy of solid cancer
M. Chmielewski, H. Abken
201810 citations Open access
Semantic Scholar
Release brakes: chimeric antigen receptor T cells with PD-1 switch receptor
M. Chmielewski, H. Abken
20162 citations
Semantic Scholar
CAR's made it to the pancreas
M. Chmielewski, A. Maliar, Z. Eshhar, H. Abken
2012Oncoimmunology1 citations Open access
Semantic Scholar
Overcoming fratricide of CD86 targeting CAR-T cells by defined logic-gate CAR strategy
T. Riet, Simon Lennartz, Niklas Bösing, Lars Fabian Prinz +4 more
2026Experimental Hematology & Oncology0 citations Open access
Semantic Scholar
Targeting Lymphoma Associated Myeloid-Monocytic Cells through CSF1R Blockade Enhances CAR-T Cell Response in Aggressive B Cell Lymphoma
D. Stahl, P. Gödel, H. Balke-Want, P. Segbers +41 more
2024Blood0 citations
Semantic Scholar
Targeting monocytic‐myeloid suppressor cells through CSF1R‐blockade enhances CD19‐CAR T‐cell response in DLBCL
P. Gödel, D. Stahl, T. Riet, R. Flümann +7 more
2023Hematological Oncology0 citations Open access
Semantic Scholar
T cells redirected by a chimeric antigen receptor recognizing HBsAg efficiently control HBV in vivo in transgenic mice
K. Krebs, N. Böttinger, Li-Rung Huang, M. Chmielewski +5 more
20140 citations
Semantic Scholar
T cells redirected by a chimeric antigen receptor efficiently control Hepatitis B Virus replication in an immunocompetent mouse model
K. Krebs, N. Böttinger, Li-Rung Huang, M. Chmielewski +9 more
20140 citations
Semantic Scholar
Adoptive transfer of chimeric antigen receptor-T regulatory cells as an effective therapy for allergic asthma
Jelena Skuljec, M. Chmielewski, C. Happle, M. Busse +2 more
2014European Respiratory Journal0 citations
Semantic Scholar
340 T CELLS REDIRECTED BY A CHIMERIC ANTIGEN RECEPTOR RECOGNIZING HBsAg EFFICIENTLY CONTROL HBV IN VIVO IN TRANSGENIC MICE
K. Krebs, N. Böttinger, Li-Rung Huang, M. Chmielewski +10 more
20130 citations Open access
Semantic Scholar
Clinical Scale Central Memory T Cell Enrichment for Adoptive T Cell Therapy
Anna Casati, J. Schmitz, H. Abken, M. Chmielewski +4 more
20100 citations
Semantic Scholar
CD28 Costimulation of Effector T Cells During An Anti-Tumor Attack Sustains Its Repression by Regulatory T Cells Which Can Be Overcome by Preventing Lck Activation.
D. Kofler, M. Chmielewski, T. Riet, A. Hombach +3 more
20090 citations
Semantic Scholar

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