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S. Linder · SciRah

Researcher profile · Semantic Scholar

S. Linder

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S. Linder — researcher profile on SciRah

h-index: 62
Works: 217
Citations: 11K

Most-cited papers

Deubiquitinase inhibition as a cancer therapeutic strategy.
Pádraig D'Arcy, Xin Wang, S. Linder
2015Pharmacology and Therapeutics309 citations Open access
Semantic Scholar
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Z. Tian, Pádraig D'Arcy, Xin Wang, A. Ray +7 more
2014Blood302 citations Open access
Semantic Scholar
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Xiao-Nan Zhang, M. Fryknäs, E. Hernlund, Walid Fayad +12 more
2014Nature Communications245 citations Open access
Semantic Scholar
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
W. Stafford, Xiao-Xiao Peng, M. Olofsson, Xiao-Nan Zhang +16 more
2018Science Translational Medicine215 citations Open access
Semantic Scholar
Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies
P. Pellegrini, A. Strambi, Chiara Zipoli, Maria Hägg-Olofsson +3 more
2014Autophagy209 citations Open access
Semantic Scholar
Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress*
M. Marino, P. Pellegrini, G. Di Lernia, M. Djavaheri-Mergny +7 more
2012Journal of Biological Chemistry175 citations Open access
Semantic Scholar
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Xin Wang, M. Mazurkiewicz, Ellin-Kristina Hillert, M. Olofsson +10 more
2016Scientific Reports146 citations Open access
Semantic Scholar
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.
Xiao-Nan Zhang, K. Selvaraju, A. Saei, Pádraig D'Arcy +3 more
2019Biochimie142 citations
Semantic Scholar
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
Wojciech Senkowski, Xiao-Nan Zhang, M. Olofsson, Ruben Isacson +6 more
2015Molecular Cancer Therapeutics129 citations Open access
Semantic Scholar
Proteasome deubiquitinases as novel targets for cancer therapy.
Pádraig D'Arcy, S. Linder
2012International Journal of Biochemistry and Cell Biology129 citations
Semantic Scholar
Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts
Petra Thulin, Gunnar Nordahl, M. Gry, G. Yimer +13 more
2014Liver international (Print)128 citations
Semantic Scholar
Drug Development Targeting the Ubiquitin–Proteasome System (UPS) for the Treatment of Human Cancers
Xiao-Nan Zhang, S. Linder, Martina Bazzaro
2020Cancers123 citations Open access
Semantic Scholar
Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
O. Brodin, S. Eksborg, M. Wallenberg, Charlotte Asker-Hagelberg +7 more
2015Nutrients119 citations Open access
Semantic Scholar
Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
Edith Emmings, S. Mullany, Z. Chang, C. Landen +2 more
2019International Journal of Molecular Sciences115 citations Open access
Semantic Scholar
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma
E. Rowinsky, A. Paner, J. Berdeja, Claudia E. Paba-Prada +7 more
2020Investigational new drugs104 citations Open access
Semantic Scholar
Proteasome-associated deubiquitinases and cancer
Arjan Mofers, P. Pellegrini, S. Linder, Pádraig D'Arcy
2017Cancer Metastasis Review98 citations Open access
Semantic Scholar
Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15
Xin Wang, Pádraig D'Arcy, Thomas R. Caulfield, A. Paulus +5 more
2015Chemical Biology and Drug Design91 citations Open access
Semantic Scholar
Alterations in the Cellular Immune Compartment of Patients Treated with Third‐Party Mesenchymal Stromal Cells Following Allogeneic Hematopoietic Stem Cell Transplantation
R. Jitschin, D. Mougiakakos, L. von Bahr, S. Völkl +5 more
2013Stem Cells79 citations Open access
Semantic Scholar
Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
Slavica Brnjic, M. Mazurkiewicz, M. Fryknäs, Chao Sun +4 more
2014Antioxidants and Redox Signaling76 citations Open access
Semantic Scholar
Iron chelators target both proliferating and quiescent cancer cells
M. Fryknäs, Xiao-Nan Zhang, Ulf Bremberg, Wojciech Senkowski +9 more
2016Scientific Reports71 citations Open access
Semantic Scholar
The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death
Xin Wang, W. Stafford, M. Mazurkiewicz, M. Fryknäs +7 more
2014Molecular Pharmacology67 citations Open access
Semantic Scholar
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells
Kasyapa S. Chitta, A. Paulus, Sharoon Akhtar, M. K. Blake +8 more
2015British Journal of Haematology62 citations Open access
Semantic Scholar
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
A. Paulus, Sharoon Akhtar, T. Caulfield, K. Samuel +18 more
2016Blood Cancer Journal61 citations Open access
Semantic Scholar
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.
M. Jarvius, M. Fryknäs, Pádraig D'Arcy, Chao Sun +6 more
2013Biochemical and Biophysical Research Communications - BBRC61 citations
Semantic Scholar
Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells
Ran Ma, G. Karthik, J. Lövrot, F. Haglund +9 more
2017Journal of the National Cancer Institute60 citations Open access
Semantic Scholar
Molecular Pathways Molecular Pathways : Translational Potential of Deubiquitinases as Drug Targets
A. D'Arcy, S. Linder
201457 citations
Semantic Scholar
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Xiao-Nan Zhang, A. de Milito, M. Olofsson, J. Gullbo +2 more
2015International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?
K. Selvaraju, M. Mazurkiewicz, Xin Wang, J. Gullbo +2 more
2015Drug resistance updates54 citations Open access
Semantic Scholar
Proteasome addiction defined in Ewing’s sarcoma is effectively targeted by a novel class of 19S proteasome inhibitors
N. Shukla, Romel Somwar, Roger S. Smith, S. Ambati +20 more
2016Cancer Research44 citations Open access
Semantic Scholar
Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells.
Ruo-Mei Li, B. Sharma, S. Linder, T. Gutteberg +2 more
2013Virology39 citations Open access
Semantic Scholar
Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
I. Kolosenko, M. Fryknäs, S. Forsberg, P. Johnsson +12 more
2015International Journal of Cancer36 citations Open access
Semantic Scholar
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
D. Sarhan, E. Wennerberg, Pádraig D'Arcy, Deepthy Gurajada +2 more
2013Cancer Immunology and Immunotherapy32 citations Open access
Semantic Scholar
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
K. Selvaraju, Arjan Mofers, P. Pellegrini, Johannes Salomonsson +12 more
2019Scientific Reports31 citations Open access
Semantic Scholar
The deubiquitinase inhibitor b‐AP15 induces strong proteotoxic stress and mitochondrial damage
Xiao-Nan Zhang, P. Pellegrini, A. Saei, Ellin-Kristina Hillert +5 more
2018Biochemical Pharmacology31 citations
Semantic Scholar
Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
T. Ribeiro, F. Lemos, M. Preto, J. Azevedo +7 more
2017PLoS ONE30 citations Open access
Semantic Scholar
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
J. Felth, K. Lesiak-Mieczkowska, Pádraig D'Arcy, C. Haglund +6 more
2013Investigational new drugs25 citations
Semantic Scholar
Targeting Mitochondrial Metabolism in Clear Cell Carcinoma of the Ovaries
Xiao-Nan Zhang, Mihir Shetty, V. Clemente, S. Linder +1 more
2021bioRxiv23 citations Open access
Semantic Scholar
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Ellin-Kristina Hillert, Slavica Brnjic, Xiao-Nan Zhang, M. Mazurkiewicz +6 more
2019Cancer Letters23 citations
Semantic Scholar
A drug screening assay on cancer cells chronically adapted to acidosis
P. Pellegrini, J. Serviss, T. Lundbäck, Nicolò Bancaro +7 more
2018Cancer Cell International22 citations Open access
Semantic Scholar
A natural anticancer agent thaspine targets human topoisomerase IB.
S. Castelli, P. Katkar, O. Vassallo, M. Falconi +2 more
2013Anti-Cancer Agents in Medicinal Chemistry21 citations Open access
Semantic Scholar
Dienone Compounds: Targets and Pharmacological Responses
Martina Bazzaro, S. Linder
2020Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Portoamides A and B are mitochondrial toxins and induce cytotoxicity on the proliferative cell layer of in vitro microtumours.
M. L. Sousa, T. Ribeiro, V. Vasconcelos, S. Linder +1 more
2019Toxicon20 citations
Semantic Scholar
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.
Xiao-Nan Zhang, A. de Milito, A. Demiroglu-Zergeroglu, J. Gullbo +2 more
2016Trends in Cancer20 citations
Semantic Scholar
The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
C. Corno, Pádraig D'Arcy, M. Bagnoli, B. Paolini +9 more
2022Frontiers in Cell and Developmental Biology18 citations Open access
Semantic Scholar
Pseudomonas aeruginosa N-3-Oxo-Dodecanoyl-Homoserine Lactone Impacts Mitochondrial Networks Morphology, Energetics, and Proteome in Host Cells
Henrik Josephson, M. Ntzouni, C. Skoglund, S. Linder +2 more
2020Frontiers in Microbiology18 citations Open access
Semantic Scholar
Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation
M. L. Sousa, M. Preto, V. Vasconcelos, S. Linder +1 more
2019Frontiers in Oncology18 citations Open access
Semantic Scholar
Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group
P. Perego, G. Hempel, S. Linder, T. Bradshaw +3 more
2018Cancer Chemotherapy and Pharmacology17 citations Open access
Semantic Scholar
MYC is downregulated by a mitochondrial checkpoint mechanism
Xiao-Nan Zhang, Arjan Mofers, P. Hydbring, M. Olofsson +3 more
2017OncoTarget16 citations Open access
Semantic Scholar
Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
Q. Cheng, H. Wållberg, Jonas Grafström, Li Lu +9 more
2016EJNMMI Research16 citations Open access
Semantic Scholar
Identification of proteasome inhibitors using analysis of gene expression profiles.
Arjan Mofers, K. Selvaraju, Johannes A Gubat, Pádraig D'Arcy +1 more
2020European Journal of Pharmacology15 citations Open access
Semantic Scholar

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