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B. Albrecht · SciRah

Researcher profile · Semantic Scholar

B. Albrecht

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B. Albrecht — researcher profile on SciRah

h-index: 28
Works: 63
Citations: 3,078

Most-cited papers

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain
B. N. Devaiah, B. Lewis, N. Cherman, M. Hewitt +5 more
2012Proceedings of the National Academy of Sciences of the United States of America358 citations Open access
Semantic Scholar
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
M. Vinogradova, Victor S. Gehling, A. Gustafson, Shilpi Arora +31 more
2016Nature Chemical Biology323 citations Open access
Semantic Scholar
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymp
Rishi G. Vaswani, Victor S. Gehling, L. Dakin, A. Cook +21 more
2016Journal of Medicinal Chemistry197 citations Open access
Semantic Scholar
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials.
B. Albrecht, Victor S. Gehling, M. Hewitt, Rishi G. Vaswani +23 more
2016Journal of Medicinal Chemistry183 citations Open access
Semantic Scholar
Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth.
Shivani Garapaty-Rao, C. Nasveschuk, A. Gagnon, E. Chan +11 more
2013Chemistry and Biology153 citations Open access
Semantic Scholar
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.
W. D. Bradley, Shilpi Arora, J. Busby, S. Balasubramanian +22 more
2014Chemistry and Biology142 citations Open access
Semantic Scholar
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
B. Albrecht, J. Harmange, D. Bauer, L. Berry +26 more
2008Journal of Medicinal Chemistry133 citations Open access
Semantic Scholar
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
F. A. Romero, J. Murray, K. Lai, V. Tsui +39 more
2017Journal of Medicinal Chemistry122 citations Open access
Semantic Scholar
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Alexander M. Taylor, A. Côté, M. Hewitt, Richard M. Pastor +40 more
2016ACS Medicinal Chemistry Letters100 citations Open access
Semantic Scholar
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
Terry D. Crawford, V. Tsui, E. M. Flynn, Shu-Mei Wang +28 more
2016Journal of Medicinal Chemistry99 citations Open access
Semantic Scholar
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
Victor S. Gehling, M. Hewitt, Rishi G. Vaswani, Y. Leblanc +20 more
2013ACS Medicinal Chemistry Letters95 citations Open access
Semantic Scholar
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
Brian L. Hodous, Stephanie D. Geuns-Meyer, P. Hughes, B. Albrecht +24 more
2007Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
A concise formal total synthesis of TMC-95A/B proteasome inhibitors.
B. Albrecht, Robert M. Williams
2003Organic Letters85 citations
Semantic Scholar
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
Terry D. Crawford, F. A. Romero, K. Lai, V. Tsui +41 more
2016Journal of Medicinal Chemistry81 citations Open access
Semantic Scholar
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition*
Srimoyee Ghosh, Alexander M. Taylor, M. Chin, Hon-Ren Huang +32 more
2016Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Pharmacological effects of nonselective and subtype‐selective nicotinic acetylcholine receptor agonists in animal models of persistent pain
BaoXi Gao, Markus Hierl, K. Clarkin, T. Juan +18 more
2010Pain67 citations
Semantic Scholar
Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2.
C. Nasveschuk, A. Gagnon, Shivani Garapaty-Rao, S. Balasubramanian +9 more
2014ACS Medicinal Chemistry Letters59 citations Open access
Semantic Scholar
Discovery, design, and synthesis of indole-based EZH2 inhibitors.
Victor S. Gehling, Rishi G. Vaswani, C. Nasveschuk, M. du Plessis +15 more
2015Bioorganic & Medicinal Chemistry Letters58 citations Open access
Semantic Scholar
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
A. Boezio, L. Berry, B. Albrecht, D. Bauer +22 more
2009Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
A concise, total synthesis of the TMC-95A/B proteasome inhibitors.
B. Albrecht, Robert M. Williams
2004Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Identification of potent, selective KDM5 inhibitors.
Victor S. Gehling, S. Bellon, J. Harmange, Y. Leblanc +17 more
2016Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.
Terry D. Crawford, Steffan Vartanian, A. Côté, S. Bellon +20 more
2017Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.
Yuan Cheng, B. Albrecht, James Brown, J. L. Buchanan +17 more
2008Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.
Brian L. Hodous, Stephanie D. Geuns-Meyer, P. Hughes, B. Albrecht +18 more
2007Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
A. Boezio, Katrina W. Copeland, K. Rex, B. Albrecht +19 more
2016Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
E. A. Peterson, Y. Teffera, B. Albrecht, D. Bauer +17 more
2015Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.
B. Albrecht, V. Berry, A. Boezio, Lei Cao +14 more
2008Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
A practical synthesis of indoles via a Pd-catalyzed C-N ring formation.
Rishi G. Vaswani, B. Albrecht, J. Audia, A. Côté +8 more
2014Organic Letters29 citations
Semantic Scholar
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
V. Cee, B. Albrecht, Stephanie D. Geuns-Meyer, P. Hughes +24 more
2007Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
Alexander M. Taylor, Rishi G. Vaswani, Victor S. Gehling, M. Hewitt +19 more
2016ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R. Kaller, Scott S. Harried, B. Albrecht, P. Amarante +33 more
2012ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation
Kong Chen, B. Campfield, S. Wenzel, Jeremy P. McAleer +13 more
2016JCI Insight23 citations Open access
Semantic Scholar
Development of methyl isoxazoleazepines as inhibitors of BET.
M. Hewitt, Y. Leblanc, Victor S. Gehling, Rishi G. Vaswani +18 more
2015Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Entry into the bi-aryl moiety of the TMC-95 proteasome inhibitors via the Stille protocol
B. Albrecht, Robert M. Williams
200121 citations
Semantic Scholar
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).
Terry D. Crawford, J. Audia, S. Bellon, D. Burdick +30 more
2017ACS Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Chemical reactivity of methoxy 4-o-aryl quinolines: identification of glutathione displacement products in vitro and in vivo.
Y. Teffera, A. Colletti, Jean Christophe Harmange, L. Hollis +4 more
2008Chemical Research in Toxicology19 citations
Semantic Scholar
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.
Shu-Mei Wang, V. Tsui, Terry D. Crawford, J. Audia +26 more
2018Journal of Medicinal Chemistry18 citations
Semantic Scholar
GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.
Alexander M. Taylor, C. Bailey, Lisa D. Belmont, R. Campbell +26 more
2022Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.
Victor S. Gehling, J. Mcgrath, M. du Plessis, A. Khanna +16 more
2020ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Synthesis and activity of substituted carbamates as potentiators of the alpha4beta2 nicotinic acetylcholine receptor.
S. Springer, Katrina S. Woodin, V. Berry, A. Boezio +11 more
2008Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Identification of a novel glutathione conjugate of diclofenac by LTQ-Orbitrap.
Y. Teffera, D. Waldon, A. Colletti, B. Albrecht +1 more
2008Drug Metabolism Letters14 citations
Semantic Scholar
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
C. Bode, A. Boezio, B. Albrecht, S. Bellon +10 more
2012Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Asymmetric synthesis of (+)-hypusine.
R. P. Jain, B. Albrecht, Duane E. Demong, Robert M. Williams
2001Organic Letters7 citations
Semantic Scholar
An Indexed Combinatorial Library: The Synthesis and Testing of Insect Repellents
W. Miles, K. Gelato, Kristen M. Pompizzi, Aislinn M. Scarbinsky +2 more
20016 citations
Semantic Scholar
Abstract LB-237: In vitro and in vivo characterization of CPI-267203, a potent Inhibitor of bromodomain-containing proteins
E. Normant, R. Cummings, S. Bellon, Christopher Bailey +8 more
20124 citations
Semantic Scholar
Discussion Addendum for: 4-Methoxy-4'-nitrophenyl. Recent Advances in the Stille Biaryl Coupling Reaction and Applications in Complex Natural Products Synthesis
Robert M. Williams, J. Stille, A. Echavarren, J. Hendrix +2 more
2011Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals3 citations Open access
Semantic Scholar
Corrigendum to “Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 6307]
A. Boezio, L. Berry, B. Albrecht, D. Bauer +22 more
20102 citations Open access
Semantic Scholar
Corrigendum to “Development of methyl isoxazoleazepines as inhibitors of BET” [Bioorg. Med. Chem. Lett. 25/9 (2015) 1842–1848]
M. Hewitt, Y. Leblanc, Victor S. Gehling, Rishi G. Vaswani +18 more
20151 citations
Semantic Scholar
Corrigendum to “synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor” [Bioorg. Med. Chem. Lett. 18 (2008) 5643–5647]
S. Springer, Katrina S. Woodin, V. Berry, A. Boezio +11 more
20091 citations
Semantic Scholar
Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.
E. A. Peterson, Y. Teffera, B. Albrecht, D. Bauer +17 more
2015Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar

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