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April Chen · SciRah

Researcher profile · Semantic Scholar

April Chen

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April Chen — researcher profile on SciRah

h-index: 15
Works: 27
Citations: 897

Most-cited papers

Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
B. Albrecht, J. Harmange, D. Bauer, L. Berry +26 more
2008Journal of Medicinal Chemistry133 citations Open access
Semantic Scholar
Rational design of a new antibiotic class for drug-resistant infections
T. Durand-Réville, Alita A. Miller, J. O'Donnell, Xiaoyun Wu +22 more
2021Nature121 citations
Semantic Scholar
Discovery of a potent, selective, and orally bioavailable c-Met inhibitor: 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (AMG 458).
Longbin Liu, A. Siegmund, N. Xi, Paula Kaplan-Lefko +18 more
2008Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514.
A. Shapiro, Ning Gao, H. Jahić, Nicole M. Carter +2 more
2017ACS Infectious Diseases62 citations
Semantic Scholar
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy
Aryun Kim, A. Kutschke, D. Ehmann, Sara A Patey +13 more
2015Antimicrobial Agents and Chemotherapy62 citations Open access
Semantic Scholar
Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases
T. Durand-Réville, Janelle Comita-Prevoir, Jing Zhang, Xiaoyun Wu +16 more
2020Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
H. Bregman, L. Berry, J. L. Buchanan, April Chen +22 more
2011Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo.
Yi-Hong Zhang, Paula Kaplan-Lefko, K. Rex, Ya-Jing Yang +10 more
2008Cancer Research55 citations Open access
Semantic Scholar
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
A. Boezio, L. Berry, B. Albrecht, D. Bauer +22 more
2009Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance
Li-Yue Huang, L. Berry, S. Ganga, Brett Janosky +4 more
2010Drug Metabolism And Disposition46 citations
Semantic Scholar
Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model.
Kerry E. Murphy-Benenato, Pratik Bhagunde, April Chen, Hajnalka E. Davis +22 more
2015Journal of Medicinal Chemistry29 citations
Semantic Scholar
In vitro pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex
J. O'Donnell, Angela Tanudra, April Chen, Alita A. Miller +2 more
2023Antimicrobial Agents and Chemotherapy27 citations Open access
Semantic Scholar
Ceftaroline efficacy against high-MIC clinical Staphylococcus aureus isolates in an in vitro hollow-fibre infection model
Renu Singh, Mashal Almutairi, R. Alm, S. Lahiri +3 more
2017Journal of Antimicrobial Chemotherapy23 citations Open access
Semantic Scholar
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
T. Furuya, A. Shapiro, Janelle Comita-Prevoir, E. Kuenstner +15 more
2020Bioorganic & Medicinal Chemistry21 citations Open access
Semantic Scholar
Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282
J. O'Donnell, Angela Tanudra, April Chen, D. Hines +2 more
2020ACS Infectious Diseases17 citations Open access
Semantic Scholar
In vivo dose response and efficacy of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against the Acinetobacter baumannii-calcoaceticus complex
J. O'Donnell, Angela Tanudra, April Chen, Joseph V. Newman +2 more
2023Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds
Li-Yue Huang, April Chen, Jonathan Roberts, Brett Janosky +3 more
2012Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Ex vivo assessment of sulbactam-durlobactam clearance during continuous renal replacement therapy to guide dosing recommendations
Y. Abouelhassan, Yu-Wei Shen, April Chen, Xiaoyi Ye +2 more
2024Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Hydrolysis of O-, N-, and N+-glucuronide metabolites in human feces.
Zhoupeng Zhang, April Chen, Niresh Hariparsad
2025Drug Metabolism And Disposition5 citations Open access
Semantic Scholar
Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Mina C. Nakhla, Janelle Comita, Adam B. Shapiro, Samir H. Moussa +5 more
2025European journal of medicinal chemistry4 citations Open access
Semantic Scholar
Pharmacokinetics of the natural antibiotic negamycin
Jian Guo, Eric Miele, April Chen, Ricardo A. Luzietti +3 more
2015Xenobiotica; the fate of foreign compounds in biological systems4 citations
Semantic Scholar
Corrigendum to “Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 6307]
A. Boezio, L. Berry, B. Albrecht, D. Bauer +22 more
20102 citations Open access
Semantic Scholar
2526. Ex Vivo Assessment of Sulbactam-Durlobactam (SUL-DUR) Clearance during Continuous Renal Replacement Therapy (CRRT)
Y. Abouelhassan, Yu-Wei Shen, April Chen, Xiaoyi Ye +2 more
2023Open Forum Infectious Diseases1 citations Open access
Semantic Scholar
from in vitro Metabolic Intrinsic Clearance
Li-Yue Huang, L. Berry, S. Ganga, Brett Janosky +3 more
20091 citations
Semantic Scholar
AMG 458, a potent small molecule c-Met inhibitor, has significant anti-tumor activity in vivo
Paula Kaplan-Lefko, K. Rex, J. Moriguchi, Ya-Jing Yang +14 more
20081 citations
Semantic Scholar
Identification, synthesis, and characterization of a unique N-glucuronide of an acid metabolite of camizestrant (AZD9833) in humans.
Zhoupeng Zhang, S. Wilkinson, P. Howe, April Chen +6 more
2026Drug Metabolism And Disposition0 citations Open access
Semantic Scholar
Small-molecule Kinase Inhibitor with Antitumor Activity Identification of a Novel Recepteur D'origine Nantais/c-met Material Supplementary Cited Articles Citing Articles E-mail Alerts Identification of a Novel Recepteur D'origine Nantais/c-met Small-molecule Kinase Inhibitor with Antitumor Activity
Yi-Hong Zhang, Paula Kaplan-Lefko, K. Rex, Ya-Jing Yang +10 more
0 citations
Semantic Scholar

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