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L. R. Thomas · SciRah

Researcher profile · Semantic Scholar

L. R. Thomas

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L. R. Thomas — researcher profile on SciRah

h-index: 25
Works: 38
Citations: 1,831

Most-cited papers

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
L. R. Thomas, Qing-Guo Wang, Brian C. Grieb, J. Phan +14 more
2015Molecules and Cells274 citations Open access
Semantic Scholar
Proteolytic control of the oncoprotein transcription factor Myc.
L. R. Thomas, W. Tansey
2011Advances in Cancer Research121 citations
Semantic Scholar
Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells.
J. Thorburn, Franklin Moore, Anuradha Rao, W. W. Barclay +4 more
2005Molecular Biology of the Cell117 citations Open access
Semantic Scholar
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
L. R. Thomas, Clare I. M. Adams, Jing Wang, April M. Weissmiller +6 more
2019Proceedings of the National Academy of Sciences of the United States of America106 citations Open access
Semantic Scholar
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
Erin R. Aho, Jing Wang, R. Gogliotti, G. C. Howard +21 more
2019Cell Reports104 citations Open access
Semantic Scholar
Direct Binding of Fas-associated Death Domain (FADD) to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor DR5 Is Regulated by the Death Effector Domain of FADD*
L. R. Thomas, A. Henson, John Calvin Reed, Freddie R. Salsbury +1 more
2004Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Tumor-derived Mutations in the TRAIL Receptor DR5 Inhibit TRAIL Signaling through the DR4 Receptor by Competing for Ligand Binding*
L. Bin, J. Thorburn, L. R. Thomas, P. Clark +2 more
2007Journal of Biological Chemistry81 citations Open access
Semantic Scholar
Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
L. R. Thomas, Hiroki Miyashita, Robin Milley Cobb, Steven E. Pierce +5 more
2008Journal of Immunology76 citations Open access
Semantic Scholar
5-Oxo-ETE analogs and the proliferation of cancer cells.
J. T. O'Flaherty, Leann C. Rogers, Christian M. Paumi, R. Hantgan +10 more
2005Biochimica et Biophysica Acta76 citations
Semantic Scholar
The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment and Can Regulate Agonist-specific Mechanisms of Receptor Activation*
L. R. Thomas, Ronald L. Johnson, John Calvin Reed, A. Thorburn
2004Journal of Biological Chemistry69 citations Open access
Semantic Scholar
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
Tessa M. Popay, Jing Wang, Clare I. M. Adams, G. C. Howard +10 more
2021eLife66 citations Open access
Semantic Scholar
The MYC–WDR5 Nexus and Cancer
L. R. Thomas, Audra M. Foshage, April M. Weissmiller, W. Tansey
2015Cancer Research61 citations Open access
Semantic Scholar
Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC inhibitors using fragment-based methods and structure-based design
Selena Chacón Simon, Feng Wang, L. R. Thomas, J. Phan +11 more
2020Journal of Medicinal Chemistry60 citations Open access
Semantic Scholar
The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm
L. Bender, M. Morgan, L. R. Thomas, Z.-G. Liu +1 more
2005Cell Death and Differentiation59 citations
Semantic Scholar
Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core
Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, Joseph Alvarado +21 more
2019Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Interaction of MYC with Host Cell Factor-1 is meditated by the evolutionarily-conserved Myc box IV motif
L. R. Thomas, Audra M. Foshage, April M. Weissmiller, Tessa M. Popay +7 more
2015Oncogene46 citations Open access
Semantic Scholar
Regulation of Fas-associated Death Domain Interactions by the Death Effector Domain Identified by a Modified Reverse Two-hybrid Screen*
L. R. Thomas, D. Stillman, A. Thorburn
2002Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)–MYC Protein–Protein Interaction
J. Macdonald, Selena Chacón Simon, Changho Han, Feng Wang +19 more
2019Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Mutations in the Pho2 (Bas2) Transcription Factor That Differentially Affect Activation with Its Partner Proteins Bas1, Pho4, and Swi5*
Leena T. Bhoite, Jason M. Allen, Emily García, L. R. Thomas +5 more
2002Journal of Biological Chemistry39 citations Open access
Semantic Scholar
An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells
M. Morgan, J. Thorburn, L. R. Thomas, Teresa M. Maxwell +2 more
2001Cell Death and Differentiation35 citations
Semantic Scholar
Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue
B. Jovanovic, Quan-Hu Sheng, R. Seitz, Kasey D. Lawrence +7 more
2017BMC Cancer34 citations Open access
Semantic Scholar
A common functional consequence of tumor-derived mutations within c-MYC
Abhishek A. Chakraborty, Claudio Scuoppo, Soumyadeep Dey, L. R. Thomas +3 more
2014Oncogene34 citations Open access
Semantic Scholar
Targeting MYC through WDR5
L. R. Thomas, Clare I. M. Adams, S. Fesik, C. M. Eischen +1 more
2020Molecular & Cellular Oncology32 citations Open access
Semantic Scholar
WIN site inhibition disrupts a subset of WDR5 function
Andrew J. Siladi, Jing Wang, Andrea C. Florian, L. R. Thomas +9 more
2022Scientific Reports29 citations Open access
Semantic Scholar
Dynamic regulation of antigen receptor gene assembly.
L. R. Thomas, Robin Milley Cobb, E. Oltz
2009Advances in Experimental Medicine and Biology28 citations
Semantic Scholar
Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608
Feng Zhang, L. R. Thomas, E. Oltz, T. Aune
2006Nature Immunology18 citations
Semantic Scholar
Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5
L. R. Thomas, L. Bender, M. Morgan, A. Thorburn
2006Cell Death and Differentiation14 citations
Semantic Scholar
pRS yeast vectors with a LYS2 marker.
P. Eriksson, L. R. Thomas, A. Thorburn, D. Stillman
2004BioTechniques14 citations Open access
Semantic Scholar
MYC and Chromatin
L. R. Thomas, W. Tansey
20158 citations Open access
Semantic Scholar
Regulation of FADD death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen
L. R. Thomas, D. Stillman, A. Thorburn
20024 citations
Semantic Scholar
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1
Tessa M. Popay, Jing Wang, Clare I. M. Adams, Simona G. Codreanu +9 more
2020bioRxiv1 citations Open access
Semantic Scholar
Author response: MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
Tessa M. Popay, Jing Wang, Clare I. M. Adams, G. C. Howard +10 more
20200 citations Open access
Semantic Scholar
Abstract 2600: Interaction of host cell factor-1 with the oncoprotein transcription factor MYC
Tessa M. Popay, L. R. Thomas, Jing Wang, Qi Liu +1 more
2019Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue
B. Jovanovic, Quan-Hu Sheng, R. Seitz, Kasey D. Lawrence +7 more
2017BMC Cancer0 citations Open access
Semantic Scholar
Abstract 4994: Understanding the MYC and WDR5 interaction at chromatin
Alissa D. Guarnaccia, April M. Weissmiller, L. R. Thomas, W. Tansey
20170 citations
Semantic Scholar
Abstract PR09: Targeting the MYC-WDR5 nexus in colorectal cancer
Audra M. Foshage, L. R. Thomas, S. Stauffer, S. Fesik +1 more
20170 citations
Semantic Scholar
Crystal structure of WDR5 in complex with MYC MbIIIb peptide
Qi Sun, J. Phan, E. Olejniczak, L. R. Thomas +2 more
20150 citations
Semantic Scholar
Mechanism of FADD-DN-Induced Apoptosis in Normal Breast Cells
L. R. Thomas
20040 citations Open access
Semantic Scholar

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