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J. Servitja · SciRah

Researcher profile · Semantic Scholar

J. Servitja

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J. Servitja — researcher profile on SciRah

h-index: 26
Works: 60
Citations: 2,717

Most-cited papers

Transcriptional networks controlling pancreatic development and beta cell function
J. Servitja, J. Ferrer
2004Diabetologia224 citations Open access
Semantic Scholar
Rac1 Function Is Required for Src-induced Transformation
J. Servitja, M. Marinissen, Akrit Sodhi, X. Bustelo +1 more
2003Journal of Biological Chemistry182 citations Open access
Semantic Scholar
Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
M. Maestro, S. Boj, R. Luco, C. Pierreux +6 more
2003Human Molecular Genetics166 citations
Semantic Scholar
Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention.
M. Párrizas, L. Brugnara, Y. Esteban, A. Gonzalez-Franquesa +8 more
2015Journal of Clinical Endocrinology and Metabolism160 citations
Semantic Scholar
Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver
J. Servitja, M. Pignatelli, M. Maestro, C. Cardalda +8 more
2009Molecular and Cellular Biology142 citations Open access
Semantic Scholar
Potent Activation of RhoA by Gαq and Gq-coupled Receptors*
H. Chikumi, J. Vázquez-Prado, J. Servitja, H. Miyazaki +1 more
2002Journal of Biological Chemistry137 citations Open access
Semantic Scholar
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Sara Ramírez, Alicia G. Gómez-Valadés, Marc Schneeberger, L. Varela +22 more
2017Cell Metabolism128 citations Open access
Semantic Scholar
Regulation of p73 by c-Abl through the p38 MAP kinase pathway
R. Sánchez-Prieto, Victor Javier Sanchez-Arevalo, J. Servitja, J. Gutkind
2002Oncogene114 citations Open access
Semantic Scholar
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.
S. Montaner, Akrit Sodhi, J. Servitja, Amanda K. Ramsdell +3 more
2004Blood110 citations
Semantic Scholar
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation*
M. Marinissen, J. Servitja, S. Offermanns, Melvin I. Simon +1 more
2003Journal of Biological Chemistry109 citations Open access
Semantic Scholar
Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.
M. Maestro, C. Cardalda, S. Boj, R. Luco +2 more
2007Endocrine Development101 citations
Semantic Scholar
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.
V. Patel, Hans M. Rosenfeldt, Ruth Lyons, J. Servitja +3 more
2007Carcinogenesis100 citations Open access
Semantic Scholar
Distinct Roles of HNF1 Β , HNF1 α , and HNF4 α in Regulating Pancreas Development, Β -Cell Function and Growth
M. Maestro, C. Cardalda, S. Boj, R. Luco +2 more
200792 citations
Semantic Scholar
Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression
Lisa Cadavez, J. Montané, G. Alcarraz‐Vizán, M. Visa +3 more
2014PLoS ONE75 citations Open access
Semantic Scholar
Nurr1 Protein Is Required for N-Methyl-d-aspartic Acid (NMDA) Receptor-mediated Neuronal Survival*
B. Barneda-Zahonero, J. Servitja, N. Badiola, A. J. Miñano-Molina +3 more
2012Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring.
M. García-Arévalo, P. Alonso-Magdalena, J. Servitja, T. Boronat-Belda +6 more
2016Endocrinology66 citations Open access
Semantic Scholar
Effects of Oxidative Stress on Phospholipid Signaling in Rat Cultured Astrocytes and Brain Slices
J. Servitja, R. Masgrau, Raúl Pardo, E. Sarri +1 more
2000Journal of Neurochemistry53 citations
Semantic Scholar
Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis
X. Molero, E. Vaquero, M. Flández, A. González +10 more
2011Gut49 citations
Semantic Scholar
Group I Metabotropic Glutamate Receptors Mediate Phospholipase D Stimulation in Rat Cultured Astrocytes
J. Servitja, R. Masgrau, E. Sarri, F. Picatoste
1999Journal of Neurochemistry48 citations Open access
Semantic Scholar
Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth
Júlia Rodríguez-Comas, Alba Moreno-Asso, J. Moreno-Vedia, Mercè Martín +9 more
2017Diabetes43 citations
Semantic Scholar
The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity
J. Mellado-Gil, E. Fuente-Martín, Petra I. Lorenzo, N. Cobo-Vuilleumier +18 more
2018Cell Death and Disease42 citations Open access
Semantic Scholar
In Situ LSPR Sensing of Secreted Insulin in Organ-on-Chip
M. A. Ortega, Júlia Rodríguez‐Comas, Ozlem Yavas, Ferran Velasco-Mallorquí +6 more
2021Biosensors37 citations Open access
Semantic Scholar
Islet amyloid polypeptide exerts a novel autocrine action in β‐cell signaling and proliferation
M. Visa, G. Alcarraz‐Vizán, J. Montané, Lisa Cadavez +4 more
2015The FASEB Journal35 citations
Semantic Scholar
Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium‐dependence of the phospholipase C response
R. Masgrau, J. Servitja, K. W. Young, Raúl Pardo +3 more
2001European Journal of Neuroscience33 citations
Semantic Scholar
Amyloid‐induced β‐cell dysfunction and islet inflammation are ameliorated by 4‐phenylbutyrate (PBA) treatment
J. Montané, Sara Pablo, Carlos Castaño, Júlia Rodríguez-Comas +9 more
2017The FASEB Journal29 citations Open access
Semantic Scholar
Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
S. Boj, J. Servitja, David Martin, Martín Ríos +3 more
2009Diabetes27 citations Open access
Semantic Scholar
High Intensity Interval Training reduces hypoglycemic events compared with continuous aerobic training in individuals with type 1 diabetes: HIIT and hypoglycemia in type 1 diabetes.
Serafin Murillo García, L. Brugnara, J. Servitja, A. Sarda
2022Diabetes & Metabolism26 citations
Semantic Scholar
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
J. Servitja, R. Masgrau, Raúl Pardo, E. Sarri +3 more
2003Neuropharmacology26 citations
Semantic Scholar
Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing
Alba Moreno-Asso, Carlos Castaño, A. Grilli, A. Novials +1 more
2013Diabetologia25 citations Open access
Semantic Scholar
Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction
Júlia Rodríguez-Comas, J. Moreno-Vedia, M. Obach, Carlos Castaño +8 more
2020Molecular Metabolism22 citations Open access
Semantic Scholar
Thyroid hormones promote endocrine differentiation at expenses of exocrine tissue.
V. Aïello, Alba Moreno-Asso, J. Servitja, Mercè Martín
2014Experimental Cell Research22 citations
Semantic Scholar
Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes
J. Servitja, R. Masgrau, E. Sarri, F. Picatoste
199822 citations Open access
Semantic Scholar
BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression
G. Alcarraz‐Vizán, Carlos Castaño, M. Visa, J. Montané +2 more
2017Cellular and Molecular Life Sciences21 citations Open access
Semantic Scholar
Protein disulfide isomerase ameliorates β-cell dysfunction in pancreatic islets overexpressing human islet amyloid polypeptide.
J. Montané, Sara de Pablo, M. Obach, Lisa Cadavez +7 more
2016Molecular and Cellular Endocrinology19 citations
Semantic Scholar
Inhibition of BACE2 counteracts hIAPP‐induced insulin secretory defects in pancreatic β‐cells
G. Alcarraz‐Vizán, P. Casini, Lisa Cadavez, M. Visa +3 more
2015The FASEB Journal19 citations
Semantic Scholar
Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors
Marta Fontcuberta-PiSunyer, Ainhoa García-Alamán, Èlia Prades, Noèlia Téllez +16 more
2023Communications Biology16 citations Open access
Semantic Scholar
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity
Sara de Pablo, Júlia Rodríguez-Comas, Daniela Díaz-Catalãn, G. Alcarraz‐Vizán +6 more
2021Scientific Reports14 citations Open access
Semantic Scholar
Late-stage differentiation of embryonic pancreatic β-cells requires Jarid2
Sara Cervantes, Marta Fontcuberta-PiSunyer, J. Servitja, Rebeca Fernández-Ruiz +5 more
2017Scientific Reports14 citations Open access
Semantic Scholar
Intracellular Ca2+ Stores Regulate Muscarinic Receptor Stimulation of Phospholipase C in Cerebellar Granule Cells
R. Masgrau, J. Servitja, E. Sarri, K. W. Young +2 more
2000Journal of Neurochemistry14 citations Open access
Semantic Scholar
EuroDia: a beta-cell gene expression resource
R. Liechti, G. Csárdi, Sven Bergmann, Frédéric Schütz +17 more
2010Database J. Biol. Databases Curation12 citations Open access
Semantic Scholar
Two phosphatidylethanol classes separated by thin layer chromatography are produced by phospholipase D in rat brain hippocampal slices
E. Sarri, J. Servitja, F. Picatoste, E. Claro
1996FEBS Letters10 citations
Semantic Scholar
ChemEmbed: a deep learning framework for metabolite identification using enhanced MS/MS data and multidimensional molecular embeddings
Muhammad Faizan-Khan, Roger Giné, Josep M. Badia, Maribel Pérez-Ribera +14 more
2026Briefings in Bioinformatics9 citations Open access
Semantic Scholar
Retinoic acid-induced differentiation into astrocytes and glutamatergic neurons is associated with expression of functional and activable phospholipase D.
M. Rujano, Pilar Pina, J. Servitja, A. Ahumada +3 more
2004Biochemical and Biophysical Research Communications - BBRC8 citations
Semantic Scholar
BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
Daniela Díaz-Catalãn, G. Alcarraz‐Vizán, Carlos Castaño, Sara de Pablo +8 more
2021Molecular Metabolism7 citations Open access
Semantic Scholar
Involvement of ET(A) and ET(B) receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
J. Servitja, R. Masgrau, E. Sarri, F. Picatoste
1998British Journal of Pharmacology7 citations
Semantic Scholar
Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice.
Vicent Ribas, S. Morón-Ros, Helena Mari, Albert Gracia-Batllori +7 more
2025American Journal of Physiology - Cell Physiology6 citations Open access
Semantic Scholar
People with type 1 diabetes exhibit lower exercise capacity compared to a control population with similar physical activity levels.
S. Murillo, L. Brugnara, Santiago Ríos, Vicent Ribas +2 more
2024Diabetes Research and Clinical Practice5 citations Open access
Semantic Scholar
Ammonium quantification in human plasma by proton nuclear magnetic resonance for staging of liver fibrosis in alcohol‐related liver disease and nonalcoholic fatty liver disease
M. Azagra, Elisa Pose, F. De Chiara, Martina Pérez +5 more
2022NMR in Biomedicine5 citations Open access
Semantic Scholar
Putting pancreatic cell plasticity to the test.
J. Ferrer, Mercè Martín, J. Servitja
2007Journal of Clinical Investigation5 citations Open access
Semantic Scholar
Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics.
Saik Ann Ooi, Dylan Valli, Mikołaj I Kuska, Helena Mari +7 more
2025Journal of Molecular Biology3 citations Open access
Semantic Scholar

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Carlos Castaño

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