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S. Khetani · SciRah

Researcher profile · Semantic Scholar

S. Khetani

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S. Khetani — researcher profile on SciRah

h-index: 37
Works: 102
Citations: 6,057

Most-cited papers

Microscale culture of human liver cells for drug development
S. Khetani, S. Bhatia
2008Nature Biotechnology1,214 citations
Semantic Scholar
Pluripotent Stem Cell-Derived Hepatocyte-Like Cells
R. Schwartz, H. E. Fleming, S. Khetani, S. Bhatia
2014Biotechnology Advances270 citations Open access
Semantic Scholar
Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system
Christopher T. Jones, M. Catanese, L. Law, S. Khetani +7 more
2010Nature Biotechnology263 citations Open access
Semantic Scholar
In vitro zonation and toxicity in a hepatocyte bioreactor.
Jared W. Allen, S. Khetani, S. Bhatia
2005Toxicological Sciences252 citations
Semantic Scholar
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
A. Ploss, S. Khetani, Christopher T. Jones, A. Syder +6 more
2010Proceedings of the National Academy of Sciences of the United States of America213 citations Open access
Semantic Scholar
Superhydrophobic Coatings with Edible Materials.
Wei Wang, Karsten Lockwood, L. M. Boyd, M. Davidson +4 more
2016ACS Applied Materials and Interfaces201 citations
Semantic Scholar
Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.
S. Khetani, Chitra Kanchagar, O. Ukairo, Stacy Krzyzewski +5 more
2013Toxicological Sciences201 citations Open access
Semantic Scholar
Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro
Dustin R. Berger, B. Ware, M. Davidson, Samuel R. Allsup +1 more
2015Hepatology193 citations
Semantic Scholar
Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.
B. Ware, Dustin R. Berger, S. Khetani
2015Toxicological Sciences178 citations Open access
Semantic Scholar
Quantum dots to monitor RNAi delivery and improve gene silencing
A. A. Chen, Austin M. Derfus, S. Khetani, Sangeeta N. Bhatia
2005Nucleic Acids Research171 citations Open access
Semantic Scholar
Microenvironmental Regulation of the Sinusoidal Endothelial Cell Phenotype In Vitro
S. March, Elliot E. Hui, Gregory H. Underhill, S. Khetani +1 more
2009Hepatology163 citations Open access
Semantic Scholar
Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies
Gregory H. Underhill, S. Khetani
2017Cellular and Molecular Gastroenterology and Hepatology151 citations Open access
Semantic Scholar
Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
Wendy Weiwei Wang, S. Khetani, Stacy Krzyzewski, D. B. Duignan +1 more
2010Drug Metabolism And Disposition150 citations
Semantic Scholar
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
S. March, V. Ramanan, Kartik Trehan, Shengyong Ng +9 more
2015Nature Protocols136 citations Open access
Semantic Scholar
Engineering tissues for in vitro applications.
S. Khetani, S. Bhatia
2006Current Opinion in Biotechnology133 citations
Semantic Scholar
Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters
Theresa Nguyen, O. Ukairo, S. Khetani, Michael McVay +5 more
2015Drug Metabolism And Disposition127 citations Open access
Semantic Scholar
Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
S. Khetani, Greg K. Szulgit, J. D. del Río, C. Barlow +1 more
2004Hepatology124 citations Open access
Semantic Scholar
Microengineered Liver Tissues for Drug Testing
S. Khetani, Dustin R. Berger, Kimberly R. Ballinger, M. Davidson +2 more
2015Journal of laboratory automation111 citations Open access
Semantic Scholar
HCV Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cell and Release of Exosomes, Which Inhibits Viral Replication
S. Giugliano, M. Kriss, L. Golden-Mason, Evgenia Dobrinskikh +13 more
2014Gastroenterology102 citations Open access
Semantic Scholar
Special Section on Prediction of Human Pharmacokinetic Parameters from In Vitro Systems Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
T. Chan, Hong-Bin Yu, A. Moore, S. Khetani +1 more
201396 citations
Semantic Scholar
A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells
B. Ware, Michael J Durham, Chase P. Monckton, S. Khetani
2017Cellular and Molecular Gastroenterology and Hepatology94 citations Open access
Semantic Scholar
Engineered Liver Platforms for Different Phases of Drug Development
B. Ware, S. Khetani
2016Trends in Biotechnology82 citations Open access
Semantic Scholar
Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers
Alice A. Chen, S. Khetani, Sunyoung Lee, S. Bhatia +1 more
2008Biomaterials80 citations Open access
Semantic Scholar
Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes
Christine Lin, Julianne Shi, A. Moore, S. Khetani
2016Drug Metabolism And Disposition75 citations Open access
Semantic Scholar
Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity
I. Rusyn, Xabier Arzuaga, R. Cattley, J. Corton +8 more
2021Hepatology73 citations Open access
Semantic Scholar
Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes
M. Davidson, Kimberly R. Ballinger, S. Khetani
2016Scientific Reports73 citations Open access
Semantic Scholar
Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac
T. Chan, Hong-Bin Yu, A. Moore, S. Khetani +1 more
2018Drug Metabolism And Disposition72 citations Open access
Semantic Scholar
Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury
Christine Lin, S. Khetani
2016BioMed Research International65 citations Open access
Semantic Scholar
Stem Cell-Derived Liver Cells for Drug Testing and Disease Modeling
M. Davidson, B. Ware, S. Khetani
2015Discover medicine63 citations
Semantic Scholar
Long‐Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures
O. Ukairo, Chitra Kanchagar, A. Moore, Julianne Shi +8 more
2013Journal of biochemical and molecular toxicology61 citations
Semantic Scholar
Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
Gregory H. Underhill, S. Khetani
2018Drug Metabolism And Disposition56 citations Open access
Semantic Scholar
Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development.
M. Davidson, David A. Kukla, S. Khetani
2017Integrative Biology53 citations Open access
Semantic Scholar
Water-Stable Metal-Organic Framework/Polymer Composites Compatible with Human Hepatocytes.
M. Neufeld, B. Ware, A. Lutzke, S. Khetani +1 more
2016ACS Applied Materials and Interfaces52 citations
Semantic Scholar
The Role of Liver Zonation in Physiology, Regeneration, and Disease.
Regeant Panday, Chase P. Monckton, S. Khetani
2022Seminars in liver disease (Print)45 citations Open access
Semantic Scholar
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model
M. Mosedale, J. Eaddy, O. J. Trask, N. Holman +8 more
2018Toxicological Sciences43 citations Open access
Semantic Scholar
The application of engineered liver tissues for novel drug discovery
Christine Lin, Kimberly R. Ballinger, S. Khetani
2015Expert Opinion on Drug Discovery39 citations
Semantic Scholar
Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver
M. Davidson, M. Lehrer, S. Khetani
2015Tissue Engineering. Part C, Methods37 citations Open access
Semantic Scholar
Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation
Grace E Brown, Yong-Duk Han, Ashlin R. Michell, Olivia T. Ly +5 more
2024Science Advances30 citations Open access
Semantic Scholar
Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC–derived atrial fibrillation model
Olivia T. Ly, Hanna Chen, Grace E Brown, L. Hong +13 more
2022JCI Insight26 citations Open access
Semantic Scholar
High Throughput Interrogation of Human Liver Stellate Cells Reveals Microenvironmental Regulation of Phenotype
Aidan Brougham-Cook, Ishita Jain, David A. Kukla, Faisal Masood +4 more
2021Acta Biomaterialia26 citations Open access
Semantic Scholar
Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling
B. Ware, Michael McVay, Wendy Y Sunada, S. Khetani
2017Toxicological Sciences26 citations
Semantic Scholar
Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models.
David A. Kukla, Alexandra Crampton, S. Khetani, D. Wood
2020Gene Expression23 citations Open access
Semantic Scholar
Emerging trends in modeling human liver disease in vitro
Gregory H. Underhill, S. Khetani
2019APL Bioengineering23 citations Open access
Semantic Scholar
Micropatterned Coculture with 3T3-J2 Fibroblasts Enhances Hepatic Functions and Drug Screening Utility of HepaRG Cells.
B. Ware, Jennifer S. E. Liu, Chase P. Monckton, Kimberly R. Ballinger +1 more
2021Toxicological Sciences22 citations Open access
Semantic Scholar
Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling
Yang Yuan, K. Cotton, Dinithi Samarasekera, S. Khetani
2023Cellular and Molecular Gastroenterology and Hepatology21 citations Open access
Semantic Scholar
Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions
Christine Lin, S. Khetani
2017Current Protocols in Toxicology19 citations Open access
Semantic Scholar
Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures
M. Davidson, S. Khetani
2019bioRxiv18 citations Open access
Semantic Scholar
A Polyelectrolyte Multilayer Platform for Investigating Growth Factor Delivery Modes in Human Liver Cultures
Christine Lin, R. Romero, L. Sorokina, Kimberly R. Ballinger +3 more
2017Journal of Biomedical Materials Research. Part A18 citations Open access
Semantic Scholar
Pluripotent Stem Cell-Derived Human Liver Organoids Enter the Realm of High-Throughput Drug Screening.
S. Khetani
2020Gastroenterology16 citations Open access
Semantic Scholar
Microfabrication of liver and heart tissues for drug development
Grace E Brown, S. Khetani
2018Philosophical Transactions of the Royal Society B: Biological Sciences16 citations Open access
Semantic Scholar

Frequent co-authors

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B. Ware — researcher profile on SciRah
S. Bhatia×9
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S. Bhatia — researcher profile on SciRah
M. Davidson×8
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Christine Lin×6
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A. Moore — researcher profile on SciRah

Gregory H. Underhill×5

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Kimberly R. Ballinger×5

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Julianne Shi — researcher profile on SciRah