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H. Kigoshi · SciRah

Researcher profile · Semantic Scholar

H. Kigoshi

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H. Kigoshi — researcher profile on SciRah

h-index: 35
Works: 268
Citations: 3,996

Most-cited papers

Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
Shin Sato, A. Murata, Tsubasa Orihara, T. Shirakawa +3 more
2011Chemistry and Biology121 citations Open access
Semantic Scholar
The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle
Takumi Chinen, Peng Liu, Shuya Shioda, J. Pagel +12 more
2015Nature Communications53 citations Open access
Semantic Scholar
Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.
M. Kita, Yuichiro Hirayama, Kozo Yoneda, Kota Yamagishi +5 more
2013Journal of the American Chemical Society46 citations
Semantic Scholar
Marine natural products that interfere with multiple cytoskeletal protein interactions.
M. Kita, H. Kigoshi
2015Natural product reports (Print)44 citations
Semantic Scholar
Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai.
A. Kawamura, M. Kita, H. Kigoshi
2015Angewandte Chemie43 citations Open access
Semantic Scholar
Total synthesis of (-)-13-oxyingenol and its natural derivative.
Takayuki Ohyoshi, Shota Funakubo, Yamato Miyazawa, K. Niida +2 more
2012Angewandte Chemie40 citations
Semantic Scholar
Stylissatin A, a cyclic peptide that inhibits nitric oxide production from the marine sponge Stylissa massa
M. Kita, B. Gise, A. Kawamura, H. Kigoshi
201336 citations
Semantic Scholar
Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A.
M. Kita, Yuichiro Hirayama, Miyuki Sugiyama, H. Kigoshi
2011Angewandte Chemie34 citations
Semantic Scholar
Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives.
M. Kita, Yuichiro Hirayama, Kota Yamagishi, Kozo Yoneda +2 more
2012Journal of the American Chemical Society30 citations
Semantic Scholar
Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound.
Kenichi Kobayashi, Yusuke Fujii, Yuichiro Hirayama, Shinichi Kobayashi +2 more
2012Organic Letters27 citations
Semantic Scholar
Total Synthesis of Mycalolides A and B through Olefin Metathesis.
M. Kita, H. Oka, Akihiro Usui, Tomoya Ishitsuka +4 more
2015Angewandte Chemie26 citations Open access
Semantic Scholar
Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
K. Yamada, M. Ojika, H. Kigoshi, K. Suenaga
2010Proceedings of the Japan Academy. Series B, Physical and biological sciences26 citations Open access
Semantic Scholar
Fluorescent Aplyronine A: Intracellular Accumulation and Disassembly of Actin Cytoskeleton in Tumor Cells
M. Kita, Kozo Yoneda, Yuichiro Hirayama, Kota Yamagishi +7 more
2012ChemBioChem25 citations
Semantic Scholar
Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives.
O. Ohno, M. Morita, Kazuhiro Kitamura, T. Teruya +4 more
2013Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling.
Kenichi Kobayashi, Yusuke Fujii, I. Hayakawa, H. Kigoshi
2011Organic Letters22 citations
Semantic Scholar
Total synthesis of auripyrones A and B and determination of the absolute configuration of auripyrone B.
I. Hayakawa, Takuma Takemura, E. Fukasawa, Yuta Ebihara +4 more
2010Angewandte Chemie22 citations
Semantic Scholar
Aplyronines D-H from the sea hare Aplysia kurodai: Isolation, structures, and cytotoxicity
M. Ojika, H. Kigoshi, K. Suenaga, Y. Imamura +5 more
201220 citations
Semantic Scholar
New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne
Yuichiro Hirayama, Peter L. Katavic, A. White, G. Pierens +5 more
201619 citations
Semantic Scholar
Discovery of G Protein-Biased EP2 Receptor Agonists.
S. Ogawa, Toshihide Watanabe, I. Sugimoto, Kazumi Moriyuki +8 more
2016ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative
Kozo Yoneda, Yaping Hu, M. Kita, H. Kigoshi
2015Scientific Reports16 citations Open access
Semantic Scholar
Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide
Meng-Hua Zhang, Taiki Sunaba, Yi-Ting Sun, T. Shibata +4 more
2020Journal of antibiotics (Tokyo. 1968)14 citations
Semantic Scholar
Anti-inflammatory marine cyclic peptide stylissatin A and its derivatives inhibit differentiation of murine preadipocytes.
Meng-Hua Zhang, Taiki Sunaba, Yi-Ting Sun, K. Sasaki +3 more
2019Chemical Communications14 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
I. Hayakawa, Akiyuki Ikedo, Takumi Chinen, T. Usui +1 more
2012Bioorganic & Medicinal Chemistry14 citations Open access
Semantic Scholar
Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids.
I. Hayakawa, K. Niida, H. Kigoshi
2015Chemical Communications13 citations Open access
Semantic Scholar
Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.
Takumi Chinen, Sayaka Kazami, Yoko Nagumo, I. Hayakawa +8 more
2013ACS Chemical Biology13 citations
Semantic Scholar
Aplysiasecosterols B and C: two new 9,11-secosteroids with a cis-fused 1,4-quinone structure from the sea hare Aplysia kurodai
M. Kita, A. Kawamura, H. Kigoshi
201612 citations Open access
Semantic Scholar
Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
Akiyuki Ikedo, I. Hayakawa, T. Usui, Sayaka Kazami +2 more
2010Bioorganic & Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin.
M. Kita, Kota Yamagishi, Kota Tsuchiya, Yudai Seguchi +2 more
2017Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
Synthetic studies toward 13-oxyingenol: construction of the fully substituted tetracyclic compound.
Takayuki Ohyoshi, Yamato Miyazawa, K. Aoki, Satomi Ohmura +3 more
2011Organic Letters11 citations
Semantic Scholar
A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
O. Kutomi, Ryosuke Yamamoto, K. Hirose, K. Mizuno +28 more
2021Science Advances10 citations Open access
Semantic Scholar
Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine.
I. Hayakawa, Ryosuke Nagatani, M. Ikeda, Dongwon Yoo +3 more
2019Organic Letters10 citations Open access
Semantic Scholar
Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain
K. Futaki, Momoko Takahashi, K. Tanabe, Akari Fujieda +2 more
2019ACS Omega10 citations Open access
Semantic Scholar
Total Synthesis of Aplysiasecosterols A and B, Two Marine 9,11-Secosteroids.
Takayuki Ohyoshi, Hidetada Iizumi, Shu Hosono, H. Tano +1 more
2023Organic Letters9 citations
Semantic Scholar
Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition-Intramolecular Aldol Reaction.
Keisuke Mitsugi, T. Takabayashi, Takayuki Ohyoshi, H. Kigoshi
2022Organic Letters9 citations
Semantic Scholar
Isolation and structure–activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)
Minako Hirukawa, Meng-Hua Zhang, L. Echenique-Díaz, K. Mizota +10 more
2020Tetrahedron Letters9 citations
Semantic Scholar
Total Synthesis of Stylissatin A, A Cyclic Peptide That Inhibits Nitric Oxide Production
Tito Akindele, B. Gise, Taiki Sunaba, M. Kita +1 more
20159 citations
Semantic Scholar
Antitumor Effects of Sea Hare-Derived Compounds in Cancer
H. Kigoshi, M. Kita
20159 citations
Semantic Scholar
N,N-Dimethylaminopyrene as a fluorescent affinity mass tag for ligand-binding mode analysis
A. Arai, Reiko Watanabe, Atsunori Hattori, Keita Iio +4 more
2020Scientific Reports8 citations Open access
Semantic Scholar
Synthesis of 2-(2-Hydroxyethoxy)-3-hydroxysqualene and Characterization of Its Anti-Inflammatory Effects
K. Sasaki, Yuri Inami, Kenichi Tominaga, H. Kigoshi +2 more
2020BioMed Research International8 citations Open access
Semantic Scholar
Binding position analysis of target proteins with the use of amidopyrene probes as LA-LDI enhancing tags.
Kozo Yoneda, Yaping Hu, Reiko Watanabe, M. Kita +1 more
2016Organic and biomolecular chemistry8 citations
Semantic Scholar
Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.
Yuichiro Hirayama, Kota Yamagishi, Tomohiro Suzuki, H. Kawagishi +2 more
2016Bioorganic & Medicinal Chemistry8 citations Open access
Semantic Scholar
Toward the synthesis of γ-pyrone-containing natural products: diastereoselective aldol-type reaction of a γ-pyrone
Takuma Takemura, I. Hayakawa, E. Fukasawa, T. Sengoku +1 more
20128 citations Open access
Semantic Scholar
Structure Revision of Trichomide D by Total Synthesis.
Masahito Yoshida, T. Matsushita, Shinji Kondo, H. Isoda +1 more
2022Journal of Natural Products7 citations
Semantic Scholar
Syntheses and aggregation properties of new squalene receptors bearing open chain ligands
Linh Ngoc Tran, T. Arimura, Kenichi Tominaga, H. Kigoshi +1 more
2021Supramolecular chemistry (Print)7 citations Open access
Semantic Scholar
Development of a novel inducer of protein-protein interactions based on aplyronine A.
Takayuki Ohyoshi, Atsuhiro Takano, M. Namiki, Tomotaka Ogura +5 more
2018Chemical Communications7 citations
Semantic Scholar
Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin
I. Hayakawa, M. Okamura, Kazuaki Suzuki, Mami Shimanuki +4 more
2017Synthesis7 citations
Semantic Scholar
Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization.
I. Hayakawa, Shuya Shioda, Takumi Chinen, Taisei Hatanaka +4 more
2016Bioorganic & Medicinal Chemistry7 citations Open access
Semantic Scholar
Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.
Y. Kato, Nobuhiro Fuchi, Y. Nishimura, Ayano Watanabe +6 more
2014Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death
Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo +6 more
2021Frontiers in Pharmacology6 citations Open access
Semantic Scholar
Synthetic studies toward aplysiasecosterol A: Construction of the novel tricyclic core
Takayuki Ohyoshi, H. Tano, Kei Akemoto, H. Kigoshi
20176 citations Open access
Semantic Scholar

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Takayuki Ohyoshi×7

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