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K. Zech · SciRah

Researcher profile · Semantic Scholar

K. Zech

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K. Zech — researcher profile on SciRah

h-index: 29
Works: 103
Citations: 2,654

Most-cited papers

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.
A. Madan, R. Graham, K. Carroll, Daniel R. Mudra +15 more
2003Drug Metabolism And Disposition361 citations
Semantic Scholar
Pharmacokinetics of pantoprazole in man.
R. Huber, M. Hartmann, H. Bliesath, R. Lühmann +2 more
1996International journal of clinical pharmacology and therapeutics151 citations
Semantic Scholar
Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity
Anna Westlind-Johnsson, R. Hermann, A. Huennemeyer, B. Hauns +5 more
2006Clinical pharmacology and therapy121 citations
Semantic Scholar
Population Pharmacokinetics and Pharmacodynamics of Ciclesonide
S. Rohatagi, V. Arya, K. Zech, R. Nave +3 more
2003Journal of clinical pharmacology105 citations
Semantic Scholar
Pharmacokinetics of [14C]Ciclesonide After Oral and Intravenous Administration to Healthy Subjects
R. Nave, T. Bethke, S. V. van Marle, K. Zech
2004Clinical Pharmacokinetics104 citations
Semantic Scholar
The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue.
E. Mutch, R. Nave, N. McCracken, K. Zech +1 more
2007Biochemical Pharmacology100 citations Open access
Semantic Scholar
Formation of fatty acid conjugates of ciclesonide active metabolite in the rat lung after 4-week inhalation of ciclesonide.
R. Nave, W. Meyer, Rainer Fuhst, K. Zech
2005Pulmonary Pharmacology & Therapeutics88 citations
Semantic Scholar
Selective sample handling and detection in high-performance liquid chromatography (Journal of chromatography library, vol. 39A)
R. W. Frei, K. Zech, P. Worsfold
198888 citations
Semantic Scholar
Risk‐Benefit Value of Inhaled Glucocorticoids: A Pharmacokinetic/ Pharmacodynamic Perspective
S. Rohatagi, S. Appajosyula, H. Derendorf, S. Szefler +3 more
2004Journal of clinical pharmacology86 citations
Semantic Scholar
Lack of pantoprazole drug interactions in man: an updated review.
V. Steinijans, R. Huber, M. Hartmann, K. Zech +3 more
1996International journal of clinical pharmacology and therapeutics74 citations
Semantic Scholar
A novel screening strategy to identify ABCB1 substrates and inhibitors
O. von Richter, H. Glavinas, P. Krajcsi, Stephanie Liehner +2 more
2008Naunyn-Schmiedeberg's Archives of Pharmacology65 citations
Semantic Scholar
In Vitro metabolism of ciclesonide in human lung and liver precision‐cut tissue slices
R. Nave, R. Fisher, K. Zech
2006Biopharmaceutics & drug disposition63 citations
Semantic Scholar
Regional and laminar distributions of alpha 1-adrenoceptors and their subtypes in human and rat hippocampus.
K. Zilles, G. Gross, A. Schleicher, S. Schildgen +5 more
1991Neuroscience62 citations
Semantic Scholar
Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals.
Augustinus Bader, K. Zech, O. Crome, U. Christians +3 more
1994Xenobiotica; the fate of foreign compounds in biological systems58 citations
Semantic Scholar
Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects
R. Nave, K. Zech, T. Bethke
2005European Journal of Clinical Pharmacology56 citations
Semantic Scholar
Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration
S. Hustvedt, Derek Grant, T. Southon, K. Zech
1997Acta Radiologica50 citations
Semantic Scholar
Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.
H. Tenor, A. Hatzelmann, R. Beume, G. Lahu +2 more
2011Handbook of Experimental Pharmacology46 citations
Semantic Scholar
Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects.
N. Nassr, A. Huennemeyer, R. Herzog, O. von Richter +5 more
2009British Journal of Clinical Pharmacology46 citations Open access
Semantic Scholar
Investigation of a Potential Food Effect on the Pharmacokinetics of Roflumilast, an Oral, Once‐Daily Phosphodiesterase 4 Inhibitor, in Healthy Subjects
B. Hauns, R. Hermann, A. Hünnemeyer, R. Herzog +3 more
2006Journal of clinical pharmacology45 citations
Semantic Scholar
Pharmacokinetics‐‐a relevant factor for the choice of a drug?
L. Benet, K. Zech
1994Alimentary Pharmacology and Therapeutics45 citations
Semantic Scholar
Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions.
Augustinus Bader, N. Frühauf, K. Zech, A. Haverich +1 more
1998Xenobiotica; the fate of foreign compounds in biological systems44 citations
Semantic Scholar
Steady-State Pharmacokinetics of Roflumilast and Roflumilast N-Oxide in Patients with Mild and Moderate Liver Cirrhosis
R. Hermann, N. Nassr, G. Lahu, É. Péterfai +4 more
2007Clinical Pharmacokinetics40 citations
Semantic Scholar
Effect of Single and Repeated Doses of Ketoconazole on the Pharmacokinetics of Roflumilast and Roflumilast N‐Oxide
G. Lahu, A. Huennemeyer, O. von Richter, R. Hermann +3 more
2008Journal of clinical pharmacology36 citations
Semantic Scholar
Roflumilast, a novel, oral, selective PDE4 inhibitor, shows high absolute bioavailability
M. David, K. Zech, M. Seiberling, C. Weimar +1 more
200436 citations Open access
Semantic Scholar
Population Pharmacokinetic Modelling of Roflumilast and Roflumilast N-Oxide by Total Phosphodiesterase-4 Inhibitory Activity and Development of a Population Pharmacodynamic-Adverse Event Model
G. Lahu, A. Hünnemeyer, E. Diletti, M. Elmlinger +4 more
2010Clinical Pharmacokinetics35 citations Open access
Semantic Scholar
Effect of Fluvoxamine on the Pharmacokinetics of Roflumilast and Roflumilast N-Oxide
O. von Richter, G. Lahu, A. Huennemeyer, R. Herzog +2 more
2007Clinical Pharmacokinetics34 citations
Semantic Scholar
PK/PD of inhaled corticosteroids: The risk/benefit of inhaled ciclesonide
S. Rohatagi, H. Derendorf, K. Zech, R. Nave +1 more
200332 citations Open access
Semantic Scholar
Effect of repeated dose of erythromycin on the pharmacokinetics of roflumilast and roflumilast N-oxide.
G. Lahu, A. Huennemeyer, R. Herzog, N. McCracken +3 more
2009International journal of clinical pharmacology and therapeutics30 citations
Semantic Scholar
Lack of a pharmacokinetic interaction between steady-state roflumilast and single-dose midazolam in healthy subjects.
N. Nassr, G. Lahu, O. von Richter, F. Reutter +6 more
2007British Journal of Clinical Pharmacology29 citations Open access
Semantic Scholar
Lack of pantoprazole drug interactions in man.
V. W. Steinijans, R. Huber, M. Hartmann, K. Zech +3 more
1994International journal of clinical pharmacology and therapeutics29 citations
Semantic Scholar
Sensitive simultaneous determination of ciclesonide, ciclesonide-M1-metabolite and fluticasone propionate in human serum by HPLC-MS/MS with APPI.
H. Mascher, K. Zech, D. Mascher
2008Journal of chromatography. B, Analytical technologies in the biomedical and life sciences28 citations
Semantic Scholar
Pharmacokinetics and drug interactions--relevant factors for the choice of a drug.
K. Zech, V. Steinijans, R. Huber, N. Kolassa +1 more
1996International journal of clinical pharmacology and therapeutics28 citations
Semantic Scholar
LACK OF DNA BINDING IN THE RAT NASAL MUCOSA AND OTHER TISSUES OF THE NASAL TOXICANTS ROFLUMILAST, A PHOSPHODIESTERASE 4 INHIBITOR, AND A METABOLITE, 4-AMINO-3,5-DICHLOROPYRIDINE, IN CONTRAST TO THE NASAL CARCINOGEN 2,6-DIMETHYLANILINE*
A. Jeffrey, Feng-Qi Luo, Shantilal Amin, J. Krzemiński +2 more
2002Drug and chemical toxicology (New York, N.Y. 1978)26 citations
Semantic Scholar
The Oral, Once‐Daily Phosphodiesterase 4 Inhibitor Roflumilast Lacks Relevant Pharmacokinetic Interactions With Inhaled Budesonide
R. Hermann, W. Siegmund, T. Giessmann, K. Westphal +6 more
2007Journal of clinical pharmacology23 citations
Semantic Scholar
Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects.
T. Bethke, T. Giessmann, K. Westphal, A. Weinbrenner +7 more
2006International journal of clinical pharmacology and therapeutics22 citations
Semantic Scholar
Pharmacokinetic disposition of inhaled ciclesonide and its metabolite desisobutyryl-ciclesonide in healthy subjects and patients with asthma are similar.
R. Nave, K. Gunawardena, K. Zech, T. Bethke
2006International journal of clinical pharmacology and therapeutics21 citations
Semantic Scholar
Magnesium Hydroxide/Aluminium Hydroxide‐Containing Antacid Does Not Affect the Pharmacokinetics of the Targeted Phosphodiesterase 4 Inhibitor Roflumilast
N. Nassr, G. Lahu, A. Hünnemeyer, O. von Richter +4 more
2007Journal of clinical pharmacology19 citations
Semantic Scholar
Direct injection of biological fluids: Application of HPLC-analysis with precolumn enrichment to the pharmacokinetic studies of lonazolac
R. Huber, K. Zech, M. Wörz, T. Kronbach +1 more
198219 citations
Semantic Scholar
Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation.
N. Knebel, R. Herzog, F. Reutter, K. Zech
2012Journal of chromatography. B, Analytical technologies in the biomedical and life sciences18 citations
Semantic Scholar
Clinical Pharmacokinetics of Urapidil
R. Kirsten, K. Nelson, V. Steinijans, K. Zech +1 more
1988Clinical Pharmacokinetics18 citations
Semantic Scholar
Biotransformation of urapidil: metabolites in serum and urine and their biological activity in vitro and in vivo.
K. Zech, Manfrid Eltze, Ulrich Kilian, K. Sanders +1 more
1984Archives internationales de pharmacodynamie et de therapie17 citations
Semantic Scholar
Glucuronide conjugates of Soraprazan (BY359), a new potassium-competitive acid blocker (P-CAB) for the treatment of acid-related diseases
J. Senn-Bilfinger, J. R. Ferguson, Michael A. Holmes, K. Lumbard +4 more
200615 citations
Semantic Scholar
Identification of enzymes involved in Phase I metabolism of ciclesonide by human liver microsomes
Caroline F. Peet, T. Enos, R. Nave, K. Zech +1 more
2005European journal of drug metabolism and pharmacokinetics15 citations
Semantic Scholar
Lack of pharmacokinetic drug-drug interaction between ciclesonide and erythromycin.
R. Nave, A. Drollmann, V. Steinijans, K. Zech +1 more
2005International journal of clinical pharmacology and therapeutics15 citations
Semantic Scholar
Pharmacokinetics and safety of Roflumilast, a once-daily, oral, selective PDE4 inhibitor, and its active metabolite Roflumilast N-oxide in healthy subjects
A. Huennemeyer, B. Hauns, M. David, G. Böhmer +5 more
200415 citations Open access
Semantic Scholar
Single‐Dose Pharmacokinetics of Roflumilast in Children and Adolescents
Kathleen A. Neville, S. Szefler, S. Abdel-Rahman, G. Lahu +5 more
2008Journal of clinical pharmacology14 citations
Semantic Scholar
Pantoprazole lacks induction of CYP1A2 activity in man.
M. Hartmann, K. Zech, H. Bliesath, V. Steinijans +3 more
1999International journal of clinical pharmacology and therapeutics14 citations
Semantic Scholar
Pharmacokinetics and Metabolism of Budipine in Animals and Humans
K. Zech, E. Sturm, G. Ludwig
198513 citations
Semantic Scholar
Phase I and pharmacokinetic study of the P-glycoprotein modulator dexniguldipine-HCL.
V. Nuessler, M. Scheulen, R. Oberneder, M. Kriegmair +5 more
1997European Journal of Medical Research12 citations
Semantic Scholar
Isolation of compounds from complex sample mixtures for identification purposes — The semi-preparative separation of natural products
K. Hupe, H. H. Lauer, K. Zech
198011 citations
Semantic Scholar

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