J. Hiscox

Most-cited papers

1. Neuropilin-1 is a host factor for SARS-CoV-2 infection

   James L. Daly, Boris Simonetti, Katja Klein, Kai-En Chen +17 more

   2020Science1,193 citations Open access

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2. Virus genomes reveal factors that spread and sustained the Ebola epidemic

   G. Dudas, L. Carvalho, T. Bedford, A. Tatem +92 more

   2017Nature398 citations Open access

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3. Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

   A. Davidson, M. Williamson, Sebastian Lewis, D. Shoemark +7 more

   2020Genome Medicine365 citations Open access

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4. Tissue-Specific Immunopathology in Fatal COVID-19

   David A. Dorward, C. D. Russell, I. Um, Mustafa Elshani +24 more

   2020American Journal of Respiratory and Critical Care Medicine269 citations Open access

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5. Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak

   L. Kafetzopoulou, S. Pullan, P. Lemey, M. Suchard +61 more

   2019Science253 citations Open access

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6. SARS-CoV-2 one year on: evidence for ongoing viral adaptation

   T. Peacock, Rebekah Penrice-Randal, J. Hiscox, W. Barclay

   2021Journal of General Virology160 citations Open access

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7. Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

   K. Ryan, K. Bewley, S. Fotheringham, G. Slack +51 more

   2021Nature Communications149 citations Open access

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8. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

   J. Huo, H. Mikolajek, Audrey Le Bas, J. Clark +29 more

   2021Nature Communications144 citations Open access

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9. Assessment of metagenomic Nanopore and Illumina sequencing for recovering whole genome sequences of chikungunya and dengue viruses directly from clinical samples

   Liana E. Kafetzopoulou, K. Efthymiadis, K. Lewandowski, A. Crook +8 more

   2018Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin105 citations Open access

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10. A Comparison of Whole Genome Sequencing of SARS-CoV-2 Using Amplicon-Based Sequencing, Random Hexamers, and Bait Capture

    Jalees A. Nasir, R. Kozak, P. Aftanas, A. Raphenya +13 more

    2020Viruses93 citations Open access

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11. Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse

    F. Seehusen, J. Clark, Parul Sharma, E. Bentley +10 more

    2022bioRxiv91 citations Open access

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12. Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site

    A. Davidson, M. Williamson, Sebastian Lewis, D. Shoemark +7 more

    2020bioRxiv83 citations Open access

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13. SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19

    E. Bentley, Adam Kirby, Parul Sharma, A. Kipar +11 more

    2021bioRxiv79 citations Open access

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14. Covid-19: variants and vaccination

    A. Darby, J. Hiscox

    2021British medical journal77 citations

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15. A Randomised -Controlled Phase 2 trial of Molnupiravir in Unvaccinated and Vaccinated Individuals with Early SARS-CoV-2

    S. Khoo, R. Fitzgerald, G. Saunders, C. Middleton +32 more

    2022medRxiv75 citations Open access

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16. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

    Sheryl Ann Ryuzo Laurent Lara Andrew Shingo Elisabeth Dia Abdukahil Abe Abel Absil Acker Adachi Adam Adrião , S. Abdukahil, Ryuzo Abe, Laurent Abel +496 more

    2021Infection75 citations Open access

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17. Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020

    C. Thompson, N. Grayson, Robert S Paton, J. Bolton +361 more

    2020Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin67 citations Open access

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18. Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

    Jie Zhou, T. Peacock, Jonathan C. Brown, D. Goldhill +25 more

    2022Cell Reports64 citations Open access

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19. Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19

    S. Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Xiao-Feng Dong +26 more

    2020medRxiv64 citations Open access

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20. Deep splicing plasticity of the human adenovirus type 5 transcriptome drives virus evolution

    I. Donovan-Banfield, A. Turnell, J. Hiscox, K. Leppard +1 more

    2020Communications Biology60 citations Open access

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21. Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial

    S. Khoo, Richard J. Fitzgerald, G. Saunders, C. Middleton +86 more

    2022Lancet. Infectious Diseases (Print)56 citations Open access

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22. Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

    S. Moore, Rebekah Penrice-Randal, Muhannad Alruwaili, Nadine P. Randle +42 more

    2020Viruses50 citations Open access

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23. Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

    K. Ryan, K. Bewley, S. Fotheringham, Phillip J. Brown +45 more

    2020bioRxiv45 citations Open access

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24. Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19

    C. Russell, A. Valančiūtė, Naomi N. Gachanja, J. Stephen +15 more

    2021American Journal of Respiratory Cell and Molecular Biology42 citations Open access

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25. Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study

    Ruth Thom, T. Tipton, T. Strecker, Y. Hall +40 more

    2020Lancet. Infectious Diseases (Print)41 citations Open access

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26. Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial

    X. Y. Poh, Chee-Wah Tan, I. R. Lee, J. Chavatte +22 more

    2022Clinical Infectious Diseases38 citations Open access

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27. Zika Virus Infection Preferentially Counterbalances Human Peripheral Monocyte and/or NK Cell Activity

    F. Lum, David Lee, Tze-Kwang Chua, Jeslin J. L. Tan +12 more

    2017Msphere38 citations Open access

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28. Recombinant MYH9 protein C‐terminal domain blocks porcine reproductive and respiratory syndrome virus internalization by direct interaction with viral glycoprotein 5

    Liangliang Li, Biyun Xue, Weiyao Sun, Guo-Qian Gu +9 more

    2018Antiviral Research37 citations

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29. T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans.

    Emily Speranza, Paula Ruibal, J. Port, Feng Feng +7 more

    2018Journal of Infectious Diseases37 citations

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30. Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

    I. Donovan-Banfield, Rebekah Penrice-Randal, Hannah Goldswain, Aleksandra Rzeszutek +30 more

    2022Nature Communications32 citations Open access

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31. Coronaviruses in animals and humans

    L. Ng, J. Hiscox

    2020British medical journal32 citations Open access

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32. Sequential Infection with Influenza A Virus Followed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Leads to More Severe Disease and Encephalitis in a Mouse Model of COVID-19

    J. Clark, Rebekah Penrice-Randal, Parul Sharma, A. Kipar +22 more

    2020bioRxiv31 citations Open access

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33. Heme oxygenase‐1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication

    Angke Zhang, Hong Duan, Na Li, Lijuan Zhao +12 more

    2017Free Radical Biology & Medicine31 citations

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34. Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies

    K. Steeds, Y. Hall, G. Slack, S. Longet +10 more

    2020Scientific Reports28 citations Open access

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35. The Secretome Profiling of a Pediatric Airway Epithelium Infected with hRSV Identified Aberrant Apical/Basolateral Trafficking and Novel Immune Modulating (CXCL6, CXCL16, CSF3) and Antiviral (CEACAM1) Proteins

    O. Touzelet, Lindsay Broadbent, S. Armstrong, Waleed Aljabr +3 more

    2019Molecular & Cellular Proteomics27 citations Open access

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36. Variation around the dominant viral genome sequence contributes to viral load and outcome in patients with Ebola virus disease

    Xiao-Feng Dong, Jordana Munoz-Basagoiti, N. Rickett, G. Pollakis +9 more

    2020Genome Biology25 citations Open access

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37. Amplicon and Metagenomic Analysis of Middle East Respiratory Syndrome (MERS) Coronavirus and the Microbiome in Patients with Severe MERS

    Waleed Aljabr, Muhannad Alruwaili, Rebekah Penrice-Randal, Abdulrahman Alrezaihi +25 more

    2021Msphere24 citations Open access

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38. Resistance of SARS-CoV-2 variants to neutralization by convalescent plasma from early COVID-19 outbreak in Singapore

    Bei Wang, Yun S. Goh, T. Prince, E. Ngoh +14 more

    2021npj Vaccines23 citations Open access

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39. Immunological observations and transcriptomic analysis of trimester‐specific full‐term placentas from three Zika virus‐infected women

    F. Lum, V. Narang, S. Hue, Jie Chen +18 more

    2019Clinical & Translational Immunology22 citations Open access

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40. Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells

    Gaopeng Hou, Biyun Xue, Liangliang Li, Yu-Chen Nan +8 more

    2019Frontiers in Microbiology21 citations Open access

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41. Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis

    J. Mellors, T. Tipton, S. K. Fehling, J. Akoi-Boré +12 more

    2022Frontiers in Immunology19 citations Open access

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42. Direct RNA sequencing of respiratory syncytial virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

    I. Donovan-Banfield, R. Milligan, Sophie A. Hall, Tian-Yi Gao +8 more

    2021bioRxiv19 citations Open access

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43. Analysis of an Ebola virus disease survivor whose host and viral markers were predictive of death indicates the effectiveness of medical countermeasures and supportive care

    Andrew Bosworth, N. Rickett, Xiao-Feng Dong, L. Ng +7 more

    2021Genome Medicine19 citations Open access

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44. Quantification of Ebola virus replication kinetics in vitro

    Laura E. Liao, J. Carruthers, S. Smither, Cleanera Team +12 more

    2020PLoS Comput. Biol.19 citations Open access

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45. Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4.

    Baoyuan Liu, Yiyang Chen, Ya-Ni Sun, Yu-Chen Nan +5 more

    2019Veterinary Microbiology18 citations

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46. Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

    Lin-Lin Song, Xi-Meng Han, Cun-Yu Jia, Xin Zhang +6 more

    2018Virology Journal18 citations Open access

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47. Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye

    Robert J. Watson, J. Tree, S. Fotheringham, Y. Hall +14 more

    2021Journal of Virology17 citations Open access

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48. TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection

    S. N. Amrun, Jeslin J. L. Tan, N. Rickett, Jonathan A. G. Cox +7 more

    2020Scientific Reports17 citations Open access

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49. Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

    Xiao-Feng Dong, Rebekah Penrice-Randal, Hannah Goldswain, T. Prince +17 more

    2022GigaScience16 citations Open access

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50. Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?

    J. Hiscox, S. Khoo, J. Stewart, A. Owen

    2021Journal of Antimicrobial Chemotherapy16 citations Open access

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