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S. Keskitalo · SciRah

Researcher profile · Semantic Scholar

S. Keskitalo

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S. Keskitalo — researcher profile on SciRah

h-index: 22
Works: 90
Citations: 2,300

Most-cited papers

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors
Terhi Karpanen, C. Heckman, S. Keskitalo, M. Jeltsch +4 more
2006The FASEB Journal321 citations
Semantic Scholar
Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos
P. Haiko, T. Makinen, S. Keskitalo, J. Taipale +5 more
2008Molecular and Cellular Biology222 citations Open access
Semantic Scholar
The protein interaction landscape of the human CMGC kinase group.
M. Varjosalo, S. Keskitalo, A. van Drogen, H. Nurkkala +3 more
2013Cell Reports216 citations Open access
Semantic Scholar
Uterine leiomyoma-linked MED12 mutations disrupt Mediator-associated CDK activity
M. Turunen, Jason M. Spaeth, S. Keskitalo, Min Ju Park +15 more
2014Cell Reports157 citations Open access
Semantic Scholar
Navigating through metaproteomics data: A logbook of database searching
T. Muth, Carolin A. Kolmeder, J. Salojärvi, S. Keskitalo +7 more
2015Proteomics124 citations Open access
Semantic Scholar
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
C. Heckman, T. Holopainen, Maria Wirzenius, S. Keskitalo +5 more
2008Cancer Research111 citations Open access
Semantic Scholar
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
J. Saarimäki-Vire, D. Balboa, M. Russell, J. Saarikettu +14 more
2017Cell Reports101 citations Open access
Semantic Scholar
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiao-Nan Liu, S. Huuskonen, T. Laitinen, T. Redchuk +12 more
2021Molecular Systems Biology90 citations Open access
Semantic Scholar
Colonic metaproteomic signatures of active bacteria and the host in obesity
Carolin A. Kolmeder, J. Ritari, F. Verdam, T. Muth +12 more
2015Proteomics71 citations Open access
Semantic Scholar
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
S. Keskitalo, E. Haapaniemi, E. Einarsdottir, K. Rajamäki +15 more
2019Frontiers in Immunology64 citations Open access
Semantic Scholar
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Iivo Hetemäki, Meri Kaustio, Matias Kinnunen, N. Heikkilä +22 more
2021Science immunology56 citations Open access
Semantic Scholar
Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis
A. Anisimov, D. Tvorogov, A. Alitalo, Veli-Matti Leppänen +16 more
2013Circulation53 citations Open access
Semantic Scholar
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiao-Nan Liu, Tiina J. Öhman, Iftekhar Chowdhury +3 more
2021bioRxiv50 citations Open access
Semantic Scholar
Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy
Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, V. Plagnol +28 more
2019Journal of Allergy and Clinical Immunology46 citations Open access
Semantic Scholar
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms
K. Kämpjärvi, N. Kim, S. Keskitalo, A. Clark +21 more
2016The Prostate46 citations
Semantic Scholar
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
Marko Pietilä, E. Pirinen, S. Keskitalo, Sisko Juutinen +4 more
2005Journal of Investigative Dermatology39 citations Open access
Semantic Scholar
Haploinsufficiency of A20 impairs protein–protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation
K. Rajamäki, S. Keskitalo, M. Seppänen, O. Kuismin +14 more
2018RMD Open32 citations Open access
Semantic Scholar
The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study.
Luisa Klotz, Melinda Farkas, N. Bain, S. Keskitalo +7 more
2010Neuroscience Letters32 citations Open access
Semantic Scholar
Hyperhomocysteinemia in Alzheimer's Disease: The Hen and the Egg?
Melinda Farkas, S. Keskitalo, Desirée E. C. Smith, N. Bain +6 more
2013Journal of Alzheimer's Disease30 citations Open access
Semantic Scholar
CMGC Kinases in Health and Cancer
Iftekhar Chowdhury, Giovanna Dashi, S. Keskitalo
2023Cancers28 citations Open access
Semantic Scholar
Anagrelide for Gastrointestinal Stromal Tumor
Olli-Pekka Pulkka, Y. Gebreyohannes, A. Wozniak, J. Mpindi +16 more
2018Clinical Cancer Research24 citations Open access
Semantic Scholar
Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome.
J. Tenorio-Laranga, Iida Peltonen, S. Keskitalo, G. Duran-Torres +7 more
2013Biochemical Pharmacology23 citations Open access
Semantic Scholar
Reduced binding of apoE4 to complement factor H promotes amyloid‐β oligomerization and neuroinflammation
L. Chernyaeva, G. Ratti, L. Teirilä, S. Fudo +20 more
2023EMBO Reports22 citations Open access
Semantic Scholar
Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis
K. Nurmi, Kristiina Silventoinen, S. Keskitalo, K. Rajamäki +28 more
2024Cell Reports Medicine21 citations Open access
Semantic Scholar
Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease
S. Keskitalo, E. Haapaniemi, V. Glumoff, Xiao-Nan Liu +12 more
2019npj Genomic Medicine20 citations Open access
Semantic Scholar
Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Ganna Reint, Zhuo-Kun Li, K. Labun, S. Keskitalo +15 more
2021bioRxiv18 citations Open access
Semantic Scholar
Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry
T. Heikkinen, K. Kämpjärvi, S. Keskitalo, P. von Nandelstadh +14 more
2017Human Mutation18 citations Open access
Semantic Scholar
Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.
E. Haapaniemi, Christopher L. Fogarty, S. Keskitalo, S. Katayama +12 more
2017Journal of Allergy and Clinical Immunology18 citations Open access
Semantic Scholar
Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.
B. Ineichen, S. Keskitalo, Melinda Farkas, N. Bain +4 more
2014Neuroscience Letters18 citations
Semantic Scholar
Altered glycosylation of several metastasis-associated glycoproteins with terminal GalNAc defines the highly invasive cancer cell phenotype
Elham Khosrowabadi, T. Wenta, S. Keskitalo, A. Manninen +1 more
2021OncoTarget17 citations Open access
Semantic Scholar
Distinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to interferon induction
Dragana Vukić, Anna Cherian, S. Keskitalo, Y. Bong +5 more
2024Nucleic Acids Research16 citations Open access
Semantic Scholar
Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein
S. Keskitalo, T. Tammela, Johannes Lyytikka, Terhi Karpanen +4 more
2007Circulation Research16 citations Open access
Semantic Scholar
Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression
Dicle Malaymar Pinar, Helka Göös, Zeng-Lai Tan, E. Kumpula +8 more
2024Molecular & Cellular Proteomics15 citations Open access
Semantic Scholar
The Impact of ETV6-NTRK3 Oncogenic Gene Fusions on Molecular and Signaling Pathway Alterations
Matias Kinnunen, Xiao-Nan Liu, E. Niemelä, Tiina J. Öhman +4 more
2023Cancers15 citations Open access
Semantic Scholar
A Family With A20 Haploinsufficiency Presenting With Novel Clinical Manifestations and Challenges for Treatment
T. Hautala, P. Vähäsalo, O. Kuismin, S. Keskitalo +17 more
2020Journal of clinical rheumatology14 citations Open access
Semantic Scholar
The thermolabile variant of 5,10-methylenetetrahydrofolate reductase is a possible risk factor for amyotrophic lateral sclerosis
P. Kühnlein, H. Jung, Melinda Farkas, S. Keskitalo +7 more
2011Amyotrophic Lateral Sclerosis13 citations Open access
Semantic Scholar
IRF2BP2 Mutation Is Associated with Increased STAT1 and STAT5 Activation in Two Family Members with Inflammatory Conditions and Lymphopenia
M. Palmroth, H. Viskari, M. Seppänen, S. Keskitalo +4 more
2021Pharmaceuticals12 citations Open access
Semantic Scholar
Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema.
V. Verstraeten, W. Holnthoner, M. V. van Steensel, J. Veraart +7 more
2009Journal of Investigative Dermatology12 citations Open access
Semantic Scholar
The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base
S. Huuskonen, Xiao-Nan Liu, Ina Pöhner, Taras Redchuk +19 more
2024Cell Discovery11 citations Open access
Semantic Scholar
Reciprocal modulation of Aβ42 aggregation by copper and homocysteine
S. Keskitalo, Melinda Farkas, M. Hanenberg, A. Szodorai +5 more
2014Frontiers in Aging Neuroscience11 citations Open access
Semantic Scholar
From rare to more common: The emerging role of omics in improving understanding and treatment of severe inflammatory and hyperinflammatory conditions.
S. Keskitalo, M. Seppänen, A. del Sol, M. Varjosalo
2025Journal of Allergy and Clinical Immunology10 citations Open access
Semantic Scholar
Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
J. Hulmi, Eeli J. Halonen, A. Sharples, T. O'Connell +6 more
2025bioRxiv9 citations Open access
Semantic Scholar
Common variable immunodeficiency in two kindreds with heterogeneous phenotypes caused by novel heterozygous NFKB1 mutations
F. Staels, Kerstin De Keukeleere, Matias Kinnunen, S. Keskitalo +19 more
2022Frontiers in Immunology7 citations Open access
Semantic Scholar
Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity
Nora Pernaa, S. Keskitalo, Iftekhar Chowdhury, A. Nissinen +11 more
2022Frontiers in Immunology7 citations Open access
Semantic Scholar
Automated Mag-Net Enrichment Unlocks Deep and Cost-Effective LC–MS Plasma Proteomics
E. Järvinen, Xiao-Nan Liu, M. Varjosalo, S. Keskitalo
2025bioRxiv6 citations Open access
Semantic Scholar
A TOM1 variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity
Heljä K M Lång, Tiffany G Roach, Maarit Hölttä, S. Keskitalo +7 more
2025Disease Models & Mechanisms4 citations Open access
Semantic Scholar
Functional omics of ORP7 in primary endothelial cells
J. Taskinen, M. Holopainen, H. Ruhanen, Miesje M. van der Stoel +5 more
2024bioRxiv4 citations Open access
Semantic Scholar
Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication.
Vaishali Chaurasiya, D. Pham, Jukka Harju, A. Juuti +10 more
2023Experimental Cell Research4 citations Open access
Semantic Scholar
Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling
E. Tuovinen, Sakari Pöysti, Firas Hamdan, K. M. Le +11 more
2022Journal of Clinical Immunology4 citations Open access
Semantic Scholar
and leads into caspase-8-dependent enhancement of NLRP 3 inflammasome activation
K. Rajamäki, S. Keskitalo, M. Seppänen, O. Kuismin +14 more
4 citations
Semantic Scholar

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