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E. Hardeman · SciRah

Researcher profile · Semantic Scholar

E. Hardeman

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E. Hardeman — researcher profile on SciRah

h-index: 49
Works: 189
Citations: 8,595

Most-cited papers

Tropomyosin – master regulator of actin filament function in the cytoskeleton
P. Gunning, E. Hardeman, P. Lappalainen, Daniel P. Mulvihill
2015Journal of Cell Science281 citations Open access
Semantic Scholar
A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.
J. Stehn, N. Haass, Teresa T. Bonello, Melissa Desouza +19 more
2013Cancer Research163 citations
Semantic Scholar
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Max Nobis, D. Herrmann, Sean C. Warren, S. Kadir +39 more
2017Cell Reports82 citations Open access
Semantic Scholar
An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake
A. Kee, Ling-Yan Yang, C. Lucas, Michael J. Greenberg +9 more
2015Traffic : the International Journal of Intracellular Transport71 citations Open access
Semantic Scholar
Cell Elasticity Is Regulated by the Tropomyosin Isoform Composition of the Actin Cytoskeleton
I. Jalilian, C. Heu, Hong-Mei Cheng, Hannah Freittag +8 more
2015PLoS ONE66 citations Open access
Semantic Scholar
Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.
Mai-Anh T Nguyen, J. Joya, A. Kee, Ana Domazetovska +10 more
2011Brain : a journal of neurology66 citations Open access
Semantic Scholar
Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton.
Joyce C. M. Meiring, Nicole S. Bryce, Yao Wang, M. H. Taft +5 more
2018Current Biology64 citations Open access
Semantic Scholar
Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia
Irina Pleines, Joanne Woods, S. Chappaz, Verity G. Kew +26 more
2017Journal of Clinical Investigation63 citations Open access
Semantic Scholar
Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments
G. Schevzov, A. Kee, Bin Wang, V. B. Sequeira +14 more
2015Molecular Biology of the Cell59 citations Open access
Semantic Scholar
Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue
Zahra Erami, D. Herrmann, Sean C. Warren, Max Nobis +30 more
2015Cell Reports56 citations Open access
Semantic Scholar
Aged skeletal muscle retains the ability to fully regenerate functional architecture
Antonio S. J. Lee, Judy E. Anderson, J. Joya, S. Head +4 more
2013BioArchitecture53 citations Open access
Semantic Scholar
Tropomyosin regulates cell migration during skin wound healing.
J. Lees, Yu Wooi Ching, Damian H. Adams, C. T. Bach +6 more
2013Journal of Investigative Dermatology49 citations Open access
Semantic Scholar
Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge
Simon Brayford, Nicole S. Bryce, G. Schevzov, Elizabeth M. Haynes +3 more
2016Current Biology48 citations Open access
Semantic Scholar
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
Mark A. Currier, J. Stehn, Ashleigh Swain, Duo Chen +14 more
2017Molecular Cancer Therapeutics45 citations
Semantic Scholar
Actin–tropomyosin distribution in non-muscle cells
D. Manstein, Joyce C. M. Meiring, E. Hardeman, P. Gunning
2019Journal of Muscle Research and Cell Motility43 citations Open access
Semantic Scholar
Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.
M. Howard, Stephen J. Palmer, K. M. Taylor, Geoffrey J. Arthurson +6 more
2012Neurobiology of Disease39 citations Open access
Semantic Scholar
Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms.
E. Hardeman, Nicole S. Bryce, P. Gunning
2020Seminars in Cell and Developmental Biology35 citations Open access
Semantic Scholar
A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics
Teresa T. Bonello, M. Jančo, Jeff W. Hook, A. Byun +7 more
2016Scientific Reports35 citations Open access
Semantic Scholar
Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells.
N. Curthoys, Hannah Freittag, A. Connor, Melissa Desouza +7 more
2014Molecular and cellular neurosciences35 citations
Semantic Scholar
Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment
Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski +8 more
2019bioRxiv34 citations Open access
Semantic Scholar
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation
M. L. Cagigas, Nicole S. Bryce, N. Ariotti, Simon Brayford +2 more
2021Nature Materials33 citations
Semantic Scholar
Tropomyosins.
P. Gunning, E. Hardeman
2017Current Biology31 citations Open access
Semantic Scholar
Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy.
J. Lindqvist, Arthur J. Cheng, G. Renaud, E. Hardeman +1 more
2013Journal of Neuropathology and Experimental Neurology31 citations Open access
Semantic Scholar
Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
J. Ross, Y. Levy, M. Ripolone, Justin Kolb +19 more
2019bioRxiv30 citations Open access
Semantic Scholar
Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens
Benjamin J. Caldwell, C. Lucas, A. Kee, K. Gaus +4 more
2014Cytoskeleton29 citations
Semantic Scholar
Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy.
J. Tinklenberg, H. Meng, Lin Yang, Fu-Jun Liu +8 more
2016American Journal of Pathology27 citations Open access
Semantic Scholar
Modulating myosin restores muscle function in a mouse model of nemaline myopathy
J. Lindqvist, Y. Levy, A. Pati-Alam, E. Hardeman +2 more
2016Annals of Neurology27 citations Open access
Semantic Scholar
Cardiac α-actin over-expression therapy in dominant ACTA1 disease.
G. Ravenscroft, E. McNamara, L. Griffiths, J. Papadimitriou +5 more
2013Human Molecular Genetics27 citations Open access
Semantic Scholar
Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice
Seham Ebrahim, De-Su Chen, M. Weiss, Lenka Malec +10 more
2019Nature Cell Biology24 citations Open access
Semantic Scholar
Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres
Joyce C. M. Meiring, Nicole S. Bryce, Maria Lastra Cagigas, A. Benda +6 more
2019Journal of Cell Science23 citations Open access
Semantic Scholar
Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1
M. Jančo, M. Rynkiewicz, Liang Li, Jeff W. Hook +6 more
2019Scientific Reports23 citations Open access
Semantic Scholar
Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in Mouse Skin In Vivo.
Bassem Akladios, Veronica Mendoza-Reinoso, M. Samuel, E. Hardeman +3 more
2017Journal of Investigative Dermatology23 citations Open access
Semantic Scholar
A robust method for particulate detection of a genetic tag for 3D electron microscopy
James Rae, C. Ferguson, N. Ariotti, R. Webb +16 more
2021eLife22 citations Open access
Semantic Scholar
On-target action of anti-tropomyosin drugs regulates glucose metabolism
A. Kee, Jayshan Chagan, J. Chan, Nicole S. Bryce +8 more
2018Scientific Reports22 citations Open access
Semantic Scholar
Combined MRI and 31P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism
C. Gineste, Y. Le Fur, C. Vilmen, A. Le Troter +5 more
2013PLoS ONE21 citations Open access
Semantic Scholar
GTF2IRD2 from the Williams–Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members
Stephen J. Palmer, K. M. Taylor, N. Santucci, Jocelyn Widagdo +5 more
2012Journal of Cell Science21 citations Open access
Semantic Scholar
The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation
P. Carmona-Mora, Jocelyn Widagdo, F. Tomasetig, Cesar P. Canales +7 more
2015Human Genetics20 citations
Semantic Scholar
Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer
Tong Xu, Mathijs P. Verhagen, Miriam Teeuwssen, Wen-Jie Sun +12 more
2024Cell Death and Differentiation19 citations Open access
Semantic Scholar
Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents
Xing Xu, Yao Wang, Nicole S. Bryce, K. Tang +9 more
2021British Journal of Cancer18 citations Open access
Semantic Scholar
High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.
Nicole S. Bryce, T. Failes, J. Stehn, K. Baker +11 more
2019Cell Systems18 citations Open access
Semantic Scholar
Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice
Andrius Masedunskas, Mark A. Appaduray, C. Lucas, Maria Lastra Cagigas +15 more
2018Journal of Cell Science18 citations Open access
Semantic Scholar
Properties of regenerated mouse extensor digitorum longus muscle following notexin injury
S. Head, P. Houweling, S. Chan, G. Chen +1 more
2014Experimental Physiology18 citations
Semantic Scholar
Highly efficient platelet generation in lung vasculature reproduced by microfluidics
Xiao-Juan Zhao, D. Alibhai, T. Walsh, N. Tarassova +17 more
2023Nature Communications17 citations Open access
Semantic Scholar
Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Yao Wang, Jeffrey H. Stear, Ashleigh Swain, Xing Xu +8 more
2020Molecular Cancer Research16 citations Open access
Semantic Scholar
ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2
A. Kee, Nicole S. Bryce, Ling-Yan Yang, Elena Polishchuk +5 more
2017Cytoskeleton16 citations Open access
Semantic Scholar
Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain
Alexandra K Suchowerska, Sandra Fok, Holly Stefen, P. Gunning +3 more
2017Frontiers in Cellular Neuroscience15 citations Open access
Semantic Scholar
Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening.
Nicole S. Bryce, E. Hardeman, P. Gunning, J. Lock
2019Current Opinion in Chemical Biology14 citations Open access
Semantic Scholar
The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome
Cesar P. Canales, Ann C. Y. Wong, P. Gunning, G. Housley +2 more
2014European Journal of Human Genetics14 citations Open access
Semantic Scholar
SUMOylation of GTF2IRD1 Regulates Protein Partner Interactions and Ubiquitin-Mediated Degradation
Jocelyn Widagdo, K. M. Taylor, P. Gunning, E. Hardeman +1 more
2012PLoS ONE14 citations Open access
Semantic Scholar
Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments
Joyce C. M. Meiring, Nicole S. Bryce, Jorge Luis Galeano Niño, Antje Gabriel +4 more
2019Scientific Reports13 citations Open access
Semantic Scholar

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