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D. Theodore · SciRah

Researcher profile · Semantic Scholar

D. Theodore

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D. Theodore — researcher profile on SciRah

h-index: 23
Works: 71
Citations: 3,035

Most-cited papers

Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.
J. Mchutchison, G. Dusheiko, M. Shiffman, M. Rodríguez-Torres +9 more
2007New England Journal of Medicine468 citations
Semantic Scholar
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
J. Feld, S. Nanda, Ying Huang, WeiPing Chen +7 more
2007Hepatology303 citations Open access
Semantic Scholar
Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia.
N. Afdhal, E. Giannini, G. Tayyab, A. Mohsin +10 more
2012New England Journal of Medicine299 citations Open access
Semantic Scholar
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection.
Man-Fung Yuen, Seng G. Lim, R. Pleśniak, K. Tsuji +30 more
2022New England Journal of Medicine209 citations Open access
Semantic Scholar
Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial.
J. Grainger, F. Locatelli, T. Chotsampancharoen, E. Donyush +18 more
2015The Lancet203 citations
Semantic Scholar
Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects
R. Chung, S. Evans, Yijun Yang, D. Theodore +5 more
2002AIDS (London)185 citations Open access
Semantic Scholar
Eltrombopag for the treatment of children with persistent and chronic immune thrombocytopenia (PETIT): a randomised, multicentre, placebo-controlled study.
J. Bussel, P. G. de Miguel, J. Despotovic, J. Grainger +15 more
2015The Lancet Haematology175 citations
Semantic Scholar
Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial
Man-Fung Yuen, J. Heo, J. Jang, Jung-Hwan Yoon +13 more
2021Nature Medicine141 citations Open access
Semantic Scholar
Eltrombopag increases platelet numbers in thrombocytopenic patients with HCV infection and cirrhosis, allowing for effective antiviral therapy.
N. Afdhal, G. Dusheiko, E. Giannini, Pei-Jer Chen +16 more
2014Gastroenterology136 citations Open access
Semantic Scholar
Social Stigmatization and Hepatitis C Virus Infection
S. Zacks, K. Beavers, D. Theodore, Karen A. Dougherty +5 more
2006Journal of Clinical Gastroenterology98 citations
Semantic Scholar
Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection.
J. Mchutchison, Z. Goodman, K. Patel, H. Makhlouf +14 more
2010Gastroenterology80 citations
Semantic Scholar
GB virus C, hepatitis G virus, or human orphan flavivirus?
D. Theodore, Stanley M. Lemon
1997Hepatology70 citations
Semantic Scholar
Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study
R. Brynes, A. Orazi, D. Theodore, P. Burgess +3 more
2015American journal of hematology/oncology58 citations Open access
Semantic Scholar
Thromboembolic Events Among Patients with Hepatitis C Virus Infection and Cirrhosis: A Matched-Cohort Study
C. Enger, U. Forssén, D. Bennett, D. Theodore +2 more
2014Advances in Therapy56 citations
Semantic Scholar
Natural history and disease manifestations of hepatitis C infection.
D. Theodore, M. Fried
2000Current Topics in Microbiology and Immunology46 citations
Semantic Scholar
Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy.
Man-Fung Yuen, J. Heo, H. Kumada, F. Suzuki +28 more
2022Journal of Hepatology45 citations Open access
Semantic Scholar
A 2-Year, Longitudinal, Prospective Study of the Effects of Eltrombopag on Bone Marrow in Patients with Chronic Immune Thrombocytopenia
R. Brynes, R. Wong, M. Thein, K. Bakshi +3 more
2016Acta Haematologica45 citations
Semantic Scholar
A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects
Kelong Han, J. Cremer, R. Elston, S. Oliver +13 more
2019Clinical pharmacology in drug development36 citations Open access
Semantic Scholar
Randomized clinical trials towards a single‐visit cure for chronic hepatitis C: Oral GSK2878175 and injectable RG‐101 in chronic hepatitis C patients and long‐acting injectable GSK2878175 in healthy participants
Yanli Deng, F. Campbell, Kelong Han, D. Theodore +13 more
2020Journal of Viral Hepatitis29 citations
Semantic Scholar
Liver biopsy in patients with inherited disorders of coagulation and chronic hepatitis C
D. Theodore, M. Fried, D. Kleiner, B. Kroner +7 more
2004Haemophilia28 citations
Semantic Scholar
Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir.
H. Tappouni, J. Rublein, Brian J. Donovan, S. Hollowell +8 more
2008American Journal of Health-System Pharmacy26 citations Open access
Semantic Scholar
Monitoring liver safety in drug development: the GSK experience.
C. Hunt, Julie I. Papay, R. Edwards, D. Theodore +6 more
2007Regulatory toxicology and pharmacology : RTP26 citations
Semantic Scholar
FINAL RESULTS OF ENABLE 1, A PHASE 3, MULTICENTER STUDY OF ELTROMBOPAG AS AN ADJUNCT FOR ANTIVIRAL TREATMENT OF HEPATITIS C VIRUS-RELATED CHRONIC LIVER DISEASE ASSOCIATED WITH THROMBOCYTOPENIA
N. Afdhal, G. Dusheiko, E. Giannini, P.-J. Chen +15 more
201123 citations
Semantic Scholar
Intensive Interferon Therapy Does Not Increase Virological Response Rates in African Americans with Chronic Hepatitis C
D. Theodore, M. Shiffman, R. Sterling, C. Bruno +8 more
2004Digestive Diseases and Sciences23 citations
Semantic Scholar
Medical resource utilisation and healthcare costs in patients with chronic hepatitis C viral infection and thrombocytopenia
F. Poordad, D. Theodore, J. Sullivan, K. Grotzinger
2011Journal of Medical Economics22 citations Open access
Semantic Scholar
Assessment of the Pharmacokinetic Interaction between Eltrombopag and Lopinavir-Ritonavir in Healthy Adult Subjects
M. B. Wire, H. Mclean, Carolyn Pendry, D. Theodore +2 more
2012Antimicrobial Agents and Chemotherapy20 citations Open access
Semantic Scholar
Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus–Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses
Kelong Han, D. Theodore, Gina McMullen, E. Swayze +7 more
2022Clinical pharmacology in drug development18 citations Open access
Semantic Scholar
Hepatoxicity in the U.S. Adult AIDS Clinical Trial Group
Julie C. Servoss, K. Sherman, G. Robbins, S. Liou +6 more
200118 citations
Semantic Scholar
Bepirovirsen, antisense oligonucleotide (ASO) against hepatitis B virus (HBV), harbors intrinsic immunostimulatory activity via Toll-like receptor 8 (TLR8) preclinically, correlating with clinical efficacy from the Phase 2a study
Shihyun You, Jared L. Delahaye, Megan E. Ermler, Jenn Singh +6 more
2022Journal of Hepatology17 citations
Semantic Scholar
Clinical Consequences of Hepatitis B Surface Antigen Loss in Chronic Hepatitis B Infection: A Systematic Literature Review and Meta-Analysis
Eleonora Morais, L. Mason, J. Dever, Pam Martin +5 more
2023Gastro Hep Advances13 citations Open access
Semantic Scholar
1185 ELTROMBOPAG IN CHRONIC LIVER DISEASE PATIENTS WITH THROMBOCYTOPENIA UNDERGOING AN ELECTIVE INVASIVE PROCEDURE: RESULTS FROM ELEVATE, A RANDOMISED CLINICAL TRIAL
N. Afdhal, E. Giannini, G. Tayyab, A. Mohsin +9 more
201013 citations
Semantic Scholar
Evaluating medical resource utilization and costs associated with thrombocytopenia in chronic liver disease patients
F. Poordad, D. Theodore, J. Sullivan, K. Grotzinger
2012Journal of Medical Economics9 citations Open access
Semantic Scholar
Efficacy and safety of bepirovirsen in patients with chronic hepatitis B virus infection not on stable nucleos (t)ide analogue therapy: interim results from the randomised phase 2b B-Clear study
Man-Fung Yuen, R. Pleśniak, Seng G. Lim, K. Tsuji +25 more
2022Journal of Hepatology8 citations
Semantic Scholar
Characteristics, Treatment Patterns, and Clinical Outcomes of Chronic Hepatitis B Across 3 Continents: Retrospective Database Study
Iain A. Gillespie, K. Chan, Yunhao Liu, Shun-Feng Hsieh +12 more
2022Advances in Therapy8 citations Open access
Semantic Scholar
Non‐cirrhotic thrombocytopenic patients with hepatitis C virus: Characteristics and outcome of antiviral therapy
E. Giannini, N. Afdhal, S. Sigal, A. Muir +9 more
2015Journal of Gastroenterology and Hepatology8 citations Open access
Semantic Scholar
Severity of liver disease among chronic hepatitis C patients: An observational study of 4594 patients in five European countries
P. Marcellin, K. Grotzinger, D. Theodore, D. Demuth +4 more
2015Journal of Gastroenterology and Hepatology7 citations
Semantic Scholar
Lack of Clinically Significant Pharmacokinetic Interaction between the Thrombopoietin Receptor Agonist Eltrombopag and Hepatitis C Virus Protease Inhibitors Boceprevir and Telaprevir
M. B. Wire, L. Fang, Azra Hussaini, J. Kleha +1 more
2014Antimicrobial Agents and Chemotherapy7 citations Open access
Semantic Scholar
Final Results of Open-Label Treatment with Eltrombopag During ENABLE 1: A Study of Eltrombopag As An Adjunct for Antiviral Treatment of Hepatitis C Virus Associated with Thrombocytopenia
G. Dusheiko, N. Afdhal, E. Giannini, Pei-Jer Chen +8 more
20117 citations
Semantic Scholar
60 RESULTS OF ENABLE 2, A PHASE 3, MULTICENTER STUDY OF ELTROMBOPAG AND PEGINTERFERON ALFA-2B TREATMENT IN PATIENTS WITH HEPATITIS C AND THROMBOCYTOPENIA
G. Dusheiko, N. Afdhal, E. Giannini, P.-J. Chen +14 more
20126 citations
Semantic Scholar
Correlation of single photon emission computed tomography parameters as a noninvasive alternative to liver biopsies in assessing liver involvement in the setting of HIV and hepatitis C virus coinfection: a multicenter trial of the Adult AIDS Clinical Trials Group.
B. Shiramizu, D. Theodore, R. Bassett, M. Coel +10 more
2003Journal of Acquired Immune Deficiency Syndromes6 citations Open access
Semantic Scholar
B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection
J. Cremer, R. Elston, F. Campbell, S. Kendrick +3 more
2023Advances in Therapy4 citations Open access
Semantic Scholar
Comparison of Pharmacokinetics of the GalNAc-Conjugated Antisense Oligonucleotide GSK3389404 in Participants with Chronic Hepatitis B Infection across the Asia-Pacific Region
Kelong Han, Hiroshi Ito, R. Elston, J. Cremer +3 more
2022Antimicrobial Agents and Chemotherapy4 citations Open access
Semantic Scholar
Reasons for nonuse of antiviral treatment in patients with chronic hepatitis C infection and thrombocytopaenia: a retrospective chart review from five European countries
M. Rizzetto, K. Grotzinger, D. Theodore, D. Demuth +4 more
2014Journal of Viral Hepatitis4 citations
Semantic Scholar
Hepatobiliary laboratory abnormalities among patients with chronic or persistent immune thrombocytopenia (ITP).
C. Enger, D. Bennett, K. Dawson, M. Aivado +2 more
2011Annals of Hepatology4 citations Open access
Semantic Scholar
WED-364 High-dimensional analysis of flow cytometry data reveals differences in post-treatment frequencies of naïve B cells, CD56dim natural killer cells, and terminally differentiated effector memory CD8+ T cells in responders versus nonresponders to bepirovirsen
T. Hogan, Eduardo Gomez Castaneda, E. P. García, R. Barnard +4 more
2024Journal of Hepatology3 citations
Semantic Scholar
Evidence of durable response to bepirovirsen in B-Clear responders: B-Sure first annual report
A. Gadano, Manuela Arbune, Masanori Atsukawa, S. Fujiyama +23 more
2023Journal of Hepatology3 citations
Semantic Scholar
Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study
Jenn Singh, B. Salaun, Shihyun You, S. Corson +2 more
2023Journal of Hepatology3 citations
Semantic Scholar
Health-related quality of life in thrombocytopenic patients with chronic hepatitis C with or without cirrhosis in the ENABLE-1 and ENABLE-2 studies
K. Grotzinger, Z. Younossi, E. Giannini, Pei-Jer Chen +2 more
2016Health and Quality of Life Outcomes3 citations Open access
Semantic Scholar
PETIT and PETIT 2: Treatment with Eltrombopag in 171 Children with Chronic Immune Thrombocytopenia (ITP)
J. Bussel, J. Grainger, P. G. de Miguel, J. Despotovic +27 more
20143 citations
Semantic Scholar
745 Efficacy and safety of eltrombopag, an oral platelet growth factor, in subjects with HCV associated thrombocytopenia: Preliminary results from a phase II dose-ranging study
J. Mchutchison, N. Afdhal, M. Schiffman, S. Gordon +6 more
20063 citations Open access
Semantic Scholar

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