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Da-Li Li · SciRah

Researcher profile · Semantic Scholar

Da-Li Li

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Da-Li Li — researcher profile on SciRah

h-index: 52
Works: 157
Citations: 8,626

Most-cited papers

Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
Song Zhang, Jiang-Tao Shen, Da-Li Li, Yiyun Cheng
2021Theranostics360 citations Open access
Semantic Scholar
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
Jian Luo, Zheng-Feng Yang, Yu Ma, Zhi-Ying Yue +15 more
2016Nature Medicine345 citations
Semantic Scholar
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL
Jiqin Zhang, Yong-Xian Hu, Jiaxuan Yang, Wei Li +18 more
2022Nature330 citations Open access
Semantic Scholar
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Tian-Shi Wang, Ying Cao, Quan Zheng, Jun Tu +22 more
2019Molecules and Cells233 citations Open access
Semantic Scholar
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Xiaohui Zhang, Biyun Zhu, Liang Chen, Ling Xie +22 more
2020Nature Biotechnology224 citations
Semantic Scholar
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos
Yanjiao Shao, Y. Guan, Liren Wang, Zhongwei Qiu +7 more
2014Nature Protocols197 citations
Semantic Scholar
Engineering a precise adenine base editor with minimal bystander editing
Liang Chen, Shun Zhang, Niannian Xue, Meng-Jia Hong +20 more
2022Nature Chemical Biology184 citations
Semantic Scholar
CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse
Y. Guan, Yanlin Ma, Qi Li, Zhen-Liang Sun +14 more
2016EMBO Molecular Medicine163 citations Open access
Semantic Scholar
CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia
Bin Fu, J. Liao, Shuanghong Chen, Wei Li +12 more
2022Nature Medicine154 citations
Semantic Scholar
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng +21 more
2022Nature Biotechnology144 citations
Semantic Scholar
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain
Xiaohui Zhang, Liang Chen, Biyun Zhu, Liren Wang +16 more
2020Nature Cell Biology123 citations
Semantic Scholar
The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
Lu Deng, Cong Jiang, Lei Chen, Jia-Li Jin +13 more
2015Molecules and Cells112 citations Open access
Semantic Scholar
Engineering a far-red light–activated split-Cas9 system for remote-controlled genome editing of internal organs and tumors
Yuanhuan Yu, Xin Wu, Ning-Zi Guan, Jiawei Shao +5 more
2020Science Advances103 citations Open access
Semantic Scholar
Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
Lin Wang, D. Aschenbrenner, Zhiyang Zeng, Xi-Ya Cao +51 more
2021Nature Genetics99 citations Open access
Semantic Scholar
Loss of KLF14 triggers centrosome amplification and tumorigenesis
Guangjian Fan, Lianhui Sun, Peipei Shan, Xian-Ying Zhang +14 more
2015Nature Communications98 citations Open access
Semantic Scholar
Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
Tian Zhou, Yu-Xin Li, Xiao-Yu Li, Fan-Zhuo Zeng +19 more
2022Nature Communications95 citations Open access
Semantic Scholar
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos
Liren Wang, Yanjiao Shao, Y. Guan, Liang Li +8 more
2015Scientific Reports92 citations Open access
Semantic Scholar
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
Huida Wan, Qi Wang, Xiuting Chen, Qiufang Zeng +12 more
2018bioRxiv90 citations Open access
Semantic Scholar
Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis
Xixi Zhang, Hai-Wei Zhang, Chengxian Xu, Xiao-Ming Li +10 more
2019Nature Communications87 citations Open access
Semantic Scholar
Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
Yongliang Zhao, Yiqing Yang, Roumei Xing, Xueqin Cui +9 more
2018Atherosclerosis87 citations
Semantic Scholar
Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants
Lei Yang, Xiaohui Zhang, Liren Wang, Shuming Yin +15 more
2018Protein & Cell84 citations Open access
Semantic Scholar
A Self-restricted CRISPR System to Reduce Off-target Effects.
Yanhao Chen, Xiaojian Liu, Yong-xian Zhang, Hui Wang +5 more
2016Molecular Therapy80 citations Open access
Semantic Scholar
In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15
Liang Li, Dazhao Mi, Haixiang Pei, Qiu-Hui Duan +6 more
2020Signal Transduction and Targeted Therapy77 citations Open access
Semantic Scholar
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
Dao-Lai Zhang, Yujing Sun, Ming-Liang Ma, Yi-Jing Wang +24 more
2018eLife77 citations Open access
Semantic Scholar
Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma
Hai-jun Wen, Huajuan Ma, Qichun Cai, Suxia Lin +15 more
2018Nature Medicine72 citations
Semantic Scholar
LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells
Zhi-Ying Yue, Zengjin Yuan, Li Zeng, Ying Wang +13 more
2017The FASEB Journal71 citations Open access
Semantic Scholar
NUDT21 regulates 3'-UTR length and microRNA-mediated gene silencing in hepatocellular carcinoma.
Meng Sun, Junyao Ding, Da-Li Li, Guoping Yang +2 more
2017Cancer Letters68 citations
Semantic Scholar
Dysfunction of Myosin Light‐Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically‐Engineered Rats
W. Peng, Miao-Xin Li, Hai-Ling Li, Kai Tang +9 more
2017Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease67 citations Open access
Semantic Scholar
Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies
Liren Wang, Linxi Li, Yanlin Ma, Handan Hu +11 more
2020Cell Research66 citations Open access
Semantic Scholar
DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development
Yin-Li Zhang, Long-Wen Zhao, Jue Zhang, Rong-Rong Le +6 more
2018EMBO Journal62 citations Open access
Semantic Scholar
Heritable expansion of the genetic code in mouse and zebrafish
Yuting Chen, Ji Ma, Wenqing Lu, Mei-Lin Tian +10 more
2016Cell Research57 citations Open access
Semantic Scholar
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN‐1 induced oxidative stress
Long Zhang, Liang Li, G. Gao, Gaigai Wei +10 more
2017International Journal of Cancer52 citations Open access
Semantic Scholar
Cas9-nickase–mediated genome editing corrects hereditary tyrosinemia in rats
Yanjiao Shao, Liren Wang, Nana Guo, Sheng-Fei Wang +13 more
2018Journal of Biological Chemistry50 citations Open access
Semantic Scholar
The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory*
Ruoyu Chen, Qiao Zhang, Xiao-Ya Duan, Philip York +13 more
2017Journal of Biological Chemistry49 citations Open access
Semantic Scholar
CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research
Jian Lu, Yanjiao Shao, Xuan Qin, Daozhi Liu +4 more
2017Scientific Reports49 citations Open access
Semantic Scholar
Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9.
Xin Wang, Yu Tang, Jian Lu, Yanjiao Shao +5 more
2016Biochemical Pharmacology49 citations
Semantic Scholar
Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats
Panpan You, Handan Hu, Yuting Chen, Yongliang Zhao +8 more
2016Scientific Reports46 citations Open access
Semantic Scholar
Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models
Y. Guan, Long Zhang, Xia Li, Xinyan Zhang +12 more
2015Journal of Immunology43 citations Open access
Semantic Scholar
Base Editing Mediated Generation of Point Mutations Into Human Pluripotent Stem Cells for Modeling Disease
Tao Qi, Fujian Wu, Yu-Quan Xie, Si-Qi Gao +5 more
2020Frontiers in Cell and Developmental Biology39 citations Open access
Semantic Scholar
RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice
Yongbo Liu, Cunxian Fan, Yi-Fan Zhang, Xian-Jun Yu +11 more
2017Cell Death and Differentiation39 citations Open access
Semantic Scholar
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ
Pei-Pei Luan, Wei-Xia Jian, Xu Xu, Wenxin Kou +8 more
2019Nature Communications38 citations Open access
Semantic Scholar
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment
Jia-Lun Li, Ruiping Wang, Jianyu Jin, Mengmeng Han +16 more
2020Cell Discovery37 citations Open access
Semantic Scholar
Bcl6 modulates innate immunity by controlling macrophage activity and plays critical role in experimental autoimmune encephalomyelitis
Qing Li, Lei Zhou, Lingdi Wang, Shiqiang Li +8 more
2020European Journal of Immunology37 citations Open access
Semantic Scholar
Amelioration of an Inherited Metabolic Liver Disease through Creation of a De Novo Start Codon by Cytidine Base Editing.
Lei Yang, Liren Wang, Yanan Huo, Xi Chen +13 more
2020Molecular Therapy33 citations Open access
Semantic Scholar
Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants
Lei Yang, Xiaohui Zhang, Liren Wang, Shuming Yin +15 more
2018Protein & Cell31 citations Open access
Semantic Scholar
CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy
Xiaohui Zhang, Liren Wang, Ming-Yao Liu, Da-Li Li
2017Science China Life Sciences31 citations
Semantic Scholar
Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions
Xiao-Man Liu, Yongping Zhang, Shu-Yan Ji, Bo-Tai Li +4 more
2015OncoTarget30 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated metabolic pathway reprogramming in a novel humanized rat model ameliorates primary hyperoxaluria type 1.
Rui Zheng, Yueyan Li, Liren Wang, Xiao-Liang Fang +5 more
2020Kidney International29 citations Open access
Semantic Scholar
A Novel Model of P‐Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids
Junfang Zhao, Zhiyang Zeng, Jialiang Sun, Yuan-Jin Zhang +4 more
2017Basic & Clinical Pharmacology & Toxicology29 citations
Semantic Scholar
Regulation of humoral immune response by HIF-1α-dependent metabolic reprogramming of the germinal center reaction.
Lingyun Li, Chunlei Feng, J. Qin, Da-Li Li +3 more
2021Cellular Immunology28 citations
Semantic Scholar

Frequent co-authors

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Ming-Yao Liu×23
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Ming-Yao Liu — researcher profile on SciRah
Liren Wang×17
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Liren Wang — researcher profile on SciRah
Yanjiao Shao×9
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Yanjiao Shao — researcher profile on SciRah
Ming-Yu Liu×8
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Ming-Yu Liu — researcher profile on SciRah

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Xiaohui Zhang×7

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Xiaohui Zhang — researcher profile on SciRah

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Shuming Yin — researcher profile on SciRah

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Lei Yang — researcher profile on SciRah

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Honghui Han — researcher profile on SciRah

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Meizhen Liu — researcher profile on SciRah