G. C. Howard

Most-cited papers

1. Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

   L. R. Thomas, Qing-Guo Wang, Brian C. Grieb, J. Phan +14 more

   2015Molecules and Cells274 citations Open access

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2. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

   Erin R. Aho, Jing Wang, R. Gogliotti, G. C. Howard +21 more

   2019Cell Reports104 citations Open access

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3. Inhibition of MYC by the SMARCB1 tumor suppressor

   April M. Weissmiller, Jing Wang, S. Lorey, G. C. Howard +3 more

   2019Nature Communications71 citations Open access

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4. Letter to the editor. Chemical-genetic strategy for inhibiting proteasome function in Saccharomyces cerevisiae.

   G. C. Howard, G. A. Collins, W. Tansey

   2012Yeast69 citations Open access

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5. MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

   Tessa M. Popay, Jing Wang, Clare I. M. Adams, G. C. Howard +10 more

   2021eLife66 citations Open access

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6. WDR5 is a conserved regulator of protein synthesis gene expression

   A. F. Bryan, Jing Wang, G. C. Howard, Alissa D. Guarnaccia +11 more

   2020Nucleic Acids Research61 citations Open access

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7. Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

   Kevin B Teuscher, S. Chowdhury, Kenneth M. Meyers, Jianhua Tian +16 more

   2022Proceedings of the National Academy of Sciences of the United States of America33 citations Open access

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8. WIN site inhibition disrupts a subset of WDR5 function

   Andrew J. Siladi, Jing Wang, Andrea C. Florian, L. R. Thomas +9 more

   2022Scientific Reports29 citations Open access

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9. The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B

   M. Bonizec, L. Hérissant, Wojciech Pokrzywa, Fu-Qiang Geng +7 more

   2014Nucleic Acids Research17 citations Open access

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10. Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

    Andrea C. Florian, Chase M. Woodley, Jing Wang, Brian C. Grieb +11 more

    2022NAR Cancer15 citations Open access

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11. Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

    G. C. Howard, Jing Wang, Kristie L. Rose, Camden Jones +16 more

    2023bioRxiv13 citations Open access

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12. Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

    Christian T. Meyer, Brianna N. Smith, Jing Wang, Kevin B Teuscher +13 more

    2024Proceedings of the National Academy of Sciences of the United States of America12 citations

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13. Ribosome-directed cancer therapies: The tip of the iceberg?

    G. C. Howard, William P. Tansey

    2025TIPS - Trends in Pharmacological Sciences9 citations Open access

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14. Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

    G. C. Howard, Jing Wang, K. Rose, Camden Jones +16 more

    2024eLife4 citations Open access

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15. Interaction of Gcn4 with target gene chromatin is modulated by proteasome function

    G. C. Howard, William P. Tansey

    2016Molecular Biology of the Cell4 citations Open access

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16. Author response: MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

    Tessa M. Popay, Jing Wang, Clare I. M. Adams, G. C. Howard +10 more

    20200 citations Open access

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17. Abstract LB-206: Inhibition of MYC by the SMARCB1 tumor suppressor

    April M. Weissmiller, Jing Wang, S. Lorey, G. C. Howard +3 more

    2018Molecular and Cellular Biology / Genetics0 citations

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