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T. Ly · SciRah

Researcher profile · Semantic Scholar

T. Ly

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T. Ly — researcher profile on SciRah

h-index: 14
Works: 50
Citations: 563

Most-cited papers

CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
N. Lukacs, Aaron A. Berlin, K. Franz-Bacon, R. Sásik +5 more
2008American Journal of Physiology - Lung cellular and Molecular Physiology67 citations Open access
Semantic Scholar
A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
S. Boehme, K. Franz-Bacon, E. P. Chen, Roman Sásik +4 more
2009International Immunology56 citations Open access
Semantic Scholar
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.
A. Moosavi-Movahedi, Shahram Hakimelahi, J. Chamani, G. Khodarahmi +10 more
2003Bioorganic & Medicinal Chemistry48 citations
Semantic Scholar
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.
Gholam Hossein Hakimelahi, T. Ly, A. Moosavi-Movahedi, Moti L. Jain +6 more
2001Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview
T. Ly, K. Bacon
2005Expert Opinion on Investigational Drugs34 citations
Semantic Scholar
Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms.
S. Boehme, E. P. Chen, K. Franz-Bacon, R. Sásik +4 more
2009International Immunology33 citations Open access
Semantic Scholar
MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction
S. Boehme, K. Franz-Bacon, John T. Ludka, Danielle DiTirro +2 more
2016PLoS ONE30 citations Open access
Semantic Scholar
The effects of a CCR3 inhibitor, AXP1275, on allergen‐induced airway responses in adults with mild‐to‐moderate atopic asthma
G. Gauvreau, J. FitzGerald, L. Boulet, R. Watson +10 more
2018Clinical and Experimental Allergy29 citations
Semantic Scholar
MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis
S. Boehme, K. Franz-Bacon, Danielle DiTirro, T. Ly +1 more
2016PLoS ONE29 citations Open access
Semantic Scholar
Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2).
S. Boehme, K. Franz-Bacon, E. P. Chen, T. Ly +2 more
2009International Immunology25 citations Open access
Semantic Scholar
A new perspective of cannabinoid 1 receptor antagonists: approaches toward peripheral CB1R blockers without crossing the blood-brain barrier.
Yen-Ku Wu, Ching-Fang Yeh, T. Ly, Ming-Shiu Hung
2011Current Topics in Medicinal Chemistry23 citations
Semantic Scholar
General Approach to 2,3-Dibenzyl-γ-butyrolactone Lignans: Application to the Total Synthesis of (±)-5'-Methoxyyatein, (±)-5'-Methoxyclusin, and (±)-4'-Hydroxycubebinone
P. K. Amancha, Hsing-Jang Liu, T. Ly, Kak‐Shan Shia
201021 citations
Semantic Scholar
A modified Robinson annulation process to α,α-disubstituted-β,γ-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal
Hsing-Jang Liu, T. Ly, Chia-Liang Tai, Jen-Dar Wu +4 more
200320 citations
Semantic Scholar
Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-oxacephem: a novel agent against resistant pathogenic microorganisms.
G. Hakimelahi, Pai-Chi Li, A. Moosavi-Movahedi, J. Chamani +7 more
2003Organic and biomolecular chemistry16 citations
Semantic Scholar
Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy enone system. Observation on a putative 1,5-hydride/1,3-alkyl shift under Lewis acid catalysis.
Ho-Hsuan Chou, H. Wu, Jen-Dar Wu, T. Ly +3 more
2008Organic Letters14 citations
Semantic Scholar
Targeting MAP3K19 prevents human lung myofibroblast activation both in vitro and in a humanized SCID model of idiopathic pulmonary fibrosis
Isabelle Jones, M. Espíndola, Rohan Narayanan, A. Coelho +5 more
2019Scientific Reports13 citations Open access
Semantic Scholar
A concise total synthesis of (+/-)-acutifolone A.
Ming-Tsang Hsieh, Hsing-Jang Liu, T. Ly, Kak‐Shan Shia
2009Organic and biomolecular chemistry10 citations
Semantic Scholar
Design and synthesis of a cephalosporin-retinoic acid prodrug activated by a monoclonal antibody-β-lactamase conjugate
G. Hakimelahi, T. Ly, Sheng-Fa Yu, M. Zakerinia +5 more
200110 citations
Semantic Scholar
α-Activated Cross Conjugated Cycloalkenone Systems in Organic Synthesis
Yen-Ku Wu, T. Ly, Kak‐Shan Shia
20108 citations
Semantic Scholar
Polyene cyclization promoted by the cross-conjugated alpha-carbalkoxy cyclohexenone system. An unusual 1,2-hydride shift under Lewis acid catalysis.
Min‐Tsang Hsieh, Ho-Hsuan Chou, Hsing-Jang Liu, H. Wu +2 more
2009Organic Letters8 citations
Semantic Scholar
Self-sensitized photooxygenation of 3,4-dialkoxyfurans to vitamin C or its derivatives.
Gholam Hossein Hakimelahi, Moti L. Jain, T. Ly, Iaohui Chen +3 more
2001Journal of Organic Chemistry8 citations
Semantic Scholar
A facile two-carbon ring expansion process based on the 2-cyano-1-vinylcycloalkanol system
Kak‐Shan Shia, Ning-Wei Jan, Jia-Liang Zhu, T. Ly +1 more
19997 citations
Semantic Scholar
Structure-Based Optimization of HIF-2α Agonists That Synergistically Enhance Erythropoietin Production with PHD Inhibitors.
Mengqi Guo, Weiwei Xu, Zhifang Bai, Ke-Ming Chen +19 more
2025Journal of Medicinal Chemistry4 citations
Semantic Scholar
Reductive Alkylation of γ-Cyano-α,β-unsaturated Ketones. A Modified Robinson Annulation Process to α,α-Disubstituted β,γ-unsaturated Cyclohexanone System
Chia-Liang Tai, T. Ly, Jen-Dar Wu, Kak‐Shan Shia +1 more
20104 citations
Semantic Scholar
Diels-Alder chemistry of 2-diethoxyphosphinylcyclohex-2-enones. A new approach to complex phosphonates and synthetic applications of the beta-keto phosphonate system.
Chiung-Fang Chien, Jen-Dar Wu, T. Ly, Kak‐Shan Shia +1 more
2002Chemical Communications4 citations
Semantic Scholar
α-Activated Cross-Conjugated Cycloalkenone Systems in Organic Synthesis
Yen-Ku Wu, T. Ly, Kak‐Shan Shia
20141 citations
Semantic Scholar
2,5-disubstituted aryl sulfonamide CCR3 antagonists
T. Ly, M. Tran, Erik Dean Raaum
20101 citations
Semantic Scholar
A Highly Effective Diels-Alder Approach to cis-Clerodane Natural Products: First Total Synthesis of Solidago Alcohol
T. Ly, Jyh-Hsiung Liao, Kak‐Shan Shia, Hsing-Jang Liu
20041 citations
Semantic Scholar
A Highly Effective Diels—Alder Approach to cis‐Clerodane Natural Products: First Total Synthesis of Solidago Alcohol (I).
T. Ly, Jyh-Hsiung Liao, Kak‐Shan Shia, Hsing-Jang Liu
20041 citations
Semantic Scholar
P3.01-054 Antagonism of a Novel Kinase, MAP3K19, By Specific Small Molecule Inhibitors Blocks Human Primary NSCLC Tumor Growth in Murine Xenograft Models: Topic: Models of Lung Cancer
S. Boehme, John T. Ludka, Danielle DiTirro, T. Ly +1 more
20170 citations Open access
Semantic Scholar
LATE-BREAKING ABSTRACT: Inhibition of MAP3K19 - A novel therapeutic approach for treatment of IPF
S. Boehme, T. Ly, K. Bacon
20150 citations
Semantic Scholar
Late-breaking abstract: Inhibition of RC kinase is a novel therapeutic approach for the treatment of COPD and IPF
S. Boehme, A. Coelho, C. Hogaboam, T. Ly +2 more
20140 citations
Semantic Scholar
Effect of muscarinic receptors inhibition on cytokine release and inflammatory cells infiltration in the airway of cat as an animal model for COPD
M. Beerahee, Jean Brooks, R. Mehta, Palvi Shah +18 more
20120 citations
Semantic Scholar
RC kinase: A novel kinase expressed by alveolar macrophages that may play a role in COPD and IPF
S. Boehme, John T. Ludka, Danielle DiTirro, A. Coelho +3 more
20120 citations
Semantic Scholar
Antagonistes ccr3 d'arylsulfonamides
T. Ly, J. Forrester
20100 citations
Semantic Scholar
Antagonistes ccr3 d'arylsulfonamides 2,5-disubstitués
T. Ly, Garrett Thomas Potter
20100 citations
Semantic Scholar
CCR3 antagonists arylsulfonamides 2,5-disubstituted
T. Ly, Garrett Potter
20100 citations
Semantic Scholar
CCR3 antagonists arylsulfonamide
T. Ly, J. Forrester
20100 citations
Semantic Scholar
Arylsulfonamides 2,5-disubstituted CCR3 antagonists
T. Ly, M. Tran, Erik Dean Raaum
20100 citations
Semantic Scholar
Pyrimidines à substitution 2-s-benzyle en tant qu'antagonistes de crth2
T. Ly, Garrett Thomas Potter, Marie-Antoinette Tran
20080 citations
Semantic Scholar
The First Total Synthesis of Xenitorins B (I) and C (II): Assignment of Absolute Configuration.
Wenju Chang, Kak‐Shan Shia, Hsing-Jang Liu, T. Ly
20070 citations
Semantic Scholar
Derives d'acide imidazo[1,2-c]pyrimidinylacetique
T. Ly, Takashi Yoshino, Y. Takekawa, Takuya Shintani +3 more
20050 citations
Semantic Scholar
Pyrimidine derivatives which are useful for the treatment of CRTH2-mediated diseases
Y. Koriyama, T. Yoshino, Hiroki Sato, Kazuho Tanaka +7 more
20040 citations
Semantic Scholar
For treatment of diseases mediated by CRTH2 suitable pyrimidine
T. Ly, Y. Koriyama, T. Yoshino, Hiroki Sato +7 more
20040 citations
Semantic Scholar
Derives de pyrimidine utiles pour le traitement des maladies mediees par crth2
T. Ly, Yuji Koriyama, Takashi Yoshino, Hiroki Sato +7 more
20040 citations
Semantic Scholar
Separation of Acids, Bases, and Neutral Compounds
Megumi Fujita, Helen M. Mah, P. Sgarbi, M. Lall +2 more
20030 citations
Semantic Scholar
A Modified Robinson Annulation Process to α,α-Disubstituted-β,γ-unsaturated Cyclohexanone System. Application to the Total Synthesis of Nanaimoal.
Hsing-Jang Liu, T. Ly, Chia-Liang Tai, Jen-Dar Wu +4 more
20030 citations
Semantic Scholar
Diels—Alder Chemistry of 2-Diethoxyphosphinylcyclohex-2-enones. A New Approach to Complex Phosphonates and Synthetic Applications of the β-Keto Phosphonate System.
Chiung-Fang Chien, Jen-Dar Wu, T. Ly, Kak‐Shan Shia +1 more
20020 citations
Semantic Scholar
Design and synthesis of a cephalosporin-retinoic acid prodrug activated by a monoclonal antibody-beta-lactamase conjugate.
G. Hakimelahi, T. Ly, S.-F. Yu, M. Zakerinia +5 more
2001Bioorganic & Medicinal Chemistry0 citations
Semantic Scholar
A Facile Two‐Carbon Ring Expansion Process Based on the 2‐Cyano‐1‐vinylcycloalkanol System.
Kak‐Shan Shia, Ning-Wei Jan, Jia-Liang Zhu, T. Ly +1 more
19990 citations
Semantic Scholar

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