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G. V. van Seventer · SciRah

Researcher profile · Semantic Scholar

G. V. van Seventer

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G. V. van Seventer — researcher profile on SciRah

h-index: 41
Works: 83
Citations: 8,338

Most-cited papers

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.
G. V. van Seventer, Y. Shimizu, K. Horgan, Stephen Shaw
1990Journal of Immunology861 citations
Semantic Scholar
Regulated expression and binding of three VLA (β1) integrin receptors on T cells
Y. Shimizu, G. V. van Seventer, K. Horgan, S. Shaw
1990Nature614 citations
Semantic Scholar
Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.
Yoji Shimizu, G. V. van Seventer, K. J. Horgan, Stephen Shaw
1990Journal of Immunology398 citations
Semantic Scholar
CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion
Yoshiya Tanaka, S. Albelda, K. J. Horgan, G. V. van Seventer +6 more
1992Journal of Experimental Medicine381 citations Open access
Semantic Scholar
Activation-independent binding of human memory T cells to adhesion molecule ELAM-1
Y. Shimizu, S. Shaw, N. Graber, T. Gopal +3 more
1991Nature369 citations
Semantic Scholar
Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions
Y. Shimizu, W. Newman, T. Gopal, K. Horgan +4 more
1991Journal of Cell Biology362 citations Open access
Semantic Scholar
Dual role of the CD44 molecule in T cell adhesion and activation.
Y. Shimizu, G. V. van Seventer, R. Siraganian, L. Wahl +1 more
1989Journal of Immunology342 citations Open access
Semantic Scholar
Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.
G. Koopman, R. Keehnen, E. Lindhout, W. Newman +4 more
1994Journal of Immunology337 citations Open access
Semantic Scholar
LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release.
D. Webb, Y. Shimizu, G. V. van Seventer, Stephen Shaw +1 more
1990Science312 citations
Semantic Scholar
Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1
G. V. van Seventer, W. Newman, Y. Shimizu, T. Nutman +6 more
1991Journal of Experimental Medicine299 citations Open access
Semantic Scholar
Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development.
B. Mcrae, R. Semnani, M. Hayes, G. V. van Seventer
1998Journal of Immunology289 citations Open access
Semantic Scholar
Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1.
C. Ockenhouse, May Ho, N. Tandon, G. V. van Seventer +5 more
1991Journal of Infectious Diseases229 citations
Semantic Scholar
Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands.
S.-K. Lo, G. V. van Seventer, S. Levin, S. Wright
1989Journal of Immunology221 citations
Semantic Scholar
Activation of LFA-1 through a Ca2(+)-dependent epitope stimulates lymphocyte adhesion
Y. van Kooyk, P. Weder, F. Hogervorst, A. Verhoeven +5 more
1991Journal of Cell Biology217 citations Open access
Semantic Scholar
Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion
Yoji Shimizu, G. V. van Seventer, E. Ennis, W. Newman +2 more
1992Journal of Experimental Medicine195 citations Open access
Semantic Scholar
Roles of multiple accessory molecules in T-cell activation.
G. V. van Seventer, Yoji Shimizu, Stephen Shaw
1991Current Opinion in Immunology171 citations
Semantic Scholar
An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes.
Jacques J. Neefjes, Birgitta S. Breur-Vriesendorp, G. V. van Seventer, Pavol Iványi +1 more
1986Human Immunology166 citations
Semantic Scholar
Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.
H. Spits, W. van Schooten, H. Keizer, G. V. van Seventer +3 more
1986Science139 citations
Semantic Scholar
Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-701
Margaret M. Morgan, Christine M. Labno, G. V. van Seventer, Michael F. Denny +2 more
2001Journal of Immunology127 citations Open access
Semantic Scholar
Hyporesponsiveness of “naive” (CD45RA+) human T cells to multiple receptor‐mediated stimuli but augmentation of responses by co‐stimuli
K. J. Horgan, G. V. van Seventer, Y. Shimizu, S. Shaw
1990European Journal of Immunology126 citations
Semantic Scholar
Timing of IFN-β Exposure during Human Dendritic Cell Maturation and Naive Th Cell Stimulation Has Contrasting Effects on Th1 Subset Generation: A Role for IFN-β-Mediated Regulation of IL-12 Family Cytokines and IL-18 in Naive Th Cell Differentiation1
T. Nagai, O. Devergne, T. Mueller, D. Perkins +2 more
2003Journal of Immunology115 citations
Semantic Scholar
Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human "naive" and "memory" CD4+ T cells
R. T. Semnani, T. Nutman, P. Hochman, S. Shaw +1 more
1994Journal of Experimental Medicine112 citations Open access
Semantic Scholar
Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2+ levels.
G. V. van Seventer, E. Bonvini, H. Yamada, A. Conti +3 more
1992Journal of Immunology111 citations
Semantic Scholar
Remote T cell co‐stimulation via LFA‐1/ICAM‐1 and CD2/LFA‐3: Demonstration with immobilized ligand/mAb and implication in monocyte‐mediated co‐stimulation
G. V. van Seventer, Y. Shimizu, K. J. Horgan, G. Luce +2 more
1991European Journal of Immunology108 citations
Semantic Scholar
Interferon-α and -β inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14+ precursors
B. Mcrae, T. Nagai, R. Semnani, J. V. van Seventer +1 more
2000106 citations
Semantic Scholar
Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells.
Y. Shimizu, G. V. van Seventer, K. Horgan, S. Shaw
1990Nature101 citations
Semantic Scholar
T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells
J. E. Maguire, Kristen M. Danahey, L. Burkly, G. V. van Seventer
1995Journal of Experimental Medicine90 citations Open access
Semantic Scholar
IFN-β Differentially Regulates CD40-Induced Cytokine Secretion by Human Dendritic Cells1
B. Mcrae, B. Beilfuss, G. V. van Seventer
2000Journal of Immunology81 citations Open access
Semantic Scholar
Are MHC class II-restricted cytotoxic T lymphocytes important?
E. Braakman, F. Rotteveel, G. V. van Bleek, G. V. van Seventer +1 more
1987Immunology today (Amsterdam. Regular ed.)80 citations
Semantic Scholar
Indocyanine green induces apoptosis in human retinal pigment epithelial cells.
K. Rezai, L. Farrokh-Siar, J. Ernest, G. V. van Seventer
2004American journal of ophthalmology-glaucoma78 citations
Semantic Scholar
Focal adhesion kinase regulates β1 integrin‐dependent T cell migration through an HEF1 effector pathway
G. V. van Seventer, H. J. Salmen, S. F. Law, G. O'Neill +5 more
2001European Journal of Immunology76 citations
Semantic Scholar
Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals.
E. M. Palmer, G. V. van Seventer
1997Journal of Immunology73 citations Open access
Semantic Scholar
Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease.
M. Fisfalen, E. M. Palmer, G. V. van Seventer, K. Soltani +5 more
1997Journal of Clinical Endocrinology and Metabolism70 citations Open access
Semantic Scholar
Human Helper T Cell Activation and Differentiation Is Suppressed by Porcine Small Intestinal Submucosa
E. M. Palmer, B. Beilfuss, T. Nagai, R. Semnani +2 more
2002Tissue engineering68 citations
Semantic Scholar
Human recombinant interferon‐β influences T helper subset differentiation by regulating cytokine secretion pattern and expression of homing receptors
B. Mcrae, L. Picker, G. V. van Seventer
1997European Journal of Immunology67 citations
Semantic Scholar
Interferon-β differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells
J. V. van Seventer, T. Nagai, G. V. van Seventer
200260 citations
Semantic Scholar
IL-12 Decreases Activation-Induced Cell Death in Human Naive Th Cells Costimulated by Intercellular Adhesion Molecule-1. I. IL-12 Alters Caspase Processing and Inhibits Enzyme Function1
E. M. Palmer, L. Farrokh-Siar, Jean Maguire van Seventer, G. V. van Seventer
2001Journal of Immunology57 citations
Semantic Scholar
Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations.
B. Breur-Vriesendorp, J. Neefjes, Bert Huis, G. V. van Seventer +2 more
1986Human Immunology45 citations
Semantic Scholar
Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway.
G. V. van Seventer, H. J. Salmen, S. F. Law, G. O'Neill +5 more
2001European Journal of Immunology43 citations
Semantic Scholar
Pyk2 is differentially regulated by β 1 integrin‐ and CD28‐mediated co‐stimulation in human CD4+ T lymphocytes
G. V. van Seventer, M. M. Mullen, J. V. van Seventer
1998European Journal of Immunology43 citations Open access
Semantic Scholar
Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras.
Maria Elena Fisfalen, Keyoumars Soltani, E. Kaplan, E. M. Palmer +5 more
1997Clinical Immunology and Immunopathology43 citations
Semantic Scholar
Blockade of TLR9 agonist-induced type I interferons promotes inflammatory cytokine IFN-gamma and IL-17 secretion by activated human PBMC.
J. Meyers, Alyson J. Mangini, T. Nagai, C. Roff +3 more
2006Cytokine41 citations
Semantic Scholar
Interferon-alpha and -beta inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14(+) precursors.
B. Mcrae, T. Nagai, R. Semnani, J. V. van Seventer +1 more
2000Blood38 citations
Semantic Scholar
The immunogenic potential of human fetal retinal pigment epithelium and its relation to transplantation.
K. Rezai, R. T. Semnani, S. C. Patel, J. Ernest +1 more
1997Investigative Ophthalmology and Visual Science36 citations
Semantic Scholar
Mechanism of inhibition and induction of cytolytic activity in cytotoxic T lymphocytes by CD3 monoclonal antibodies.
G. V. van Seventer, K. C. Kuijpers, R. V. van Lier, E. D. de Groot +2 more
1987Journal of Immunology34 citations
Semantic Scholar
Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells.
J. V. van Seventer, T. Nagai, G. V. van Seventer
2002Journal of Neuroimmunology32 citations
Semantic Scholar
Evidence for a regulatory role of the T8 (CD8) antigen in antigen‐specific and anti‐T3‐(CD3)‐induced lytic activity of allospecific cytotoxic T lymphocyte clones
G. V. van Seventer, R. V. van Lier, H. Spits, P. Iványi +1 more
1986European Journal of Immunology32 citations
Semantic Scholar
Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a Fas ligand and PGE2 independent pathway.
K. Rezai, R. T. Semnani, L. Farrokh-Siar, K. Hamann +3 more
1999Current Eye Research31 citations
Semantic Scholar
Human fetal retinal pigment epithelial cells induce apoptosis in the T-cell line Jurkat.
L. Farrokh-Siar, K. Rezai, R. T. Semnani, S. Patel +4 more
1999Investigative Ophthalmology and Visual Science29 citations
Semantic Scholar
O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents.
M. Dolan, Bradford L. McRae, Elizabeth Ferries-Rowe, M. Belanich +5 more
1999Clinical Cancer Research26 citations
Semantic Scholar

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