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Zang-Wei Xu · SciRah

Researcher profile · Semantic Scholar

Zang-Wei Xu

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Zang-Wei Xu — researcher profile on SciRah

h-index: 13
Works: 25
Citations: 480

Most-cited papers

Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening
E. Bobkova, Michael J. Weber, Zang-Wei Xu, Yan-Ling Zhang +6 more
2010Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells
K. Nagashima, S. Shumway, S. Sathyanarayanan, A. Chen +25 more
2010Journal of Biological Chemistry48 citations Open access
Semantic Scholar
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor.
Xiao-Shen Ma, D. Sloman, Ruchia Duggal, Kenneth D. Anderson +24 more
2024Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Brandon A. Vara, Samuel M. Levi, Abdelghani Achab, D. Candito +16 more
2021ACS Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
Jian Liu, D. Guiadeen, Arto D Krikorian, Xiaolei Gao +30 more
2016ACS Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
R. Palte, S. E. Schneider, M. Altman, R. Hayes +10 more
2020ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
Yun Wang, Kelvin Zhang, Peter Georgiev, Steven Wells +9 more
2020PLoS ONE31 citations Open access
Semantic Scholar
Identification of Direct Target Engagement Biomarkers for Kinase-Targeted Therapeutics
C. Paweletz, J. Andersen, R. Pollock, K. Nagashima +9 more
2011PLoS ONE30 citations Open access
Semantic Scholar
Identification of Potent Reverse Indazole Inhibitors for HPK1.
Elsie C. Yu, J. Methot, X. Fradera, C. Lesburg +11 more
2021ACS Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
A new subdivision of mammalian neostriatum with functional implications to learning and memory
S. Shu, Xin-min Bao, Sheng-Xiu Li, D. Niu +2 more
1999Journal of Neuroscience Research28 citations
Semantic Scholar
Development of High-Throughput TR-FRET and AlphaScreen® Assays for Identification of Potent Inhibitors of PDK1
Zang-Wei Xu, K. Nagashima, Dong-Yu Sun, T. Rush +4 more
2009Journal of biomolecular screening26 citations Open access
Semantic Scholar
Integration of Affinity Selection–Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway
V. Kutilek, C. Andrews, M. Richards, Zang-Wei Xu +25 more
2016Journal of biomolecular screening22 citations Open access
Semantic Scholar
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Brian M. Lacey, Zang-Wei Xu, X. Chai, J. Laskey +24 more
2020SLAS discovery : advancing life sciences R & D21 citations Open access
Semantic Scholar
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Jian Liu, D. Guiadeen, Arto D Krikorian, Xiaolei Gao +31 more
2020Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Discovery of novel BTK inhibitors with carboxylic acids.
Xiaolei Gao, James Wang, Jian Liu, D. Guiadeen +29 more
2017Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
S. B. Boga, A. Alhassan, Jian Liu, D. Guiadeen +27 more
2017Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
The spatial and temporal expression of HNK-1 by myogenic and skeletogenic cells in the embryonic rat
P. Bannerman, T. Oliver, W. L. Nichols, Zang-Wei Xu
1998Cell and Tissue Research7 citations
Semantic Scholar
Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.
Dong-Yu Sun, Joon Jung, T. Rush, Zang-Wei Xu +4 more
2010Combinatorial chemistry & high throughput screening6 citations
Semantic Scholar
Discovery of Potent and Selective Benzothiophene Difluoromethyl Phosphonate (DFMP) PTPN2/N1-Dual Inhibitors.
Xiao-Mei Zheng, David Candito, James P. Jewell, M. Childers +48 more
2026Journal of Medicinal Chemistry1 citations
Semantic Scholar
Functional antagonism of IL-1α induced gene expression profiles define the cAMP/PKA pathway as a unique regulator of IL-1α signaling networks
David L. Murray, Eric N. Johnson, Ping Wang, J. Gauthier +7 more
2009Journal of Receptor and Signal Transduction Research1 citations
Semantic Scholar
Discovery of Novel Oral Covalent Inhibitors Targeting Active GTP-Bound KRASG12C with Potent Antitumor Activity
Juan del Pozo, Elisabeth T. Hennessy, Patrick Schoepf, Kazuaki Shibata +39 more
2026Journal of Medicinal Chemistry0 citations
Semantic Scholar
Abstract 2097: ABT co-dose accelerated target validation with a fit-for-purpose HPK1 inhibitor tool
Joey L Methot, Joanna L Chen, Elsie Yu, Ryan D. Otte +7 more
2024Cancer Research0 citations
Semantic Scholar
Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines
K. Nagashima, S. Shumway, S. Sathyanarayanan, A. Chen +24 more
20100 citations
Semantic Scholar
Pathway‐specific regulation of IL‐1 stimulated gene changes in human lung fibroblasts: cAMP defines a unique pattern of functional antagonism
D. Murray, Nan Bing, Kejun Liu, P. Wang +8 more
20060 citations
Semantic Scholar
Characterization of T-cell phenotypes important as disease progression markers in HIV-1 infected adolescents
Zang-Wei Xu
0 citations Open access
Semantic Scholar

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Brian M. Lacey×7
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Brian M. Lacey — researcher profile on SciRah
E. Bobkova×6
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E. Bobkova — researcher profile on SciRah
Alan B. Northrup×6
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Alan B. Northrup — researcher profile on SciRah
M. Mansueto×6
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J. Andersen — researcher profile on SciRah

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I. Kariv — researcher profile on SciRah

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Hai-Yan Xu — researcher profile on SciRah

A. Pasternak×5

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P. Blume-Jensen×4

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P. Blume-Jensen — researcher profile on SciRah

K. Nagashima×4

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K. Nagashima — researcher profile on SciRah

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X. Fradera — researcher profile on SciRah

Shuhei Kawamura×4

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Shuhei Kawamura — researcher profile on SciRah