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A. Parplys · SciRah

Researcher profile · Semantic Scholar

A. Parplys

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A. Parplys — researcher profile on SciRah

h-index: 13
Works: 35
Citations: 599

Most-cited papers

Cdc45 is limiting for replication initiation in humans
Carsten Köhler, Dennis Koalick, Anja Fabricius, A. Parplys +3 more
2016Cell Cycle70 citations Open access
Semantic Scholar
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
A. Parplys, Wei-Xing Zhao, N. Sharma, Torsten Groesser +10 more
2015Nucleic Acids Research70 citations Open access
Semantic Scholar
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study
M. Schroeder, B. Schaumburg, Z. Mueller, A. Parplys +21 more
2021Emerging Microbes and Infections69 citations Open access
Semantic Scholar
DNA damage by X-rays and their impact on replication processes.
A. Parplys, E. Petermann, C. Petersen, E. Dikomey +1 more
2012Radiotherapy and Oncology56 citations
Semantic Scholar
PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
Stephanie Wurster, F. Hennes, A. Parplys, J. Seelbach +7 more
2016OncoTarget51 citations Open access
Semantic Scholar
Non-catalytic Roles For XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability
K. Trego, Torsten Groesser, Albert R. Davalos, A. Parplys +12 more
2016Molecules and Cells50 citations Open access
Semantic Scholar
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation
A. Parplys, J. Seelbach, S. Becker, M. Behr +9 more
2015Cell Cycle37 citations Open access
Semantic Scholar
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer
F. Meyer, S. Becker, S. Classen, A. Parplys +9 more
2020Cells31 citations Open access
Semantic Scholar
RAD51AP1-deficiency in vertebrate cells impairs DNA replication
A. Parplys, K. Kratz, M. C. Speed, Stanley G. Leung +2 more
2014DNA Repair28 citations Open access
Semantic Scholar
Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients
N. de Buhr, A. Parplys, M. Schroeder, Timo Henneck +10 more
2022Journal of Innate Immunity22 citations Open access
Semantic Scholar
Sex hormone and metabolic dysregulations are associated with critical illness in male Covid-19 patients
M. Schroeder, B. Schaumburg, Zacharias Müller, A. Parplys +23 more
202018 citations Open access
Semantic Scholar
Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2−/− mice
R. Barikbin, L. Berkhout, J. Bolik, D. Schmidt-Arras +9 more
2018Scientific Reports17 citations Open access
Semantic Scholar
Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner
J. Rieckhoff, F. Meyer, S. Classen, A. Zielinski +6 more
2020Cancers15 citations Open access
Semantic Scholar
Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines
F. Subtil, Carolin Gröbner, Niklas Recknagel, A. Parplys +6 more
2022Cancers11 citations Open access
Semantic Scholar
Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities
N. Struve, K. Hoffer, Anna-Sophie Weik, Britta Riepen +18 more
2021Neuro-Oncology Advances10 citations Open access
Semantic Scholar
Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application.
Bastian Salewsky, Gabriele Hildebrand, Susanne Rothe, A. Parplys +8 more
2016Molecular Therapy10 citations Open access
Semantic Scholar
DNA Repair.
K. Borgmann, S. Köcher, M. Kriegs, W. Mansour +3 more
2016Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer10 citations
Semantic Scholar
BRCA1 mislocalization leads to aberrant DNA damage response in heterozygous ABRAXAS1 mutation carrier cells.
M. Bose, Juliane Sachsenweger, Niina Laurila, A. Parplys +16 more
2019Human Molecular Genetics7 citations Open access
Semantic Scholar
DNA Fiber Spreading Assay to Test HDACi Effects on DNA and Its Replication.
T. Nikolova, Anja Göder, A. Parplys, K. Borgmann
2017Methods in molecular biology7 citations
Semantic Scholar
Mechanistic insights of radiation-induced endothelial senescence impelling glioblastoma genomic instability at relapse
Charlotte Degorre, Ophélie Renoult, A. Parplys, Hala Awada +11 more
2021bioRxiv3 citations Open access
Semantic Scholar
Constitutive gp130 activation rapidly accelerates the transformation of human hepatocytes via an impaired oxidative stress response
D. Heim, I. Gil-Ibanez, J. Herden, A. Parplys +5 more
2016OncoTarget3 citations Open access
Semantic Scholar
Alteration in ATR protein level does not account for the inherent radiosensitivity of HPV-positive head and neck squamous cell carcinoma
Sibylla Kohl, F. Subtil, Vanessa Climenti, Houmam Anees +5 more
2025Translational Oncology2 citations Open access
Semantic Scholar
Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers
E. Dikomey, K. Borgmann, S. Köcher, M. Kriegs +4 more
20162 citations
Semantic Scholar
Sex hormone dysregulations are associated with disease severity in critically ill male COVID-19 patients - a retrospective analysis
M. Schroeder, B. Schaumburg, Z. Mueller, A. Parplys +21 more
20210 citations Open access
Semantic Scholar
PH-0234: The Adaptive Resistome in TNBC: Functional Targeting in Patient-derived Organoids and Cell Lines
S. Classen, E. Rahlf, J. Görte, A. Parplys +6 more
20200 citations
Semantic Scholar
Basic Radiobiology
A. Parplys, K. Borgmann
2019Radiation Oncology0 citations Open access
Semantic Scholar
Abstract 339: Heterozygous germline mutation in ABRAXAS causes BRCA1 mislocalization and DNA damage response defects
R. Winqvist, M. Bose, Juliane Sachsenweger, Niina Laurila +18 more
2018Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
EP-2286: CHK1-mediated replication fork stabilization confers radioresistance in HR deficient tumor cells
I. Bold, A. Specht, A. Parplys, W. Mansour +7 more
20180 citations Open access
Semantic Scholar
OC-0379: DNA repair and stemness determine the sensitizing effect of CHK1, RAD51 and PARP1 inhibition in TNBC
F. Meyer, S. Becker, A. Niecke, Britta Riepen +12 more
20180 citations Open access
Semantic Scholar
P0302 : Constitutive gp130 activation accelerates transformation of proliferating human hepatocytes via increased levels of oxidative stress
Ines Gil-Ibanez, D. Heim, J. Herden, A. Parplys +5 more
20150 citations
Semantic Scholar
Repair pathway crosstalk in genome stability maintenance through BRCA1/2‐mediated homologous recombination (352.1)
P. Cooper, K. Trego, Torsten Groesser, A. Parplys +4 more
20140 citations
Semantic Scholar
Investigating the role of DNA repair enzymes in DNA replication and recombination (735.3)
Clayton Speed, C. Wiese, A. Parplys, J. Robert Hatherill
20140 citations
Semantic Scholar
92 FORCED IL-6 SIGNALING IS SUFFICIENT TO PROMOTE MALIGNANT TRANSFORMATION IN TELOMERASE-IMMORTALIZED HUMAN FETAL HEPATOCYTES FOLLOWING CHALLENGE WITH OXIDATIVE STRESS
D. Heim, A. Parplys, S. Rose-John, A. Lohse +2 more
20130 citations Open access
Semantic Scholar
519 FORCED ACTIVATION OF BETA-CATENIN-REGULATED TRANSCRIPTION PREDISPOSES TELOMERASE- IMMORTALIZED HUMAN FETAL HEPATOCYTES TO ACQUIRE CANCER CELL CHARACTERISTICS: A MODEL FOR MULTI-STEP HEPATOCARCINOGENESIS
D. Heim, A. Parplys, A. Lohse, T. Brümmendorf +1 more
20090 citations
Semantic Scholar
Targeting the human bone sialoprotein by human IgG and avian IgY monoclonal antibodies
I. Braren, Kerstin Greunke, A. Parplys, R. Bredehorst +1 more
20070 citations
Semantic Scholar

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