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K. Bacon · SciRah

Researcher profile · Semantic Scholar

K. Bacon

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K. Bacon — researcher profile on SciRah

h-index: 52
Works: 135
Citations: 15K

Most-cited papers

A new class of membrane-bound chemokine with a CX3C motif
J. Bazan, K. Bacon, G. Hardiman, Wei Wang +5 more
1997Nature2,163 citations
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Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.
Jeffrey K. Harrison, Yan Jiang, Shi-Zong Chen, Yi-Yang Xia +9 more
1998Proceedings of the National Academy of Sciences of the United States of America1,208 citations Open access
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A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells
G. Adema, F. Hartgers, R. Verstraten, E. D. de Vries +8 more
1997Nature590 citations Open access
Semantic Scholar
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
Jane Y. Wu, Li-Li Feng, H. Park, N. Havlioglu +6 more
2001Nature438 citations Open access
Semantic Scholar
Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia.
D. Maciejewski-Lenoir, Shi-Zhong Chen, Lilli Feng, R. Maki +1 more
1999Journal of Immunology379 citations
Semantic Scholar
Chemokine/chemokine receptor nomenclature
K. Bacon, M. Baggiolini, H. Broxmeyer, R. Horuk +15 more
2003360 citations
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TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.
A. Vicari, D. Figueroa, J. Hedrick, Jessica S. Foster +7 more
1997Immunity328 citations Open access
Semantic Scholar
CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
Ningshu Liu, N. Ohnishi, Lin Ni, S. Akira +1 more
2003Nature Immunology309 citations
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In Vivo Inhibition of CC and CX3C Chemokine–induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II
Shi-Zhong Chen, K. Bacon, Li Li, G. Garcia +7 more
1998Journal of Experimental Medicine267 citations Open access
Semantic Scholar
The Chemokine Fractalkine Inhibits Fas-Mediated Cell Death of Brain Microglia
S. Boehme, F. Lio, D. Maciejewski-Lenoir, K. Bacon +1 more
2000Journal of Immunology213 citations Open access
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Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication.
Li-Li Feng, Shi-Zhong Chen, G. Garcia, Yi-Yang Xia +5 more
1999Kidney International208 citations Open access
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The Orally Available Spleen Tyrosine Kinase Inhibitor 2-[7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide Dihydrochloride (BAY 61-3606) Blocks Antigen-Induced Airway Inflammation in Rodents
Noriyuki Yamamoto, Keisuke Takeshita, M. Shichijo, T. Kokubo +7 more
2003Journal of Pharmacology and Experimental Therapeutics203 citations
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Chemokine/Chemokine Receptor Nomenclature
K. Bacon, M. Baggiolini, H. Broxmeyer, R. Horuk +15 more
2002185 citations
Semantic Scholar
NF‐κB‐dependent fractalkine induction in rat aortic endothelial cells stimulated by IL‐1β, TNF‐α, and LPS
G. Garcia, Yi-Yang Xia, Shi-Zhong Chen, Yibin Wang +5 more
2000173 citations
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An Orally Bioavailable Small Molecule Antagonist of CRTH2, Ramatroban (BAY u3405), Inhibits Prostaglandin D2-Induced Eosinophil Migration in Vitro
H. Sugimoto, M. Shichijo, T. Iino, Yoshihisa Manabe +4 more
2003Journal of Pharmacology and Experimental Therapeutics166 citations
Semantic Scholar
RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells
K. Bacon, M. C. Szabo, H. Yssel, J. Bolen +1 more
1996Journal of Experimental Medicine160 citations Open access
Semantic Scholar
Histamine H4 and H2 Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8+ T Cells
F. Gantner, Katsuya Sakai, M. Tusche, W. Cruikshank +2 more
2002Journal of Pharmacology and Experimental Therapeutics154 citations
Semantic Scholar
Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration.
S. Boehme, Susan K. Sullivan, P. Crowe, Mark Santos +3 more
1999Journal of Immunology154 citations Open access
Semantic Scholar
Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.
T. Murata, M. Shimada, Sachiko Sakakibara, T. Yoshino +13 more
2003Bioorganic & Medicinal Chemistry Letters147 citations Open access
Semantic Scholar
A selective novel low‐molecular‐weight inhibitor of IκB kinase‐β (IKK‐β) prevents pulmonary inflammation and shows broad anti‐inflammatory activity
K. Ziegelbauer, F. Gantner, N. Lukacs, Aaron A. Berlin +10 more
2005144 citations Open access
Semantic Scholar
Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis.
K. Bacon, J. Harrison
2000Journal of Neuroimmunology142 citations
Semantic Scholar
Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo
Keisuke Takeshita, Katsuya Sakai, K. Bacon, F. Gantner
2003Journal of Pharmacology and Experimental Therapeutics126 citations
Semantic Scholar
Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse.
Keisuke Takeshita, T. Yamasaki, S. Akira, F. Gantner +1 more
2004International Immunology117 citations Open access
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Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents
T. Murata, M. Shimada, Sachiko Sakakibara, Takashi Yoshino +13 more
2004107 citations Open access
Semantic Scholar
NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS.
G. Garcia, Y. Xia, S. Chen, Y. Wang +5 more
2000Journal of Leukocyte Biology102 citations
Semantic Scholar
Primary sensory neurons migrate in response to the chemokine RANTES.
L. Bolin, R. Murray, N. Lukacs, R. Strieter +3 more
1998Journal of Neuroimmunology92 citations
Semantic Scholar
Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor‐homologous molecule expressed on Th2 cells/DP2
Chitose Yoshimura-Uchiyama, M. Iikura, Munehiro Yamaguchi, H. Nagase +6 more
2004Clinical and Experimental Allergy88 citations
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Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.
M. Stadler, J. Bitzer, Anke Mayer-Bartschmid, H. Müller +5 more
2007Journal of Natural Products85 citations Open access
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CD40‐dependent and ‐independent activation of human tonsil B cells by CpG oligodeoxynucleotides
F. Gantner, P. Hermann, Kosuke Nakashima, S. Matsukawa +2 more
2003European Journal of Immunology84 citations Open access
Semantic Scholar
Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk*
N. Noraz, K. Schwarz, Marcos W. Steinberg, V. Dardalhon +6 more
2000Journal of Biological Chemistry79 citations Open access
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CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation.
Keisuke Takeshita, T. Yamasaki, K. Nagao, H. Sugimoto +3 more
2004International Immunology78 citations Open access
Semantic Scholar
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.
K. Ziegelbauer, F. Gantner, N. Lukacs, Aaron A. Berlin +10 more
2005British Journal of Pharmacology74 citations
Semantic Scholar
Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D2-Induced Eosinophilia in Rats
M. Shichijo, H. Sugimoto, K. Nagao, H. Inbe +4 more
2003Journal of Pharmacology and Experimental Therapeutics68 citations
Semantic Scholar
RANTES-induced T cell activation correlates with CD3 expression.
D. Dairaghi, K. Soo, E. Oldham, B. Premack +3 more
1998Journal of Immunology68 citations Open access
Semantic Scholar
CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
N. Lukacs, Aaron A. Berlin, K. Franz-Bacon, R. Sásik +5 more
2008American Journal of Physiology - Lung cellular and Molecular Physiology67 citations Open access
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Growth Inhibition of Multiple Myeloma Cells by a Novel IκB Kinase Inhibitor
T. Sanda, S. Iida, Hiroka Ogura, K. Asamitsu +4 more
2005Clinical Cancer Research66 citations Open access
Semantic Scholar
Macrophage inflammatory protein-1β induces migration and activation of human thymocytes
D. Dairaghi, K. Franz-Bacon, E. Callas, J. Cupp +5 more
199862 citations Open access
Semantic Scholar
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity.
T. Murata, M. Shimada, H. Kadono, Sachiko Sakakibara +8 more
2004Bioorganic & Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
S. Boehme, K. Franz-Bacon, E. P. Chen, Roman Sásik +4 more
2009International Immunology56 citations Open access
Semantic Scholar
Chemokines in disease models and pathogenesis.
K. Bacon, J. Oppenheim
1998Cytokine & growth factor reviews55 citations
Semantic Scholar
Molecular Determinants of Receptor Binding and Signaling by the CX3C Chemokine Fractalkine* 210
L. Mizoue, Susan K. Sullivan, D. S. King, T. Kledal +3 more
2001Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Chemokine Receptor CCR3 Function Is Highly Dependent on Local pH and Ionic Strength*
D. Dairaghi, E. Oldham, K. Bacon, T. Schall
1997Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Chemokine receptor antagonism as a new therapy for multiple sclerosis
R. Ransohoff, K. Bacon
2000Expert Opinion on Investigational Drugs51 citations
Semantic Scholar
Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis.
G. Garcia, Yi-Yang Xia, J. Harrison, C. Wilson +3 more
2003American Journal of Pathology49 citations Open access
Semantic Scholar
Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan
Keisuke Takeshita, K. Bacon, F. Gantner
2004Journal of Pharmacology and Experimental Therapeutics41 citations
Semantic Scholar
Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4.
H. Okigami, Keisuke Takeshita, M. Tajimi, H. Komura +4 more
2007European Journal of Pharmacology39 citations
Semantic Scholar
Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene
Naomi Taylor, K. Bacon, Susan M. Smith, T. Jahn +6 more
1996Journal of Experimental Medicine39 citations Open access
Semantic Scholar
Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor.
T. Sanda, S. Iida, Hiroka Ogura, K. Asamitsu +4 more
2005Clinical Cancer Research37 citations
Semantic Scholar
Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview
T. Ly, K. Bacon
2005Expert Opinion on Investigational Drugs34 citations
Semantic Scholar
Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms.
S. Boehme, E. P. Chen, K. Franz-Bacon, R. Sásik +4 more
2009International Immunology33 citations Open access
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F. Gantner — researcher profile on SciRah
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Keisuke Takeshita — researcher profile on SciRah
T. Schall×8
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T. Murata×7
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Li-Li Feng — researcher profile on SciRah

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Yi-Yang Xia — researcher profile on SciRah

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G. Garcia — researcher profile on SciRah

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