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O. Segatto · SciRah

Researcher profile · Semantic Scholar

O. Segatto

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O. Segatto — researcher profile on SciRah

h-index: 34
Works: 66
Citations: 4,280

Most-cited papers

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.
P. Di Fiore, J. Pierce, M. Kraus, O. Segatto +2 more
1987Science1,016 citations
Semantic Scholar
Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene
O. Segatto, C. King, J. Pierce, P. Di Fiore +1 more
1988Molecular and Cellular Biology198 citations Open access
Semantic Scholar
Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma.
G. Kendre, K. Murugesan, T. Brummer, O. Segatto +2 more
2022Journal of Hepatology163 citations Open access
Semantic Scholar
Inhibition of ErbB-2 Mitogenic and Transforming Activity by RALT, a Mitogen-Induced Signal Transducer Which Binds to the ErbB-2 Kinase Domain
Loredana Fiorentino, C. Pertica, Monia Fiorini, C. Talora +5 more
2000Molecular and Cellular Biology151 citations Open access
Semantic Scholar
Constitutive phosphorylation of Shc proteins in human tumors.
G. Pelicci, L. Lanfrancone, A. Salcini, A. Romano +5 more
1995Oncogene144 citations
Semantic Scholar
Feedback inhibition by RALT controls signal output by the ErbB network
S. Anastasi, L. Fiorentino, Monia Fiorini, R. Fraioli +5 more
2003Oncogene137 citations Open access
Semantic Scholar
EGF receptor and erbB-2 tyrosine kinase domains confer cell specificity for mitogenic signaling.
P. Di Fiore, O. Segatto, W. G. Taylor, S. Aaronson +1 more
1990Science136 citations Open access
Semantic Scholar
Mig-6 controls EGFR trafficking and suppresses gliomagenesis
Hao-Qiang Ying, Hong-Wu Zheng, Kenneth L. Scott, R. Wiedemeyer +18 more
2010Proceedings of the National Academy of Sciences of the United States of America133 citations Open access
Semantic Scholar
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation
Y. Frosi, S. Anastasi, C. Ballarò, Giulia Varsano +5 more
2010Journal of Cell Biology130 citations Open access
Semantic Scholar
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
O. Segatto, S. Anastasi, S. Alemà
2011Journal of Cell Science124 citations Open access
Semantic Scholar
The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand.
F. Lonardo, E. di Marco, C. King, J. Pierce +3 more
1990The New biologist122 citations
Semantic Scholar
Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin
S. Anastasi, G. Sala, Hui-Ping Chen, E. Caprini +5 more
2005Oncogene117 citations
Semantic Scholar
Changes in expression of alpha 6/beta 4 integrin heterodimer in primary and metastatic breast cancer.
P. Natali, M. Nicotra, C. Botti, M. Mottolese +2 more
1992British Journal of Cancer112 citations Open access
Semantic Scholar
Shc products are substrates of erbB-2 kinase.
O. Segatto, G. Pelicci, S. Giuli, G. Digiesi +4 more
1993Oncogene106 citations
Semantic Scholar
Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways.
C. Talora, Samantha Cialfi, O. Segatto, S. Morrone +5 more
2005Experimental Cell Research78 citations
Semantic Scholar
Epigenetic silencing of miR-145-5p contributes to brain metastasis
S. Donzelli, F. Mori, T. Bellissimo, A. Sacconi +15 more
2015OncoTarget77 citations Open access
Semantic Scholar
Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control
Monia Fiorini, C. Ballarò, G. Sala, G. Falcone +2 more
2002Oncogene77 citations Open access
Semantic Scholar
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity
S. Anastasi, M. Baietti, Y. Frosi, S. Alemà +1 more
2007Oncogene75 citations
Semantic Scholar
The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency
F. Fazioli, Uh-Hyun Kim, Sue Goo Rhee, C. Molloy +2 more
1991Molecular and Cellular Biology75 citations Open access
Semantic Scholar
Analysis of protein-protein interactions involved in the activation of the Shc/Grb-2 pathway by the ErbB-2 kinase.
A. Ricci, L. Lanfrancone, R. Chiari, G. Belardo +4 more
1995Oncogene69 citations
Semantic Scholar
Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance
L. Fouassier, M. Marzioni, M. B. Afonso, S. Dooley +9 more
2019Liver international (Print)66 citations Open access
Semantic Scholar
The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.
E. Finzi, T. Fleming, O. Segatto, C. Y. Pennington +3 more
1987Proceedings of the National Academy of Sciences of the United States of America66 citations Open access
Semantic Scholar
FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma.
Giulia Cristinziano, M. Porru, Dante Lamberti, S. Buglioni +15 more
2021Journal of Hepatology62 citations Open access
Semantic Scholar
The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.
P. Di Fiore, O. Segatto, Fulvio Lonardo, F. Fazioli +2 more
1990Molecular and Cellular Biology60 citations Open access
Semantic Scholar
FGFR2 Inhibition in Cholangiocarcinoma.
A. Vogel, O. Segatto, A. Stenzinger, A. Saborowski
2022Annual Review of Medicine58 citations Open access
Semantic Scholar
The role of autophosphorylation in modulation of erbB-2 transforming function.
O. Segatto, F. Lonardo, J. Pierce, D. P. Bottaro +1 more
1990The New biologist58 citations
Semantic Scholar
Current and novel therapeutic opportunities for systemic therapy in biliary cancer
J. Marín, M. G. Prete, A. Lamarca, S. Tavolari +20 more
2020British Journal of Cancer57 citations Open access
Semantic Scholar
Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved‐like phenotype
C. Ballarò, S. Ceccarelli, C. Tiveron, L. Tatangelo +3 more
2005EMBO Reports48 citations Open access
Semantic Scholar
The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction
O. Segatto, F. Lonardo, D. Wexler, F. Fazioli +4 more
1991Molecular and Cellular Biology47 citations Open access
Semantic Scholar
Analysis of the antigenic profile of uveal melanoma lesions with anti-cutaneous melanoma-associated antigen and anti-HLA monoclonal antibodies.
P. Natali, A. Bigotti, M. Nicotra, R. M. Nardi +3 more
1989Cancer Research44 citations
Semantic Scholar
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
D. Calvisi, L. Boulter, J. Vaquero, A. Saborowski +31 more
2023Nature reviews: Gastroenterology & hepatology40 citations Open access
Semantic Scholar
Negative regulation of receptor tyrosine kinase signals
Monia Fiorini, M. Alimandi, Loredana Fiorentino, Gianluca Sala +1 more
2001FEBS Letters40 citations Open access
Semantic Scholar
Analysis with monoclonal antibodies of the molecular and cellular heterogeneity of human high molecular weight melanoma associated antigen.
M. Ziai, Luisa Imberti, M. Nicotra, Gianna Badaracco +3 more
1987Cancer Research39 citations
Semantic Scholar
Production and Characterization of Murine mAbs to the Extracellular Domain of Human Neu Oncogene Product GP185HER2
G. Digiesi, Patrizio Giacomini, R. Fraioli, Massimo Mariani +3 more
1992Hybridoma37 citations
Semantic Scholar
Expression of gp 185HER‐2 in human cutaneous melanoma: Implications for experimental immunotherapeutics
P. Natali, M. Nicotra, G. Digiesi, R. Cavaliere +3 more
1994International Journal of Cancer33 citations
Semantic Scholar
miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling
C. Migliore, Elena Morando, Elena Ghiso, S. Anastasi +9 more
2018EMBO Molecular Medicine29 citations Open access
Semantic Scholar
HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma
Dante Lamberti, Giulia Cristinziano, M. Porru, C. Leonetti +9 more
2018Hepatology29 citations Open access
Semantic Scholar
Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics.
S. Anastasi, Dante Lamberti, S. Alemà, O. Segatto
2016Seminars in Cell and Developmental Biology26 citations
Semantic Scholar
Identification and biochemical characterization of novel putative substrates for the epidermal growth factor receptor kinase.
F. Fazioli, D. P. Bottaro, Liliana Minichiello, Alberto Auricchio +3 more
1992Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Multiple epitope recognition: An approach to improved radioimmunodetection of tumor‐associated antigens
P. Giacomini, O. Segatto, Pier Giorgio Natali
1987International Journal of Cancer26 citations
Semantic Scholar
A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB‐2.
P. Di Fiore, K. Helin, M. H. Kraus, J. Pierce +3 more
1992EMBO Journal21 citations Open access
Semantic Scholar
Therapeutic targeting of ERBB2 in breast cancer: understanding resistance in the laboratory and combating it in the clinic
A. Fabi, M. Mottolese, O. Segatto
2014Journal of molecular medicine19 citations
Semantic Scholar
erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.
O. Segatto, F. Lonardo, K. Helin, D. Wexler +3 more
1992Oncogene17 citations
Semantic Scholar
Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens
P. Natali, O. Segatto, S. Ferrone, R. Tosi +1 more
2004Immunogenetics13 citations
Semantic Scholar
Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation
Małgorzata Milewska, D. Romano, A. Herrero, M. L. Guerriero +7 more
2015PLoS ONE12 citations Open access
Semantic Scholar
Lymphoid stroma of Warthin's tumor: phenotypic analogies with gut-associated lymphoid tissue.
O. Segatto, P. Giacomini, L. Santoro, A. Perrino +1 more
1985Clinical Immunology and Immunopathology12 citations
Semantic Scholar
Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma.
A. Saborowski, A. Vogel, O. Segatto
2021Trends in Cancer10 citations
Semantic Scholar
Making sense of Cbp/p300 loss of function mutations in skin tumorigenesis
S. Anastasi, S. Alemà, O. Segatto
2020Journal of Pathology9 citations Open access
Semantic Scholar
The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity
P. Di Fiore, O. Segatto, Fulvio Lonardo, F. Fazioli +2 more
19908 citations
Semantic Scholar
A pervasive role for MIG6 in restraining cell proliferation
S. Anastasi, Loriana Castellani, S. Alemà, O. Segatto
2013Cell Death and Differentiation5 citations Open access
Semantic Scholar

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P. Di Fiore×14
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P. Di Fiore — researcher profile on SciRah
S. Alemà×11
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S. Anastasi×11
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J. Pierce×8
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S. Aaronson — researcher profile on SciRah

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F. Fazioli — researcher profile on SciRah

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A. Vogel — researcher profile on SciRah

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M. Nicotra — researcher profile on SciRah

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P. Natali — researcher profile on SciRah

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Monia Fiorini×4

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Monia Fiorini — researcher profile on SciRah

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F. Lonardo — researcher profile on SciRah