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M. Labroli · SciRah

Researcher profile · Semantic Scholar

M. Labroli

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M. Labroli — researcher profile on SciRah

h-index: 11
Works: 33
Citations: 1,096

Most-cited papers

Total Syntheses of Ningalin A, Lamellarin O, Lukianol A, and Permethyl Storniamide A Utilizing Heterocyclic Azadiene Diels−Alder Reactions
D. Boger, Christopher W. Boyce, M. Labroli, C. Sehon +1 more
1999324 citations
Semantic Scholar
Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
T. Guzi, K. Paruch, M. Dwyer, M. Labroli +13 more
2011Molecular Cancer Therapeutics174 citations
Semantic Scholar
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonis
J. Tagat, S. Mccombie, D. Nazareno, M. Labroli +8 more
2004Journal of Medicinal Chemistry140 citations Open access
Semantic Scholar
TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci
Sang-Ho Lee, Hao Wang, M. Labroli, Sandra Koseoglu +28 more
2016Science Translational Medicine97 citations
Semantic Scholar
Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.
P. Mann, Anna Müller, Li Xiao, P. M. Pereira +23 more
2013ACS Chemical Biology58 citations
Semantic Scholar
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.
M. Labroli, K. Paruch, M. Dwyer, Carmen S. Alvarez +11 more
2011Bioorganic & Medicinal Chemistry Letters58 citations Open access
Semantic Scholar
Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets
P. Mann, Anna Müller, K. Wolff, T. Fischmann +18 more
2016PLoS Pathogens47 citations Open access
Semantic Scholar
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.
M. Dwyer, K. Keertikar, K. Paruch, Carmen S. Alvarez +8 more
2013Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1.
M. Dwyer, K. Paruch, M. Labroli, Carmen S. Alvarez +11 more
2011Bioorganic & Medicinal Chemistry Letters34 citations
Semantic Scholar
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
J. Sanders, D. Beshore, J. Culberson, James I. Fells +13 more
2017Journal of Medicinal Chemistry20 citations
Semantic Scholar
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Hao Wang, A. Ishchenko, Jason W Skudlarek, Pamela Shen +37 more
2024Nature Microbiology16 citations
Semantic Scholar
Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Shu-Wei Yang, Jian-Ping Pan, Christine Yang, M. Labroli +14 more
2016Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
Discovery of potent wall teichoic acid early stage inhibitors.
M. Labroli, J. Caldwell, Christine Yang, Sang-Ho Lee +9 more
2016Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.
M. Labroli, M. Dwyer, R. Shen, Janeta Popovici-Muller +12 more
2014Bioorganic & Medicinal Chemistry11 citations
Semantic Scholar
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase
Scott S. Walker, M. Labroli, R. Painter, J. Wiltsie +17 more
2017PLoS ONE10 citations Open access
Semantic Scholar
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
Mihirbaran Mandal, Z. Tan, Christina B. Madsen-Duggan, A. Buevich +33 more
2017Journal of Medicinal Chemistry8 citations Open access
Semantic Scholar
Syntheses of 5´-amino-2´,5´-dideoxy-2´,2´-difluorocytidine derivatives as novel anticancer nucleoside analogs
M. Labroli, M. Dwyer, R. Shen, Janeta Popovici-Muller +5 more
20147 citations
Semantic Scholar
Synthesis of Amino-Acid Functionalized β-Carbolines as Topoisomerase II Inhibitors.
A. M. Deveau, M. Labroli, C. Dieckhaus, Mary T. Barthen +2 more
20016 citations
Semantic Scholar
A convergent preparation of the CHK1 inhibitor MK-8776 (SCH 900776)
M. Labroli, M. Dwyer, Cory Poker, Kerry M. Keertikar +2 more
20165 citations
Semantic Scholar
7.16 – DNA Topoisomerase Inhibitors
T. Macdonald, M. Labroli, J. Tepe
19995 citations
Semantic Scholar
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.
Michael A. Plotkin, M. Labroli, Jeffrey W. Schubert, Anthony W. Shaw +21 more
2024ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
Jason W Skudlarek, Andrew J Cooke, Helen J. Mitchell, K. Babaoglu +43 more
2024Journal of Medicinal Chemistry4 citations
Semantic Scholar
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA
Yan Hou, T. Mayhood, P. Sheth, Christopher M. Tan +5 more
2016Journal of biomolecular screening4 citations Open access
Semantic Scholar
Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.
Mihirbaran Mandal, Maria Madeira, Rupesh P. Amin, A. Buevich +27 more
2022Journal of Medicinal Chemistry2 citations Open access
Semantic Scholar
Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.
Olga Berejnaia, Hao Wang, M. Labroli, Christine Yang +9 more
2017Analytical Biochemistry2 citations
Semantic Scholar
N-Benzylidenebenzenesulfonamide as a Benzaldehyde Equivalent in the Knoevenagel Reaction
W. W. Zajac, T. Walters, J. Buzby, J. L. Gagnon +1 more
20062 citations
Semantic Scholar
Total Syntheses of Ningalin A (V), Lamellarin O (VI), Lukianol A (VII), and Permethyl Storniamide A (VIII) Utilizing Heterocyclic Azadiene Diels—Alder Reactions.
D. Boger, Christopher W. Boyce, M. Labroli, C. Sehon +1 more
19991 citations
Semantic Scholar
Structural characterization of a novel class of antibacterials that target the lipopolysaccharide transporter MsbA in multidrug-resistant Acinetobacter baumannii
Daniel Klein, Hao Wang, A. Ishchenko, Jason W Skudlarek +25 more
2025Structural Dynamics0 citations Open access
Semantic Scholar
Syntheses of 5′‐Amino‐2′,5′‐dideoxy‐2′,2′‐difluorocytidine Derivatives as Novel Anticancer Nucleoside Analogues.
M. Labroli, M. Dwyer, R. Shen, Janeta Popovici-Muller +5 more
20140 citations
Semantic Scholar
Novel pyrazolopyrimidines as novel cyćlin dependent kinaseinhibitors
T. Guzi, K. Paruch, M. Dwyer, M. Labroli +1 more
20080 citations
Semantic Scholar
Pharmaceutical compositions containing the CCR5 antagonistic piperazine derivatives
B. Baroudy, J. Clader, H. Josien, S. Mccombie +11 more
20000 citations
Semantic Scholar
Piperazine derivatives, which are useful as CCR5 antagonists
B. Baroudy, J. Clader, S. Mccombie, B. Mckittrick +11 more
20000 citations
Semantic Scholar
N-Benzylidenebenzenesulfonamide as a Benzaldehyde Equivalent in the Knoevenagel Reaction.
W. W. Jun. Zajac, T. Walters, J. Buzby, J. L. Gagnon +1 more
19940 citations
Semantic Scholar

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