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L. Lannfelt · SciRah

Researcher profile · Semantic Scholar

L. Lannfelt

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L. Lannfelt — researcher profile on SciRah

h-index: 97
Works: 479
Citations: 54K

Most-cited papers

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle, B. Grenier-Boley, R. Sims, J. Bis +464 more
2019Nature Genetics2,491 citations Open access
Semantic Scholar
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
M. Nikpay, A. Goel, H. Won, Leanne M. Hall +147 more
2015Nature Genetics2,050 citations Open access
Semantic Scholar
The Amyloid-β Pathway in Alzheimer’s Disease
H. Hampel, John Hardy, Kaj Blennow, Christopher Chen +11 more
2021Molecular Psychiatry1,755 citations Open access
Semantic Scholar
The genetic architecture of type 2 diabetes
C. Fuchsberger, J. Flannick, T. Teslovich, A. Mahajan +297 more
2016Nature1,074 citations Open access
Semantic Scholar
Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease
R. Sims, S. J. van der Lee, A. Naj, C. Bellenguez +236 more
2017Nature Genetics944 citations Open access
Semantic Scholar
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
Chad J. Swanson, Yong Zhang, S. Dhadda, Jinping Wang +12 more
2020Alzheimer's Research & Therapy717 citations Open access
Semantic Scholar
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
R. Scott, L. Scott, R. Mägi, L. Marullo +171 more
2017Diabetes684 citations Open access
Semantic Scholar
Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Maitrayee Sardar Sinha, Anna Ansell-Schultz, L. Civitelli, Camilla Hildesjö +4 more
2018Acta Neuropathologica472 citations Open access
Semantic Scholar
Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease
Linda Söderberg, Malin Johannesson, Patrik Nygren, Hanna Laudon +4 more
2022Neurotherapeutics367 citations Open access
Semantic Scholar
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
M. Willem, S. Tahirovic, M. Busche, S. V. Ovsepian +23 more
2015Nature366 citations Open access
Semantic Scholar
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease
H. Kvartsberg, F. Duits, M. Ingelsson, N. Andreasen +13 more
2015Alzheimer's & Dementia311 citations Open access
Semantic Scholar
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
P. Surendran, F. Drenos, R. Young, H. Warren +206 more
2016Nature Genetics280 citations Open access
Semantic Scholar
Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody
V. Logovinsky, A. Satlin, Robert Y. K. Lai, Chad J. Swanson +4 more
2016Alzheimer's Research & Therapy252 citations Open access
Semantic Scholar
Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease
J. Dumanski, J. Lambert, C. Rasi, V. Giedraitis +12 more
2016American Journal of Human Genetics239 citations Open access
Semantic Scholar
Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
Sofia Söllvander, Elisabeth Nikitidou, Robin Brolin, Linda Söderberg +3 more
2016Molecular Neurodegeneration227 citations Open access
Semantic Scholar
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
S. Sood, I. Gallagher, K. Lunnon, E. Rullman +13 more
2015Genome Biology220 citations Open access
Semantic Scholar
Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
D. Sehlin, Xiao-Tian T. Fang, L. Cato, G. Antoni +2 more
2016Nature Communications205 citations Open access
Semantic Scholar
Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
G. Hultqvist, S. Syvänen, Xiao-Tian T. Fang, L. Lannfelt +1 more
2017Theranostics200 citations Open access
Semantic Scholar
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease
Bence György, Camilla Lööv, M. Zaborowski, Shuko Takeda +12 more
2018Molecular Therapy: Nucleic Acids159 citations Open access
Semantic Scholar
Self‐reported sleep disturbance is associated with Alzheimer's disease risk in men
C. Benedict, L. Byberg, J. Cedernaes, Pleunie S. Hogenkamp +5 more
2015Alzheimer's & Dementia158 citations Open access
Semantic Scholar
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
P. Surendran, E. Feofanova, N. Lahrouchi, I. Ntalla +278 more
2020Nature Genetics145 citations Open access
Semantic Scholar
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
D. Adlam, Timothy M. Olson, N. Combaret, J. Kovacic +233 more
2019Journal of the American College of Cardiology144 citations Open access
Semantic Scholar
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease
Carlo Condello, T. Lemmin, Jan Stöhr, M. Nick +14 more
2018Proceedings of the National Academy of Sciences of the United States of America129 citations Open access
Semantic Scholar
Abstract 4683: Smoking is associated with mosaic loss of chromosome Y
J. Dumanski, C. Rasi, M. Lönn, H. Davies +13 more
2015126 citations
Semantic Scholar
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Philipp S. Wild, Janine F. Felix, A. Schillert, A. Teumer +120 more
2017Journal of Clinical Investigation117 citations Open access
Semantic Scholar
Aβ and tau prion-like activities decline with longevity in Alzheimer’s disease brains
A. Aoyagi, Carlo Condello, Jan Stöhr, Weizhou Yue +13 more
2019Science Translational Medicine114 citations Open access
Semantic Scholar
Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
Xiao-Tian T. Fang, D. Sehlin, L. Lannfelt, S. Syvänen +1 more
2017Biological Procedures Online89 citations Open access
Semantic Scholar
Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals
Marcus Danielsson, J. Halvardson, H. Davies, Behrooz Torabi Moghadam +9 more
2019European Journal of Human Genetics88 citations Open access
Semantic Scholar
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease
Julia Remnestål, D. Just, N. Mitsios, C. Fredolini +13 more
2016PROTEOMICS - Clinical Applications88 citations Open access
Semantic Scholar
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle, B. Grenier-Boley, R. Sims, J. Bis +464 more
2019Nature Genetics85 citations Open access
Semantic Scholar
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease
P. E. Khoonsari, Anna Häggmark, M. Lönnberg, M. Mikus +7 more
2016PLoS ONE85 citations Open access
Semantic Scholar
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
S. Syvänen, G. Hultqvist, T. Gustavsson, A. Gumucio +5 more
2018Alzheimer's Research & Therapy79 citations Open access
Semantic Scholar
Shared genetic contribution to ischemic stroke and Alzheimer's disease
M. Traylor, Poneh Adib-Samii, D. Harold, M. Dichgans +204 more
2016Annals of Neurology69 citations Open access
Semantic Scholar
Mosaic loss of chromosome Y in leukocytes matters
L. Forsberg, J. Halvardson, Edyta Rychlicka-Buniowska, Marcus Danielsson +10 more
2018Nature Genetics64 citations
Semantic Scholar
The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, M. Zyśk +4 more
2018Journal of Neuroinflammation61 citations Open access
Semantic Scholar
Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ42 Protofibrils in Alzheimer’s Disease
Sofia Söllvander, Frida Ekholm-Pettersson, R. Brundin, G. Westman +4 more
2015Journal of Alzheimer's Disease54 citations Open access
Semantic Scholar
ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
E. Nordström, F. Eriksson, J. Sigvardson, Malin Johannesson +18 more
2021Neurobiology of Disease52 citations Open access
Semantic Scholar
A low-frequency inactivating AKT2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk
Alisa K. Manning, H. Highland, Jessica A. Gasser, X. Sim +259 more
2017Diabetes52 citations Open access
Semantic Scholar
A bispecific Tribody PET radioligand for visualization of amyloid‐beta protofibrils – a new concept for neuroimaging
S. Syvänen, Xiao-Tian T. Fang, G. Hultqvist, Silvio R. Meier +2 more
2017NeuroImage49 citations Open access
Semantic Scholar
Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
Gabriel Gustafsson, V. Lindström, Jinar Rostami, E. Nordström +4 more
2017Journal of Neuroinflammation47 citations Open access
Semantic Scholar
Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Silvio R. Meier, S. Syvänen, G. Hultqvist, Xiao-Tian T. Fang +4 more
2018Journal of Nuclear Medicine46 citations Open access
Semantic Scholar
High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease
Malin Degerman Gunnarsson, M. Ingelsson, K. Blennow, H. Basun +2 more
2016Alzheimer's Research & Therapy44 citations Open access
Semantic Scholar
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
S. Syvänen, Xiao-Tian T. Fang, Rebecca Faresjö, Johanna Rokka +4 more
2020ACS Chemical Neuroscience39 citations Open access
Semantic Scholar
Improved Differential Diagnosis of Alzheimer’s Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers
P. E. Khoonsari, G. Shevchenko, Stephanie Herman, Julia Remnestål +9 more
2019Journal of Alzheimer's Disease39 citations Open access
Semantic Scholar
Rapid amyloid‐β oligomer and protofibril accumulation in traumatic brain injury
Sami Abu Hamdeh, E. Waara, C. Möller, Linda Söderberg +6 more
2018Brain Pathology39 citations Open access
Semantic Scholar
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation
María Pagnon de la Vega, V. Giedraitis, W. Michno, L. Kilander +17 more
2021Science Translational Medicine37 citations Open access
Semantic Scholar
Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models
Jochim Reinert, B. C. Richard, H. Klafki, B. Friedrich +8 more
2016Acta Neuropathologica Communications37 citations Open access
Semantic Scholar
DT‐01‐07: TREATMENT OF EARLY AD SUBJECTS WITH BAN2401, AN ANTI‐Aβ PROTOFIBRIL MONOCLONAL ANTIBODY, SIGNIFICANTLY CLEARS AMYLOID PLAQUE AND REDUCES CLINICAL DECLINE
Chad J. Swanson, Yong Zhang, S. Dhadda, Jinping Wang +5 more
201833 citations
Semantic Scholar
Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors
Gabriel Gustafsson, F. Eriksson, C. Möller, Tomás Lopes da Fonseca +4 more
2016Cellular and molecular neurobiology33 citations Open access
Semantic Scholar
Plasma Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men
V. Giedraitis, M. Irizarry, E. Ingelsson, M. D. Gunnarsson +5 more
201632 citations
Semantic Scholar

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