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Pádraig D'Arcy · SciRah

Researcher profile · Semantic Scholar

Pádraig D'Arcy

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Pádraig D'Arcy — researcher profile on SciRah

h-index: 28
Works: 76
Citations: 3,274

Most-cited papers

Inhibition of proteasome deubiquitinating activity as a new cancer therapy
Pádraig D'Arcy, Slavica Brnjic, M. Olofsson, M. Fryknäs +7 more
2011Nature Medicine487 citations Open access
Semantic Scholar
Deubiquitinase inhibition as a cancer therapeutic strategy.
Pádraig D'Arcy, Xin Wang, S. Linder
2015Pharmacology and Therapeutics309 citations Open access
Semantic Scholar
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Z. Tian, Pádraig D'Arcy, Xin Wang, A. Ray +7 more
2014Blood302 citations Open access
Semantic Scholar
Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Xiao-Nan Zhang, M. Fryknäs, E. Hernlund, Walid Fayad +12 more
2014Nature Communications245 citations Open access
Semantic Scholar
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells
Xin Wang, M. Mazurkiewicz, Ellin-Kristina Hillert, M. Olofsson +10 more
2016Scientific Reports146 citations Open access
Semantic Scholar
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.
Xiao-Nan Zhang, K. Selvaraju, A. Saei, Pádraig D'Arcy +3 more
2019Biochimie142 citations
Semantic Scholar
Proteasome deubiquitinases as novel targets for cancer therapy.
Pádraig D'Arcy, S. Linder
2012International Journal of Biochemistry and Cell Biology129 citations
Semantic Scholar
Proteasome-associated deubiquitinases and cancer
Arjan Mofers, P. Pellegrini, S. Linder, Pádraig D'Arcy
2017Cancer Metastasis Review98 citations Open access
Semantic Scholar
Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15
Xin Wang, Pádraig D'Arcy, Thomas R. Caulfield, A. Paulus +5 more
2015Chemical Biology and Drug Design91 citations Open access
Semantic Scholar
Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress
Slavica Brnjic, M. Mazurkiewicz, M. Fryknäs, Chao Sun +4 more
2014Antioxidants and Redox Signaling76 citations Open access
Semantic Scholar
Iron chelators target both proliferating and quiescent cancer cells
M. Fryknäs, Xiao-Nan Zhang, Ulf Bremberg, Wojciech Senkowski +9 more
2016Scientific Reports71 citations Open access
Semantic Scholar
The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death
Xin Wang, W. Stafford, M. Mazurkiewicz, M. Fryknäs +7 more
2014Molecular Pharmacology67 citations Open access
Semantic Scholar
Doxorubicin sensitizes human tumor cells to NK and T cell-mediated killing by augmented TRAIL-receptor signaling
E. Wennerberg, D. Sarhan, M. Carlsten, V. Kaminskyy +4 more
2013International Journal of Cancer67 citations Open access
Semantic Scholar
Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.
M. Jarvius, M. Fryknäs, Pádraig D'Arcy, Chao Sun +6 more
2013Biochemical and Biophysical Research Communications - BBRC61 citations
Semantic Scholar
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19
V. Clemente, Pádraig D'Arcy, Martina Bazzaro
2020International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Xiao-Nan Zhang, A. de Milito, M. Olofsson, J. Gullbo +2 more
2015International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?
K. Selvaraju, M. Mazurkiewicz, Xin Wang, J. Gullbo +2 more
2015Drug resistance updates54 citations Open access
Semantic Scholar
Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties
Walid Fayad, Linda Rickardson, C. Haglund, M. Olofsson +4 more
2011Chemical Biology and Drug Design52 citations
Semantic Scholar
Oncogenic Functions of the Cancer-Testis Antigen SSX on the Proliferation, Survival, and Signaling Pathways of Cancer Cells
Pádraig D'Arcy, Wessen Maruwge, B. Wolahan, Li-Min Ma +1 more
2014PLoS ONE48 citations Open access
Semantic Scholar
Proteasome addiction defined in Ewing’s sarcoma is effectively targeted by a novel class of 19S proteasome inhibitors
N. Shukla, Romel Somwar, Roger S. Smith, S. Ambati +20 more
2016Cancer Research44 citations Open access
Semantic Scholar
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
Li-Min Ma, Wessen Maruwge, Angela Strambi, Pádraig D'Arcy +5 more
2014Cell Death and Disease39 citations Open access
Semantic Scholar
Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor.
S. Andersson, Pádraig D'Arcy, O. Larsson, B. Sehat
2009Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
Multipotent mesenchymal stromal cells express FoxP3: a marker for the immunosuppressive capacity?
M. Sundin, Pádraig D'Arcy, C. C. Johansson, A. Barrett +6 more
2011Journal of immunotherapy34 citations Open access
Semantic Scholar
The Oncoprotein SS18-SSX1 Promotes p53 Ubiquitination and Degradation by Enhancing HDM2 Stability
Pádraig D'Arcy, Wessen Maruwge, B. Ryan, B. Brodin
2008Molecular Cancer Research33 citations Open access
Semantic Scholar
A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells
D. Sarhan, E. Wennerberg, Pádraig D'Arcy, Deepthy Gurajada +2 more
2013Cancer Immunology and Immunotherapy32 citations Open access
Semantic Scholar
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
K. Selvaraju, Arjan Mofers, P. Pellegrini, Johannes Salomonsson +12 more
2019Scientific Reports31 citations Open access
Semantic Scholar
The deubiquitinase inhibitor b‐AP15 induces strong proteotoxic stress and mitochondrial damage
Xiao-Nan Zhang, P. Pellegrini, A. Saei, Ellin-Kristina Hillert +5 more
2018Biochemical Pharmacology31 citations
Semantic Scholar
Activated monocytes augment TRAIL‐mediated cytotoxicity by human NK cells through release of IFN‐γ
D. Sarhan, Pádraig D'Arcy, E. Wennerberg, Majken Lidén +4 more
2013European Journal of Immunology31 citations Open access
Semantic Scholar
Reactivation of p53 function in synovial sarcoma cells by inhibition of p53-HDM2 interaction.
Pádraig D'Arcy, B. Ryan, B. Brodin
2009Cancer Letters27 citations
Semantic Scholar
Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.
M. Tornkvist, N. Natalishvili, Yun-Tao Xie, A. Girnita +4 more
2008Biochemical and Biophysical Research Communications - BBRC26 citations
Semantic Scholar
Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System
D. Sarhan, Pádraig D'Arcy, A. Lundqvist
2014International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
J. Felth, K. Lesiak-Mieczkowska, Pádraig D'Arcy, C. Haglund +6 more
2013Investigational new drugs25 citations
Semantic Scholar
Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling
Wessen Maruwge, Pádraig D'Arcy, Annika Folin, Slavica Brnjic +5 more
2008OncoTargets and Therapy24 citations Open access
Semantic Scholar
Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Ellin-Kristina Hillert, Slavica Brnjic, Xiao-Nan Zhang, M. Mazurkiewicz +6 more
2019Cancer Letters23 citations
Semantic Scholar
A drug screening assay on cancer cells chronically adapted to acidosis
P. Pellegrini, J. Serviss, T. Lundbäck, Nicolò Bancaro +7 more
2018Cancer Cell International22 citations Open access
Semantic Scholar
Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.
Xiao-Nan Zhang, A. de Milito, A. Demiroglu-Zergeroglu, J. Gullbo +2 more
2016Trends in Cancer20 citations
Semantic Scholar
The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
C. Corno, Pádraig D'Arcy, M. Bagnoli, B. Paolini +9 more
2022Frontiers in Cell and Developmental Biology18 citations Open access
Semantic Scholar
Abstract C84: Inhibition of proteasome deubiquitinating activity as a novel cancer therapy.
Pádraig D'Arcy, Slavica Brnjic, M. Olofsson, Marten Fryknas +7 more
201117 citations
Semantic Scholar
MYC is downregulated by a mitochondrial checkpoint mechanism
Xiao-Nan Zhang, Arjan Mofers, P. Hydbring, M. Olofsson +3 more
2017OncoTarget16 citations Open access
Semantic Scholar
Identification of proteasome inhibitors using analysis of gene expression profiles.
Arjan Mofers, K. Selvaraju, Johannes A Gubat, Pádraig D'Arcy +1 more
2020European Journal of Pharmacology15 citations Open access
Semantic Scholar
Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment
Xiao-Nan Zhang, B. Espinosa, A. Saei, Pádraig D'Arcy +2 more
2019Oxidative Medicine and Cellular Longevity14 citations Open access
Semantic Scholar
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
Arjan Mofers, P. Perego, K. Selvaraju, L. Gatti +3 more
2019PLoS ONE14 citations Open access
Semantic Scholar
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
M. Mazurkiewicz, Ellin-Kristina Hillert, Xin Wang, P. Pellegrini +4 more
2017OncoTarget14 citations Open access
Semantic Scholar
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells.
D. Colombo, L. Gatti, Linda Sjöstrand, N. Carenini +8 more
2022Biochemical Pharmacology13 citations
Semantic Scholar
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570
P. Pellegrini, K. Selvaraju, Elena Faustini, Arjan Mofers +5 more
2020International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.
E. Hernlund, M. Olofsson, Walid Fayad, M. Fryknäs +9 more
2012European Journal of Cancer12 citations
Semantic Scholar
Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
Chao Sun, Peristera Roboti, Marjo-Riitta Puumalainen, M. Fryknäs +6 more
2014PLoS ONE10 citations Open access
Semantic Scholar
Feasibility of Coacervate-Like Nanostructure for Instant Drug Nanoformulation
Geyunjian H. Zhu, M. Azharuddin, Bapan Pramanik, K. Roberg +18 more
2023ACS Applied Materials and Interfaces9 citations Open access
Semantic Scholar
Transient interdomain interactions in free USP14 shape its conformational ensemble
Johannes Salomonsson, Björn Wallner, Linda Sjöstrand, Pádraig D'Arcy +2 more
2024Protein Science8 citations Open access
Semantic Scholar
Synthesis and bio-properties of 4-piperidone containing compounds as curcumin mimics
A. S. Girgis, Pádraig D'Arcy, Dalia R. Aboshouk, M. Bekheit
2022RSC Advances8 citations Open access
Semantic Scholar

Frequent co-authors

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S. Linder×35
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S. Linder — researcher profile on SciRah
Xiao-Nan Zhang×13
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Xiao-Nan Zhang — researcher profile on SciRah
M. Olofsson×11
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M. Olofsson — researcher profile on SciRah
J. Gullbo×11
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J. Gullbo — researcher profile on SciRah

×10

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M. Fryknäs — researcher profile on SciRah

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R. Larsson — researcher profile on SciRah

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Xin Wang — researcher profile on SciRah

K. Selvaraju×9

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K. Selvaraju — researcher profile on SciRah

M. Mazurkiewicz×8

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M. Mazurkiewicz — researcher profile on SciRah

Arjan Mofers×7

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Arjan Mofers — researcher profile on SciRah

P. Pellegrini×7

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P. Pellegrini — researcher profile on SciRah

Slavica Brnjic×6

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Slavica Brnjic — researcher profile on SciRah