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J. Stehn · SciRah

Researcher profile · Semantic Scholar

J. Stehn

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J. Stehn — researcher profile on SciRah

h-index: 20
Works: 45
Citations: 2,080

Most-cited papers

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
A. Brunet, F. Kanai, J. Stehn, Jian Xu +6 more
2002Journal of Cell Biology581 citations Open access
Semantic Scholar
2012 Landes Bioscience. Do not distribute. The actin cytoskeleton as a sensor and mediator of apoptosis
Melissa Desouza, P. Gunning, J. Stehn
2012254 citations
Semantic Scholar
A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.
J. Stehn, N. Haass, Teresa T. Bonello, Melissa Desouza +19 more
2013Cancer Research163 citations
Semantic Scholar
Cytoplasmic Localization of Tristetraprolin Involves 14-3-3-dependent and -independent Mechanisms*
Barbra A. Johnson, J. Stehn, M. Yaffe, T. Blackwell
2002Journal of Biological Chemistry137 citations Open access
Semantic Scholar
Specialisation of the tropomyosin composition of actin filaments provides new potential targets for chemotherapy.
J. Stehn, G. Schevzov, G. O'Neill, P. Gunning
2006Current Cancer Drug Targets95 citations
Semantic Scholar
Tropomyosin Isoform Expression Regulates the Transition of Adhesions To Determine Cell Speed and Direction
C. T. Bach, S. Creed, Jessie Zhong, Maha Mahmassani +7 more
2009Molecular and Cellular Biology84 citations Open access
Semantic Scholar
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function
Anhco Nguyen, Deborah M. Rothman, J. Stehn, B. Imperiali +1 more
2004Nature Biotechnology83 citations
Semantic Scholar
Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations.
M. Vázquez, M. Nitz, J. Stehn, M. B. Yaffe +1 more
2003Journal of the American Chemical Society81 citations
Semantic Scholar
Cell Elasticity Is Regulated by the Tropomyosin Isoform Composition of the Actin Cytoskeleton
I. Jalilian, C. Heu, Hong-Mei Cheng, Hannah Freittag +8 more
2015PLoS ONE66 citations Open access
Semantic Scholar
Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.
G. O'Neill, J. Stehn, P. Gunning
2008Seminars in Cancer Biology61 citations
Semantic Scholar
Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments
G. Schevzov, A. Kee, Bin Wang, V. B. Sequeira +14 more
2015Molecular Biology of the Cell59 citations Open access
Semantic Scholar
Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser1917 Is Mediated by Protein Kinase CβII and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells1
R. Ludowyke, Z. Elgundi, T. Kranenburg, J. Stehn +3 more
2006Journal of Immunology54 citations
Semantic Scholar
Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
S. Creed, Melissa Desouza, J. Bamburg, P. Gunning +1 more
2011Experimental Cell Research51 citations
Semantic Scholar
New approaches to targeting the actin cytoskeleton for chemotherapy.
Teresa T. Bonello, J. Stehn, P. Gunning
2009Future Medicinal Chemistry49 citations
Semantic Scholar
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
Mark A. Currier, J. Stehn, Ashleigh Swain, Duo Chen +14 more
2017Molecular Cancer Therapeutics45 citations
Semantic Scholar
Tropomyosin isoforms define distinct microfilament populations with different drug susceptibility.
S. Creed, Nicole S. Bryce, Perttu Naumanen, R. Weinberger +3 more
2008European Journal of Cell Biology42 citations
Semantic Scholar
A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics
Teresa T. Bonello, M. Jančo, Jeff W. Hook, A. Byun +7 more
2016Scientific Reports35 citations Open access
Semantic Scholar
Validation of an Algorithm to Quantify Changes in Actin Cytoskeletal Organization
Howard J Vindin, L. Bischof, P. Gunning, J. Stehn
2014Journal of biomolecular screening24 citations Open access
Semantic Scholar
On-target action of anti-tropomyosin drugs regulates glucose metabolism
A. Kee, Jayshan Chagan, J. Chan, Nicole S. Bryce +8 more
2018Scientific Reports22 citations Open access
Semantic Scholar
Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins
Melissa Desouza-Armstrong, Peter W. Gunning, J. Stehn
2017Cytoskeleton22 citations
Semantic Scholar
High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Nicole S. Bryce, T. Failes, J. Stehn, K. Baker +11 more
2019Cell Systems18 citations Open access
Semantic Scholar
Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Yao Wang, Jeffrey H. Stear, Ashleigh Swain, Xing Xu +8 more
2020Molecular Cancer Research16 citations Open access
Semantic Scholar
The actin cytoskeleton as a sensor and mediator of apoptosis
Melissa Desouza, Peter W. Gunning, J. Stehn
2012BioArchitecture11 citations Open access
Semantic Scholar
Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells
J. Glass, P. Phillips, P. Gunning, J. Stehn
2015BMC Cancer10 citations Open access
Semantic Scholar
Therapeutic Targeting of the Actin Cytoskeleton in Cancer
Teresa T. Bonello, J. Coombes, G. Schevzov, P. Gunning +1 more
20128 citations
Semantic Scholar
Small molecule targeting of the actin associating protein tropomyosin Tpm3.1 increases neuroblastoma cell response to inhibition of Rac‐mediated multicellular invasion
C. Mitchell, J. Stehn, G. O'Neill
2018Cytoskeleton4 citations Open access
Semantic Scholar
MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach
J. Stehn, S. Floyd, E. Wilker, H. Reinhardt +6 more
2023Frontiers in Molecular Biosciences3 citations Open access
Semantic Scholar
Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser Is Mediated by Protein Kinase C II and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells
T. Biden, J. Stehn, C. Schmitz‐Peiffer, E. William +3 more
20062 citations
Semantic Scholar
Structure of the Anti-Cancer Compound TR100 Target-Sites on Tpm3.1 Tropomyosin
M. Rynkiewicz, J. Stehn, P. Gunning, William Lehman
20171 citations Open access
Semantic Scholar
Synergistic action of first-in-class anti-tropomyosin compound, ATM-3507 (Anisina) and microtubule targeting inhibitors in pre-clinical models of non-small cell lung cancer (NSCLC)
J. Stehn, A. Mariana, T. Failes, V. Ashokakumar +7 more
20161 citations
Semantic Scholar
Abstract 5230: Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy
V. B. Sequeira, J. Stehn, N. Haass, Teresa T. Bonello +13 more
20121 citations
Semantic Scholar
Abstract 5817: Anti-tropomyosin drugs prevent the rescue of vincristine-induced mitotic spindle defects
P. Gunning, Yao Wang, Jeffrey H. Stear, Ashleigh Swain +7 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Abstract B27: First-in-class cytoskeletal targeting drug, Anisina, enhances effectiveness of microtubule inhibitors in a preclinical model of neuroblastoma
J. Stehn, Mark A. Currier, Duo Chen, Eleanor Eiffe +4 more
20160 citations
Semantic Scholar
Developing a new melanoma drug
J. Stehn, Alexander J. Stevenson, L. Spoerri, S. Daignault +4 more
20160 citations
Semantic Scholar
Determining the impact of the actin cytoskeleton on the mechanical properties of cells
I. Jalilian, G. Schevzov, T. Fath, C. Heu +6 more
20140 citations Open access
Semantic Scholar
Abstract B50: Synergistic anti-neuroblastoma efficacy using combinatorial cytoskeletal inhibitors
J. Stehn, Duo Chen, Mark A. Currier, D. Eaves +4 more
20140 citations
Semantic Scholar
Abstract C208: Targeting the actin cytoskeleton of neuroblastoma: Elucidating the mechanism by which a novel class of anti-cancer compounds induces tumor cell death.
Melissa Desouza, Margaret Nguyen, P. Gunning, J. Stehn
20130 citations
Semantic Scholar
Cytoskeleton in Tumor Cells A Novel Class of Anticancer Compounds Targets the Actin
J. Stehn, N. Haass, Teresa T. Bonello, Melissa Desouza +19 more
20130 citations
Semantic Scholar
Abstract 1827: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells
J. Stehn, N. Haass, Melissa Desouza, Gregg Kottyan +11 more
20120 citations
Semantic Scholar
Developing chemotherapeutics which disable the actin cytoskeleton of melanoma cells
J. Stehn, N. Haass, E. Hardeman, D. Winlaw +10 more
20110 citations
Semantic Scholar
Abstract A178: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells.
J. Stehn, N. Haass, Teresa T. Bonello, Melissa Desouza +13 more
20110 citations
Semantic Scholar
334 Tropomyosin Tm5NM1: A novel target for cancer therapy
J. Stehn, G. Schevzov, Teresa T. Bonello, A. McCluskey +6 more
20100 citations
Semantic Scholar
2656: Chk1 Phosphorylates Poly-A Binding Protein, Triggering Translocation to the Nucleus
S. Floyd, J. Stehn, E. Wilker, M. Yaffe
20060 citations
Semantic Scholar
Onset of Stimulated Degranulation of II and Coincides with the β Protein Kinase C Is Mediated by 1917 Chain IIA on Ser Phosphorylation of Nonmuscle Myosin Heavy Hughes
R. Ludowyke, Z. Elgundi, T. Kranenburg, J. Stehn +3 more
20060 citations
Semantic Scholar
Multiple roles for 14-3-3 proteins in nucleo-cytoplasmic transport
A. Brunet, F. Kanai, J. Stehn, M. Greenberg +1 more
20020 citations
Semantic Scholar

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