Researcher profile · Semantic Scholar

M. Skingle

h-index: 21
Works: 42
Citations: 1,484

Most-cited papers

GR127935: a potent and selective 5-HT1D receptor antagonist.
M. Skingle, D. Beattie, D. Scopes, S. J. Starkey +3 more
1995Behavioural Brain Research174 citations Open access
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5-HT1D as well as 5-HT1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphé nucleus.
S. J. Starkey, M. Skingle
1994Neuropharmacology161 citations
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Serotonin and Migraine
P. P. A. Humphrey, W. Feniuk, M. Perren, Isabel J. M. Beresford +2 more
1990Annals of the New York Academy of Sciences128 citations
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Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
J. Clitherow, D. Scopes, M. Skingle, C. Jordan +6 more
1994Journal of Medicinal Chemistry95 citations Open access
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Effects of the 5-HT1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis.
M. Skingle, Andrew J. Sleight, W. Feniuk
1995Neuropharmacology79 citations
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The effects of a series of capsaicin analogues on nociception and body temperature in the rat.
A. Hayes, A. Oxford, M. Reynolds, A. H. Shingler +3 more
1984Life Science69 citations
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Antinociceptive activity of clonidine in the mouse, rat and dog.
M. Skingle, A. Hayes, M. Tyers
1982Life Science66 citations
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Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat
A. Hayes, J. Scadding, M. Skingle, M. Tyers
1981The Journal of pharmacy and pharmacology58 citations
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Lack of Antinociceptive Activity of Sumatriptan in Rodents
M. Skingle, P. Birch, G. E. Leighton, P. Humphrey
1990Cephalalgia56 citations
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Effects of single doses of capsaicin on nociceptive thresholds in the rodent.
A. Hayes, M. Skingle, M. Tyers
1981Neuropharmacology56 citations
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Preclinical target validation using patient-derived cells
A. Edwards, C. Arrowsmith, C. Bountra, Mark E. Bunnage +57 more
2015Nature reviews. Drug discovery54 citations
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Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig
M. Skingle, G. A. Higgins, W. Feniuk
1994Journal of Psychopharmacology53 citations
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Evidence that the unilateral activation of 5‐HT1D receptors in the substantia nigra of the guinea‐pig elicits contralateral rotation
Guy A. Higgins, C. C. Jordan, M. Skingle
1991British Journal of Pharmacology47 citations Open access
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Antinociceptive profile of dynorphin in the rat.
A. Hayes, M. Skingle, M. Tyers
1983Life Science43 citations
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Alpha-adrenoceptor-mediated antinociception and sedation in the rat and dog.
A. Hayes, M. Skingle, M. Tyers
1986Neuropharmacology37 citations
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Reversal by β‐funaltrexamine of the antinociceptive effect of opioid agonists in the rat
A. Hayes, M. Skingle, M. Tyers
1986British Journal of Pharmacology36 citations Open access
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FURTHER STUDIES ON OPIATE RECEPTORS THAT MEDIATE ANTI‐NOCICEPTION: TOOTH PULP STIMULATION IN THE DOG
M. Skingle, M. Tyers
1980British Journal of Pharmacology36 citations Open access
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Effect of β‐funaltrexamine on opioid side‐effects produced by morphine and U‐50, 488H
A. Hayes, M. Skingle, M. Tyers
1985The Journal of pharmacy and pharmacology32 citations
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Antagonism of alpha-adrenoceptor agonist-induced antinociception in the rat.
A. Hayes, M. Skingle, M. Tyers
1986Neuropharmacology29 citations
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The pharmacology of fluparoxan: a selective α2‐adrenoceptor antagonist
C. Halliday, B. J. Jones, M. Skingle, D. Walsh +2 more
199125 citations Open access
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Evaluation of antinociceptive activity using electrical stimulation of the tooth pulp in the conscious dog
M. Skingle, M. Tyers
197922 citations
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An open toolkit for tracking open science partnership implementation and impact
E. R. Gold, S. Ali-Khan, L. Allen, Lluis Ballell +36 more
2019Gates Open Research21 citations Open access
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Exogenous melatonin entrains rhythm and reduces amplitude of endogenous melatonin: An in vivo microdialysis study
W. Drijfhout, E. J. Homan, H. F. Brons, N. Oakley +3 more
1996Journal of Pineal Research19 citations
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Evolution of a Novel Series of ((N,N-Dimethylamino)propyl)- and Piperazinylbenzanilides as the First Selective 5-HT1D Antagonists.
J. Clitherow, D. Scopes, M. Skingle, C. Jordan +12 more
199418 citations
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Evaluation of the receptor selectivities of opioid drugs by investigating the block of their effect on urine output by beta-funaltrexamine.
A. Hayes, M. Skingle, M. Tyers
1987Journal of Pharmacology and Experimental Therapeutics16 citations
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Inhibition of DOI-induced wet dog shakes in the guinea-pig by 5-HT2 receptor antagonists
M. Skingle, Nicola Cole, G. Higgins, W. Feniuk
1991Journal of Psychopharmacology13 citations
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The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist.
C. Halliday, B. J. Jones, M. Skingle, D. Walsh +2 more
1991British Journal of Pharmacology10 citations
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Effects of opiates on urine output in the water-loaded rat and reversal by beta-funaltrexamine.
M. Skingle, A. Hayes, M. Tyers
1985Neuropeptides8 citations
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Supporting the vital role of boundary-spanning physician researchers in the advancement of medical innovation
Michael M. Hopkins, Fabien Ibanez, M. Skingle
2021Future healthcare journal6 citations Open access
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Involvement of 5 -HT1D receptors in cortical extracellular 5-HT release in guinea-pigs on exposure to the elevated plus maze
A. Rex, H. Fink, M. Skingle, Charles A. Marsden
1996Journal of Psychopharmacology6 citations
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Further Studies on the Mechanism of the Antimigraine Action of Sumatriptan
P. Humphrey, W. Feniuk, M. Perren, M. Skingle +2 more
19896 citations
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Proceedings: Evaluation of narcotic and narcotic antagonist analgesic drugs in the dog dental pulp stimulation test.
A. Marriott, M. Skingle, M. Tyers
1975British Journal of Pharmacology2 citations
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An open toolkit for tracking open science partnership implementation and impact [version 1; peer review: awaiting peer review].
E. R. Gold, S. Ali-Khan, L. Allen, Lluis Ballell +37 more
20191 citations
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1.16 – Industry–Academic Relationships
M. Darnbrough, M. Skingle
20071 citations
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Section Review—Central & Peripheral Nervous Systems: The Evolution of Selective 5-HTID Receptor Antagonists
J. Clitherow, Dic Scopes, D. Beattie, M. Skingle
19951 citations
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An open toolkit for tracking open science partnership implementation and impact [version 1; peer review: 1 approved, 1 approved with reservations]
E. R. Gold, S. Ali-Khan, L. Allen, Lluis Ballell +36 more
20190 citations
Semantic Scholar
Learning to innovate: how do we turn scientists into industrial innovators?
M. Skingle
20160 citations
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The RAE: an industrial perspective
M. Skingle
19990 citations
Semantic Scholar
Central & Peripheral Nervous Systems The evolution of selective 5-HT1 D receptor antagonists
Dic Scopes, D. Beattie, M. Skingle
19950 citations
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Thepharmacology offluparoxan: a selective a2-adrenoceptor antagonist
C. Halliday, B. J. Jones, M. Skingle, D. Walsh +2 more
19910 citations
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25. Functional identification of opioid receptors in vivo using β-FNA
A. Hayes, M. Skingle, M. Sheehan, M. Tyers
19850 citations
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Investigations into the classification of alpha-adrenoceptors that mediate antinociception and sedation.
M. Skingle
19840 citations
Semantic Scholar

D. Scopes

×3

H. Connor×3

G. Higgins×3

W. H. Lee×3

C. Halliday×3

B. J. Jones×3

D. Walsh×3

H. Wise×3