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K. Adkison · SciRah

Researcher profile · Semantic Scholar

K. Adkison

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K. Adkison — researcher profile on SciRah

h-index: 21
Works: 44
Citations: 2,588

Most-cited papers

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs
Kelly M. Mahar Doan, J. Humphreys, Lindsey O. Webster, S. Wring +4 more
2002Journal of Pharmacology and Experimental Therapeutics623 citations
Semantic Scholar
Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics.
D. Shen, A. Artru, K. Adkison
2004Advanced Drug Delivery Reviews285 citations
Semantic Scholar
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance.
B. Ring, J. Chien, K. Adkison, H. Jones +14 more
2011Journal of Pharmacy and Science191 citations
Semantic Scholar
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
P. Poulin, Rhys D. O. Jones, H. Jones, C. Gibson +14 more
2011Journal of Pharmacy and Science181 citations
Semantic Scholar
Hepatotoxicity Observed in Clinical Trials of Aplaviroc (GW873140)
W. Nichols, H. Steel, T. Bonny, K. Adkison +4 more
2007Antimicrobial Agents and Chemotherapy159 citations Open access
Semantic Scholar
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution.
Rhys D. O. Jones, H. Jones, M. Rowland, C. Gibson +14 more
2011Journal of Pharmacy and Science138 citations
Semantic Scholar
Antiviral activity and safety of 873140, a novel CCR5 antagonist, during short-term monotherapy in HIV-infected adults
J. Lalezari, M. Thompson, P. Kumar, P. Piliero +8 more
2005AIDS (London)116 citations
Semantic Scholar
Efficacy and safety of dolutegravir-rilpivirine for maintenance of virological suppression in adults with HIV-1: 100-week data from the randomised, open-label, phase 3 SWORD-1 and SWORD-2 studies.
M. Aboud, C. Orkin, D. Podzamczer, J. Bogner +13 more
2019The Lancet HIV111 citations
Semantic Scholar
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.
R. Vuppugalla, P. Marathe, Handan He, Rhys D. O. Jones +13 more
2011Journal of Pharmacy and Science69 citations
Semantic Scholar
Cassette dosing: rapid in vivo assessment of pharmacokinetics
L. Frick, K. Adkison, K. Wells-Knecht, P. Woollard +1 more
199869 citations
Semantic Scholar
Steady-State Brain Concentrations of Antihistamines in Rats
Kelly M. Mahar Doan, S. Wring, Larry J. Shampine, Kelly H. Jordan +6 more
2004Pharmacology63 citations
Semantic Scholar
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 1: goals, properties of the PhRMA dataset, and comparison with literature datasets.
P. Poulin, H. Jones, Rhys D. O. Jones, J. Yates +13 more
2011Journal of Pharmacy and Science57 citations
Semantic Scholar
Oral sulfasalazine as a clinical BCRP probe substrate: pharmacokinetic effects of genetic variation (C421A) and pantoprazole coadministration.
K. Adkison, S. Vaidya, Daniel Y. Lee, S. Koo +7 more
2010Journal of Pharmacy and Science49 citations
Semantic Scholar
The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.
K. Adkison, S. Vaidya, Daniel Y. Lee, S. Koo +6 more
2008British Journal of Clinical Pharmacology48 citations Open access
Semantic Scholar
Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.
D. Uehling, K. H. Donaldson, D. N. Deaton, Clifton E. Hyman +12 more
2002Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Pharmacokinetics of Antiretroviral Drug Varies With Formulation in the Target Population of Children With HIV‐1
P. Kasirye, L. Kendall, K. Adkison, C. Tumusiime +9 more
2012Clinical pharmacology and therapy42 citations
Semantic Scholar
Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.
D. Uehling, B. Shearer, K. H. Donaldson, E. Chao +13 more
2006Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Perspectives on the Barrier to Resistance for Dolutegravir + Lamivudine, a Two-Drug Antiretroviral Therapy for HIV-1 Infection
M. Boffito, L. Waters, P. Cahn, R. Paredes +6 more
2019AIDS Research and Human Retroviruses36 citations Open access
Semantic Scholar
Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open‐Label, Randomized Study
K. Adkison, Allen Wolstenholme, Y. Lou, Zhi-Ping Zhang +6 more
2017Clinical pharmacology and therapy35 citations Open access
Semantic Scholar
Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial
V. Musiime, L. Kendall, S. Bakeera-Kitaka, W. Snowden +9 more
2010Antiviral Therapy30 citations Open access
Semantic Scholar
Monitoring liver safety in drug development: the GSK experience.
C. Hunt, Julie I. Papay, R. Edwards, D. Theodore +6 more
2007Regulatory toxicology and pharmacology : RTP26 citations
Semantic Scholar
Covariate effects and population pharmacokinetics of lamivudine in HIV-infected children.
C. Piana, Wei Zhao, K. Adkison, D. Burger +3 more
2014British Journal of Clinical Pharmacology19 citations Open access
Semantic Scholar
Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of GSK2336805, an Inhibitor of Hepatitis C Virus (HCV) NS5A, in Healthy Subjects and Subjects Chronically Infected with HCV Genotype 1
D. Wilfret, J. Walker, K. Adkison, L. A. Jones +9 more
2013Antimicrobial Agents and Chemotherapy19 citations Open access
Semantic Scholar
Antiviral activity and safety of aplaviroc, a CCR5 antagonist, in combination with lopinavir/ritonavir in HIV‐infected, therapy‐naïve patients: results of the EPIC study (CCR100136) *
P. Yeni, A. Lamarca, D. Berger, P. Cimoch +10 more
2009HIV Medicine16 citations Open access
Semantic Scholar
High-throughput screening for lead optimization: a rational approach.
M. Bajpai, K. Adkison
2000Current opinion in drug discovery & development16 citations
Semantic Scholar
Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.
B. Shearer, E. Chao, D. Uehling, D. N. Deaton +7 more
2007Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
K. Adkison, D. G. Barrett, D. N. Deaton, R. Gampe +10 more
2006Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Development of Dolutegravir Single-entity and Fixed-dose Combination Formulations for Children
Rajendra Singh, K. Adkison, M. Baker, R. Parasrampuria +5 more
2021The Pediatric Infectious Disease Journal8 citations
Semantic Scholar
Bioequivalence and Food Effect Assessment of 2 Fixed‐Dose Combination Formulations of Dolutegravir and Lamivudine
T. Dumitrescu, Kavita Peddiraju, Caifeng Fu, K. Bakshi +7 more
2019Clinical pharmacology in drug development8 citations Open access
Semantic Scholar
Bioequivalence of a Fixed-Dose Combination Tablet of the Complete Two-Drug Regimen of Dolutegravir and Rilpivirine for Treatment of HIV-1 Infection
R. Mehta, Allen Wolstenholme, Kristin Di Lullo, Caifeng Fu +6 more
2018Antimicrobial Agents and Chemotherapy8 citations Open access
Semantic Scholar
Double-blind , randomized , placebo-controlled study to assess the safety , antiviral activity and pharmacokinetics of GSK 2336805 when given as monotherapy and in combination with peginterferon alfa-2 a and ribavirin in hepatitis C virus genotype 1-infected treatment-naive subjects
S. Gardner, A. Cutrell, Cindy Elko-Simms, K. Adkison +4 more
20148 citations
Semantic Scholar
A model-based approach for the evaluation of once daily dosing of lamivudine in HIV-infected children.
C. Piana, Wei Zhao, K. Adkison, D. Burger +3 more
2014British Journal of Clinical Pharmacology8 citations Open access
Semantic Scholar
The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects.
K. Adkison, Anne Shachoy-Clark, L. Fang, Y. Lou +3 more
2006British Journal of Clinical Pharmacology7 citations Open access
Semantic Scholar
Discovery of a Potent and Selective α1A Antagonist
K. Adkison, K. Halm, J. E. Shaffer, D. Drewry +2 more
20026 citations
Semantic Scholar
Role of choroid plexus epithelium in the removal of valproic acid from the central nervous system.
K. Adkison, A. Artru, K. Powers, D. Nochlin +1 more
1995Epilepsy Research6 citations
Semantic Scholar
Pharmacokinetics of lamivudine, abacavir and zidovudine administered twice daily as syrups versus scored tablets in HIV-1-infected Ugandan children
Pk Gitta, L. Kendall, V. Musiime, K. Adkison +12 more
2010Journal of the International AIDS Society5 citations Open access
Semantic Scholar
Pharmacokinetics, Safety, and Tolerability of a Single Oral Dose of Abacavir/Dolutegravir/Lamivudine Combination Tablets in Healthy Japanese Study Participants
Rajendra P. Singh, K. Adkison, Allen Wolstenholme, J. Hopking +1 more
2021Clinical pharmacology in drug development4 citations Open access
Semantic Scholar
The Effect of Moderate- and High-Fat Meals on the Bioavailability of Dolutegravir/Rilpivirine Fixed-Dose Combination Tablet
R. Mehta, Joseph Piscitelli, Allen Wolstenholme, Caifeng Fu +3 more
2020Clinical Pharmacology : Advances and Applications3 citations Open access
Semantic Scholar
A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects
David A. Wilfret, Jill Walker, C. Voitenleitner, S. Baptiste-Brown +10 more
2014Clinical pharmacology in drug development3 citations
Semantic Scholar
, of Aplaviroc ( GW 873140 ) Hepatotoxicity Observed in Clinical Trials
W. Nichols, H. Steel, T. Bonny, K. Adkison +4 more
20081 citations
Semantic Scholar
Discovery of a potent and selective alpha 1A antagonist. Utilization of a rapid screening method to obtain pharmacokinetic parameters.
K. Adkison, K. Halm, J. E. Shaffer, D. Drewry +2 more
1998Pharmaceutical biotechnology1 citations
Semantic Scholar
Pharmacokinetics of lamivudine, abacavir and
Pk Gitta, L. Kendall, Musiime, K. Adkison +12 more
20100 citations
Semantic Scholar
Cathepsin K complexed with a semicarbazone inhibitor
K. Adkison, D. G. Barrett, D. N. Deaton, R. Gampe +6 more
20060 citations
Semantic Scholar
10th Symposium of the Austrian Pharmacological Society (APHAR)
M. Latorre, J. Bartolomé-Nebreda, M. García-López, R. González-Muñiz +47 more
2004Pharmacology0 citations
Semantic Scholar

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