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Thomas P. Flagg · SciRah

Researcher profile · Semantic Scholar

Thomas P. Flagg

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Thomas P. Flagg — researcher profile on SciRah

h-index: 25
Works: 66
Citations: 1,872

Most-cited papers

Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection
Thomas P. Flagg, D. Enkvetchakul, J. Koster, C. Nichols
2010Physiological Reviews291 citations Open access
Semantic Scholar
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1
Thomas P. Flagg, H. Kurata, Ricard Masia, G. Caputa +4 more
2008Circulation Research136 citations Open access
Semantic Scholar
Distinct Cellular and Molecular Mechanisms Underlie Functional Remodeling of Repolarizing K+ Currents With Left Ventricular Hypertrophy
Céline Marionneau, S. Brunet, Thomas P. Flagg, T. Pilgram +2 more
2008Circulation Research119 citations Open access
Semantic Scholar
Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions*
Dana S. Yoo, Thomas P. Flagg, O. Olsen, V. Raghuram +2 more
2004Journal of Biological Chemistry108 citations Open access
Semantic Scholar
Differential KATP channel pharmacology in intact mouse heart
A. Glukhov, Thomas P. Flagg, V. Fedorov, I. Efimov +1 more
2009Journal of Molecular and Cellular Cardiology94 citations Open access
Semantic Scholar
Hyperinsulinism induced by targeted suppression of beta cell KATP channels
J. Koster, M. Remedi, Thomas P. Flagg, James D. Johnson +3 more
2002Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Tolerance for ATP-Insensitive KATP Channels in Transgenic Mice
J. Koster, A. Knopp, Thomas P. Flagg, K. Markova +5 more
2001Circulation Research71 citations Open access
Semantic Scholar
Cardiac sarcolemmal KATP channels: Latest twists in a questing tale!
Hai-Xia Zhang, Thomas P. Flagg, C. Nichols
2009Journal of Molecular and Cellular Cardiology64 citations Open access
Semantic Scholar
Ca2+-Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy
Thomas P. Flagg, O. Cazorla, M. Remedi, T. Haim +7 more
2008Circulation Research59 citations Open access
Semantic Scholar
Disruption of Sarcolemmal ATP sensitive potassium Channel Activity Impairs the Cardiac Response to Systolic Overload
Xinli Hu, Xin Xu, Yimin Huang, J. Fassett +5 more
2008Circulation Research56 citations Open access
Semantic Scholar
Sarcolemmal KATP channels : what do we really know?
Thomas P. Flagg, C. Nichols
200556 citations
Semantic Scholar
Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel
A. Noonan, R. Eisch, D. Liewehr, T. Sissung +7 more
2013Clinical Cancer Research49 citations Open access
Semantic Scholar
Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland.
K. Gregerson, Thomas P. Flagg, Thomas J. O'Neill, Mark Anderson +3 more
2001Endocrinology49 citations
Semantic Scholar
A Mutation Linked with Bartter's Syndrome Locks Kir 1.1a (Romk1) Channels in a Closed State
Thomas P. Flagg, Margaret L. Tate, J. Mérot, P. Welling
1999The Journal of General Physiology48 citations Open access
Semantic Scholar
Palmitate Attenuates Myocardial Contractility through Augmentation of Repolarizing Kv Currents
T. Haim, Wei Wang, Thomas P. Flagg, M. Tones +4 more
2009Journal of Molecular and Cellular Cardiology44 citations Open access
Semantic Scholar
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.
P. Schaeffer, J. Desantiago, John Yang, Thomas P. Flagg +7 more
2009American Journal of Physiology. Heart and Circulatory Physiology44 citations Open access
Semantic Scholar
Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels.
Thomas P. Flagg, F. Charpentier, J. E. Manning Fox, M. Remedi +4 more
2004American Journal of Physiology. Heart and Circulatory Physiology42 citations
Semantic Scholar
Potent Inhibition of hERG Channels by the Over-the-Counter Antidiarrheal Agent Loperamide.
Michael G Klein, M. Haigney, P. Mehler, N. Fatima +2 more
2016JACC Clinical Electrophysiology40 citations Open access
Semantic Scholar
Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury
J. Elrod, Maddison D. Harrell, Thomas P. Flagg, S. Gundewar +4 more
2008Circulation40 citations Open access
Semantic Scholar
MDR1 P-glycoprotein Reduces Influx of Substrates without Affecting Membrane Potential*
G. Luker, Thomas P. Flagg, Q. Sha, K. Luker +3 more
2001Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Promoter DNA Methylation Regulates Murine SUR1 (Abcc8) and SUR2 (Abcc9) Expression in HL-1 Cardiomyocytes
N. Fatima, J. Schooley, W. Claycomb, Thomas P. Flagg
2012PLoS ONE29 citations Open access
Semantic Scholar
Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP).
Thomas P. Flagg, M. Remedi, Ricard Masia, Jefferson Gomes +3 more
2005Journal of Molecular and Cellular Cardiology28 citations
Semantic Scholar
Molecular mechanism of a COOH‐terminal gating determinant in the ROMK channel revealed by a Bartter's disease mutation
Thomas P. Flagg, Dana S. Yoo, C. Sciortino, Margaret L. Tate +2 more
2002Journal of Physiology28 citations Open access
Semantic Scholar
Sarcolemmal K(ATP) channels: what do we really know?
Thomas P. Flagg, C. Nichols
2005Journal of Molecular and Cellular Cardiology26 citations
Semantic Scholar
Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart.
Thomas P. Flagg, Brianne Patton, Ricard Masia, C. Mansfield +3 more
2007American Journal of Physiology. Heart and Circulatory Physiology25 citations
Semantic Scholar
Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility.
Sandip M. Prasad, Ashraf S. Al-Dadah, Gregory D. Byrd, Thomas P. Flagg +4 more
2006Annals of Thoracic Surgery23 citations
Semantic Scholar
SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs
Guzal Khayrullina, Kasey E. Moritz, J. Schooley, N. Fatima +7 more
2020Skeletal Muscle21 citations Open access
Semantic Scholar
Random assembly of SUR subunits in KATP channel complexes
Wayland W. L. Cheng, Ailing Tong, Thomas P. Flagg, C. Nichols
2008Channels21 citations Open access
Semantic Scholar
Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice.
H. Dobrzynski, R. Billeter, I. Greener, James O. Tellez +5 more
2006Journal of Molecular and Cellular Cardiology19 citations
Semantic Scholar
“Cardiac KATP”
Thomas P. Flagg, C. Nichols
2011Circulation: Arrhythmia and Electrophysiology17 citations Open access
Semantic Scholar
Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study
Michael G Klein, M. Krantz, N. Fatima, A. Watters +7 more
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease15 citations Open access
Semantic Scholar
Sarcolemmal KATP Channels in the Heart: Molecular Mechanisms Brought to Light, but Physiologic Consequences Still in the Dark
Thomas P. Flagg, Colin G. Nichols
2001Cardiovascular Electrophysiology14 citations
Semantic Scholar
Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart.
Michael G Klein, M. Shou, J. Stohlman, S. Solhjoo +5 more
2017Heart Rhythm13 citations Open access
Semantic Scholar
The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells: A Potential Cardioprotective and Neuroprotective Mechanism
Tanisha L. Currie, M. Engler, Cara H. Olsen, V. Krauthamer +3 more
2022Molecules11 citations Open access
Semantic Scholar
Considerations for Optimizing Warfighter Psychological Health with a Research-Based Flavonoid Approach: A Review
Tanisha L. Currie, M. Engler, V. Krauthamer, Jonathan M. Scott +2 more
2023Nutrients10 citations Open access
Semantic Scholar
Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation
Narayanan Puthillathu Vasudevan, D. Soni, J. Moffett, Jishnu K. S. Krishnan +7 more
2023International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis
N. Fatima, D. Cohen, Gauthaman Sukumar, T. Sissung +7 more
2015Frontiers in Pharmacology8 citations Open access
Semantic Scholar
Acetate transiently inhibits myocardial contraction by increasing mitochondrial calcium uptake
J. Schooley, A. Namboodiri, Rachel T Cox, Rolf Bünger +1 more
2014BMC Physiology6 citations Open access
Semantic Scholar
Novel cholesterol‐dependent regulation of cardiac KATP subunit expression revealed using histone deacetylase inhibitors
R. Geiger, N. Fatima, J. Schooley, Jeremy T. Smyth +2 more
2020Physiological Reports5 citations Open access
Semantic Scholar
KATP channels: From structure to disease
C. Nichols, J. Koster, D. Enkvetchakul, Thomas P. Flagg
20065 citations
Semantic Scholar
Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes
R. Geiger, Michael G Klein, N. Fatima, R. Goldstein +3 more
2020JACC Clinical Electrophysiology4 citations Open access
Semantic Scholar
The Effects of Blackcurrant and Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells
Tanisha L. Currie, M. Engler, Cara H. Olsen, V. Krauthamer +3 more
2022The FASEB Journal2 citations
Semantic Scholar
Abstract 17074: Methadone Potently Blocks Cardiac IK1 Leading to Membrane Instability
M. Klein, R. Geiger, M. Krantz, R. H. Goldstein +2 more
2020Circulation2 citations
Semantic Scholar
Transcriptional reprogramming in SMA mouse hearts reveals signatures of early heart failure and dysregulated calcium signaling.
Cecelia C. Mangione, A. Frank, C. Dalgard, Barrington G. Burnett +1 more
2025Human Molecular Genetics1 citations Open access
Semantic Scholar
Dangerous Needle Stick.
M. Krantz, Thomas P. Flagg, M. Haigney
2020Circulation1 citations Open access
Semantic Scholar
Hemodynamic Effects of Late Sodium Current Inhibitors in a Swine Model of Heart Failure.
R. Goldstein, Michael G Klein, Sean P Ouimet, M. Shou +3 more
2019Journal of Cardiac Failure1 citations
Semantic Scholar
Avoiding the chopping block in curricular reform: reimagining physiology laboratories in the era of integrated medical curricula.
Thomas P. Flagg, Stephen W Rothwell, Brian E. Neubauer
2017Advances in Physiology Education1 citations Open access
Semantic Scholar
A Family of Ion Channels
Thomas P. Flagg, C. Nichols
20111 citations
Semantic Scholar
Myocardial Ischemia / Reperfusion Injury Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in
Colin G. Nichols, W. Coetzee, D. Lefer, J. Elrod +4 more
20081 citations
Semantic Scholar
Ion channels (genetics)
C. Nichols, Thomas P. Flagg
20081 citations
Semantic Scholar

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Michael G Klein

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