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E. Pękala · SciRah

Researcher profile · Semantic Scholar

E. Pękala

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E. Pękala — researcher profile on SciRah

h-index: 27
Works: 167
Citations: 2,685

Most-cited papers

Cinnamic acid derivatives in cosmetics: current use and future prospects
Agnieszka Gunia-Krzyżak, K. Słoczyńska, Justyna Popiół, Paulina Koczurkiewicz +2 more
2018International Journal of Cosmetic Science152 citations Open access
Semantic Scholar
Fibroblast-to-myofibroblast transition in bronchial asthma
M. Michalik, K. Wójcik-Pszczoła, M. Paw, D. Wnuk +4 more
2018Cellular and Molecular Life Sciences146 citations Open access
Semantic Scholar
Metabolic stability and its role in the discovery of new chemical entities
K. Słoczyńska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, K. Wójcik-Pszczoła +3 more
2019Acta Pharmaceutica127 citations Open access
Semantic Scholar
Piperlongumine (piplartine) as a lead compound for anticancer agents - Synthesis and properties of analogues: A mini-review.
K. Piska, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz, K. Wójcik-Pszczoła +1 more
2018European journal of medicinal chemistry121 citations Open access
Semantic Scholar
Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents
K. Piska, Paulina Koczurkiewicz, Adam Bucki, K. Wójcik-Pszczoła +2 more
2017Investigational new drugs61 citations Open access
Semantic Scholar
Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer
Bartosz Gąsiorkiewicz, P. Koczurkiewicz-Adamczyk, K. Piska, E. Pękala
2020Investigational new drugs59 citations Open access
Semantic Scholar
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
K. Wójcik-Pszczoła, G. Chłoń-Rzepa, A. Jankowska, M. Ślusarczyk +8 more
2020International Journal of Molecular Sciences51 citations Open access
Semantic Scholar
Novel non-sulfonamide 5-HT6 receptor partial inverse agonist in a group of imidazo[4,5-b]pyridines with cognition enhancing properties.
David Vanda, Miroslav Soural, Vittorio Canale, Séverine Chaumont-Dubel +11 more
2018European journal of medicinal chemistry42 citations Open access
Semantic Scholar
Saponins as chemosensitizing substances that improve effectiveness and selectivity of anticancer drug—Minireview of in vitro studies
Paulina Koczurkiewicz, Katarzyna Klaś, K. Grabowska, K. Piska +6 more
2019Phytotherapy Research40 citations Open access
Semantic Scholar
Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.
K. Piska, Paulina Koczurkiewicz, D. Wnuk, E. Karnas +6 more
2019Chemico-Biological Interactions39 citations Open access
Semantic Scholar
Antidepressant pharmaceuticals in aquatic systems, individual-level ecotoxicological effects: growth, survival and behavior.
K. Słoczyńska, J. Orzeł, A. Murzyn, Justyna Popiół +3 more
2023Aquatic Toxicology29 citations Open access
Semantic Scholar
Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases
A. Fijałkowska, B. Muszyńska, K. Sułkowska-Ziaja, K. Kała +8 more
2020Scientific Reports29 citations Open access
Semantic Scholar
A Comparative Survey of Anti-Melanoma and Anti-Inflammatory Potential of Usnic Acid Enantiomers—A Comprehensive In Vitro Approach
Agnieszka Galanty, P. Zagrodzki, J. Gdula-Argasińska, K. Grabowska +5 more
2021Pharmaceuticals28 citations Open access
Semantic Scholar
Two new triterpenoid saponins from the leaves of Impatiens parviflora DC. and their cytotoxic activity
K. Grabowska, I. Podolak, A. Galanty, P. Żmudzki +4 more
201728 citations Open access
Semantic Scholar
Dual 5-HT6 and D3 Receptor Antagonists in a Group of 1 H-Pyrrolo[3,2- c]quinolines with Neuroprotective and Procognitive Activity.
Katarzyna Grychowska, Séverine Chaumont-Dubel, R. Kurczab, Paulina Koczurkiewicz +14 more
2019ACS Chemical Neuroscience26 citations Open access
Semantic Scholar
Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells - involvement of carbonyl reductase 1.
P. Koczurkiewicz-Adamczyk, K. Piska, Agnieszka Gunia-Krzyżak, Adam Bucki +8 more
2020European Journal of Pharmaceutical Sciences25 citations Open access
Semantic Scholar
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3.
Agnieszka Gunia-Krzyżak, D. Żelaszczyk, A. Rapacz, Ewa Żesławska +7 more
2017Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin
P. Koczurkiewicz-Adamczyk, Katarzyna Klaś, Agnieszka Gunia-Krzyżak, K. Piska +7 more
2021International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
A dual-acting 5-HT6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.
Vittorio Canale, Katarzyna Grychowska, R. Kurczab, Mateusz Ryng +16 more
2020European journal of medicinal chemistry23 citations Open access
Semantic Scholar
Usnic acid reactive metabolites formation in human, rat, and mice microsomes. Implication for hepatotoxicity.
K. Piska, A. Galanty, Paulina Koczurkiewicz, P. Żmudzki +3 more
2018Food and Chemical Toxicology23 citations Open access
Semantic Scholar
1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity
Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, P. Koczurkiewicz-Adamczyk +9 more
2022Biomolecules21 citations Open access
Semantic Scholar
(+)-Usnic Acid as a Promising Candidate for a Safe and Stable Topical Photoprotective Agent
Agnieszka Galanty, Justyna Popiół, Magdalena Paczkowska-Walendowska, E. Studzińska-Sroka +4 more
2021Molecules21 citations Open access
Semantic Scholar
3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.
Monika A. Marcinkowska, M. Kołaczkowski, K. Kamiński, Adam Bucki +10 more
2017ACS Chemical Neuroscience21 citations Open access
Semantic Scholar
The Involvement of Xanthone and (E)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents
Justyna Popiół, Agnieszka Gunia-Krzyżak, K. Słoczyńska, P. Koczurkiewicz-Adamczyk +7 more
2020International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Antiallodynic and antihyperalgesic activity of new 3,3‐diphenyl‐propionamides with anticonvulsant activity in models of pain in mice
A. Rapacz, J. Obniska, Paulina Koczurkiewicz, K. Wójcik-Pszczoła +6 more
2018European Journal of Pharmacology19 citations Open access
Semantic Scholar
Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties
A. Waszkielewicz, K. Słoczyńska, E. Pękala, P. Żmudzki +3 more
2017Chemical Biology and Drug Design19 citations Open access
Semantic Scholar
Imidazopyridine-Based 5-HT6 Receptor Neutral Antagonists: Impact of N1-Benzyl and N1-Phenylsulfonyl Fragments on Different Receptor Conformational States.
David Vanda, Vittorio Canale, Séverine Chaumont-Dubel, R. Kurczab +11 more
2021Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy
A. Rapacz, K. Kamiński, J. Obniska, Paulina Koczurkiewicz +2 more
2017Naunyn-Schmiedeberg's Archives of Pharmacology18 citations Open access
Semantic Scholar
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
K. Wójcik-Pszczoła, A. Jankowska, M. Ślusarczyk, B. Jakieła +9 more
2021Bioorganic chemistry (Print)17 citations Open access
Semantic Scholar
Novel Antibacterial, Cytotoxic and Catalytic Activities of Silver Nanoparticles Synthesized from Acidophilic Actinobacterial SL19 with Evidence for Protein as Coating Biomolecule
Magdalena Wypij, M. Ostrowski, K. Piska, K. Wójcik-Pszczoła +3 more
2022Journal of Microbiology and Biotechnology16 citations Open access
Semantic Scholar
Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling.
K. Wójcik-Pszczoła, G. Chłoń-Rzepa, A. Jankowska, E. Ellen +9 more
2019European Journal of Pharmacology16 citations Open access
Semantic Scholar
Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group
Justyna Popiół, Agnieszka Gunia-Krzyżak, K. Piska, D. Żelaszczyk +10 more
2019Molecules16 citations Open access
Semantic Scholar
Synthesis, Anticonvulsant, and Antinociceptive Activity of New 3-(2-Chlorophenyl)- and 3-(3-Chlorophenyl)-2,5-dioxo-pyrrolidin-1-yl-acetamides
Małgorzata Góra, A. Czopek, A. Rapacz, A. Gębska +3 more
2021Molecules15 citations Open access
Semantic Scholar
Aclarubicin: contemporary insights into its mechanism of action, toxicity, pharmacokinetics, and clinical standing
A. Murzyn, J. Orzeł, Natalia Obajtek, A. Mróz +6 more
2024Cancer Chemotherapy and Pharmacology14 citations Open access
Semantic Scholar
The impact of ZnO and TiO2 on the stability of clotrimazole under UVA irradiation: Identification of photocatalytic degradation products and in vitro cytotoxicity assessment
Agata Kryczyk, P. Żmudzki, Paulina Koczurkiewicz, J. Piotrowska +2 more
2017Journal of Pharmaceutical and Biomedical Analysis14 citations Open access
Semantic Scholar
Pyridine derivatives as candidates for selective and sensitive fluorescent biosensors for lung cancer cell imaging and iron ions detection
Monika Topa-Skwarczyńska, Patryk Szymaszek, P. Fiedor, A. Chachaj-Brekiesz +10 more
2022Dyes and pigments12 citations Open access
Semantic Scholar
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
K. Wójcik-Pszczoła, K. Pociecha, G. Chłoń-Rzepa, M. Zadrożna +7 more
2023International Immunopharmacology11 citations Open access
Semantic Scholar
Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
P. Koczurkiewicz-Adamczyk, Bartosz Gąsiorkiewicz, K. Piska, Agnieszka Gunia-Krzyżak +8 more
2022Life Science11 citations Open access
Semantic Scholar
Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.
M. Drop, Florian Jacquot, Vittorio Canale, Séverine Chaumont-Dubel +19 more
2021Bioorganic chemistry (Print)11 citations Open access
Semantic Scholar
Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains
K. Klesiewicz, E. Karczewska, P. Nowak, Iwona Skiba-Kurek +9 more
2018Journal of antibiotics (Tokyo. 1968)11 citations Open access
Semantic Scholar
Chemopreventive and Anticancer Activities of Bacopa Monnieri Extracted from Artificial Digestive Juices
Paulina Koczurkiewicz, Maciej Łojewski, K. Piska, M. Michalik +5 more
2017Natural Product Communications11 citations Open access
Semantic Scholar
In silico and in vitro evaluation of a safety profile of a cosmetic ingredient: 4-methoxychalcone (4-MC).
Agnieszka Gunia-Krzyżak, Justyna Popiół, K. Słoczyńska, D. Żelaszczyk +6 more
2023Toxicology in Vitro10 citations Open access
Semantic Scholar
Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation
K. Wójcik-Pszczoła, G. Chłoń-Rzepa, A. Jankowska, Bruno Ferreira +5 more
2022Pharmaceuticals10 citations Open access
Semantic Scholar
In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives
M. A. Marć, Enrique Domínguez-Álvarez, K. Słoczyńska, P. Żmudzki +2 more
2017Applied Biochemistry and Biotechnology10 citations Open access
Semantic Scholar
Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model EpiskinTM: Perspectives for Application as Potential Sunscreen Agents
K. Słoczyńska, Justyna Popiół, Agnieszka Gunia-Krzyżak, P. Koczurkiewicz-Adamczyk +2 more
2022Molecules9 citations Open access
Semantic Scholar
Multidirectional anti-melanoma effect of galactolipids (MGDG-1 and DGDG-1) from Impatiens parviflora DC. and their synergy with doxorubicin.
K. Grabowska, A. Galanty, P. Koczurkiewicz-Adamczyk, Dagmara Wróbel-Biedrawa +6 more
2021Toxicology in Vitro9 citations Open access
Semantic Scholar
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives
A. Czopek, A. Partyka, Adam Bucki, M. Pawłowski +9 more
2020Molecules9 citations Open access
Semantic Scholar
Photostability of Terbinafine Under UVA Irradiation: The Effect of UV Absorbers
A. Kryczyk-Poprawa, P. Żmudzki, Paulina Koczurkiewicz, E. Pękala +1 more
2019Photochemistry and Photobiology9 citations Open access
Semantic Scholar
Biotransformation of 4‐fluoro‐N‐(1‐{2‐[(propan‐2‐yl)phenoxy]ethyl}‐8‐azabicyclo[3.2.1]octan‐3‐yl)‐benzenesulfonamide, a novel potent 5‐HT7 receptor antagonist with antidepressant‐like and anxiolytic properties: In vitro and in silico approach
K. Słoczyńska, K. Wójcik-Pszczoła, Vittorio Canale, P. Żmudzki +2 more
2018Journal of biochemical and molecular toxicology9 citations Open access
Semantic Scholar
Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols.
A. Rapacz, A. Waszkielewicz, K. Pańczyk, Karolina Pytka +6 more
2017MedChemComm9 citations Open access
Semantic Scholar

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K. Wójcik-Pszczoła×23
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Paulina Koczurkiewicz×22
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K. Piska×21
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P. Koczurkiewicz-Adamczyk×18
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Justyna Popiół×9

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