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P. Dalby · SciRah

Researcher profile · Semantic Scholar

P. Dalby

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P. Dalby — researcher profile on SciRah

h-index: 36
Works: 174
Citations: 4,220

Most-cited papers

Strategy and success for the directed evolution of enzymes.
P. Dalby
2011Current Opinion in Structural Biology207 citations
Semantic Scholar
Two strategies to engineer flexible loops for improved enzyme thermostability
Hao-Ran Yu, Yihan Yan, Cheng Zhang, P. Dalby
2017Scientific Reports185 citations Open access
Semantic Scholar
The global landscape of approved antibody therapies
Xiaochen Lyu, Qi-Chao Zhao, Julia Y. Hui, Tiffany Wang +7 more
2022Antibody Therapeutics176 citations Open access
Semantic Scholar
Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off
Hao-Ran Yu, P. Dalby
2018Proceedings of the National Academy of Sciences of the United States of America127 citations Open access
Semantic Scholar
Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics
Hao-Ran Yu, P. Dalby
2018Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
Hot spots-making directed evolution easier.
Hao-Ran Yu, Shuang Ma, Yiwen Li, P. Dalby
2022Biotechnology Advances92 citations Open access
Semantic Scholar
Challenges in scaling up AAV-based gene therapy manufacturing.
Ziyu Jiang, P. Dalby
2023Trends in Biotechnology91 citations Open access
Semantic Scholar
A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/omega-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol
Mark E. Smith, Bing H. Chen, E. Hibbert, Ursula Kaulmann +9 more
201081 citations
Semantic Scholar
A beginner's guide to molecular dynamics simulations and the identification of cross-correlation networks for enzyme engineering.
Hao-Ran Yu, P. Dalby
2020Methods in Enzymology76 citations
Semantic Scholar
Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment.
Nesrine Chakroun, David Hilton, Shahina S. Ahmad, Geoffrey W. Platt +1 more
2016Molecular Pharmaceutics67 citations Open access
Semantic Scholar
Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes
Chris Grant, Dawid Deszcz, Yu-Chia Wei, R. J. Martínez-Torres +7 more
2014Scientific Reports65 citations Open access
Semantic Scholar
Advancements in the co-formulation of biologic therapeutics
Veeren M. Chauhan, Hong-Yu Zhang, P. Dalby, J. Aylott
2020Journal of Controlled Release53 citations Open access
Semantic Scholar
The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands*
L. Rayner, G. Hui, J. Gor, R. Heenan +2 more
2015Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination $
L. Rios‐Solis, P. Morris, Chris Grant, A. Odeleye +5 more
201546 citations Open access
Semantic Scholar
Rational substrate and enzyme engineering of transketolase for aromatics.
P. Payongsri, D. Steadman, J. Strafford, Andrew MacMurray +2 more
2012Organic and biomolecular chemistry41 citations Open access
Semantic Scholar
Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy.
Y. Abe, J. Gor, D. Bracewell, S. Perkins +1 more
2010Biochemical Journal41 citations Open access
Semantic Scholar
Tm-Values and Unfolded Fraction Can Predict Aggregation Rates for Granulocyte Colony Stimulating Factor Variant Formulations but Not under Predominantly Native Conditions.
Mathew J. Robinson, P. Matejtschuk, A. Bristow, P. Dalby
2018Molecular Pharmaceutics40 citations Open access
Semantic Scholar
The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability.
L. Rayner, Nilufar Kadkhodayi-Kholghi, R. Heenan, J. Gor +2 more
2013Journal of Molecular Biology40 citations Open access
Semantic Scholar
Directed evolution to re-adapt a co-evolved network within an enzyme
J. Strafford, P. Payongsri, E. Hibbert, P. Morris +6 more
2012Journal of Biotechnology38 citations Open access
Semantic Scholar
α,α′‐Dihydroxyketone Formation Using Aromatic and Heteroaromatic Aldehydes with Evolved Transketolase Enzymes.
J. Galman, D. Steadman, S. Bacon, P. Morris +4 more
201138 citations
Semantic Scholar
Computational Design To Reduce Conformational Flexibility and Aggregation Rates of an Antibody Fab Fragment.
Cheng Zhang, Maariyah Samad, Hao-Ran Yu, Nesrine Chakroun +2 more
2018Molecular Pharmaceutics35 citations Open access
Semantic Scholar
The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region
L. Rayner, G. Hui, J. Gor, R. Heenan +2 more
2014Journal of Biological Chemistry34 citations Open access
Semantic Scholar
α, α -Dihydroxy Ketones and 2-Amino-1,3-diols: Synthetic and Process Strategies Using Biocatalysts
H. Hailes, P. Dalby, G. Lye, F. Baganz +3 more
201034 citations
Semantic Scholar
Identification of Protein–Excipient Interaction Hotspots Using Computational Approaches
T. Barata, Cheng Zhang, P. Dalby, S. Brocchini +1 more
2016International Journal of Molecular Sciences33 citations Open access
Semantic Scholar
Virus lasers for biological detection
J. Hales, G. Matmon, P. Dalby, J. Ward +1 more
2019Nature Communications31 citations Open access
Semantic Scholar
Transketolase catalysed upgrading of L-arabinose: the one-step stereoselective synthesis of L-gluco-heptulose
Fabiana Subrizi, Max Cárdenas-Fernández, G. Lye, J. Ward +3 more
201630 citations Open access
Semantic Scholar
Yeast-surface expressed BVDV E2 protein induces a Th1/Th2 response in naïve T cells.
R. Patterson, J. Nerren, M. Kogut, P. Court +4 more
2012Developmental and Comparative Immunology30 citations Open access
Semantic Scholar
Machine Learning Integrating Protein Structure, Sequence, and Dynamics to Predict the Enzyme Activity of Bovine Enterokinase Variants
N. A. E. Venanzi, Andrea Basciu, A. Vargiu, A. Kiparissides +2 more
2024Journal of Chemical Information and Modeling29 citations Open access
Semantic Scholar
Second generation engineering of transketolase for polar aromatic aldehyde substrates.
P. Payongsri, D. Steadman, H. Hailes, P. Dalby
2015Enzyme and Microbial Technology29 citations Open access
Semantic Scholar
An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics, and smFRET Identifies an Aggregation Mechanism.
Nuria Codina, David Hilton, Cheng Zhang, Nesrine Chakroun +3 more
2019Journal of Molecular Biology27 citations Open access
Semantic Scholar
An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations
Akash Pandya, M. Howard, M. Zloh, P. Dalby
2018Pharmaceutics27 citations Open access
Semantic Scholar
Evaluation of CV2025 ω-transaminase for the bioconversion of lignin breakdown products into value-added chemicals: synthesis of vanillylamine from vanillin
C.-J. Du, Leonardo Rios-Solis, John M. Ward, P. Dalby +1 more
201427 citations
Semantic Scholar
A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding.
K. Mahendrarajah, P. Dalby, B. Wilkinson, S. Jackson +1 more
2011Analytical Biochemistry27 citations
Semantic Scholar
Single active‐site mutants are sufficient to enhance serine:pyruvate α‐transaminase activity in an ω‐transaminase
Dawid Deszcz, P. Affaticati, N. Ladkau, Alex Gegel +3 more
2015The FEBS Journal26 citations Open access
Semantic Scholar
A toolbox approach for the rapid evaluation of multi-step enzymatic syntheses comprising a ‘mix and match’ E. coli expression system with microscale experimentation
L. Rios-Solis, M. Halim, A. Cázares, P. Morris +5 more
201126 citations
Semantic Scholar
Structural stability of E. coli transketolase to temperature and pH denaturation.
R. Jahromi, P. Morris, R. J. Martínez-Torres, P. Dalby
2011Journal of Biotechnology24 citations
Semantic Scholar
Fine‐tuning the activity and stability of an evolved enzyme active‐site through noncanonical amino‐acids
Henry C. Wilkinson, P. Dalby
2020The FEBS Journal22 citations Open access
Semantic Scholar
Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α‐hydroxyketones
Hao-Ran Yu, Roberto Icken Hernández López, D. Steadman, D. Méndez-Sánchez +6 more
2019The FEBS Journal21 citations
Semantic Scholar
Optimal synthesis of chromatographic trains for downstream protein processing
Eleftheria M. Polykarpou, P. Dalby, L. Papageorgiou
2011Biotechnology progress (Print)21 citations
Semantic Scholar
Impact of cofactor-binding loop mutations on thermotolerance and activity of E. coli transketolase.
P. Morris, Leonardo Rios-Solis, R. García-Arrazola, G. Lye +1 more
2016Enzyme and Microbial Technology20 citations Open access
Semantic Scholar
Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale.
M. Gaudet, Nina Remtulla, S. Jackson, E. Main +3 more
2010Protein Science18 citations Open access
Semantic Scholar
Optically Induced Thermal Gradients for Protein Characterization in Nanolitre-scale Samples in Microfluidic Devices
D. Sagar, S. Aoudjane, M. Gaudet, G. Aeppli +1 more
2013Scientific Reports17 citations Open access
Semantic Scholar
Freeze drying formulation using microscale and design of experiment approaches: a case study using granulocyte colony-stimulating factor
Y. Grant, P. Matejtschuk, C. Bird, M. Wadhwa +1 more
2011Biotechnology Letters17 citations
Semantic Scholar
The Two-Species Model of transketolase explains donor substrate-binding, inhibition and heat-activation
Henry C. Wilkinson, P. Dalby
2020Scientific Reports16 citations Open access
Semantic Scholar
Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes
P. Affaticati, S. Dai, P. Payongsri, H. Hailes +2 more
2016Scientific Reports16 citations Open access
Semantic Scholar
An MILP formulation for the synthesis of protein purification processes
Eleftheria M. Polykarpou, P. Dalby, L. Papageorgiou
201216 citations Open access
Semantic Scholar
Lyophilization to enable distribution of ChAdOx1 and ChAdOx2 adenovirus-vectored vaccines without refrigeration
Chen Zhang, Adam Berg, Carina C. D. Joe, P. Dalby +1 more
2023npj Vaccines15 citations Open access
Semantic Scholar
Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation
Cheng Zhang, Nuria Codina, J. Tang, Hao-Ran Yu +3 more
2021Computational and Structural Biotechnology Journal15 citations Open access
Semantic Scholar
A generic hierarchical screening method for the analysis of microscale refolds using an automated robotic platform
Gemma C. Ordidge, Gareth J. Mannall, J. Liddell, P. Dalby +1 more
2012Biotechnology progress (Print)15 citations
Semantic Scholar
Engineering of enzymes using non-natural amino acids
Yiwen Li, P. Dalby
2022Bioscience Reports14 citations Open access
Semantic Scholar

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