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V. Gurtu · SciRah

Researcher profile · Semantic Scholar

V. Gurtu

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V. Gurtu — researcher profile on SciRah

h-index: 12
Works: 40
Citations: 1,527

Most-cited papers

Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
Jayan Nagendran, S. Archer, D. Soliman, V. Gurtu +9 more
2007Circulation559 citations Open access
Semantic Scholar
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
E. Michelakis, V. Gurtu, Linda Webster, Gareth D. Barnes +18 more
2017Science Translational Medicine281 citations Open access
Semantic Scholar
Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.
R. Paulin, P. Dromparis, G. Sutendra, V. Gurtu +7 more
2014Cell Metabolism192 citations Open access
Semantic Scholar
A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted.
Jayan Nagendran, V. Gurtu, D. Fu, J. Dyck +4 more
2008Journal of Thoracic and Cardiovascular Surgery116 citations Open access
Semantic Scholar
A miR-208–Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension
R. Paulin, G. Sutendra, V. Gurtu, P. Dromparis +4 more
2015Circulation Research109 citations Open access
Semantic Scholar
Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.
A. Kinnaird, P. Dromparis, Bruno Saleme, V. Gurtu +10 more
2016European Urology70 citations
Semantic Scholar
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity
Bruno Saleme, V. Gurtu, Yong-Neng Zhang, A. Kinnaird +4 more
2019Science Translational Medicine67 citations Open access
Semantic Scholar
Emerging therapies and future directions in pulmonary arterial hypertension.
V. Gurtu, E. Michelakis
2015Canadian Journal of Cardiology34 citations
Semantic Scholar
A Paradigm Shift Is Needed in the Field of Pulmonary Arterial Hypertension for Its Entrance Into the Precision Medicine Era.
V. Gurtu, E. Michelakis
2016Circulation Research22 citations Open access
Semantic Scholar
Abstract 278: Phosphodiesterase-5 is Highly Expressed in the Hypertrophied Human Right Ventricle and Acute Inhibition Causes Increased Contractility via cGMP-Inhibition of Phosphodiesterase-3
Jayan Nagendran, S. Archer, D. Soliman, V. Gurtu +5 more
200721 citations
Semantic Scholar
The relationship between peripheral arterial tonometry and classic measures of endothelial function
B. Martin, V. Gurtu, Sammy Y. Chan, T. Anderson
2013Vascular Medicine17 citations
Semantic Scholar
Hemodynamic reserve predicts early right heart failure after LVAD implantation
J. Read, N. Azih, Carli Peters, V. Gurtu +16 more
2022The Journal of Heart and Lung Transplantation13 citations
Semantic Scholar
Interaction with p53 explains a pro-proliferative function for VHL in cancer
A. Kinnaird, Aristeidis E. Boukouris, Bruno Saleme, P. Dromparis +4 more
2020Journal of molecular medicine6 citations
Semantic Scholar
The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults
S. Mak, S. Kolker, N. Girdharry, R. Bentley +6 more
2022Pulmonary Circulation5 citations Open access
Semantic Scholar
Body Habitus Considerations During Right Heart Catheterization
N. Girdharry, R. Bentley, F. Valle, E. Karvasarski +4 more
2021CJC Open4 citations Open access
Semantic Scholar
Impact of Myocardial Load on the Preservation of Donor Heart Function during Ex Vivo Perfusion
Christopher W. White, S. Shan, S. Hatami, V. Gurtu +8 more
20164 citations Open access
Semantic Scholar
Cell-Based Gene Therapy in Pulmonary Arterial Hypertension: Journeys in Translational Medicine.
V. Gurtu, E. Michelakis
2015Circulation Research3 citations
Semantic Scholar
Expression of Pyruvate Dehydrogenase Kinase (PDK) in Lungs during Progression of Pulmonary Hypertension Syndrome in Broilers
Xiao-Juan Huang, Xiao-Qing Liu, Wang Xu, Yuan-Liang Li +96 more
2024Pakistan Veterinary Journal2 citations Open access
Semantic Scholar
EX VIVO PERFUSION IN A LOADED STATE IMPROVES THE PRESERVATION OF DONOR HEART FUNCTION
Christopher W. White, S. Shan, S. Hatami, V. Gurtu +8 more
20152 citations Open access
Semantic Scholar
Abstract 3155: Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle: Direct Implications for Patients with Pulmonary Hypertension
Jayan Nagendran, S. Archer, V. Gurtu, Linda Webster +3 more
20061 citations
Semantic Scholar
Contemporary pulmonary hypertension haemodynamic definitions stratify mortality risk in candidates for advanced heart failure therapies
S. P. Wright, Elizabeth Karvasarki, T. Buchan, V. Gurtu +4 more
2025European Respiratory Journal0 citations Open access
Semantic Scholar
Assessing Cardiac Recovery for Decommissioning of LVAD Support: Structure versus Function
R. S. Gabarin, V. Gurtu, D. Brahmbhatt, F. Billia +1 more
2022The Journal of Heart and Lung Transplantation0 citations
Semantic Scholar
LINKS BETWEEN CORONARY MICROVASCULAR DYSFUNCTION AND EVIDENCE OF HEART FAILURE WITH PRESERVED EJECTIVE FRACTION
J. Park, S. Miner, V. Gurtu, F. Valle +1 more
2022Canadian Journal of Cardiology0 citations Open access
Semantic Scholar
MILD PULMONARY HYPERTENSION IN ADVANCED HEART FAILURE PATIENTS IS ASSOCIATED WITH BOTH ABNORMAL RESISTIVE AND PULSATILE LOAD AND LOWER 3-YEAR SURVIVAL
V. Gurtu, E. Karvasarski, J. Vishram-Nielsen, A. Alba +2 more
2021Canadian Journal of Cardiology0 citations
Semantic Scholar
THE ROLE OF PROVOCATIVE TESTING DURING HEMODYNAMIC ASSESSMENT TO IMPROVE PULMONARY HYPERTENSION DIAGNOSIS IN OLDER ADULTS
S. Kolker, N. Girdharry, F. Valle, V. Gurtu +2 more
2021Canadian Journal of Cardiology0 citations
Semantic Scholar
Abstract 17443: Targeting Pyruvate Dehydrogenase Kinase With Dichloroacetate in Pulmonary Arterial Hypertension: A Variable Clinical Response Driven by Genetic Polymorphisms in Sirtuin-3 and Uncoupling Protein-2
V. Gurtu, Linda Webster, A. Kinnaird, Aristeidis E. Boukouris +5 more
20170 citations
Semantic Scholar
Abstract 18017: Metabolic Modulation as a Novel Therapy for Chemotherapy-Induced Cardiotoxicity
Bruno Saleme, V. Gurtu, A. Kinnaird, Aristeidis E. Boukouris +3 more
20170 citations
Semantic Scholar
THE VON HIPPEL LINDAU (VHL) TUMOR SUPPRESSOR INHIBITS P53 TARGET GENE EXPRESSION TO PROMOTE APOPTOSIS‐RESISTANCE IN CANCER: MP60‐14
A. Kinnaird, P. Dromparis, Aristeidis E. Boukouris, V. Gurtu +4 more
20170 citations
Semantic Scholar
MP85-01 MYOCYTE ENHANCER FACTOR 2A (MEF2A) IS UP-REGULATED IN CLEAR CELL RENAL CELL CARCINOMA
A. Kinnaird, Bruno Saleme, V. Gurtu, Sotirios D. Zervopoulos +6 more
20160 citations Open access
Semantic Scholar
Abstract 17922: Scleroderma Associated Pulmonary Arterial Hypertension is Associated With a High Prevalence of Aortic Stenosis
V. Gurtu, A. Kinnaird, Linda Webster, E. Michelakis
20160 citations
Semantic Scholar
Abstract 17957: Obesity From Leptin Receptor Deficiency Provides Resistance to the Development of Pulmonary Hypertension
V. Gurtu, A. Kinnaird, S. Proctor, G. Sutendra +1 more
20160 citations
Semantic Scholar
Abstract 19353: Prohibitin: A Potential Circulating Mitokine That May be Involved in Pulmonary Arterial Hypertension
R. Paulin, A. Kinnaird, Aristeidis E. Boukouris, V. Gurtu +2 more
2015Circulation0 citations
Semantic Scholar
Abstract 18488: Metabolic Modulation of the Diseased Human Lung; A Translational, Novel ex vivo Lung Perfusion Model
V. Gurtu, A. Kinnaird, Christopher White, R. Paulin +3 more
2015Circulation0 citations
Semantic Scholar
Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy?
R. Paulin, Heng-Jia Zang, Aristeidis E. Boukouris, V. Gurtu +2 more
2015Circulation0 citations
Semantic Scholar
Abstract 18991: A Mir-208-mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension
R. Paulin, G. Sutendra, V. Gurtu, P. Dromparis +1 more
2013Circulation0 citations
Semantic Scholar
Abstract 18830: Mitochondrial Suppression Due to Loss of Sirt3 Deacetylase Activity Causes Pulmonary Arterial Hypertension
R. Paulin, P. Dromparis, G. Sutendra, V. Gurtu +7 more
2013Circulation0 citations
Semantic Scholar
Abstract 17011: Loss-of-function SIRT3 Single Nucleotide Polymorphisms in Patients With Pulmonary Arterial Hypertension (PAH): Insights into the Metabolic Basis of PAH
V. Gurtu, R. Paulin, Linda Webster, I. Paterson +3 more
20130 citations
Semantic Scholar
Abstract 16947: Initial Brain Natriuretic Peptide Levels, but not Hemodynamics, Predict 5-Year Survival in Patients with Pulmonary Arterial Hypertension
V. Gurtu, L. Morrison, Linda Webster, I. Paterson +1 more
20120 citations
Semantic Scholar
Abstract 976: Hyperpolarized Mitochondria in Right Ventricular Hypertrophy: a Target for Ventricular-Specific Therapies
Jayan Nagendran, V. Gurtu, J. Dyck, D. Ross +2 more
20070 citations
Semantic Scholar
Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility Heart Failure
Jayan Nagendran, S. Archer, D. Soliman, V. Gurtu +9 more
20070 citations
Semantic Scholar

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E. Michelakis×28
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