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G. Lahu · SciRah

Researcher profile · Semantic Scholar

G. Lahu

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G. Lahu — researcher profile on SciRah

h-index: 21
Works: 84
Citations: 1,448

Most-cited papers

Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity
Anna Westlind-Johnsson, R. Hermann, A. Huennemeyer, B. Hauns +5 more
2006Clinical pharmacology and therapy121 citations
Semantic Scholar
Modeling of tumor growth and anticancer effects of combination therapy
Gilbert Koch, A. Walz, G. Lahu, J. Schropp
2009Journal of Pharmacokinetics and Pharmacodynamics119 citations
Semantic Scholar
Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum
S. Röpcke, O. Holz, Gereon Lauer, M. Müller +6 more
2012PLoS ONE70 citations Open access
Semantic Scholar
Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults
M. V. van Duinen, A. Sambeth, P. Heckman, S. Smit +5 more
2018Neuropharmacology61 citations Open access
Semantic Scholar
Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.
A. Blokland, M. V. van Duinen, A. Sambeth, P. Heckman +4 more
2019Neurobiology of Aging60 citations Open access
Semantic Scholar
Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques
V. Rodriguez-Romero, R. Bergstrom, B. Decker, G. Lahu +2 more
2019Clinical and Translational Science55 citations Open access
Semantic Scholar
An experimental medicine study of the phosphodiesterase-4 inhibitor, roflumilast, on working memory-related brain activity and episodic memory in schizophrenia patients
J. Gilleen, Yakub Farah, Cathy A. Davison, Sarah Kerins +9 more
2018Psychopharmacology51 citations Open access
Semantic Scholar
Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.
H. Tenor, A. Hatzelmann, R. Beume, G. Lahu +2 more
2011Handbook of Experimental Pharmacology46 citations
Semantic Scholar
Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects.
N. Nassr, A. Huennemeyer, R. Herzog, O. von Richter +5 more
2009British Journal of Clinical Pharmacology46 citations Open access
Semantic Scholar
Safety, tolerability, pharmacokinetics and pharmacodynamics of the anti‐CD38 cytolytic antibody TAK‐079 in healthy subjects
E. Fedyk, Lin Zhao, A. Koch, G. Smithson +6 more
2020British Journal of Clinical Pharmacology40 citations Open access
Semantic Scholar
Steady-State Pharmacokinetics of Roflumilast and Roflumilast N-Oxide in Patients with Mild and Moderate Liver Cirrhosis
R. Hermann, N. Nassr, G. Lahu, É. Péterfai +4 more
2007Clinical Pharmacokinetics40 citations
Semantic Scholar
Effect of Single and Repeated Doses of Ketoconazole on the Pharmacokinetics of Roflumilast and Roflumilast N‐Oxide
G. Lahu, A. Huennemeyer, O. von Richter, R. Hermann +3 more
2008Journal of clinical pharmacology36 citations
Semantic Scholar
Population Pharmacokinetic Modelling of Roflumilast and Roflumilast N-Oxide by Total Phosphodiesterase-4 Inhibitory Activity and Development of a Population Pharmacodynamic-Adverse Event Model
G. Lahu, A. Hünnemeyer, E. Diletti, M. Elmlinger +4 more
2010Clinical Pharmacokinetics35 citations Open access
Semantic Scholar
Effect of Fluvoxamine on the Pharmacokinetics of Roflumilast and Roflumilast N-Oxide
O. von Richter, G. Lahu, A. Huennemeyer, R. Herzog +2 more
2007Clinical Pharmacokinetics34 citations
Semantic Scholar
Effect of repeated dose of erythromycin on the pharmacokinetics of roflumilast and roflumilast N-oxide.
G. Lahu, A. Huennemeyer, R. Herzog, N. McCracken +3 more
2009International journal of clinical pharmacology and therapeutics30 citations
Semantic Scholar
Lack of a pharmacokinetic interaction between steady-state roflumilast and single-dose midazolam in healthy subjects.
N. Nassr, G. Lahu, O. von Richter, F. Reutter +6 more
2007British Journal of Clinical Pharmacology29 citations Open access
Semantic Scholar
Pharmacokinetic evaluation of roflumilast
G. Lahu, N. Nassr, A. Hünnemeyer
2011Expert Opinion on Drug Metabolism & Toxicology24 citations
Semantic Scholar
The Oral, Once‐Daily Phosphodiesterase 4 Inhibitor Roflumilast Lacks Relevant Pharmacokinetic Interactions With Inhaled Budesonide
R. Hermann, W. Siegmund, T. Giessmann, K. Westphal +6 more
2007Journal of clinical pharmacology23 citations
Semantic Scholar
High absolute bioavailability of the new oral phosphodiesterase-4 inhibitor roflumilast.
T. Bethke, G. Lahu
2011International journal of clinical pharmacology and therapeutics22 citations
Semantic Scholar
Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects.
T. Bethke, T. Giessmann, K. Westphal, A. Weinbrenner +7 more
2006International journal of clinical pharmacology and therapeutics22 citations
Semantic Scholar
Pharmacokinetics of teduglutide in subjects with renal impairment
R. Nave, A. Halabi, R. Herzog, P. Schaffer +5 more
2012European Journal of Clinical Pharmacology21 citations
Semantic Scholar
Effect of Steady‐State Enoxacin on Single‐Dose Pharmacokinetics of Roflumilast and Roflumilast N‐Oxide
G. Lahu, N. Nassr, R. Herzog, M. Elmlinger +3 more
2011Journal of clinical pharmacology21 citations
Semantic Scholar
Transdermal fentanyl matrix patches Matrifen and Durogesic DTrans are bioequivalent.
H. Kress, H. Boss, T. Delvin, G. Lahu +4 more
2010European journal of pharmaceutics and biopharmaceutics21 citations
Semantic Scholar
The effects of roflumilast, a phosphodiesterase type-4 inhibitor, on EEG biomarkers in schizophrenia: A randomised controlled trial
J. Gilleen, J. Nottage, Farah Yakub, Sarah Kerins +9 more
2020Journal of Psychopharmacology20 citations
Semantic Scholar
A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
C. Scarpignato, Eckhard Leifke, N. Smith, D. Mulford +3 more
2021Journal of clinical pharmacology19 citations Open access
Semantic Scholar
No Dose Adjustment on Coadministration of the PDE4 Inhibitor Roflumilast With a Weak CYP3A, CYP1A2, and CYP2C19 Inhibitor: An Investigation Using Cimetidine
G. Böhmer, C. Gleiter, K. Mörike, N. Nassr +2 more
2011Journal of clinical pharmacology19 citations
Semantic Scholar
Population Pharmacokinetics and Pharmacodynamics of Inhaled Ciclesonide and Fluticasone Propionate in Patients With Persistent Asthma
Jian Xu, R. Nave, G. Lahu, E. Derom +1 more
2010Journal of clinical pharmacology19 citations
Semantic Scholar
The Targeted Oral, Once‐Daily Phosphodiesterase 4 Inhibitor Roflumilast and the Leukotriene Receptor Antagonist Montelukast Do Not Exhibit Significant Pharmacokinetic Interactions
G. Böhmer, N. Nassr, M. Wenger, A. Hünnemeyer +4 more
2009Journal of clinical pharmacology19 citations
Semantic Scholar
Magnesium Hydroxide/Aluminium Hydroxide‐Containing Antacid Does Not Affect the Pharmacokinetics of the Targeted Phosphodiesterase 4 Inhibitor Roflumilast
N. Nassr, G. Lahu, A. Hünnemeyer, O. von Richter +4 more
2007Journal of clinical pharmacology19 citations
Semantic Scholar
Influence of renal impairment on the pharmacokinetics of oral roflumilast: an open-label, parallel-group, single-center study.
T. Bethke, M. Hartmann, A. Hünnemeyer, G. Lahu +1 more
2011International journal of clinical pharmacology and therapeutics18 citations
Semantic Scholar
A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection
C. Scarpignato, C. Howden, Eckhard Leifke, D. Mulford +3 more
2023Alimentary Pharmacology and Therapeutics17 citations Open access
Semantic Scholar
A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram
A. Takano, T. Uz, J. Garcia-Segovia, Max C. Tsai +5 more
2018Molecular Imaging and Biology16 citations Open access
Semantic Scholar
Absence of Pharmacokinetic Interaction Between Roflumilast and Digoxin in Healthy Adults
G. Eckermann, G. Lahu, N. Nassr, T. Bethke
2012Journal of clinical pharmacology16 citations
Semantic Scholar
No relevant cardiac, pharmacokinetic or safety interactions between roflumilast and inhaled formoterol in healthy subjects: an open-label, randomised, actively controlled study
C. D. De Mey, N. Nassr, G. Lahu
2011BMC clinical pharmacology15 citations Open access
Semantic Scholar
719 PHARMACOKINETICS OF INTRANASAL FENTANYL SPRAY (INFS) IN SUBJECTS WITH COMMON COLD
R. Nave, E. H. Sides, T. Colberg, X. Meng +2 more
200914 citations
Semantic Scholar
Single‐Dose Pharmacokinetics of Roflumilast in Children and Adolescents
Kathleen A. Neville, S. Szefler, S. Abdel-Rahman, G. Lahu +5 more
2008Journal of clinical pharmacology14 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial
Stefan Roepcke, N. Plock, Josh J Yuan, E. Fedyk +3 more
2018Pharmacology Research & Perspectives13 citations Open access
Semantic Scholar
Multi-response model for rheumatoid arthritis based on delay differential equations in collagen-induced arthritic mice treated with an anti-GM-CSF antibody
Gilbert Koch, Thomas Wagner, C. Plater-Zyberk, G. Lahu +1 more
2012Journal of Pharmacokinetics and Pharmacodynamics12 citations
Semantic Scholar
Pharmacokinetic/Pharmacodynamic Modeling of the PDE4 Inhibitor TAK‐648 in Type 2 Diabetes: Early Translational Approaches for Human Dose Prediction
N. Plock, S. Vollert, M. Mayer, G. Hanauer +1 more
2017Clinical and Translational Science11 citations Open access
Semantic Scholar
Application of population pharmacokinetic modeling to explore the impact of alternative roflumilast dosing regimens on tolerability.
G. Lahu, A. Facius
2013International journal of clinical pharmacology and therapeutics11 citations
Semantic Scholar
718 PHARMACOKINETICS OF INTRANASAL FENTANYL SPRAY (INFS) IN SUBJECTS WITH SEASONAL ALLERGIC RHINITIS WITH AND WITHOUT PRIOR ADMINISTRATION OF OXYMETAZOLINE
R. Nave, E. H. Sides, T. Colberg, X. Meng +2 more
200911 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease
A. Facius, Eleonora Marostica, P. Gardiner, H. Watz +1 more
2018Clinical Pharmacokinetics10 citations Open access
Semantic Scholar
Constant-load exercise decreases the serum concentration of myeloperoxidase in healthy smokers and smokers with COPD
O. Holz, Stefan Roepcke, H. Watz, U. Tegtbur +2 more
2015International Journal of COPD10 citations Open access
Semantic Scholar
American Society for Clinical Pharmacology and Therapeutics
T. Moriyama, L. Janke, C. Suiter, L. Li +25 more
2018Clinical Pharmacology & Therapeutics9 citations Open access
Semantic Scholar
Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults.
G. Böhmer, C. Gleiter, A. Hünnemeyer, G. Lahu +1 more
2011International journal of clinical pharmacology and therapeutics9 citations
Semantic Scholar
Lack of pharmacokinetic and pharmacodynamic interactions of roflumilast with (R, S)-warfarin in healthy adult subjects.
N. McCracken, G. Lahu, T. Bethke
2011International journal of clinical pharmacology and therapeutics8 citations
Semantic Scholar
CHRONOPHARMACOLOGY OF ROFLUMILAST: A COMPARATIVE PHARMACOKINETIC STUDY OF MORNING VERSUS EVENING ADMINISTRATION IN HEALTHY ADULTS
T. Bethke, A. Huennemeyer, G. Lahu, B. Lemmer
2010Chronobiology International8 citations
Semantic Scholar
Modeling and Simulation of Pivotal Clinical Trials Using Linked Models for Multiple Endpoints in Chronic Obstructive Pulmonary Disease With Roflumilast
A. Facius, Andreas Krause, L. Claret, R. Bruno +1 more
2017Journal of clinical pharmacology7 citations
Semantic Scholar
Population Pharmacokinetic Meta-Analysis to Bridge Ferumoxytol Plasma Pharmacokinetics Across Populations
N. Plock, A. Facius, G. Lahu, N. Wood +3 more
2014Clinical Pharmacokinetics7 citations Open access
Semantic Scholar
A first-in-human phase I study of 4SC-201, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumors.
A. Brunetto, J. Ang, R. Lal, D. Olmos +6 more
2009Journal of Clinical Oncology7 citations
Semantic Scholar

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