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D. Skrastina · SciRah

Researcher profile · Semantic Scholar

D. Skrastina

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D. Skrastina — researcher profile on SciRah

h-index: 19
Works: 68
Citations: 1,162

Most-cited papers

T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles.
T. Fehr, D. Skrastina, P. Pumpens, R. Zinkernagel
1998Proceedings of the National Academy of Sciences of the United States of America186 citations Open access
Semantic Scholar
Construction and Immunological Evaluation of Multivalent Hepatitis B Virus (HBV) Core Virus-Like Particles Carrying HBV and HCV Epitopes
I. Sominskaya, D. Skrastina, A. Dišlers, D. Vasiljev +4 more
2010Clinical and Vaccine Immunology86 citations Open access
Semantic Scholar
N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus.
C. Bremer, I. Sominskaya, D. Skrastina, P. Pumpens +7 more
2011Journal of Hepatology62 citations Open access
Semantic Scholar
A hantavirus nucleocapsid protein segment exposed on hepatitis B virus core particles is highly immunogenic in mice when applied without adjuvants or in the presence of pre-existing anti-core antibodies.
Astrid Geldmacher, D. Skrastina, G. Borisova, I. Petrovskis +3 more
2005Vaccine52 citations
Semantic Scholar
An amino-terminal segment of hantavirus nucleocapsid protein presented on hepatitis B virus core particles induces a strong and highly cross-reactive antibody response in mice.
Astrid Geldmacher, D. Skrastina, I. Petrovskis, G. Borisova +12 more
2004Virology52 citations Open access
Semantic Scholar
Potato Virus Y-Like Particles as a New Carrier for the Presentation of Foreign Protein Stretches
Ieva Kalnciema, D. Skrastina, V. Ose, P. Pumpens +1 more
2012Molecular Biotechnology51 citations
Semantic Scholar
Silica Nanoparticles as the Adjuvant for the Immunisation of Mice Using Hepatitis B Core Virus-Like Particles
D. Skrastina, I. Petrovskis, I. Liekniņa, J. Bogans +5 more
2014PLoS ONE50 citations Open access
Semantic Scholar
Recombinant virus-like particles as a carrier of B- and T-cell epitopes of hepatitis C virus (HCV).
M. Mihailova, Mechthild Boos, I. Petrovskis, V. Ose +7 more
2006Vaccine48 citations
Semantic Scholar
A VLP Library of C-Terminally Truncated Hepatitis B Core Proteins: Correlation of RNA Encapsidation with a Th1/Th2 Switch in the Immune Responses of Mice
I. Sominskaya, D. Skrastina, I. Petrovskis, Andris Dishlers +8 more
2013PLoS ONE41 citations Open access
Semantic Scholar
Assembly of bacteriophage Qbeta virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris.
J. Freivalds, A. Dišlers, V. Ose, D. Skrastina +4 more
2006Journal of Biotechnology41 citations
Semantic Scholar
Evaluation of HBs, HBc, and frCP Virus-Like Particles for Expression of Human Papillomavirus 16 E7 Oncoprotein Epitopes
P. Pumpens, R. Ražanskas, P. Pushko, R. Renhof +8 more
2002Intervirology41 citations
Semantic Scholar
HIV-1 Reverse Transcriptase Promotes Tumor Growth and Metastasis Formation via ROS-Dependent Upregulation of Twist
E. Bayurova, J. Jansons, D. Skrastina, O. Smirnova +24 more
2019Oxidative Medicine and Cellular Longevity34 citations Open access
Semantic Scholar
Characterization of human adipose-derived stem cells cultured in autologous serum after subsequent passaging and long term cryopreservation.
A. Bogdanova, U. Bērziņš, S. Nikulshin, D. Skrastina +3 more
2014Journal of Stem Cells34 citations
Semantic Scholar
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model
O. Trofimova, K. Korotkaja, D. Skrastina, J. Jansons +3 more
2021Vaccines31 citations Open access
Semantic Scholar
High immunogenicity of a hydrophilic component of the hepatitis B virus preS1 sequence exposed on the surface of three virus-like particle carriers.
D. Skrastina, A. Bulavaitė, I. Sominskaya, L. Kovalevska +4 more
2008Vaccine29 citations
Semantic Scholar
Behavior of a Short preS1 Epitope on the Surface of Hepatitis B Core Particles
G. Borisova, O. Borschukova, D. Skrastina, A. Dišlers +3 more
1999Biological chemistry29 citations
Semantic Scholar
Construction and Immunogenicity of a Novel Multivalent Vaccine Prototype Based on Conserved Influenza Virus Antigens
A. Kirsteina, I. Akopjana, J. Bogans, I. Liekniņa +10 more
2020Vaccines24 citations Open access
Semantic Scholar
Semliki Forest virus biodistribution in tumor-free and 4T1 mammary tumor-bearing mice: a comparison of transgene delivery by recombinant virus particles and naked RNA replicon
J. Vasilevska, D. Skrastina, K. Spunde, H. Garoff +2 more
2012Cancer Gene Therapy24 citations Open access
Semantic Scholar
Mosaic hepatitis B virus core particles presenting the complete preS sequence of the viral envelope on their surface.
A. Kazaks, G. Borisova, Svetlana Cvetkova, L. Kovalevska +5 more
2004Journal of General Virology21 citations Open access
Semantic Scholar
The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles
Andris Dishlers, D. Skrastina, Regīna Renhofa, I. Petrovskis +5 more
2015Molecular Biotechnology19 citations Open access
Semantic Scholar
Chimeric Bacteriophage fr Virus-Like Particles Harboring the Immunodominant C-Terminal Region of Hamster Polyomavirus VP1 Induce a Strong VP1-Specific Antibody Response in Rabbits and Mice
T. Voronkova, Adrian Grosch, A. Kazaks, V. Ose +7 more
2002Viral immunology19 citations
Semantic Scholar
Potato Virus M-Like Nanoparticles: Construction and Characterization
Ieva Kalnciema, Ina Baļķe, D. Skrastina, V. Ose +1 more
2015Molecular Biotechnology14 citations
Semantic Scholar
Signal sequences modulate the immunogenic performance of human hepatitis C virus E2 gene.
I. Sominskaya, Ekaterina Alekseeva, D. Skrastina, V. Mokhonov +8 more
2006Molecular Immunology14 citations
Semantic Scholar
High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model
A. Zajakina, J. Vasilevska, D. Zhulenkovs, D. Skrastina +3 more
2014BMC Cancer13 citations Open access
Semantic Scholar
Chimeric Derivatives of Hepatitis B Virus Core Particles Carrying Major Epitopes of the Rubella Virus E1 Glycoprotein
D. Skrastina, I. Petrovskis, R. Petraitytė, I. Sominskaya +5 more
2013Clinical and Vaccine Immunology13 citations Open access
Semantic Scholar
N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone
Karl D. Brune, I. Liekniņa, Grigorij Sutov, Alexander R. Morris +14 more
2021ChemBioChem12 citations Open access
Semantic Scholar
Stop Codon Insertion Restores the Particle Formation Ability of Hepatitis B Virus Core-Hantavirus Nucleocapsid Protein Fusions
A. Kazaks, S. Lachmann, D. Koletzki, I. Petrovskis +10 more
2003Intervirology10 citations
Semantic Scholar
PreS1 Containing HBc VLPs for the Development of a Combined Therapeutic/Prophylactic Hepatitis B Vaccine
Andris Dishlers, I. Petrovskis, D. Skrastina, Ieva Zarina +6 more
2023Microorganisms9 citations Open access
Semantic Scholar
Comparison of Bacterial Expression Systems Based on Potato Virus Y-like Particles for Vaccine Generation
Anete Ogrina, D. Skrastina, Ina Baļķe, Ieva Kalnciema +3 more
2022Vaccines9 citations Open access
Semantic Scholar
Identifying Key Drivers of Efficient B Cell Responses: On the Role of T Help, Antigen-Organization, and Toll-like Receptor Stimulation for Generating a Neutralizing Anti-Dengue Virus Response
Janusz Sobczak, Irena Barkovska, Ina Baļķe, Dominik A. Rothen +9 more
2024Vaccines8 citations Open access
Semantic Scholar
Reciprocal Inhibition of Immunogenic Performance in Mice of Two Potent DNA Immunogens Targeting HCV-Related Liver Cancer
J. Jansons, D. Skrastina, Alisa Kurlanda, S. Petkov +7 more
2021Microorganisms8 citations Open access
Semantic Scholar
The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response
J. Jansons, I. Sominskaya, N. Petrakova, E. Starodubova +10 more
2019Cells7 citations Open access
Semantic Scholar
Magnetic nanoparticles for efficient cell transduction with Semliki Forest virus.
Baiba Kurena, Aleksandra Vežāne, D. Skrastina, O. Trofimova +1 more
2017Journal of Virological Methods7 citations
Semantic Scholar
Comparative protein profiling of B16 mouse melanoma cells susceptible and non-susceptible to alphavirus infection: Effect of the tumor microenvironment
J. Vasilevska, G. D. de Souza, Maria Stensland, D. Skrastina +5 more
2016Cancer Biology & Therapy7 citations Open access
Semantic Scholar
Development of rapid antigen test prototype for detection of SARS-CoV-2 in saliva samples
Agnija Kivrāne, Viktorija Igumnova, Elza Elizabete Liepina, D. Skrastina +7 more
2022Upsala Journal of Medical Sciences6 citations Open access
Semantic Scholar
Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regimen
Ekaterina Alekseeva, I. Sominskaya, D. Skrastina, I. Egorova +8 more
2009Genetic Vaccines and Therapy6 citations Open access
Semantic Scholar
Toward a SARS-CoV-2 VLP Vaccine: HBc/G as a Carrier for SARS-CoV-2 Spike RBM and Nucleocapsid Protein-Derived Peptides
I. Petrovskis, D. Skrastina, J. Jansons, A. Dišlers +6 more
2024Vaccines5 citations Open access
Semantic Scholar
Bacterial expression systems based on Tymovirus-like particles for the presentation of vaccine antigens
Anete Ogrina, Ina Baļķe, Ieva Kalnciema, D. Skrastina +3 more
2023Frontiers in Microbiology5 citations Open access
Semantic Scholar
Bacteriophage-Derived Double-Stranded RNA Exerts Anti-SARS-CoV-2 Activity In Vitro and in Golden Syrian Hamsters In Vivo
K. Vaivode, Irina Verhovcova, D. Skrastina, R. Petrovska +6 more
2022Pharmaceuticals5 citations Open access
Semantic Scholar
Expression of the Reverse Transcriptase Domain of Telomerase Reverse Transcriptase Induces Lytic Cellular Response in DNA-Immunized Mice and Limits Tumorigenic and Metastatic Potential of Murine Adenocarcinoma 4T1 Cells
J. Jansons, E. Bayurova, D. Skrastina, Alisa Kurlanda +19 more
2020Vaccines5 citations Open access
Semantic Scholar
Characterisation and In Vivo Safety of Canine Adipose-Derived Stem Cells
U. Bērziņš, Ilze Matīse-VanHoutana, I. Petersone, I. Dūrītis +7 more
2018Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.4 citations Open access
Semantic Scholar
Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids
Y. Dekhtyar, M. Romanova, Anna Kachanovska, D. Skrastina +3 more
20124 citations
Semantic Scholar
Expression and characterisation of the ryegrass mottle virus non-structural proteins
Ina Baļķe, Gunta Resevica, D. Skrastina, A. Zeltins
20104 citations Open access
Semantic Scholar
Immunodominance of t cell epitopes on foreign sequences of the hepatitis b virus nucleocapsid fusion proteins
V. Zaķis, D. Skrastina, G. Borisova, I. Kuranova
19924 citations
Semantic Scholar
Synthesis and Immunological Evaluation of Virus-Like Particle-Milbemycin A3/A4 Conjugates
A. Zeltins, M. Turks, D. Skrastina, J. Lugiņina +4 more
2017Antibiotics3 citations Open access
Semantic Scholar
New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines
J. Jansons, Daria Avdoshina, Alesja Dudorova, Elena Royo Rubio +10 more
2025Infectious Agents and Cancer2 citations Open access
Semantic Scholar
New mouse model based on adenocarcinoma 4T1 cells expressing HPV16 E6 and E7 applied to assess the efficacy of therapeutic and prophylactic E6/E7-based HPV16 vaccines
J. Jansons, Daria Avdoshina, Alesja Dudorova, Elena Royo Rubio +10 more
2025Research Square2 citations Open access
Semantic Scholar
High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model
A. Zajakina, J. Vasilevska, D. Zhulenkovs, D. Skrastina +3 more
2014BMC Cancer2 citations Open access
Semantic Scholar
Active immunization with bacteriophage AP205 VLPs results in reduced amyloid load and microgliosis in 5xFAD female mice
V. Pilipenko, I. Liekniņa, D. Skrastina, Selen Aktas +4 more
2025Naunyn-Schmiedeberg's Archives of Pharmacology1 citations Open access
Semantic Scholar
Alphavirus-driven Interferon Gamma (IFNg) Expression Inhibits Tumour Growth in Orthotopic 4T1 Breast Cancer Model
O. Trofimova, K. Korotkaja, D. Skrastina, J. Jansons +3 more
20211 citations Open access
Semantic Scholar

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