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S. R. Nahorski · SciRah

Researcher profile · Semantic Scholar

S. R. Nahorski

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S. R. Nahorski — researcher profile on SciRah

h-index: 60
Works: 400
Citations: 13K

Most-cited papers

Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells*
G. Willars, S. R. Nahorski, R. A. John Challiss
1998Journal of Biological Chemistry187 citations Open access
Semantic Scholar
Intracellular signalling: Receptor-specific messenger oscillations
M. Nash, K. W. Young, R. A. John Challiss, S. R. Nahorski
2001Nature141 citations
Semantic Scholar
Non-visual GRKs: are we seeing the whole picture?
J. Willets, R. A. John Challiss, S. R. Nahorski
2003TIPS - Trends in Pharmacological Sciences132 citations
Semantic Scholar
The muscarinic M5 receptor: a silent or emerging subtype?
R. Eglen, S. R. Nahorski
2000British Journal of Pharmacology126 citations Open access
Semantic Scholar
Determinants of Metabotropic Glutamate Receptor-5-mediated Ca2+ and Inositol 1,4,5-Trisphosphate Oscillation Frequency
M. Nash, M. Schell, P. Atkinson, N. Johnston +2 more
2002Journal of Biological Chemistry109 citations Open access
Semantic Scholar
Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization*
G. Willars, A. Heding, M. Vrecl, R. Sellar +3 more
1999Journal of Biological Chemistry109 citations Open access
Semantic Scholar
New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.
R. A. Wilcox, W. Primrose, S. R. Nahorski, R. A. John Challiss
1998TIPS - Trends in Pharmacological Sciences109 citations
Semantic Scholar
Gq/11 and Gi/o activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor‐subtype
E. Akam, R. A. John Challiss, S. R. Nahorski
2001British Journal of Pharmacology105 citations Open access
Semantic Scholar
Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.
M. Nash, K. W. Young, G. Willars, R. A. John Challiss +1 more
2001Biochemical Journal72 citations Open access
Semantic Scholar
Rapid Down-regulation of the Type I Inositol 1,4,5-Trisphosphate Receptor and Desensitization of Gonadotropin-releasing Hormone-mediated Ca2+ Responses in αT3–1 Gonadotropes*
G. Willars, Jean E. Royall, S. R. Nahorski, F. El-Gehani +2 more
2001Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Lysophosphatidic Acid-induced Ca2+ Mobilization Requires Intracellular Sphingosine 1-Phosphate Production
K. W. Young, M. Bootman, D. Channing, P. Lipp +4 more
2000Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Modulation of Gq protein-coupled IP3 and Ca2+ signaling by the membrane potential
D. Billups, B. Billups, R. A. John Challiss, S. R. Nahorski
2006Journal of Neuroscience66 citations Open access
Semantic Scholar
Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.
K. W. Young, J. Willets, Mikako Parkinson, Paula J. Bartlett +3 more
2003Cell Calcium64 citations
Semantic Scholar
Role of Ca2+ Feedback on Single Cell Inositol 1,4,5-Trisphosphate Oscillations Mediated by G-protein-coupled Receptors*
K. W. Young, M. Nash, R. A. John Challiss, S. R. Nahorski
2003Journal of Biological Chemistry64 citations Open access
Semantic Scholar
Differential expression and regulation of ryanodine receptor and myo-inositol 1,4,5-trisphosphate receptor Ca2+ release channels in mammalian tissues and cell lines.
J. Mackrill, R. A. John Challiss, D. O'Connell, F. Lai +1 more
1997Biochemical Journal64 citations Open access
Semantic Scholar
Single Cell Analysis and Temporal Profiling of Agonist-mediated Inositol 1,4,5-Trisphosphate, Ca2+, Diacylglycerol, and Protein Kinase C Signaling using Fluorescent Biosensors*
Paula J. Bartlett, K. W. Young, S. R. Nahorski, R. A. John Challiss
2005Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Functional Selectivity of Muscarinic Receptor Antagonists for Inhibition of M3-Mediated Phosphoinositide Responses in Guinea Pig Urinary Bladder and Submandibular Salivary Gland
C. Nelson, Paul Gupta, C. Napier, S. R. Nahorski +1 more
2004Journal of Pharmacology and Experimental Therapeutics60 citations
Semantic Scholar
Effects of varying the expression level of recombinant human mGlu1α receptors on the pharmacological properties of agonists and antagonists
E. Hermans, R. A. John Challiss, S. R. Nahorski
1999British Journal of Pharmacology60 citations Open access
Semantic Scholar
Visualizing phosphoinositide signalling in single neurons gets a green light.
S. R. Nahorski, K. W. Young, R. A. John Challiss, M. Nash
2003Trends in Neurosciences57 citations
Semantic Scholar
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells*
J. Willets, R. A. John Challiss, S. R. Nahorski
2002Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Reassessment of the Ca2+ Sensing Property of a Type I Metabotropic Glutamate Receptor by Simultaneous Measurement of Inositol 1,4,5-Trisphosphate and Ca2+ in Single Cells*
M. Nash, R. Saunders, K. W. Young, R. A. John Challiss +1 more
2001Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor
E. Hermans, S. R. Nahorski, R. Challiss
199853 citations
Semantic Scholar
G protein-coupled receptor kinases 3 and 6 use different pathways to desensitize the endogenous M3 muscarinic acetylcholine receptor in human SH-SY5Y cells.
J. Willets, R. A. John Challiss, Eamonn Kelly, S. R. Nahorski
2001Molecular Pharmacology50 citations
Semantic Scholar
A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.
R. Saunders, S. R. Nahorski, R. A. John Challiss
1998Neuropharmacology48 citations
Semantic Scholar
Imaging of Muscarinic Acetylcholine Receptor Signaling in Hippocampal Neurons: Evidence for Phosphorylation-Dependent and -Independent Regulation by G-Protein-Coupled Receptor Kinases
J. Willets, M. Nash, R. A. John Challiss, S. R. Nahorski
2004Journal of Neuroscience47 citations Open access
Semantic Scholar
Sphingosine 1-phosphate: a Ca2+ release mediator in the balance.
K. W. Young, S. R. Nahorski
2002Cell Calcium47 citations
Semantic Scholar
Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitization.
G. Willars, C. McArdle, S. R. Nahorski
1998Biochemical Journal47 citations Open access
Semantic Scholar
Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling.
J. Willets, R. Mistry, S. R. Nahorski, R. A. John Challiss
2003Molecular Pharmacology45 citations
Semantic Scholar
Roles of Phosphorylation-dependent and -independent Mechanisms in the Regulation of M1 Muscarinic Acetylcholine Receptors by G Protein-coupled Receptor Kinase 2 in Hippocampal Neurons*
J. Willets, S. R. Nahorski, R. A. John Challiss
2005Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Cell type-specific differences in the coupling of recombinant mGlu1α receptors to endogenous G protein sub-populations
J. Selkirk, G. W. Price, S. R. Nahorski, R. A. John Challiss
200141 citations
Semantic Scholar
Muscarinic M3 receptor coupling and regulation.
S. R. Nahorski, Andrew B. Tobin, G. Willars
1997Life Science40 citations
Semantic Scholar
Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells
Elizabeth M. Rosethorne, S. R. Nahorski, R. A. John Challiss
2008Biochemical Pharmacology38 citations Open access
Semantic Scholar
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation.
K. W. Young, R. A. John Challiss, S. R. Nahorski, J. Mackrill
1999Biochemical Journal36 citations Open access
Semantic Scholar
Synaptic Activity Augments Muscarinic Acetylcholine Receptor-stimulated Inositol 1,4,5-Trisphosphate Production to Facilitate Ca2+ Release in Hippocampal Neurons*
M. Nash, J. Willets, B. Billups, R. A. John Challiss +1 more
2004Journal of Biological Chemistry34 citations Open access
Semantic Scholar
Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors
M. Waugh, R. A. John Challiss, G. Berstein, S. R. Nahorski +1 more
199934 citations Open access
Semantic Scholar
Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium‐dependence of the phospholipase C response
R. Masgrau, J. Servitja, K. W. Young, Raúl Pardo +3 more
2001European Journal of Neuroscience33 citations
Semantic Scholar
Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release.
K. W. Young, S. R. Nahorski
2001Seminars in Cell and Developmental Biology33 citations
Semantic Scholar
Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.
G. Willars, W. Müller-Esterl, S. R. Nahorski
1999American Journal of Physiology33 citations
Semantic Scholar
Constitutive Activity and Inverse Agonism at the M2 Muscarinic Acetylcholine Receptor
Carl P. Nelson, S. R. Nahorski, R. A. John Challiss
2006Journal of Pharmacology and Experimental Therapeutics32 citations
Semantic Scholar
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons1
Carl P. Nelson, S. R. Nahorski, R. A. John Challiss
2008Journal of Neurochemistry31 citations Open access
Semantic Scholar
Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors.
M. Waugh, R. A. John Challiss, G. Berstein, S. R. Nahorski +1 more
1999Biochemical Journal30 citations Open access
Semantic Scholar
Altered Expression of Gq/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca2+ Signaling
P. Atkinson, K. W. Young, S. Ennion, J. Kew +2 more
2006Molecular Pharmacology27 citations
Semantic Scholar
NMDA‐receptor regulation of muscarinic‐receptor stimulated inositol 1,4,5‐trisphosphate production and protein kinase C activation in single cerebellar granule neurons
K. W. Young, M. Garro, R. A. John Challiss, S. R. Nahorski
2004Journal of Neurochemistry27 citations Open access
Semantic Scholar
Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+ - and protein kinase C-dependent pathway.
H. Warwick, S. R. Nahorski, R. A. John Challiss
2005Journal of Neurochemistry26 citations
Semantic Scholar
Effects of Human Type 1α Metabotropic Glutamate Receptor Expression Level on Phosphoinositide and Ca2+ Signalling in an Inducible Cell Expression System
E. Hermans, K. W. Young, R. Challiss, S. R. Nahorski
1998Journal of Neurochemistry26 citations
Semantic Scholar
Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling.
P. Atkinson, K. W. Young, S. Ennion, J. Kew +2 more
2006Molecular Pharmacology25 citations
Semantic Scholar
Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion.
K. W. Young, D. Billups, Carl P. Nelson, N. Johnston +4 more
2005Molecular and cellular neurosciences25 citations
Semantic Scholar
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation
K. W. Young, R. A. John Challiss, S. R. Nahorski, J. Mackrill
199925 citations Open access
Semantic Scholar
Role of Ca 2 Feedback on Single Cell Inositol 1 , 4 , 5-Trisphosphate Oscillations Mediated by G-protein-coupled Receptors *
K. W. Young, M. Nash, R. A. John Challiss, S. R. Nahorski
200324 citations
Semantic Scholar
Homologous and heterologous uncoupling of muscarinic M3 and α1B adrenoceptors to Gαq/11 in SH‐SY5Y human neuroblastoma cells
R. A. Bundey, S. R. Nahorski
200124 citations Open access
Semantic Scholar

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R. A. John Challiss×38
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R. A. John Challiss — researcher profile on SciRah
K. W. Young×19
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K. W. Young — researcher profile on SciRah
M. Nash×9
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M. Nash — researcher profile on SciRah
J. Willets×9
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J. Willets — researcher profile on SciRah

×7

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G. Willars — researcher profile on SciRah

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P. Atkinson — researcher profile on SciRah

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J. Mackrill — researcher profile on SciRah

Carl P. Nelson×3

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Carl P. Nelson — researcher profile on SciRah

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M. Schell — researcher profile on SciRah

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N. Johnston — researcher profile on SciRah

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C. McArdle — researcher profile on SciRah

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D. Billups — researcher profile on SciRah