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M. Pasparakis · SciRah

Researcher profile · Semantic Scholar

M. Pasparakis

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M. Pasparakis — researcher profile on SciRah

h-index: 99
Works: 302
Citations: 45K

Most-cited papers

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L. Galluzzi, I. Vitale, S. Aaronson, J. Abrams +165 more
2018Cell Death and Differentiation6,079 citations Open access
Semantic Scholar
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
M. Fritsch, S. Günther, Robin Schwarzer, M. Albert +10 more
2019Nature995 citations
Semantic Scholar
Z-nucleic acid sensing triggers ZBP1-dependent necroptosis and inflammation
Huipeng Jiao, Laurens Wachsmuth, S. Kumari, Robin Schwarzer +8 more
2020Nature457 citations Open access
Semantic Scholar
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I. Vitale, F. Pietrocola, E. Guilbaud, S. Aaronson +224 more
2023Cell Death and Differentiation346 citations Open access
Semantic Scholar
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease
N. Lalaoui, Steven E. Boyden, H. Oda, G. Wood +50 more
2019Nature287 citations Open access
Semantic Scholar
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.
Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, A. Tresch +1 more
2020Immunity254 citations Open access
Semantic Scholar
The interplay of IKK, NF‐κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation
V. Kondylis, S. Kumari, Katerina Vlantis, M. Pasparakis
2017Immunological Reviews202 citations
Semantic Scholar
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Jan Wenzel, J. Lampe, Helge Mueller-Fielitz, Raphael Schuster +42 more
2021Nature Neuroscience194 citations Open access
Semantic Scholar
ADAR1 averts fatal type I interferon induction by ZBP1
Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann +13 more
2022Nature191 citations Open access
Semantic Scholar
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation
Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe +8 more
2020Nature Communications170 citations Open access
Semantic Scholar
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
T. MacVicar, Yohsuke Ohba, H. Nolte, F. Mayer +15 more
2019Nature164 citations
Semantic Scholar
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
K. Aden, F. Tran, Go Ito, Raheleh Sheibani-Tezerji +22 more
2018Journal of Experimental Medicine159 citations Open access
Semantic Scholar
A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain
A. Polykratis, Arne Martens, R. Eren, Y. Shirasaki +9 more
2019Nature Cell Biology152 citations
Semantic Scholar
New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8.
Robin Schwarzer, Lucie Laurien, M. Pasparakis
2020Current Opinion in Cell Biology144 citations Open access
Semantic Scholar
Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke
M. Naito, Dai-Chao Xu, Palak Amin, Jinwoo Lee +5 more
2020Proceedings of the National Academy of Sciences of the United States of America144 citations Open access
Semantic Scholar
Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment.
C. Eftychi, Robin Schwarzer, Katerina Vlantis, Laurens Wachsmuth +6 more
2019Immunity113 citations Open access
Semantic Scholar
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
A. D’Cruz, M. Speir, Meghan Bliss-Moreau, Sylvia Dietrich +12 more
2018Science Signaling103 citations Open access
Semantic Scholar
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
L. Taraborrelli, N. Peltzer, A. Montinaro, S. Kupka +16 more
2018Nature Communications93 citations Open access
Semantic Scholar
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
D. Priem, M. Devos, Sarah Druwé, Arne Martens +7 more
2019Cell Death and Disease89 citations Open access
Semantic Scholar
CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice
J. Pedragosa, F. Miró-Mur, Amaia Otxoa-de-Amezaga, C. Justicia +4 more
2020Journal of Cerebral Blood Flow and Metabolism82 citations Open access
Semantic Scholar
RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome
Matija Zelic, J. Roderick, Joanne A. O’Donnell, J. Lehman +5 more
2018Journal of Clinical Investigation79 citations Open access
Semantic Scholar
ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
L. Koerner, Laurens Wachsmuth, S. Kumari, Robin Schwarzer +3 more
2024Cell Death and Differentiation76 citations Open access
Semantic Scholar
Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth
Lars M. Schiffmann, J. P. Werthenbach, F. Heintges-Kleinhofer, J. Seeger +16 more
2020Nature Communications75 citations Open access
Semantic Scholar
RIP Kinases in Liver Cell Death, Inflammation and Cancer.
V. Kondylis, M. Pasparakis
2019Trends in Molecular Medicine73 citations
Semantic Scholar
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes
Chrysanthi Moschandrea, V. Kondylis, I. Evangelakos, Marija Herholz +17 more
2023Nature68 citations Open access
Semantic Scholar
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
G. Liccardi, L. Ramos García, T. Tenev, Alessandro Annibaldi +21 more
2019Molecules and Cells61 citations Open access
Semantic Scholar
Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
Jessica Gräb, I. Suárez, Edeltraud van Gumpel, S. Winter +11 more
2019Nature Communications60 citations Open access
Semantic Scholar
OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis
Lien Verboom, Arne Martens, D. Priem, E. Hoste +13 more
2019bioRxiv53 citations Open access
Semantic Scholar
CCR2+ monocytic myeloid‐derived suppressor cells (M‐MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor‐β1
Astrid Lebrun, Sandra Lo Re, M. Chantry, X. IzquierdoCarerra +10 more
2017Journal of Pathology53 citations Open access
Semantic Scholar
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.
T. Imai, Juan Lin, G. G. Kaya, Eunjin Ju +5 more
2024Immunity50 citations Open access
Semantic Scholar
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
Hannah Schünke, U. Göbel, I. Dikič, M. Pasparakis
2021Nature Communications50 citations Open access
Semantic Scholar
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
M. Armaka, C. Ospelt, M. Pasparakis, G. Kollias
2018Nature Communications48 citations Open access
Semantic Scholar
RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation
J. Wong, Ricard Garcia-Carbonell, Matija Zelic, S. Ho +15 more
2019Cellular and Molecular Gastroenterology and Hepatology47 citations Open access
Semantic Scholar
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
V. Koliaraki, N. Chalkidi, Ana Henriques, C. Tzaferis +6 more
2019Cell Reports46 citations Open access
Semantic Scholar
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
Takayuki Imanishi, M. Unno, Natsumi Yoneda, Y. Motomura +4 more
2023Science Advances45 citations Open access
Semantic Scholar
Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation
N. Oikonomou, M. Schuijs, Antonis Chatzigiagkos, A. Androulidaki +4 more
2021Mucosal Immunology43 citations Open access
Semantic Scholar
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity
M. Cabeza-Cabrerizo, C. Minutti, M. P. Da Costa, A. Cardoso +14 more
2021Science immunology41 citations Open access
Semantic Scholar
Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis
T. Van, A. Polykratis, B. Straub, V. Kondylis +2 more
2017Journal of Clinical Investigation35 citations Open access
Semantic Scholar
RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury
S. Krishna-Subramanian, S. Singer, M. Armaka, J. Banales +6 more
2019Cell Death and Differentiation32 citations Open access
Semantic Scholar
IκB kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma
Malamati Vreka, I. Lilis, M. Papageorgopoulou, Georgia A. Giotopoulou +13 more
2018Cancer Research32 citations Open access
Semantic Scholar
Dendritic cell RIPK1 maintains immune homeostasis by preventing inflammation and autoimmunity
Joanne A. O’Donnell, J. Lehman, J. Roderick, D. Martinez-Marin +8 more
2017Journal of Immunology31 citations Open access
Semantic Scholar
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF
Annika Hausmann, Boas Felmy, L. Kunz, Sanne Kroon +23 more
2021Journal of Experimental Medicine30 citations Open access
Semantic Scholar
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation
S. Kumari, T. Van, D. Preukschat, Hannah Schuenke +4 more
2021Life Science Alliance28 citations Open access
Semantic Scholar
The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression.
A. Torgovnick, J. Heger, Vasiliki Liaki, J. Isensee +24 more
2018Cell Reports28 citations Open access
Semantic Scholar
RANK drives structured intestinal epithelial expansion during pregnancy
Masahiro Onji, Verena Sigl, Thomas Lendl, M. Novatchkova +22 more
2024Nature27 citations Open access
Semantic Scholar
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation
Fabian Schorn, J. Paul Werthenbach, Mattes Hoffmann, Mila Daoud +10 more
2023EMBO Journal23 citations Open access
Semantic Scholar
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Masahiro Nagata, Yasmin Carvalho Schäfer, Laurens Wachsmuth, M. Pasparakis
2024EMBO Journal21 citations Open access
Semantic Scholar
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
L. Koerner, M. Schmiel, Tsun-Po Yang, M. Peifer +2 more
2022bioRxiv19 citations Open access
Semantic Scholar
Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages
Sebastian J. Theobald, Jessica Gräb, M. Fritsch, I. Suárez +7 more
2021Cell Death Discovery19 citations Open access
Semantic Scholar
Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes
A. Androulidaki, Laurens Wachsmuth, A. Polykratis, M. Pasparakis
2018PLoS ONE19 citations Open access
Semantic Scholar

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