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A. O. Isaac · SciRah

Researcher profile · Semantic Scholar

A. O. Isaac

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A. O. Isaac — researcher profile on SciRah

h-index: 13
Works: 42
Citations: 573

Most-cited papers

Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders
A. Singh, A. O. Isaac, Xiu Luo, M. Mohan +5 more
2009PLoS Pathogens97 citations Open access
Semantic Scholar
Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis
A. Singh, M. Mohan, A. O. Isaac, Xiu Luo +3 more
2009PLoS ONE63 citations Open access
Semantic Scholar
Kenyan purple tea anthocyanins ability to cross the blood brain barrier and reinforce brain antioxidant capacity in mice
K. Rashid, F. Wachira, J. Nyabuga, B. Wanyonyi +2 more
2014Nutritional neuroscience60 citations
Semantic Scholar
Antioxidant, antimicrobial and synergistic activities of tea polyphenols.
K. Rashid, F. Wachira, R. Ngure, JN Nyabuga +3 more
201445 citations
Semantic Scholar
Oral administration of Coenzyme Q10 protects mice against oxidative stress and neuro-inflammation during experimental cerebral malaria.
J. Nyariki, L. Ochola, N. Jillani, Nemwel O. Nyamweya +4 more
2019Parasitology international38 citations
Semantic Scholar
Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex.
V. Dukhande, A. O. Isaac, T. Chatterji, J. C. K. Lai
2009Brain Research27 citations
Semantic Scholar
Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae
Fauzia K Musasia, A. O. Isaac, D. Masiga, Irene Omedo +3 more
2013Malaria Journal26 citations Open access
Semantic Scholar
Coenzyme Q10 nullified khat-induced hepatotoxicity, nephrotoxicity and inflammation in a mouse model
Chepukosi Kennedy, P. Okanya, J. Nyariki, Peris Amwayi +2 more
2020Heliyon23 citations Open access
Semantic Scholar
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
Victoria K. Mwaeni, J. Nyariki, N. Jillani, George Omwenga +2 more
2021BMC Pharmacology and Toxicology20 citations Open access
Semantic Scholar
Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model.
K. Rashid, F. Wachira, J. Nyariki, A. O. Isaac
2014Parasitology international20 citations
Semantic Scholar
Manganese Treatment Modulates the Expression of Peroxisome Proliferator-activated Receptors in Astrocytoma and Neuroblastoma Cells
A. O. Isaac, I. Kawikova, A. Bothwell, C. Daniels +1 more
2006Neurochemical Research19 citations
Semantic Scholar
A glyphosate-based herbicide disrupted hematopoiesis and induced organ toxicities, ameliorated by vitamin B12 in a mouse model
D. Ngatuni, P. Wairagu, N. Jillani, A. O. Isaac +1 more
2022Saudi Journal of Biological Sciences14 citations Open access
Semantic Scholar
Metabolic and Antioxidant System Alterations in an Astrocytoma Cell Line Challenged with Mitochondrial DNA Deletion
A. O. Isaac, V. Dukhande, J. C. K. Lai
2007Neurochemical Research14 citations
Semantic Scholar
Vitamin B12 blocked Trypanosoma brucei rhodesiense-driven disruption of the blood brain barrier, and normalized nitric oxide and malondialdehyde levels in a mouse model.
James O. Oula, J. Mose, Naomi N Waiganjo, Kennedy W. Chepukosi +3 more
2023Parasitology international13 citations
Semantic Scholar
Calcium carbide–induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model
Pherah A. Ouma, Victoria K. Mwaeni, P. Amwayi, A. O. Isaac +1 more
2022Laboratory Animal Research13 citations Open access
Semantic Scholar
Sodium Metabisulfite-Induced Hematotoxicity, Oxidative Stress, and Organ Damage Ameliorated by Standardized Ginkgo biloba in Mice
Nancy Wairimu, P. Wairagu, Kennedy W. Chepukosi, George F. Obiero +3 more
2023Journal of Toxicology10 citations Open access
Semantic Scholar
Correction: Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis
A. Singh, M. Mohan, A. O. Isaac, Xiu Luo +3 more
2009PLoS ONE10 citations Open access
Semantic Scholar
Coenzyme Q10 exhibits anti-inflammatory and immune-modulatory thereby decelerating the occurrence of experimental cerebral malaria.
J. Nyariki, N. Kimani, P. Kibet, G. Kinuthia +1 more
2023Molecular and biochemical parasitology (Print)9 citations
Semantic Scholar
Coenzyme Q_10 prevented Trypanosoma brucei rhodesiense-mediated breach of the blood brain barrier, inflammation and organ damage in late stage of Human African Trypanosomiasis
Lynn Kitwan, Celestine Makobe, R. Mdachi, Dawn Maranga +2 more
2022Journal of Parasitic Diseases9 citations Open access
Semantic Scholar
Co-administration of chloroquine and coenzyme Q10 improved treatment outcome during experimental cerebral malaria
David B. Ouko, P. Amwayi, L. Ochola, P. Wairagu +2 more
2022Journal of Parasitic Diseases7 citations Open access
Semantic Scholar
Manganese exacerbated chronic khat-induced neurological deficits, inflammation and organ toxicity in a mouse model
Kennedy W. Chepukosi, J. Nyariki, N. Jillani, P. Okanya +1 more
2021Toxicology and Environmental Health Sciences6 citations
Semantic Scholar
Ginkgo biloba attenuated detrimental inflammatory and oxidative events due to Trypanosoma brucei rhodesiense in mice treated with melarsoprol
Janet Khatenje Wendo, J. Mbaria, J. Nyariki, A. O. Isaac
2024PLoS Neglected Tropical Diseases5 citations Open access
Semantic Scholar
Coenzyme Q10 and endogenous antioxidants neuro-protect mice brain against deleterious effects of melarsoprol and Trypanasoma brucei rhodesiense
J. Nyariki, J. Thuita, A. Wambugu, Nemwel O. Nyamweya +3 more
20185 citations
Semantic Scholar
Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense
J. Nyariki, J. Thuita, G. Nyambati, A. O. Isaac
20145 citations Open access
Semantic Scholar
Coenzyme Q10 Ameliorates potassium cyanide-induced toxicosis in a mouse model
Francis Gitonga, Kipchumba Biwott, G. Gitau, Okanya Patrick Wafula +3 more
2021Scientific African4 citations Open access
Semantic Scholar
Vitamin B_12 and coenzyme Q_10 ameliorated alcohol-driven impairment of hematological parameters, inflammation, and organ damage in a mouse model
Biwott Kipchumba, A. O. Isaac, Victoria K. Mwaeni, George Omwenga +2 more
2023Nutrire3 citations
Semantic Scholar
In silico Analysis of Coenzyme Q10 interaction with the Heme-hemoglobin Complex: Implications for Oxidative Stress and Inflammation in Severe Malaria
David B. Ouko, F. Musila, P. Amwayi, Victoria K. Mwaeni +4 more
2026Advances in Biomarker Sciences and Technology2 citations Open access
Semantic Scholar
Alcohol spiked with zolpidem and midazolam potentiates inflammation, oxidative stress and organ damage in a mouse model
Biwott Kipchumba, Francis Gitonga, Careen Jepchirchir, Grace Gitau +4 more
2023Forensic Toxicology2 citations
Semantic Scholar
Oral Administration of Coenzyme Q10 has the Capacity to Stimulate Innate Lymphoid Cells Class Two during Experimental Cerebral Malaria
J. Nyariki, Daniel Mokaya, N. Jillani, Nemwel O. Nyamweya +1 more
20192 citations
Semantic Scholar
Amoxicillin and cotrimoxazole-driven dysbiosis disrupted blood cell levels, cytokine balance and induced oxido-nitrosative stress in young mice
Kiptoo K. Cosmas, Silas Kiruki, O. Njiri, G. Nyambati +4 more
2026Advances in Biomarker Sciences and Technology1 citations Open access
Semantic Scholar
Sequential exposure to multiple antibiotics depleted glutathione in hepatocytes, disrupted hematological profile, and inflammatory responses in a mouse model
Winnie Chepkirui Langatt, George Omwenga, George F. Obiero, Chepukosi Kennedy +2 more
2025Comparative Clinical Pathology1 citations
Semantic Scholar
Sex-specific induction of CYP6 cytochrome P450 genes in cadmium and lead tolerant Anopheles gambiae
Fauzia K Musasia, A. O. Isaac, D. Masiga, Irene Omedo +3 more
2013Malaria Journal1 citations Open access
Semantic Scholar
Co-administration of chloroquine and co-enzyme Q10 reduces neurological deficits, brain edema, and breach of the blood-brain barrier in experimental cerebral malaria
David B. Ouko, Kennedy W. Chepukosi, P. Amwayi, Vionah Moraa Nyandoro +2 more
2026Aspects of Molecular Medicine0 citations Open access
Semantic Scholar
Calcium carbide–induced derangement of hematopoiesis and organ toxicity ameliorated by cyanocobalamin in a mouse model
Pherah A. Ouma, Victoria K. Mwaeni, P. Amwayi, A. O. Isaac +1 more
2022Laboratory Animal Research0 citations Open access
Semantic Scholar
Ubidercarenone Decelerates the Manifestation of Experimental Cerebral Malaria in C57BL/6J Mice by ameliorating the Host Inflammatory Response
J. Nyariki, L. Ochola, David O. Bosire, A. O. Isaac
2022ASRIC Journal on Health Sciences0 citations Open access
Semantic Scholar
Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
Victoria K. Mwaeni, J. Nyariki, N. Jillani, George Omwenga +2 more
2021BMC Pharmacology and Toxicology0 citations Open access
Semantic Scholar
Coenzyme Q10 and cerebral malaria in mice: Questionable interpretations, improbable usefulness in humans.
Nyariki James Nyabuga, A. O. Isaac
2020Parasitology international0 citations
Semantic Scholar
Coenzyme Q10 Protect Mice Against Inflammatory Responses During Experimental Cerebral Malaria
J. Nyariki, Daniel Mokaya, N. Jillani, Nemwel O. Nyamweya +2 more
2019Journal of Natural Sciences Research0 citations Open access
Semantic Scholar
Effects of Kenyan purple tea anthocyanins in the brain and interaction with coenzyme-Q10 in a mouse model.
K. Rashid, F. Wachira, J. K. Wanyoko, L. Kerio +3 more
20120 citations
Semantic Scholar
Prion Disease Pathogenesis
A. Singh, M. Mohan, A. O. Isaac, Xiu Luo +3 more
20110 citations
Semantic Scholar
Isolation and biochemical characterization of transferrin from the tsetse fly, Glossina morsitan centralis
A. O. Isaac, Dorington Ogoyi, M. Limo
20060 citations
Semantic Scholar
Chronic Hypoxia-induced Upregulation of Lactate Dehydrogenase activity is associated with increased LDH-1 protein expression increases in glycolytic flux in cultured hypoxic neurons
A. O. Isaac, Y. Xia, S. Hong, K. Behar +2 more
20040 citations
Semantic Scholar

Frequent co-authors

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J. Nyariki×26
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J. Nyariki — researcher profile on SciRah
N. Jillani×8
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N. Jillani — researcher profile on SciRah
Victoria K. Mwaeni×6
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Victoria K. Mwaeni — researcher profile on SciRah
P. Amwayi×6
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P. Amwayi — researcher profile on SciRah

×5

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K. Rashid — researcher profile on SciRah

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A. Singh — researcher profile on SciRah

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Xiu Luo — researcher profile on SciRah

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M. Mohan — researcher profile on SciRah

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Neena Singh — researcher profile on SciRah

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F. Wachira — researcher profile on SciRah

Nemwel O. Nyamweya×4

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Nemwel O. Nyamweya — researcher profile on SciRah

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P. Okanya — researcher profile on SciRah