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M. Mansueto · SciRah

Researcher profile · Semantic Scholar

M. Mansueto

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M. Mansueto — researcher profile on SciRah

h-index: 12
Works: 30
Citations: 399

Most-cited papers

Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication
K. Leigh, Mayuri Sharma, M. Mansueto, A. Boeszoermenyi +5 more
2015Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
Semantic Scholar
Dissecting Therapeutic Resistance to ERK Inhibition
Sharda S. Jha, E. Morris, A. Hruza, M. Mansueto +13 more
2016Molecular Cancer Therapeutics54 citations
Semantic Scholar
A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism
M. Mansueto, Abigail Reens, L. Rakhilina, An Chi +2 more
2019Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
Jian Liu, D. Guiadeen, Arto D Krikorian, Xiaolei Gao +30 more
2016ACS Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
R. Palte, S. E. Schneider, M. Altman, R. Hayes +10 more
2020ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
Jongwon Lim, Elizabeth H Kelley, J. Methot, Hua Zhou +14 more
2016Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.
R. Quiroz, Michael H. Reutershan, S. E. Schneider, D. Sloman +33 more
2021Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry.
Xiu-Juan Wen, Chang Liu, Kiersten Tovar, Patrick J. Curran +13 more
2024Journal of the American Chemical Society16 citations
Semantic Scholar
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
V. Simov, M. Altman, E. Bianchi, Sonia DelRizzo +17 more
2021European journal of medicinal chemistry16 citations
Semantic Scholar
A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions
Han Chen, M. Coseno, Scott B. Ficarro, M. Mansueto +6 more
2016ACS Infectious Diseases14 citations Open access
Semantic Scholar
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Jian Liu, D. Guiadeen, Arto D Krikorian, Xiaolei Gao +31 more
2020Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Discovery of novel BTK inhibitors with carboxylic acids.
Xiaolei Gao, James Wang, Jian Liu, D. Guiadeen +29 more
2017Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Rapid label-free cell-based Approach Membrane Permeability Assay using MALDI-hydrogen-deuterium exchange mass spectrometry for peptides.
A. Makarov, Yuan Jiang, Christopher Sondey, Min-Jia Zhang +8 more
2022Analytica Chimica Acta10 citations
Semantic Scholar
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
S. B. Boga, A. Alhassan, Jian Liu, D. Guiadeen +27 more
2017Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Activation of Hepatocyte Growth Factor/MET Signaling as a Mechanism of Acquired Resistance to a Novel YAP1/TEAD Small Molecule Inhibitor.
Casey J Moure, Brandon A. Vara, Mangeng M Cheng, Christopher Sondey +16 more
2024Molecular Cancer Therapeutics9 citations
Semantic Scholar
Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model
Hai-Yan Xu, E. Muise, Sarah Javaid, Lan Chen +11 more
2019Journal of Cellular and Molecular Medicine9 citations Open access
Semantic Scholar
The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1.
Joanna L Chen, Joey L Methot, M. Mitcheltree, Andrew J. Musacchio +16 more
2025ACS Medicinal Chemistry Letters5 citations
Semantic Scholar
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.
Shuhei Kawamura, R. Palte, Hai-Young Kim, J. Saurí +4 more
2022Bioorganic & Medicinal Chemistry5 citations
Semantic Scholar
High-throughput evaluation of novel WRN inhibitors.
Haiyan Xu, R. Palte, M. Rickard, Soon Woo Kwon +21 more
2025SLAS discovery : advancing life sciences R & D3 citations Open access
Semantic Scholar
Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies.
Brandon A. Vara, Jong-Hwan Lim, Casey J Moure, S. E. Schneider +24 more
2026Journal of Medicinal Chemistry2 citations
Semantic Scholar
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
R. Palte, Mihir Mandal, J. Sikorska, A. Villafania +21 more
2026Nature Communications2 citations Open access
Semantic Scholar
From KRASG12D to Pan-KRAS Inhibitors─A Journey Enabled by Synthetic Innovation and Structure-Based Drug Design.
Xiao-Shen Ma, D. Sloman, Timothy J Henderson, D. J. Bennett +32 more
2026Journal of Medicinal Chemistry1 citations
Semantic Scholar
Discovery of Potent and Selective Benzothiophene Difluoromethyl Phosphonate (DFMP) PTPN2/N1-Dual Inhibitors.
Xiao-Mei Zheng, David Candito, James P. Jewell, M. Childers +48 more
2026Journal of Medicinal Chemistry1 citations
Semantic Scholar
Discovery of an NRAS isoform and activation-state selective macrocyclic peptide
K. Hallenbeck, Yun-Peng Zhou, Hubert Josien, Songnian Lin +14 more
2026bioRxiv0 citations Open access
Semantic Scholar
WRN helicase structural flexibility showcased through fragment-based lead discovery of inhibitors
R. Palte, Mihir Mandal, J. Sikorska, A. Villafania +19 more
2025Structural Dynamics0 citations Open access
Semantic Scholar
Abstract 3938: Discovery of a novel small molecule inhibitor of the YAP1/TAZ-TEAD transcriptional complex
Casey J. Moure, Christopher Sondey, M. Cheng, M. Mansueto +16 more
2022Cancer Research0 citations
Semantic Scholar
Abstract LB-029: Identification of predictive genetic signatures of Cytarabine responsiveness in acute myeloid leukemia using a novel 3D translational culture model of primary bone marrow
Hai-Yan Xu, E. Muise, Sarah Javaid, Lan Chen +11 more
2019Tumor Biology0 citations Open access
Semantic Scholar
Dissecting Therapeutic Resistance to ERK Inhibition Rat Wild Type SCH772984 in complex with (3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)-N-[3-(pyridin-4-yl)-2H-indazol-5-yl]pyrrolidine-3-carboxamide
Sharda S. Jha, E. Morris, A. Hruza, M. Mansueto +13 more
20160 citations
Semantic Scholar
Structure of herpesvirus nuclear egress complex subunit M50
K. Leigh, A. Boeszoermenyi, M. Mansueto, Mayuri Sharma +5 more
20150 citations
Semantic Scholar
Reevaluation of Molecular Mechanisms of Syk Activation
M. Mansueto, R. Miller, L. Rakhilina, Abigail Reens +2 more
20150 citations
Semantic Scholar

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