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G. Ashley · SciRah

Researcher profile · Semantic Scholar

G. Ashley

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G. Ashley — researcher profile on SciRah

h-index: 29
Works: 91
Citations: 3,675

Most-cited papers

Long-term stabilization of maleimide-thiol conjugates.
Shaun D. Fontaine, Ralph R. Reid, Louise H. Robinson, G. Ashley +1 more
2015Bioconjugate chemistry381 citations
Semantic Scholar
Hydrogel drug delivery system with predictable and tunable drug release and degradation rates
G. Ashley, Jeff Henise, Ralph R. Reid, D. Santi
2013Proceedings of the National Academy of Sciences of the United States of America338 citations Open access
Semantic Scholar
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.
R. Mcdaniel, A. Thamchaipenet, C. Gustafsson, H. Fu +2 more
1999Proceedings of the National Academy of Sciences of the United States of America307 citations Open access
Semantic Scholar
A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
Ralph R. Reid, Misty Piagentini, E. Rodriguez, G. Ashley +5 more
2003Biochemistry286 citations
Semantic Scholar
Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.
C. Reeves, S. Murli, G. Ashley, Misty Piagentini +2 more
2001Biochemistry179 citations
Semantic Scholar
Translation and protein synthesis: macrolides.
L. Katz, G. Ashley
2005Chemical Reviews166 citations
Semantic Scholar
Ribonucleotide reductases: radical enzymes with suicidal tendencies.
J. Stubbe, S. Booker, J. Broderick, Shi-Shan Mao +5 more
1993Nucleic Acids Symposium Series153 citations
Semantic Scholar
A multiplasmid approach to preparing large libraries of polyketides.
Qun Xue, G. Ashley, C. Hutchinson, D. Santi
1999Proceedings of the National Academy of Sciences of the United States of America148 citations Open access
Semantic Scholar
Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates
D. Santi, Eric L Schneider, Ralph R. Reid, Louise H. Robinson +1 more
2012Proceedings of the National Academy of Sciences of the United States of America104 citations Open access
Semantic Scholar
Physical and biological properties of cationic triesters of phosphatidylcholine.
R. Macdonald, G. Ashley, M. Shida, V. Rakhmanova +10 more
1999Biophysical Journal103 citations Open access
Semantic Scholar
Modeling, synthesis, and hybridization properties of (L)-ribonucleic acid
G. Ashley
199290 citations
Semantic Scholar
Location of the redox-active thiols of ribonucleotide reductase: sequence similarity between the Escherichia coli and Lactobacillus leichmannii enzymes.
Ae Ning I. Lin, G. Ashley, JoAnne Stubbe
1987Biochemistry68 citations
Semantic Scholar
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Jeff Henise, B. R. Hearn, G. Ashley, D. Santi
2015Bioconjugate chemistry64 citations
Semantic Scholar
Chemical synthesis of oligodeoxynucleotide dumbbells.
G. Ashley, D. M. Kushlan
1991Biochemistry60 citations
Semantic Scholar
Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation.
D. Santi, Eric L Schneider, G. Ashley
2014Journal of Medicinal Chemistry59 citations
Semantic Scholar
Characterization of the macrolide P-450 hydroxylase from Streptomyces venezuelae which converts narbomycin to picromycin.
M. Betlach, J. Kealey, G. Ashley, R. Mcdaniel
1998Biochemistry54 citations
Semantic Scholar
Gain-of-Function Mutagenesis of a Modular Polyketide Synthase
R. Mcdaniel, C. M. Kao, Hong Fu, P. Hevezi +5 more
199752 citations
Semantic Scholar
Biosynthesis of 2-Nor-6-deoxyerythronolide B by Rationally Designed Domain Substitution
Lu Liu, A. Thamchaipenet, Hong Fu, M. Betlach +1 more
199749 citations
Semantic Scholar
The biosynthesis of lipoic acid. Cloning of lip, a lipoate biosynthetic locus of Escherichia coli.
M. Hayden, I. Huang, D. Bussiere, G. Ashley
1992Journal of Biological Chemistry49 citations Open access
Semantic Scholar
The mechanism of Lactobacillus leichmannii ribonucleotide reductase. Evidence for 3' carbon-hydrogen bond cleavage and a unique role for coenzyme B12.
G. Ashley, G. Harris, J. Stubbe
1986Journal of Biological Chemistry48 citations
Semantic Scholar
New insight into the mechanism of base propenal formation during bleomycin-mediated DNA degradation
G. Mcgall, L. Rabow, G. Ashley, S.-H. Wu +2 more
199246 citations
Semantic Scholar
Thiol protease‐like active site found in the enzyme dienelactone hydrolase: Localization using biochemical, genetic, and structural tools
D. Pathak, G. Ashley, D. Ollis
1991Proteins: Structure, Function, and Bioinformatics44 citations
Semantic Scholar
Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.
Eric L Schneider, Jeff Henise, Ralph R. Reid, G. Ashley +1 more
2016Bioconjugate chemistry43 citations
Semantic Scholar
Genetically Engineered Analogs of Ascomycin for Nerve Regeneration
W. Revill, J. Voda, C. Reeves, L. Chung +10 more
2002Journal of Pharmacology and Experimental Therapeutics43 citations
Semantic Scholar
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.
Zhi-Hao Hu, B. Pfeifer, Elizabeth S. Chao, S. Murli +5 more
2003Microbiology41 citations Open access
Semantic Scholar
Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.
C. Carreras, Scott Frykman, S. Ou, Lawrence Cadapan +8 more
2002Journal of Biotechnology37 citations
Semantic Scholar
Current ideas on the chemical mechanism of ribonucleotide reductases.
G. Ashley, J. Stubbe
1985Pharmacology and Therapeutics37 citations
Semantic Scholar
Purification and properties of cytidine deaminase from escherichia coli.
G. Ashley, Paul A. Bartlett
1984Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Hugo G Menzella, Thomas-Toan Tran, J. Carney, Janice Lau-Wee +9 more
2009Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Selective abstraction of 2H from C-1' of the C residue in AGC.ICT by the radical center at C-2 of activated neocarzinostatin chromophore: structure of the drug/DNA complex responsible for bistranded lesion formation.
Susan M. Meschwitz, Ronald G. Schultz, G. Ashley, Irving H. Goldberg
1992Biochemistry29 citations
Semantic Scholar
A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.
Eric L Schneider, B. R. Hearn, S. Pfaff, Ralph R. Reid +4 more
2017ACS Chemical Biology28 citations
Semantic Scholar
Conformational properties of DNA hairpins with TTT and TTTT loops.
S. M. Baxter, Miriam B. Greizerstein, Diana M. Kushlan, G. Ashley
1993Biochemistry27 citations
Semantic Scholar
Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers
N. Meher, G. Ashley, A. Bidkar, Suchi Dhrona +8 more
2022ACS Applied Materials and Interfaces25 citations Open access
Semantic Scholar
PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89
D. Beckford-Vera, Shaun D. Fontaine, H. VanBrocklin, B. R. Hearn +3 more
2019Molecular Cancer Therapeutics24 citations Open access
Semantic Scholar
Preparation of Erythromycin Analogs Having Functional Groups at C-15
G. Ashley, Mark A. Burlingame, Ruchir P. Desai, Hong Fu +6 more
2006Journal of antibiotics (Tokyo. 1968)22 citations
Semantic Scholar
Chemobiosynthesis of Novel 6-Deoxyerythronolide B Analogues by Mutation of the Loading Module of 6-Deoxyerythronolide B Synthase 1
S. Murli, Karen S Macmillan, Zhi-Hao Hu, G. Ashley +4 more
2005Applied and Environmental Microbiology22 citations Open access
Semantic Scholar
Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft
Shaun D. Fontaine, B. Hann, Ralph R. Reid, G. Ashley +1 more
2019Cancer Chemotherapy and Pharmacology20 citations
Semantic Scholar
Precursor‐Directed Biosynthesis of 6‐Deoxyerythronolide B Analogs in Streptomycescoelicolor: Understanding Precursor Effects
T. Leaf, Lawrence Cadapan, C. Carreras, R. Regentin +4 more
2000Biotechnology progress (Print)20 citations
Semantic Scholar
Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.
Eric L Schneider, B. R. Hearn, S. Pfaff, Shaun D. Fontaine +7 more
2016Bioconjugate chemistry19 citations Open access
Semantic Scholar
Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.
Eric L Schneider, Jeff Henise, Ralph R. Reid, G. Ashley +1 more
2016Bioconjugate chemistry19 citations
Semantic Scholar
Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.
G. Ashley, Paul A. Bartlett
1984Journal of Biological Chemistry19 citations
Semantic Scholar
A once-monthly GLP-1 receptor agonist for treatment of diabetic cats.
Eric L Schneider, Ralph R. Reid, D. Parkes, T. Lutz +2 more
2019Domestic Animal Endocrinology18 citations Open access
Semantic Scholar
Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system
B. R. Hearn, Shaun D. Fontaine, S. Pfaff, Eric L Schneider +3 more
2018Journal of Controlled Release18 citations Open access
Semantic Scholar
A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules
Nobuo Machinaga, G. Ashley, Ralph R. Reid, Atsushi Yamasaki +5 more
2018Translational Vision Science & Technology18 citations Open access
Semantic Scholar
2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase.
G. Harris, G. Ashley, Morris J. Robins, R. L. Tolman +1 more
1987Biochemistry17 citations
Semantic Scholar
A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models
Shaun D. Fontaine, G. Ashley, P. Houghton, R. Kurmasheva +7 more
2020Cancer Research15 citations Open access
Semantic Scholar
Inactivation of the Lactobacillus leichmannii ribonucleoside triphosphate reductase by 2'-chloro-2'-deoxyuridine 5'-triphosphate: stoichiometry of inactivation, site of inactivation, and mechanism of the protein chromophore formation.
G. Ashley, G. Harris, J. Stubbe
1988Biochemistry14 citations
Semantic Scholar
β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.
Eric L Schneider, Louise H. Robinson, Ralph R. Reid, G. Ashley +1 more
2013Bioconjugate chemistry13 citations
Semantic Scholar
Autoclave sterilization of tetra‐polyethylene glycol hydrogel biomaterials with β‐eliminative crosslinks
Jeff Henise, B. Yao, G. Ashley, D. Santi
2020Engineering Reports12 citations Open access
Semantic Scholar
A long-acting C-natriuretic peptide for achondroplasia
Eric L Schneider, C. Carreras, Ralph R. Reid, G. Ashley +1 more
2022Proceedings of the National Academy of Sciences of the United States of America11 citations Open access
Semantic Scholar

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