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M. Kołaczkowski · SciRah

Researcher profile · Semantic Scholar

M. Kołaczkowski

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M. Kołaczkowski — researcher profile on SciRah

h-index: 32
Works: 160
Citations: 3,458

Most-cited papers

Drug resistance mechanisms and their regulation in non-albicans Candida species.
A. Kołaczkowska, M. Kołaczkowski
2016Journal of Antimicrobial Chemotherapy84 citations
Semantic Scholar
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
Anna Więckowska, M. Kołaczkowski, Adam Bucki, Justyna Godyń +13 more
2016European journal of medicinal chemistry81 citations Open access
Semantic Scholar
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders.
A. Newman-Tancredi, R. Depoortère, M. Kleven, M. Kołaczkowski +1 more
2021Pharmacology and Therapeutics78 citations Open access
Semantic Scholar
Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system.
T. Plech, B. Kaproń, J. Luszczki, Agata Paneth +4 more
2014European journal of medicinal chemistry65 citations Open access
Semantic Scholar
Metabolic carbonyl reduction of anthracyclines — role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents
K. Piska, Paulina Koczurkiewicz, Adam Bucki, K. Wójcik-Pszczoła +2 more
2017Investigational new drugs61 citations Open access
Semantic Scholar
Management of Dementia-Related Psychosis, Agitation and Aggression: A Review of the Pharmacology and Clinical Effects of Potential Drug Candidates
Monika A. Marcinkowska, J. Śniecikowska, N. Fajkis, P. Paśko +2 more
2020CNS Drugs49 citations Open access
Semantic Scholar
Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties.
M. Jastrzębska-Więsek, A. Partyka, J. Rychtyk, J. Śniecikowska +4 more
2018ACS Chemical Neuroscience49 citations Open access
Semantic Scholar
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain.
K. Sałat, M. Kołaczkowski, A. Furgala, Adriana Rojek +3 more
2017Neuropharmacology47 citations Open access
Semantic Scholar
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.
Anna Więckowska, T. Wichur, Justyna Godyń, Adam Bucki +16 more
2018ACS Chemical Neuroscience46 citations Open access
Semantic Scholar
Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.
K. Piska, Paulina Koczurkiewicz, D. Wnuk, E. Karnas +6 more
2019Chemico-Biological Interactions39 citations Open access
Semantic Scholar
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
G. Chłoń-Rzepa, A. Jankowska, M. Ślusarczyk, Artur Świerczek +6 more
2018European journal of medicinal chemistry39 citations Open access
Semantic Scholar
Idalopirdine – a small molecule antagonist of 5-HT6 with therapeutic potential against obesity
M. Dudek, Monika A. Marcinkowska, Adam Bucki, Adrian Olczyk +1 more
2015Metabolic brain disease37 citations Open access
Semantic Scholar
Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating
M. Kotańska, Klaudia Lustyk, Adam Bucki, Monika A. Marcinkowska +2 more
2018Metabolic brain disease34 citations Open access
Semantic Scholar
Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.
A. Czopek, M. Kołaczkowski, Adam Bucki, H. Byrtus +7 more
2015Bioorganic & Medicinal Chemistry34 citations Open access
Semantic Scholar
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
G. Chłoń-Rzepa, M. Ślusarczyk, A. Jankowska, Alicja Gawalska +9 more
2018European journal of medicinal chemistry33 citations Open access
Semantic Scholar
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.
A. Partyka, G. Chłoń-Rzepa, A. Wąsik, M. Jastrzębska-Więsek +5 more
2015Bioorganic & Medicinal Chemistry33 citations Open access
Semantic Scholar
Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity.
J. Śniecikowska, M. Głuch-Lutwin, Adam Bucki, Anna Więckowska +13 more
2019Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity.
Monika A. Marcinkowska, M. Kołaczkowski, K. Kamiński, Adam Bucki +11 more
2016European journal of medicinal chemistry29 citations Open access
Semantic Scholar
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
M. Kołaczkowski, Monika A. Marcinkowska, Adam Bucki, J. Śniecikowska +9 more
2015European journal of medicinal chemistry29 citations Open access
Semantic Scholar
From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery.
J. Śniecikowska, A. Newman-Tancredi, M. Kołaczkowski
2019Current Topics in Medicinal Chemistry27 citations Open access
Semantic Scholar
Cinnamic acid derivatives as chemosensitising agents against DOX-treated lung cancer cells - involvement of carbonyl reductase 1.
P. Koczurkiewicz-Adamczyk, K. Piska, Agnieszka Gunia-Krzyżak, Adam Bucki +8 more
2020European Journal of Pharmaceutical Sciences25 citations Open access
Semantic Scholar
H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice
M. Dudek, K. Kuder, M. Kołaczkowski, Adrian Olczyk +6 more
2016Metabolic brain disease25 citations Open access
Semantic Scholar
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.
T. Wichur, Justyna Godyń, Izabella Góral, G. Latacz +14 more
2021European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Discovery of Novel pERK1/2- or β-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile
J. Śniecikowska, M. Głuch-Lutwin, Adam Bucki, Anna Więckowska +12 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
Adam Bucki, Monika A. Marcinkowska, J. Śniecikowska, Krzysztof Więckowski +10 more
2017Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.
A. Zagórska, M. Kołaczkowski, Adam Bucki, A. Siwek +6 more
2015European journal of medicinal chemistry24 citations Open access
Semantic Scholar
Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
Tomasz Kostrzewa, Karol Wołosewicz, M. Jamrozik, Joanna Drzeżdżon +6 more
2021International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats
M. Jastrzębska-Więsek, A. Siwek, A. Partyka, B. Szewczyk +4 more
2015Naunyn-Schmiedeberg's Archives of Pharmacology22 citations Open access
Semantic Scholar
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
T. Wichur, Anna Pasieka, Justyna Godyń, Dawid Panek +13 more
2021European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Anti‐Alzheimer's multitarget‐directed ligands with serotonin 5‐HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity
Monika A. Marcinkowska, Adam Bucki, Dawid Panek, A. Siwek +8 more
2019Archiv der Pharmazie21 citations Open access
Semantic Scholar
Novel and effective synthesis protocol of AgNPs functionalized using L-cysteine as a potential drug carrier
M. Wojnicki, M. Luty-Błocho, M. Kotańska, Magdalena Wytrwał +5 more
2017Naunyn-Schmiedeberg's Archives of Pharmacology21 citations Open access
Semantic Scholar
3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.
Monika A. Marcinkowska, M. Kołaczkowski, K. Kamiński, Adam Bucki +10 more
2017ACS Chemical Neuroscience21 citations Open access
Semantic Scholar
Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT6 partial agonist in rats
M. Jastrzębska-Więsek, A. Siwek, A. Partyka, L. Antkiewicz-Michaluk +4 more
2016Naunyn-Schmiedeberg's Archives of Pharmacology20 citations Open access
Semantic Scholar
Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents
A. Zagórska, Adam Bucki, M. Kołaczkowski, A. Siwek +8 more
2016Journal of Enzyme Inhibition and Medicinal Chemistry20 citations Open access
Semantic Scholar
Metabolic and Cardiovascular Benefits and Risks of EMD386088—A 5-HT6 Receptor Partial Agonist and Dopamine Transporter Inhibitor
M. Kotańska, J. Śniecikowska, M. Jastrzębska-Więsek, M. Kołaczkowski +1 more
2017Frontiers in Neuroscience19 citations Open access
Semantic Scholar
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress
M. Głuch-Lutwin, Kinga Sałaciak, Alicja Gawalska, M. Jamrozik +4 more
2021Psychopharmacology18 citations Open access
Semantic Scholar
Exploring the antiplatelet activity of serotonin 5-HT2A receptor antagonists bearing 6-fluorobenzo[d]isoxazol-3-yl)propyl) motif- as potential therapeutic agents in the prevention of cardiovascular diseases.
Monika A. Marcinkowska, M. Kubacka, A. Zagórska, Anna Jaromin +2 more
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie18 citations Open access
Semantic Scholar
Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity.
A. Jankowska, G. Satała, M. Kołaczkowski, Adam Bucki +11 more
2020European journal of medicinal chemistry18 citations Open access
Semantic Scholar
The preclinical discovery and development of cariprazine for the treatment of schizophrenia
A. Wesołowska, A. Partyka, M. Jastrzębska-Więsek, M. Kołaczkowski
2018Expert Opinion on Drug Discovery18 citations Open access
Semantic Scholar
Antipsychotic-like effects of zolpidem in Wistar rats.
P. Mierzejewski, M. Kołaczkowski, Monika A. Marcinkowska, A. Wesołowska +3 more
2016European Journal of Pharmacology17 citations Open access
Semantic Scholar
Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
Monika A. Marcinkowska, B. Mordyl, Nikola Fajkis-Zajączkowska, A. Siwek +13 more
2022European journal of medicinal chemistry14 citations
Semantic Scholar
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling
Karolina Pytka, M. Głuch-Lutwin, Elżbieta Żmudzka, Kinga Sałaciak +13 more
2018Frontiers in Pharmacology14 citations Open access
Semantic Scholar
Structural Modeling of TRPA1 Ion Channel—Determination of the Binding Site for Antagonists
Alicja Gawalska, M. Kołaczkowski, Adam Bucki
2022Molecules13 citations Open access
Semantic Scholar
Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents
Monika A. Marcinkowska, M. Kotańska, A. Zagórska, J. Śniecikowska +9 more
2018Journal of Enzyme Inhibition and Medicinal Chemistry13 citations Open access
Semantic Scholar
The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression.
M. Głuch-Lutwin, Kinga Sałaciak, Karolina Pytka, Alicja Gawalska +5 more
2022Behavioural Brain Research12 citations Open access
Semantic Scholar
ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety
A. Partyka, A. Wąsik, M. Jastrzębska-Więsek, P. Mierzejewski +3 more
2016Naunyn-Schmiedeberg's Archives of Pharmacology12 citations Open access
Semantic Scholar
Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity
G. Chłoń-Rzepa, Adam Bucki, M. Kołaczkowski, A. Partyka +8 more
2016Journal of Enzyme Inhibition and Medicinal Chemistry12 citations Open access
Semantic Scholar
Aminoalkyl Derivatives of 8‐Alkoxypurine‐2,6‐diones: Multifunctional 5‐HT1A/5‐HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity
G. Chłoń-Rzepa, A. Zagórska, P. Żmudzki, Adam Bucki +8 more
2016Archiv der Pharmazie12 citations Open access
Semantic Scholar
Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
P. Koczurkiewicz-Adamczyk, Bartosz Gąsiorkiewicz, K. Piska, Agnieszka Gunia-Krzyżak +8 more
2022Life Science11 citations Open access
Semantic Scholar
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
Adam Bucki, Monika A. Marcinkowska, J. Śniecikowska, A. Zagórska +11 more
2020European journal of medicinal chemistry11 citations Open access
Semantic Scholar

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