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S. Mccombie · SciRah

Researcher profile · Semantic Scholar

S. Mccombie

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S. Mccombie — researcher profile on SciRah

h-index: 25
Works: 147
Citations: 4,056

Most-cited papers

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
A. Trkola, S. Kuhmann, J. Strizki, Elizabeth Maxwell +13 more
2002Proceedings of the National Academy of Sciences of the United States of America335 citations Open access
Semantic Scholar
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
J. Strizki, Serena Xu, Nicole E. Wagner, Lisa Wojcik +21 more
2001Proceedings of the National Academy of Sciences of the United States of America316 citations Open access
Semantic Scholar
Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry
Fotini Tsamis, S. Gavrilov, F. Kajumo, Christoph Seibert +11 more
2003Journal of Virology233 citations Open access
Semantic Scholar
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonis
J. Tagat, S. Mccombie, D. Nazareno, M. Labroli +8 more
2004Journal of Medicinal Chemistry140 citations Open access
Semantic Scholar
Interaction of small molecule inhibitors of HIV-1 entry with CCR5.
Christoph Seibert, W. Ying, S. Gavrilov, Fotini Tsamis +10 more
2006Virology139 citations Open access
Semantic Scholar
Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5.
M. Vierboom, P. Zavodny, Chuan-Chu Chou, J. Tagat +9 more
2005Arthritis & Rheumatism106 citations
Semantic Scholar
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.
J. Tagat, R. Steensma, S. Mccombie, Dennis V. Nazareno +9 more
2001Journal of Medicinal Chemistry94 citations Open access
Semantic Scholar
Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.
W. Greenlee, J. Clader, Theodros Asberom, S. Mccombie +20 more
2001Il Farmaco64 citations
Semantic Scholar
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element.
J. Tagat, S. Mccombie, R. Steensma, Sue-Ing Lin +5 more
2001Bioorganic & Medicinal Chemistry Letters60 citations Open access
Semantic Scholar
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides.
S. Mccombie, J. Tagat, S. Vice, Sue-Ing Lin +9 more
2003Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Concise formation of 4-benzyl piperidines and related derivatives using a Suzuki protocol.
S. Vice, Tom Bara, Annette Bauer, C. A. Evans +7 more
2001Journal of Organic Chemistry41 citations
Semantic Scholar
One-pot, three-component synthesis of arylidenesuccinates and related compounds
S. Mccombie, C. A. Luchaco
199741 citations
Semantic Scholar
Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors
B. Shankar, M. Kirkup, S. Mccombie, J. Clader +1 more
199638 citations
Semantic Scholar
Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry
Michael W. Miller, F. ViceSusan, S. Mccombie
199834 citations
Semantic Scholar
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides.
A. Palani, Sherry Shapiro, J. Clader, W. Greenlee +5 more
2003Bioorganic & Medicinal Chemistry Letters31 citations Open access
Semantic Scholar
GENERATION AND IN SITU ACYLATION OF ENAMINONE ANIONS : A CONVENIENT SYNTHESIS OF 3-CARBETHOXY-4(1H)-PYRIDINONES AND -4-PYRONES AND RELATED COMPOUNDS
S. Mccombie, W. Metz, D. Nazareno, B. Shankar +1 more
199129 citations
Semantic Scholar
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Pauline C. Ting, Joe F. Lee, Jie Wu, S. Umland +14 more
2005Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
The Barton-McCombie Reaction
S. Mccombie, W. Motherwell, M. Tozer
201226 citations
Semantic Scholar
Controlling benzylic functionality and stereochemistry: 1. Synthesis of the secopseudopterosin aglycone
S. Mccombie, B. Cox, Sue-Ing Lin, A. Ganguly +1 more
199125 citations Open access
Semantic Scholar
Reflections on the mechanism of the Barton-McCombie Deoxygenation and on its consequences†
S. Mccombie, B. Quiclet-Sire, S. Zard
2018Tetrahedron23 citations
Semantic Scholar
Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
J. Clader, W. Billard, H. Binch, Lian-Yong Chen +11 more
2004Bioorganic & Medicinal Chemistry23 citations
Semantic Scholar
Synthetic inhibitors of interleukin-6 II: 3,5-diaryl pyridines and meta-terphenyls
J. Tagat, S. Mccombie, B. E. Barton, J. Jackson +1 more
199523 citations
Semantic Scholar
Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.
S. Mccombie, R. Bishop, D. Carr, E. Dobek +7 more
199322 citations
Semantic Scholar
Alkylation of 2-oxy-substituted 1-sulfonylallyl and 1-sulfonylvinyl anions. New routes to functionalized carbocycles and dihydrofurans
A. Padwa, W. Bullock, A. D. Dyszlewski, S. Mccombie +2 more
199122 citations
Semantic Scholar
Synthesis and in vitro activity of the penem antibiotics
S. Mccombie, A. Ganguly
1988Medicinal research reviews (Print)21 citations
Semantic Scholar
A novel method for the synthesis of aryl sulfones
Steensma Ruo, Sharen Galabi, J. Tagat, S. Mccombie
200120 citations
Semantic Scholar
Reduction of Saturated Alcohols and Amines to Alkanes
S. Mccombie
199120 citations
Semantic Scholar
A concise route to the oxathiazepine containing eudistomin skeleton and some carba-analogs
M. Kirkup, B. Shankar, S. Mccombie, A. Ganguly +1 more
198920 citations
Semantic Scholar
Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands.
Brian J. Lavey, J. Kozlowski, B. Shankar, J. Spitler +11 more
2007Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Synthesis of mono- and difluoronaphthoic acids.
J. Tagat, S. Mccombie, D. Nazareno, Craig D. Boyle +5 more
2002Journal of Organic Chemistry19 citations
Semantic Scholar
(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor
M. Kirkup, R. Rizvi, B. Shankar, S. Dugar +9 more
199619 citations
Semantic Scholar
Suzuki Arylation of 1,1-Dibromo-1-alkenes: Synthesis of Tetra-substituted Alkenes
A. Bauer, Michael W. Miller, S. Vice, S. Mccombie
200118 citations
Semantic Scholar
Synthesis and anti-herpes activity of some a-ring functionalized dehydroabietane derivatives
J. Tagat, D. Nazareno, M. Puar, S. Mccombie +1 more
199418 citations
Semantic Scholar
Synthesis and chemistry of thia-analogs of the anti-mitotic podophyllium lignans
S. Mccombie, J. Tagat, W. Metz, D. Nazareno +1 more
199318 citations
Semantic Scholar
SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin
N. Reynolds, S. Mccombie, B. Shankar, W. Bishop +1 more
1997Archives of Dermatological Research17 citations Open access
Semantic Scholar
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.
J. Kozlowski, Guo-Wei Zhou, J. Tagat, Sue-Ing Lin +9 more
2002Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Stereospecific synthesis of the aglycone of pseudopterosin E
A. Ganguly, S. Mccombie, B. Cox, Sue-Ing Lin +1 more
199016 citations Open access
Semantic Scholar
Indolocarbazole nitrogens linked by three-atom bridges: a potent new class of PKC inhibitors
S. Vice, W. Bishop, S. Mccombie, H. Dao +2 more
199415 citations
Semantic Scholar
Indolocarbazoles. 2. Synthetic studies towards staurosporine. An unexpected 1,2 migration of indolocarbazole nitrogen results in a novel and potent Protein kinase C inhibitor.
B. Shankar, S. Mccombie, M. Kirkup, A. Viet +2 more
199315 citations
Semantic Scholar
A novel application of “benzotriazole” methodology : Reactions of polyhydroxylated bis-(benzotriazolyl) piperidines with mono- and bidentate nucleophiles.
B. Shankar, M. Kirkup, S. Mccombie, A. Ganguly
199315 citations
Semantic Scholar
Gamma-lactams and related compounds as cholesterol absorption inhibitors: homologs of the beta-lactam cholesterol absorption inhibitor SCH 484611
S. Dugar, M. Kirkup, J. Clader, Sue-Ing Lin +4 more
199514 citations
Semantic Scholar
Controlling Benzylic and Anomeric Functionality and Stereochemistry: Methodology and Syntheses Utilising Intramolecular Ionic Hydrogenation
S. Mccombie, C. Ortiz, B. Cox, A. Ganguly
199314 citations
Semantic Scholar
Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand.
D. Mullins, N. Adham, D. Hesk, Yu-Sheng Wu +7 more
2008European Journal of Pharmacology11 citations
Semantic Scholar
Indolocarbazoles. 4. Synthetic studies towards staurosporine and tjipanazoles: Reactions of indolocarbazole with glycals
B. Shankar, S. Mccombie
199411 citations
Semantic Scholar
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.
E. Gilbert, Guo-Wei Zhou, Michael K. C. Wong, Ling Tong +17 more
2010Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
New reactions of hydrazides. Part 1: Directed ortho- and lateral metalation of aromatic carbocyclic and heterocyclic systems
S. Mccombie, Sue-Ing Lin, S. Vice
199910 citations
Semantic Scholar
Cyclofunctionalisation of epoxyalcohol derivatives. 4. Cyclisation of sulfonylacetate dianions: A synthesis of “MeBMT”
S. Mccombie, B. Shankar, A. Ganguly
198910 citations
Semantic Scholar
Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.
S. Mccombie, Sue-Ing Lin, J. Tagat, D. Nazareno +9 more
2002Bioorganic & Medicinal Chemistry Letters9 citations Open access
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Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.
Craig D. Boyle, Samuel Chackalamannil, John W. Clader, William J. Greenlee +18 more
2001Bioorganic & Medicinal Chemistry Letters8 citations Open access
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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.
Craig D. Boyle, S. Vice, J. Campion, S. Chackalamannil +12 more
2002Bioorganic & Medicinal Chemistry Letters7 citations Open access
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