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K. Eklund · SciRah

Researcher profile · Semantic Scholar

K. Eklund

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K. Eklund — researcher profile on SciRah

h-index: 35
Works: 125
Citations: 8,835

Most-cited papers

FinnGen provides genetic insights from a well-phenotyped isolated population
M. Kurki, J. Karjalainen, P. Palta, Timo P. Sipilä +164 more
2023Nature3,914 citations Open access
Semantic Scholar
Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation
K. Rajamäki, J. Lappalainen, K. Öörni, E. Välimäki +3 more
2010PLoS ONE1,040 citations Open access
Semantic Scholar
Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome
K. Rajamäki, Tommy Nordström, K. Nurmi, K. Åkerman +3 more
2013Journal of Biological Chemistry334 citations Open access
Semantic Scholar
Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway
K. Niemi, L. Teirilä, J. Lappalainen, K. Rajamäki +6 more
2011Journal of Immunology283 citations Open access
Semantic Scholar
Immune functions of serum amyloid A.
K. Eklund, K. Niemi, P. Kovanen
2012Critical Reviews in Immunology240 citations
Semantic Scholar
Novel Odoribacter splanchnicus Strain and Its Outer Membrane Vesicles Exert Immunoregulatory Effects in vitro
K. Hiippala, G. Barreto, C. Burrello, A. Díaz-Basabe +8 more
2020Frontiers in Microbiology202 citations Open access
Semantic Scholar
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Rubina Tabassum, Joel T. Rämö, P. Ripatti, J. Koskela +255 more
2019Nature Communications167 citations Open access
Semantic Scholar
Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes
Meri Kaustio, E. Haapaniemi, Helka Göös, T. Hautala +25 more
2017Journal of Allergy and Clinical Immunology120 citations Open access
Semantic Scholar
Mast cells in the pathogenesis of rheumatic diseases and as potential targets for anti‐rheumatic therapy
K. Eklund
2007Immunological Reviews103 citations
Semantic Scholar
Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis
G. Barreto, M. Manninen, K. Eklund
2020Biology97 citations Open access
Semantic Scholar
Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population
M. Kurki, J. Karjalainen, P. Palta, Timo P. Sipilä +164 more
2023Nature95 citations Open access
Semantic Scholar
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
Eevi Kaasinen, O. Kuismin, K. Rajamäki, H. Ristolainen +31 more
2019Nature Communications81 citations Open access
Semantic Scholar
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation*
M. Lorey, Katriina Rossi, K. Eklund, T. Nyman +1 more
2017Molecular & Cellular Proteomics76 citations Open access
Semantic Scholar
Treatment response and drug retention rates in 24 195 biologic-naïve patients with axial spondyloarthritis initiating TNFi treatment: routine care data from 12 registries in the EuroSpA collaboration
L. Ørnbjerg, C. H. Brahe, J. Askling, A. Ciurea +28 more
2019Annals of the Rheumatic Diseases71 citations Open access
Semantic Scholar
p38&dgr; MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis
K. Rajamäki, M. Mäyränpää, A. Risco, J. Tuimala +5 more
2016Arteriosclerosis, Thrombosis and Vascular Biology68 citations Open access
Semantic Scholar
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
S. Keskitalo, E. Haapaniemi, E. Einarsdottir, K. Rajamäki +15 more
2019Frontiers in Immunology64 citations Open access
Semantic Scholar
Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis
G. Barreto, A. Soininen, P. Ylinen, J. Sandelin +3 more
2015Arthritis Research & Therapy60 citations Open access
Semantic Scholar
Ethanol Inhibits Activation of NLRP3 and AIM2 Inflammasomes in Human Macrophages–A Novel Anti-Inflammatory Action of Alcohol
K. Nurmi, J. Virkanen, K. Rajamäki, K. Niemi +2 more
2013PLoS ONE59 citations Open access
Semantic Scholar
Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages
E. Välimäki, Wojciech Cypryk, J. Virkanen, K. Nurmi +5 more
2016Journal of Immunology58 citations Open access
Semantic Scholar
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Iivo Hetemäki, Meri Kaustio, Matias Kinnunen, N. Heikkilä +22 more
2021Science immunology56 citations Open access
Semantic Scholar
Cost–utility of different treatment strategies after the failure of tumour necrosis factor inhibitor in rheumatoid arthritis in the Finnish setting
T. Hallinen, E. Soini, K. Eklund, K. Puolakka
2010Rheumatology55 citations Open access
Semantic Scholar
Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy
Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, V. Plagnol +28 more
2019Journal of Allergy and Clinical Immunology46 citations Open access
Semantic Scholar
Retention and response rates in 14 261 PsA patients starting TNF inhibitor treatment-results from 12 countries in EuroSpA.
C. H. Brahe, L. Ørnbjerg, L. Jacobsson, M. Nissen +28 more
2020Rheumatology45 citations Open access
Semantic Scholar
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
A. Palomäki, A. Palotie, J. Koskela, K. Eklund +4 more
2021Annals of the Rheumatic Diseases44 citations Open access
Semantic Scholar
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Erik L. Bao, Satish K. Nandakumar, Xiaotian Liao, A. Bick +335 more
2020Nature44 citations Open access
Semantic Scholar
Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration
U. Lindström, D. di Giuseppe, B. Delcoigne, B. Glintborg +27 more
2021Annals of the Rheumatic Diseases43 citations Open access
Semantic Scholar
Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation
K. Nurmi, Ilona Kareinen, J. Virkanen, K. Rajamäki +7 more
2016Journal of Innate Immunity43 citations Open access
Semantic Scholar
Tumor necrosis factor primes and metal particles activate the NLRP3 inflammasome in human primary macrophages
Eemeli Jämsen, J. Pajarinen, V. Kouri, A. Rahikkala +5 more
2020Acta Biomaterialia42 citations Open access
Semantic Scholar
Efficacy and effectiveness of tumour necrosis factor inhibitors in the treatment of rheumatoid arthritis in randomized controlled trials and routine clinical practice
K. Aaltonen, Suvi Ylikylä, Jaana Tuulikki Joensuu, P. Isomäki +6 more
2017Rheumatology42 citations
Semantic Scholar
IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3
V. Kouri, Juri Olkkonen, K. Nurmi, N. Peled +4 more
2022Rheumatology38 citations Open access
Semantic Scholar
Behçet disease (BD) and BD‐like clinical phenotypes: NF‐κB pathway in mucosal ulcerating diseases
S. Perazzio, Eric J. Allenspach, K. Eklund, M. Varjosalo +3 more
2020Scandinavian Journal of Immunology36 citations Open access
Semantic Scholar
Hydroxychloroquine for the prevention of recurrent cardiovascular events in myocardial infarction patients: rationale and design of the OXI trial.
O. Hartman, P. Kovanen, J. Lehtonen, K. Eklund +1 more
2016European Heart Journal - Cardiovascular Pharmacotherapy35 citations Open access
Semantic Scholar
Real‐World Six‐ and Twelve‐Month Drug Retention, Remission, and Response Rates of Secukinumab in 2,017 Patients With Psoriatic Arthritis in Thirteen European Countries
B. Michelsen, S. Georgiadis, D. di Giuseppe, A. Loft +29 more
2021Arthritis care & research33 citations Open access
Semantic Scholar
Haploinsufficiency of A20 impairs protein–protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation
K. Rajamäki, S. Keskitalo, M. Seppänen, O. Kuismin +14 more
2018RMD Open32 citations Open access
Semantic Scholar
Correlations between macrophage polarizing cytokines, inflammatory mediators, osteoclast activity, and toll-like receptors in tissues around aseptically loosened hip implants.
Eemeli Jämsen, V. Kouri, M. Ainola, S. Goodman +3 more
2017Journal of Biomedical Materials Research. Part A32 citations
Semantic Scholar
Hydroxychloroquine reduces interleukin-6 levels after myocardial infarction: The randomized, double-blind, placebo-controlled OXI pilot trial.
Lotta Ulander, H. Tolppanen, O. Hartman, T. Rissanen +17 more
2021International Journal of Cardiology29 citations Open access
Semantic Scholar
[Large-vessel vasculitides].
K. Eklund, T. Pettersson
2011Duodecim lääketieteellinen aikakauskirja27 citations
Semantic Scholar
Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus
A. Salem, R. Almahmoudi, J. Hagström, H. Stark +3 more
2019International Journal of Molecular Sciences25 citations Open access
Semantic Scholar
Maintained efficacy of the tyrosine kinase inhibitor imatinib mesylate in a patient with rheumatoid arthritis.
K. Eklund, K. Lindstedt, C. Sandler, P. Kovanen +5 more
2008Journal of clinical rheumatology25 citations
Semantic Scholar
Engineering Inflammation‐Resistant Cartilage: Bridging Gene Therapy and Tissue Engineering
A. Bonato, P. Fisch, S. Ponta, D. Fercher +5 more
2023Advanced Healthcare Materials24 citations Open access
Semantic Scholar
Competitive colonization of prosthetic surfaces by staphylococcus aureus and human cells.
R. Pérez-Tanoira, X. Han, A. Soininen, A. Aarnisalo +4 more
2017Journal of Biomedical Materials Research. Part A24 citations
Semantic Scholar
Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report
A. Salem, R. Almahmoudi, D. Listyarifah, M. Siponen +4 more
2017Cellular Oncology24 citations Open access
Semantic Scholar
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
Sini Karinen, K. Juurikka, Roosa Hujanen, Wafa Wahbi +6 more
2021Oncogenesis22 citations Open access
Semantic Scholar
Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages
Yan Chen, Jian G. Wen, Jin-Jin Feng, Yi-He Wang +4 more
2019Pediatric Research22 citations Open access
Semantic Scholar
Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus
Katariina Mähönen, A. Hau, V. Bondet, D. Duffy +3 more
2022Acta Dermato-Venereologica21 citations Open access
Semantic Scholar
Food allergy alters jejunal circular muscle contractility and induces local inflammatory cytokine expression in a mouse model
J. Valeur, J. Lappalainen, H. Rita, A. H. Lin +4 more
2009BMC Gastroenterology20 citations Open access
Semantic Scholar
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
E. Sliz, J. Tyrmi, N. Rahmioglu, K. Zondervan +323 more
2023Nature Communications18 citations Open access
Semantic Scholar
Long-term follow up of families with pathogenic NFKB1 variants reveals incomplete penetrance and frequent inflammatory sequelae.
E. Tuovinen, O. Kuismin, Leila Soikkonen, T. Martelius +11 more
2022Clinical Immunology18 citations Open access
Semantic Scholar
Altered Expression of Toll-like Receptors in Human Oral Epithelium in Oral Lichenoid Reactions
A. Salem, R. Mustafa, D. Listyarifah, A. Al-Samadi +3 more
2017American journal of dermatopathology18 citations
Semantic Scholar
DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP
Juri Olkkonen, V. Kouri, Elina Kuusela, M. Ainola +3 more
2017Journal of Circadian Rhythms18 citations Open access
Semantic Scholar

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