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B. Gutbier · SciRah

Researcher profile · Semantic Scholar

B. Gutbier

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B. Gutbier — researcher profile on SciRah

h-index: 22
Works: 83
Citations: 1,904

Most-cited papers

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia
M. Witzenrath, F. Pache, D. Lorenz, U. Koppe +15 more
2011Journal of Immunology276 citations Open access
Semantic Scholar
Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia
M. Witzenrath, B. Gutbier, A. Hocke, B. Schmeck +7 more
2006Critical Care Medicine145 citations
Semantic Scholar
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia*
M. Witzenrath, B. Schmeck, J. Doehn, T. Tschernig +10 more
2009Critical Care Medicine135 citations
Semantic Scholar
Streptococcus pneumoniae Stimulates a STING- and IFN Regulatory Factor 3-Dependent Type I IFN Production in Macrophages, which Regulates RANTES Production in Macrophages, Cocultured Alveolar Epithelial Cells, and Mouse Lungs
U. Koppe, Katrin Högner, J. Doehn, H. Müller +9 more
2012Journal of Immunology133 citations
Semantic Scholar
Antibiotic treatment–induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia
O. Robak, M. Heimesaat, A. Kruglov, Sandra Prepens +18 more
2018Journal of Clinical Investigation91 citations Open access
Semantic Scholar
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia
K. Dietert, B. Gutbier, S. Wienhold, K. Reppe +19 more
2017PLoS ONE87 citations Open access
Semantic Scholar
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction
C. Tabeling, Hanpo Yu, Liming Wang, H. Ranke +13 more
2015Proceedings of the National Academy of Sciences of the United States of America86 citations Open access
Semantic Scholar
Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.
J. Doehn, K. Fischer, K. Reppe, B. Gutbier +7 more
2013Journal of Antimicrobial Chemotherapy82 citations
Semantic Scholar
Simvastatin attenuates ventilator-induced lung injury in mice
H. Müller, K. Hellwig, S. Rosseau, T. Tschernig +8 more
2010Critical Care74 citations Open access
Semantic Scholar
Prognostic and Pathogenic Role of Angiopoietin‐1 and ‐2 in Pneumonia
B. Gutbier, Anne-Kathrin Neuhauß, K. Reppe, Carolin Ehrler +10 more
2018American Journal of Respiratory and Critical Care Medicine72 citations
Semantic Scholar
Adrenomedullin attenuates ventilator-induced lung injury in mice
H. Müller, M. Witzenrath, T. Tschernig, B. Gutbier +4 more
2010Thorax67 citations Open access
Semantic Scholar
Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia.
K. Reppe, T. Tschernig, A. Lührmann, V. van Laak +10 more
2009American Journal of Respiratory Cell and Molecular Biology64 citations
Semantic Scholar
RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.
B. Gutbier, S. Kube, K. Reppe, A. Santel +4 more
2010Pulmonary Pharmacology & Therapeutics57 citations
Semantic Scholar
The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
H. Müller, A. Hocke, K. Hellwig, B. Gutbier +9 more
2011Pulmonary Pharmacology & Therapeutics52 citations Open access
Semantic Scholar
Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue
Kolja Szymanski, M. Toennies, A. Becher, D. Fatykhova +16 more
2012European Respiratory Journal51 citations Open access
Semantic Scholar
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia
B. Gutbier, Xiaohui Jiang, K. Dietert, Carolin Ehrler +11 more
2017Critical Care41 citations Open access
Semantic Scholar
Role of sphingosine kinase 1 in allergen-induced pulmonary vascular remodeling and hyperresponsiveness.
R. Haberberger, C. Tabeling, S. Runciman, B. Gutbier +6 more
2009Journal of Allergy and Clinical Immunology36 citations
Semantic Scholar
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia*
M. Witzenrath, B. Gutbier, B. Schmeck, H. Tenor +11 more
2009Critical Care Medicine34 citations
Semantic Scholar
Role of platelet-activating factor in pneumolysin-induced acute lung injury
M. Witzenrath, B. Gutbier, J. Owen, B. Schmeck +7 more
2007Critical Care Medicine34 citations
Semantic Scholar
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
E. Kostadinova, Catherine Chaput, B. Gutbier, J. Lippmann +5 more
2016Scientific Reports30 citations Open access
Semantic Scholar
Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
H. Müller-Redetzky, Ute Kellermann, S. Wienhold, B. Gutbier +15 more
2020Anesthesiology28 citations
Semantic Scholar
Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung
P. J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo +29 more
2024Nature Communications23 citations Open access
Semantic Scholar
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation
L. Erfinanda, L. Zou, B. Gutbier, L. Kneller +21 more
2022Science Translational Medicine21 citations
Semantic Scholar
Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus
N. Veith, T. Tschernig, B. Gutbier, M. Witzenrath +3 more
2014Respiratory Research21 citations Open access
Semantic Scholar
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension
C. Tabeling, Carla R. González Calera, J. Lienau, Jakob Höppner +15 more
2022Frontiers in Immunology18 citations Open access
Semantic Scholar
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia
T. Herta, A. Bhattacharyya, M. Rosolowski, C. Conrad +8 more
2021Frontiers in Immunology18 citations Open access
Semantic Scholar
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2
B. Gutbier, Stefanie M. Schönrock, Carolin Ehrler, R. Haberberger +22 more
2018Critical Care Medicine17 citations Open access
Semantic Scholar
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
H. Müller-Redetzky, S. Wienhold, J. Berg, A. Hocke +11 more
2015Journal of Antimicrobial Chemotherapy17 citations
Semantic Scholar
Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage
Katrin Radloff, B. Gutbier, C. Dunne, Hanieh Moradian +14 more
2023Molecular Therapy: Nucleic Acids16 citations Open access
Semantic Scholar
Bioengineering the Lung : Molecules , Materials , Matrix , Morphology , and Mechanics Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM 5 expression and long-term smoke exposure
B. Gutbier, K. Fischer, J. Doehn, Carolin von Lachner +11 more
201516 citations
Semantic Scholar
Digital Image Analyses on Whole‐Lung Slides in Mouse Models of Acute Pneumonia
K. Dietert, G. Nouailles, B. Gutbier, K. Reppe +9 more
2018American Journal of Respiratory Cell and Molecular Biology11 citations
Semantic Scholar
Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice
A. Lask, B. Gutbier, O. Kershaw, G. Nouailles +6 more
2022Scientific Reports9 citations Open access
Semantic Scholar
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
C. Tabeling, H. Scheer, Stefanie M. Schönrock, F. Runge +9 more
2014American Journal of Respiratory Cell and Molecular Biology9 citations
Semantic Scholar
The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment
Sara Timm, M. Lettau, J. Hegermann, M. L. Rocha +10 more
2023Histochemistry and Cell Biology8 citations Open access
Semantic Scholar
Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections.
Sandra Jagdmann, D. Berchtold, B. Gutbier, M. Witzenrath +3 more
2021Journal of Neuroimmunology8 citations Open access
Semantic Scholar
Diabetes impairs IFNγ-dependent antibacterial defense in the lungs.
Facundo Fiocca Vernengo, Ivo Röwekamp, Léa Boillot, Sandra Caesar +10 more
2024Mucosal Immunology5 citations Open access
Semantic Scholar
Neutrophil-chemoattractant CXCL5 increases lung barrier permeability in acute lung injury.
Sarah Berger, C. Goekeri, P. Pennitz, B. Gutbier +21 more
2025Mucosal Immunology4 citations Open access
Semantic Scholar
Trimodulin supports antibacterial defence and restricts inflammation in preclinical pneumonia models
G. Nouailles, Romina Bischoff, K. Linke, Alexander Taylor +19 more
2025European Respiratory Journal3 citations Open access
Semantic Scholar
Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection
N. Nieuwenhuizen, G. Nouailles, J. Sutherland, Joanna Żyła +15 more
2024mBio3 citations Open access
Semantic Scholar
Loss of CFTR causes endothelial barrier failure in pneumonia via inhibition of WNK1 and TRPV4 activation
L. Erfinanda, Zou Lin, B. Gutbier, K. Reppe +5 more
20173 citations
Semantic Scholar
Acute Moraxella catarrhalis Airway Infection of Chronically Smoke-Exposed Mice Increases Mechanisms of Emphysema Development: A Pilot Study
K. Fischer, J. Doehn, C. Herr, C. Lachner +10 more
2018European Journal of Microbiology & Immunology2 citations Open access
Semantic Scholar
Role of Transient Receptor Potential Vanilloid 4 for the Development of Acute Lung Injury in Pneumococcal Pneumonia
B. Schneider, B. Gutbier, K. Reppe, J. Lienau +6 more
2018Pneumologie1 citations
Semantic Scholar
Vasculotide reduced pulmonary hyperpermeability in pneumococcal pneumonia
B. Gutbier, Xiaohui Jiang, Carolin Ehrler, T. Mitchell +5 more
20161 citations
Semantic Scholar
The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-induced Barrier Disruption
B. Gutbier, Xiaohui Jiang, Carolin Ehrler, T. Mitchell +5 more
20161 citations
Semantic Scholar
Role of angiopoietins Ang-1 and Ang-2 for the development of acute lung injury in pneumococcal pneumonia
B. Gutbier, K. Reppe, Anne-Kathrin Neuhauss, A. Santel +6 more
2011European Respiratory Journal1 citations
Semantic Scholar
ETB receptor deficiency amplifies allergic airway inflammation and hyperresponsiveness
C. Tabeling, Carla R. González Calera, B. Gutbier, Laura Michalick +12 more
2025ERJ Open Research0 citations Open access
Semantic Scholar
Neutrophil-chemoattractant CXCL5 disrupts the lung barrier during acute lung injury
G. Nouailles, Sarah Berger, C. Goekeri, P. Pennitz +19 more
2025Airway cell biology and immunopathology0 citations
Semantic Scholar
Late Breaking Abstract - Insights into Trimodulin’s Protective Role in Severe Pneumonia: Evidence from Preclinical Models
G. Nouailles, Romina Bischoff, K. Linke, Alexander Taylor +19 more
2025Respiratory infections and bronchiectasis0 citations
Semantic Scholar
Neutrophil-chemoattractant CXCL5 disrupts the lung barrier during acute lung injury
Sarah Berger, C. Goekeri, P. Pennitz, B. Gutbier +18 more
2024Airway cell biology and immunopathology0 citations
Semantic Scholar
Effect of hyperglycemia and angiopoietin-like-4 on pneumolysin-induced pulmonary barrier dysfunction
Yadong Wang, Laura Kneller, Timothy J. Mitchell, M. Witzenrath +1 more
2024Respiratory infections and bronchiectasis0 citations
Semantic Scholar

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