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Takumi Chinen · SciRah

Researcher profile · Semantic Scholar

Takumi Chinen

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Takumi Chinen — researcher profile on SciRah

h-index: 15
Works: 38
Citations: 689

Most-cited papers

Synthesis and Structure−Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure
Yuri Yamazaki, Koji Tanaka, B. Nicholson, Gordafaried Deyanat-Yazdi +18 more
201295 citations Open access
Semantic Scholar
The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle
Takumi Chinen, Peng Liu, Shuya Shioda, J. Pagel +12 more
2015Nature Communications53 citations Open access
Semantic Scholar
Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.
M. Kita, Yuichiro Hirayama, Kozo Yoneda, Kota Yamagishi +5 more
2013Journal of the American Chemical Society46 citations
Semantic Scholar
MOZART1 and γ-tubulin complex receptors are both required to turn γ-TuSC into an active microtubule nucleation template
Tien-chen Lin, A. Neuner, D. Flemming, Peng Liu +4 more
2016Journal of Cell Biology45 citations Open access
Semantic Scholar
Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue.
Tsubasa Watanabe, Takamichi Imaizumi, Takumi Chinen, Yoko Nagumo +4 more
2010Organic Letters44 citations
Semantic Scholar
Robust classification of cell cycle phase and biological feature extraction by image-based deep learning
Y. Nagao, M. Sakamoto, Takumi Chinen, Yasushi Okada +1 more
2020Molecular Biology of the Cell42 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
Yuri Yamazaki, Makiko Sumikura, Y. Masuda, Yoshiki Hayashi +10 more
2012Bioorganic & Medicinal Chemistry41 citations
Semantic Scholar
Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway.
Takumi Chinen, Yoko Nagumo, Tsubasa Watanabe, Takamichi Imaizumi +5 more
2010Toxicology Letters34 citations
Semantic Scholar
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.
Yoshiki Hayashi, Haruka Takeno, Takumi Chinen, Kyohei Muguruma +7 more
2014ACS Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Construction of Multidrug-Sensitive Yeast with High Sporulation Efficiency
Takumi Chinen, Yu Ota, Yoko Nagumo, H. Masumoto +1 more
2011Bioscience, biotechnology and biochemistry27 citations
Semantic Scholar
Terpendole E and its Derivative Inhibit STLC‐ and GSK‐1‐Resistant Eg5
Y. Tarui, Takumi Chinen, Yoko Nagumo, T. Motoyama +7 more
2014ChemBioChem25 citations
Semantic Scholar
Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B.
Shun-ichiro Uesugi, Tsubasa Watanabe, Takamichi Imaizumi, Yu Ota +8 more
2015Journal of Organic Chemistry23 citations Open access
Semantic Scholar
Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae
Katsuyuki Sakai, Yufu Unten, M. Iwatsuki, Hirotaka Matsuo +12 more
2019Journal of antibiotics (Tokyo. 1968)18 citations Open access
Semantic Scholar
Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay.
Katsuyuki Sakai, T. Hirose, M. Iwatsuki, Takumi Chinen +9 more
2018Journal of Natural Products17 citations
Semantic Scholar
Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system.
Takumi Chinen, Yoko Nagumo, T. Usui
2014Journal of General and Applied Microbiology17 citations Open access
Semantic Scholar
Eudistomin C, an Antitumor and Antiviral Natural Product, Targets 40S Ribosome and Inhibits Protein Translation
Yu Ota, Takumi Chinen, Keisuke Yoshida, S. Kudo +11 more
2016ChemBioChem15 citations
Semantic Scholar
Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus
Katsuyuki Sakai, T. Suga, M. Iwatsuki, Takumi Chinen +5 more
2018Journal of antibiotics (Tokyo. 1968)14 citations
Semantic Scholar
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
I. Hayakawa, Akiyuki Ikedo, Takumi Chinen, T. Usui +1 more
2012Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.
Takumi Chinen, Sayaka Kazami, Yoko Nagumo, I. Hayakawa +8 more
2013ACS Chemical Biology13 citations
Semantic Scholar
Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor.
Kana Shintani, Haruna Ebisu, Minagi Mukaiyama, Taisei Hatanaka +6 more
2020ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria
Katsuyuki Sakai, Yufu Unten, Aoi Kimishima, K. Nonaka +9 more
2021Journal of Industrial Microbiology & Biotechnology9 citations Open access
Semantic Scholar
Pyrenocine A induces monopolar spindle formation and suppresses proliferation of cancer cells.
Y. Myobatake, Shinji Kamisuki, Senko Tsukuda, T. Higashi +13 more
2019Bioorganic & Medicinal Chemistry8 citations
Semantic Scholar
Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.
Sota Honma, Aoi Kimishima, Atsushi Kimishima, Masako Honsho +12 more
2024Bioscience, biotechnology and biochemistry7 citations Open access
Semantic Scholar
Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure-Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi.
Aoi Kimishima, Daichi Hagimoto, Masako Honsho, Katsuyuki Sakai +8 more
2024Organic Letters7 citations
Semantic Scholar
Temperature-Modulated Pyroelectricity Measurements of a Thin Ferroelectric Crystal With in-Plane Polarization and the Thermal Analysis Based on One-Dimensional Layer Models
Kaoru Yamamoto, Ayumi Kawasaki, Takumi Chinen, Kayo Ryugo
2021Crystals7 citations Open access
Semantic Scholar
Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization.
I. Hayakawa, Shuya Shioda, Takumi Chinen, Taisei Hatanaka +4 more
2016Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death
Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo +6 more
2021Frontiers in Pharmacology6 citations Open access
Semantic Scholar
The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene.
Sota Honma, Aoi Kimishima, Satoshi Kato, Akari Horiuchi +12 more
2024Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
Multidrug Sensitive Yeast Strains, Useful Tools for Chemical Genetics
Takumi Chinen, K. Hamada, A. Taguchi, Yukihiro Asami +3 more
20175 citations Open access
Semantic Scholar
A Combination Strategy of Multidrug-Sensitive Budding Yeast and Chemical Modifications Enabling to Find a New Overlooked Antifungal Compound, Sakurafusariene, from In-House Fractionated Library.
Aoi Kimishima, Yuki Ono, Katsuyuki Sakai, Kazunari Sakai +11 more
2023Journal of Agricultural and Food Chemistry4 citations
Semantic Scholar
Construction of a New Drug and Agrochemical Candidates Screening Platform Utilizing Drug-Hypersensitive Fission Yeast to Discover Overlooked Natural Products.
Aoi Kimishima, Sota Negami, Sota Honma, S. A. Kawashima +11 more
2025Journal of Natural Products3 citations
Semantic Scholar
Ufisonitriles A and B, Antimalarial Isonitriles with Mitochondrial Function Inhibitory Activity Produced by Amycolatopsis sp. OK19-0009.
E. Arakawa, Yoshihiro Watanabe, Hayama Tsutsumi, Akari Ikeda +15 more
2025Journal of Natural Products2 citations
Semantic Scholar
Structure–Activity Relationship Study of Gatastatin Based on the Topliss Tree Approach
I. Hayakawa, H. Kigoshi, Shuya Shioda, Takumi Chinen +1 more
2019Heterocycles2 citations Open access
Semantic Scholar
Identification and structure–activity relationship studies of clavatol as an antifungal compound against pathogenic plant fungi using a drug-hypersensitive fission yeast screening system
Aoi Kimishima, Sota Negami, Wakana Yoda, T. Kamo +12 more
2026Journal of pesticide science0 citations Open access
Semantic Scholar
Discovery of an anti-malarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity.
Aoi Kimishima, Atsuka Nishitomi, Iori Tsuruoka, Katsuyuki Sakai +19 more
2024Bioscience, biotechnology and biochemistry0 citations Open access
Semantic Scholar
Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of laeA gene introduction
Aoi Kimishima, Sota Honma, Atsushi Kimishima, Atsuka Nishitomi +12 more
2024Journal of pesticide science0 citations Open access
Semantic Scholar
Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates
Aoi Kimishima, Atsuka Nishitomi, Iori Tsuruoka, Masako Honsho +10 more
2024Journal of pesticide science0 citations Open access
Semantic Scholar
Isolation of microorganisms from the feces of Kitasato Yakumo beef cattle as bioactive natural product producers.
Aoi Kimishima, Atsuka Nishitomi, N. Kondo, Sota Honma +10 more
2024Bioscience, biotechnology and biochemistry0 citations Open access
Semantic Scholar

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Katsuyuki Sakai×8

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Masako Honsho×8

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Hiroki Kojima×8

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