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K. Hertogs · SciRah

Researcher profile · Semantic Scholar

K. Hertogs

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K. Hertogs — researcher profile on SciRah

h-index: 45
Works: 111
Citations: 5,962

Most-cited papers

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs
K. Hertogs, M. de Béthune, V. Miller, T. Ivens +13 more
1998Antimicrobial Agents and Chemotherapy413 citations Open access
Semantic Scholar
Genotypic Correlates of Phenotypic Resistance to Efavirenz in Virus Isolates from Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Therapy
L. Bacheler, S. Jeffrey, G. Hanna, R. D'Aquila +11 more
2001Journal of Virology251 citations Open access
Semantic Scholar
Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure
V. Miller, C. Sabin, K. Hertogs, S. Bloor +9 more
2000AIDS (London)251 citations Open access
Semantic Scholar
A randomized trial assessing the impact of phenotypic resistance testing on antiretroviral therapy
C. Cohen, S. Hunt, M. Sension, C. Farthing +8 more
2002AIDS (London)204 citations Open access
Semantic Scholar
Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples
K. Hertogs, S. Bloor, S. Kemp, C. van den Eynde +6 more
2000AIDS (London)190 citations Open access
Semantic Scholar
A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance
B. Larder, S. Bloor, S. Kemp, K. Hertogs +8 more
1999Antimicrobial Agents and Chemotherapy187 citations Open access
Semantic Scholar
Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management: recommendations for the European setting
Miller, A. Vandamme, C. Loveday, S. Staszewski +14 more
2001185 citations Open access
Semantic Scholar
Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors
Olivia Goethals, R. Clayton, Marcia Van Ginderen, Inge Vereycken +12 more
2008Journal of Virology181 citations Open access
Semantic Scholar
Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples
B. Larder, K. Hertogs, S. Bloor, C. van den Eynde +4 more
2000AIDS (London)163 citations Open access
Semantic Scholar
Binding Kinetics of Darunavir to Human Immunodeficiency Virus Type 1 Protease Explain the Potent Antiviral Activity and High Genetic Barrier
I. Dierynck, M. D. de Wit, Emmanuel Gustin, I. Keuleers +3 more
2007Journal of Virology162 citations Open access
Semantic Scholar
Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virologic, immunologic, and toxicity parameters
M. Dybul, Tae-Wook Chun, C. Yoder, B. Hidalgo +15 more
2001Proceedings of the National Academy of Sciences of the United States of America159 citations Open access
Semantic Scholar
A Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutational Pattern Confers Phenotypic Lamivudine Resistance in the Absence of Mutation 184V
K. Hertogs, S. Bloor, V. De Vroey, C. van den Eynde +8 more
2000Antimicrobial Agents and Chemotherapy124 citations Open access
Semantic Scholar
Prevalence of genotypic and phenotypic resistance to anti-retroviral drugs in a cohort of therapy-naïve HIV-1 infected US military personnel
S. Wegner, S. Brodine, J. Mascola, S. Tasker +11 more
2000AIDS (London)123 citations Open access
Semantic Scholar
Baseline HIV drug resistance profile predicts response to ritonavir-saquinavir protease inhibitor therapy in a community setting.
P. Harrigan, K. Hertogs, W. Verbiest, Rudi Pauwels +7 more
1999AIDS (London)119 citations Open access
Semantic Scholar
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
J. Guillemont, E. Pasquier, Patrice Palandjian, Daniel F. J. Vernier +17 more
2005Journal of Medicinal Chemistry113 citations
Semantic Scholar
Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management: recommendations for the European setting. The EuroGUidelines Group for HIV resistance.
Miller, A. Vandamme, C. Loveday, S. Staszewski +48 more
2001AIDS (London)101 citations
Semantic Scholar
Non-nucleoside reverse transcriptase inhibitor resistance among patients failing a nevirapine plus protease inhibitor-containing regimen
J. Casado, K. Hertogs, L. Ruiz, F. Dronda +8 more
2000AIDS (London)101 citations Open access
Semantic Scholar
Delayed central nervous system virus suppression during highly active antiretroviral therapy is associated with HIV encephalopathy, but not with viral drug resistance or poor central nervous system drug penetration
C. Eggers, K. Hertogs, Hans-Jörg Stürenburg, J. van Lunzen +1 more
2003AIDS (London)98 citations Open access
Semantic Scholar
Long-cycle structured intermittent versus continuous highly active antiretroviral therapy for the treatment of chronic infection with human immunodeficiency virus: effects on drug toxicity and on immunologic and virologic parameters.
M. Dybul, Elizabeth Nies-Kraske, M. Daucher, K. Hertogs +12 more
2003Journal of Infectious Diseases94 citations
Semantic Scholar
Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action
Dirk Jochmans, J. Deval, B. Kesteleyn, H. Van Marck +10 more
2006Journal of Virology89 citations Open access
Semantic Scholar
Dual resistance to zidovudine and lamivudine in patients treated with zidovudine-lamivudine combination therapy: association with therapy failure.
Veronica Miller, Andrew N. Phillips, C. Rottmann, S. Staszewski +7 more
1998Journal of Infectious Diseases84 citations
Semantic Scholar
Primary Genotypic and Phenotypic HIV‐1 Drug Resistance in Recent Seroconverters in Madrid
C. Briones, M. Pérez-Olmeda, C. Rodríguez, J. del Romero +2 more
2001Journal of Acquired Immune Deficiency Syndromes83 citations Open access
Semantic Scholar
High prevalence of genotypic and phenotypic HIV-1 drug-resistant strains among patients receiving antiretroviral therapy in Abidjan, Côte d'Ivoire.
Christiane Adjé, R. Cheingsong, T. Roels, C. Maurice +13 more
2001Journal of Acquired Immune Deficiency Syndromes80 citations Open access
Semantic Scholar
Drug-resistant reverse transcriptase genotyping and phenotyping of B and non-B subtypes (F and A) of human immunodeficiency virus type I found in Brazilian patients failing HAART.
Elena Caride, R. Brindeiro, K. Hertogs, B. Larder +9 more
2000Virology80 citations Open access
Semantic Scholar
HIV Drug Susceptibility and Treatment Response to Mega-Haart Regimen in Patients from the Frankfurt HIV Cohort
V. Miller, A. Cozzi-Lepri, K. Hertogs, P. Gute +6 more
2000Antiviral Therapy78 citations Open access
Semantic Scholar
Laboratory Guidelines for the Practical Use of HIV Drug Resistance Tests in Patient Follow-Up
A. Vandamme, F. Houÿez, Dénes Bánhegyi, B. Clotet +15 more
2001Antiviral Therapy76 citations Open access
Semantic Scholar
Interference between D30N and L90M in Selection and Development of Protease Inhibitor-Resistant Human Immunodeficiency Virus Type 1
W. Sugiura, Z. Matsuda, Y. Yokomaku, K. Hertogs +12 more
2002Antimicrobial Agents and Chemotherapy74 citations Open access
Semantic Scholar
High Degree of Interlaboratory Reproducibility of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Sequencing of Plasma Samples from Heavily Treated Patients
R. Shafer, K. Hertogs, A. Zolopa, A. Warford +5 more
2001Journal of Clinical Microbiology74 citations Open access
Semantic Scholar
Long-term efficacy of routine access to antiretroviral-resistance testing in HIV type 1-infected patients: results of the clinical efficacy of resistance testing trial.
S. Wegner, M. Wallace, N. Aronson, S. Tasker +17 more
2004Clinical Infectious Diseases72 citations Open access
Semantic Scholar
Oligosaccharide concentrations in colostrum, transition milk, and mature milk of primi- and multiparous Holstein cows during the first week of lactation.
A. Fischer-Tlustos, K. Hertogs, J. K. van Niekerk, M. Nagorske +2 more
2020Journal of Dairy Science71 citations Open access
Semantic Scholar
Synthesis of novel diarylpyrimidine analogues of TMC278 and their antiviral activity against HIV-1 wild-type and mutant strains.
Céline Mordant, B. Schmitt, E. Pasquier, Christophe Demestre +9 more
2007European journal of medicinal chemistry71 citations
Semantic Scholar
ANTIVIRAL ACTIVITY OF TENOFOVIR (PMPA) AGAINST NUCLEOSIDE-RESISTANT CLINICAL HIV SAMPLES
Michael D. Miller, N. Margot, K. Hertogs, B. Larder +1 more
2001Nucleosides, Nucleotides & Nucleic Acids71 citations
Semantic Scholar
Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes.
Á. Holguín, E. Paxinos, K. Hertogs, Chad Womac +1 more
2004Journal of Clinical Virology67 citations
Semantic Scholar
Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles.
Olivia Goethals, A. Vos, Marcia Van Ginderen, Peggy Geluykens +4 more
2010Virology64 citations Open access
Semantic Scholar
Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride
V. Miller, M. de Béthune, A. Kober, M. Stürmer +4 more
1998Antimicrobial Agents and Chemotherapy60 citations Open access
Semantic Scholar
Correlation between Viral Resistance to Zidovudine and Resistance at the Reverse Transcriptase Level for a Panel of Human Immunodeficiency Virus Type 1 Mutants
J. Lennerstrand, K. Hertogs, D. Stammers, B. Larder
2001Journal of Virology58 citations Open access
Semantic Scholar
Genotypic and Phenotypic Evidence of Different Drug-Resistance Mutation Patterns between B and Non-B Subtype Isolates of Human Immunodeficiency Virus Type 1 found in Brazilian Patients Failing HAART
E. Caride, K. Hertogs, B. Larder, P. Dehertogh +9 more
2004Virus genes57 citations Open access
Semantic Scholar
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
W. Verschueren, I. Dierynck, K. Amssoms, Li-Li Hu +6 more
2005Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Testing Genotypic and Phenotypic Resistance in Human Immunodeficiency Virus Type 1 Isolates of Clade B and Other Clades from Children Failing Antiretroviral Therapy
Patrícia A. Brindeiro, R. Brindeiro, Cláudio Mortensen, K. Hertogs +7 more
2002Journal of Clinical Microbiology55 citations Open access
Semantic Scholar
Prevalence of Protease and Reverse Transcriptase Drug Resistance Mutations over Time in Drug-Naïve Human Immunodeficiency Virus Type 1-Positive Individuals in Rio de Janeiro, Brazil
A. T. Dumans, M. Soares, D. Pieniążek, M. Kalish +3 more
2002Antimicrobial Agents and Chemotherapy54 citations Open access
Semantic Scholar
A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies.
M. Pellis, E. Pardon, Kourosh Zolghadr, Ulrich Rothbauer +8 more
2012Archives of Biochemistry and Biophysics53 citations Open access
Semantic Scholar
CRF06‐cpx: A New Circulating Recombinant Form of HIV‐1 in West Africa Involving Subtypes A, G, K, and J
C. Montavon, Coumba Toure-Kane, J. Nkengasong, L. Vergne +4 more
2002Journal of Acquired Immune Deficiency Syndromes47 citations Open access
Semantic Scholar
Comparative Analysis of Two Commercial Phenotypic Assays for Drug Susceptibility Testing of Human Immunodeficiency Virus Type 1
S. Qari, R. Respess, H. Weinstock, Elise M. Beltrami +5 more
2002Journal of Clinical Microbiology46 citations Open access
Semantic Scholar
High Prevalence of Genotypic and Phenotypic HIV‐1 Drug‐Resistant Strains Among Patients Receiving Antiretroviral Therapy in Abidjan, Côte d'lvoire
Christiane Adjé, R. Cheingsong, T. Roels, C. Maurice +14 more
200145 citations
Semantic Scholar
Sustained and specific in vitro inhibition of HIV-1 replication by a protease inhibitor encapsulated in gp120-targeted liposomes.
R. Clayton, A. Ohagen, F. Nicol, A. D. del Vecchio +13 more
2009Antiviral Research42 citations
Semantic Scholar
Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirus
T. Ivens, C. van den Eynde, K. van Acker, E. Nijs +5 more
2005Journal of Virological Methods42 citations Open access
Semantic Scholar
Alternation of Antiretroviral Drug Regimens for HIV Infection
J. Martinez-Picado, E. Negredo, L. Ruiz, A. Shintani +10 more
2003Annals of Internal Medicine42 citations
Semantic Scholar
Despite high concordance, distinct mutational and phenotypic drug resistance profiles in human immunodeficiency virus type 1 RNA are observed in gastrointestinal mucosal biopsy specimens and peripheral blood mononuclear cells compared with plasma.
M. Poles, J. Elliott, Johan Vingerhoets, L. Michiels +5 more
2001Journal of Infectious Diseases41 citations Open access
Semantic Scholar
Resistance profiles in patients with viral rebound on potent antiretroviral therapy.
Alessandro Cozzi Lepri, C. Sabin, S. Staszewski, K. Hertogs +4 more
2000Journal of Infectious Diseases41 citations
Semantic Scholar
Correlation of Phenotypic Zidovudine Resistance with Mutational Patterns in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1: Interpretation of Established Mutations and Characterization of New Polymorphisms at Codons 208, 211, and 214
M. Stürmer, S. Staszewski, H. Doerr, B. Larder +2 more
2003Antimicrobial Agents and Chemotherapy40 citations Open access
Semantic Scholar

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