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D. Sehlin · SciRah

Researcher profile · Semantic Scholar

D. Sehlin

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D. Sehlin — researcher profile on SciRah

h-index: 36
Works: 134
Citations: 3,885

Most-cited papers

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
Gabriel Gustafsson, Camilla Lööv, E. Persson, Diana F. Lázaro +11 more
2018Cellular and molecular neurobiology90 citations Open access
Semantic Scholar
Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
S. Syvänen, G. Hultqvist, T. Gustavsson, A. Gumucio +5 more
2018Alzheimer's Research & Therapy79 citations Open access
Semantic Scholar
Engineered antibodies: new possibilities for brain PET?
D. Sehlin, S. Syvänen, B. Ballanger, H. Barthel +38 more
2019European Journal of Nuclear Medicine and Molecular Imaging75 citations Open access
Semantic Scholar
Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer’s Disease
M. Olsen, Ximena Aguilar, D. Sehlin, Xiao-Tian T. Fang +3 more
2018Molecular Imaging and Biology74 citations Open access
Semantic Scholar
High detection sensitivity with antibody‐based PET radioligand for amyloid beta in brain
Xiao-Tian T. Fang, G. Hultqvist, Silvio R. Meier, G. Antoni +2 more
2019NeuroImage65 citations Open access
Semantic Scholar
Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Rebecca Faresjö, Gillian Bonvicini, Xiao-Tian T. Fang, Ximena Aguilar +2 more
2021Fluids and Barriers of the CNS63 citations Open access
Semantic Scholar
The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
Sofia Söllvander, Elisabeth Nikitidou, Linn Gallasch, M. Zyśk +4 more
2018Journal of Neuroinflammation61 citations Open access
Semantic Scholar
SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
T. Gustavsson, S. Syvänen, P. O'Callaghan, D. Sehlin
2020Translational Neurodegeneration58 citations Open access
Semantic Scholar
Brain delivery of biologics using a cross‐species reactive transferrin receptor 1 VNAR shuttle
D. Sehlin, P. Stocki, T. Gustavsson, G. Hultqvist +3 more
2020The FASEB Journal53 citations Open access
Semantic Scholar
In vivo imaging of alpha-synuclein with antibody-based PET.
Sahar Roshanbin, Meng-Fei Xiong, G. Hultqvist, Linda Söderberg +7 more
2022Neuropharmacology52 citations Open access
Semantic Scholar
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
W. Michno, Sofie Nyström, Patrick Wehrli, T. Lashley +11 more
2019Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
D. Sehlin, Xiao-Tian T. Fang, Silvio R. Meier, Malin Jansson +1 more
2017Scientific Reports48 citations Open access
Semantic Scholar
Extracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons
C. Beretta, Elisabeth Nikitidou, Linn Streubel-Gallasch, M. Ingelsson +2 more
2020Scientific Reports47 citations Open access
Semantic Scholar
Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
Silvio R. Meier, S. Syvänen, G. Hultqvist, Xiao-Tian T. Fang +4 more
2018Journal of Nuclear Medicine46 citations Open access
Semantic Scholar
Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease
Mara Zielinski, Fernanda S. Peralta Reyes, L. Gremer, S. Schemmert +11 more
2023Nature Neuroscience42 citations Open access
Semantic Scholar
Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
S. Syvänen, Xiao-Tian T. Fang, Rebecca Faresjö, Johanna Rokka +4 more
2020ACS Chemical Neuroscience39 citations Open access
Semantic Scholar
Blood‐brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy
Sofia Gustafsson, T. Gustavsson, Sahar Roshanbin, G. Hultqvist +3 more
2018Neuropharmacology38 citations Open access
Semantic Scholar
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation
María Pagnon de la Vega, V. Giedraitis, W. Michno, L. Kilander +17 more
2021Science Translational Medicine37 citations Open access
Semantic Scholar
Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
F. Rofo, Canan Ugur Yilmaz, N. Metzendorf, T. Gustavsson +6 more
2021Theranostics37 citations Open access
Semantic Scholar
11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention
Silvio R. Meier, D. Sehlin, Sahar Roshanbin, Victoria Lim Falk +6 more
2021Journal of Nuclear Medicine36 citations Open access
Semantic Scholar
Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.
S. Syvänen, D. Edén, D. Sehlin
2017Biochemical and Biophysical Research Communications - BBRC34 citations Open access
Semantic Scholar
Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
F. Rofo, N. Metzendorf, Cristina Saubi, Laura Suominen +4 more
2022Alzheimer's Research & Therapy32 citations Open access
Semantic Scholar
Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease
Silvio R. Meier, D. Sehlin, G. Hultqvist, S. Syvänen
2021Molecular Imaging and Biology32 citations Open access
Semantic Scholar
Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease
T. Gustavsson, N. Metzendorf, Elin Wik, Sahar Roshanbin +8 more
2023Alzheimer's Research & Therapy31 citations Open access
Semantic Scholar
Brain tissue Aβ42 levels are linked to shunt response in idiopathic normal pressure hydrocephalus.
Sami Abu Hamdeh, J. Virhammar, D. Sehlin, I. Alafuzoff +2 more
2018Journal of Neurosurgery31 citations
Semantic Scholar
A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice
F. Rofo, Silvio R. Meier, N. Metzendorf, Jamie I. Morrison +4 more
2022Neurotherapeutics29 citations Open access
Semantic Scholar
Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting
Xiao-Tian T. Fang, Jonas Eriksson, G. Antoni, U. Yngve +4 more
2017Neuropharmacology29 citations Open access
Semantic Scholar
Bispecific brain-penetrant antibodies for treatment of Alzheimer’s disease
D. Sehlin, G. Hultqvist, Wojciech Michno, Ximena Aguilar +5 more
2025The journal of prevention of Alzheimer's disease27 citations Open access
Semantic Scholar
Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer’s disease
W. Michno, Patrick Wehrli, Silvio R. Meier, D. Sehlin +4 more
2019Journal of Neurochemistry27 citations Open access
Semantic Scholar
Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease
M. Zyśk, F. Clausen, Ximena Aguilar, D. Sehlin +2 more
2019Journal of Alzheimer's Disease27 citations Open access
Semantic Scholar
In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease
Meng-Fei Xiong, Sahar Roshanbin, Johanna Rokka, E. Schlein +4 more
2021NeuroImage26 citations Open access
Semantic Scholar
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
Rebecca Faresjö, D. Sehlin, S. Syvänen
2023Fluids and Barriers of the CNS25 citations Open access
Semantic Scholar
ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
Gillian Bonvicini, S. Syvänen, K. G. Andersson, M. Haaparanta-Solin +2 more
2022Translational Neurodegeneration24 citations Open access
Semantic Scholar
Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
F. Rofo, J. Buijs, Ronny Falk, Ken Honek +7 more
2021Translational Neurodegeneration24 citations Open access
Semantic Scholar
Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis
Ulrika H. Julku, Meng-Fei Xiong, Elin Wik, Sahar Roshanbin +2 more
2022Fluids and Barriers of the CNS23 citations Open access
Semantic Scholar
Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
Sahar Roshanbin, Ulrika H. Julku, Meng-Fei Xiong, Jonas Eriksson +6 more
2022Pharmaceutics22 citations Open access
Semantic Scholar
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo
Gillian Bonvicini, Sunitha Singh, Lisa Sandersjöö, D. Sehlin +2 more
2025Fluids and Barriers of the CNS20 citations Open access
Semantic Scholar
Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues
Yea-Rin Lee, Ibrahim Kaya, Elin Wik, S. Baijnath +7 more
2025Analytical Chemistry20 citations Open access
Semantic Scholar
Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?
Sara Lopes van den Broek, V. Shalgunov, Rocío García Vázquez, N. Beschorner +6 more
2022Pharmaceuticals19 citations Open access
Semantic Scholar
Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
Rebecca Faresjö, E. Sjöström, Tiffany Dallas, M. Berglund +3 more
2024mAbs18 citations Open access
Semantic Scholar
Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
Sofia Gustafsson, D. Sehlin, E. Lampa, M. Hammarlund-Udenaes +1 more
2019Scientific Reports18 citations Open access
Semantic Scholar
Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
E. Schlein, Ken G. Andersson, Tiffany Dallas, S. Syvänen +1 more
2024mAbs17 citations Open access
Semantic Scholar
PET Imaging in Preclinical Anti-Aβ Drug Development
S. Syvänen, Silvio R. Meier, Sahar Roshanbin, Meng-Fei Xiong +8 more
2022Pharmaceutical Research17 citations Open access
Semantic Scholar
Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
Rebecca Faresjö, H. Lindberg, S. Ståhl, John Löfblom +2 more
2022Pharmaceutical Research17 citations Open access
Semantic Scholar
Passive and receptor mediated brain delivery of an anti-GFAP nanobody.
Silvio R. Meier, D. Sehlin, S. Syvänen
2022Nuclear Medicine and Biology15 citations Open access
Semantic Scholar
PET imaging of TREM2 in amyloid-beta induced neuroinflammation
Amelia D Dahlén, Sahar Roshanbin, Ximena Aguilar, Nadja M Bucher +3 more
2025European Journal of Nuclear Medicine and Molecular Imaging14 citations Open access
Semantic Scholar
A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Inga Petersen, Jamie I. Morrison, Alex Petrovic, Neira Babic +10 more
2024Scientific Reports13 citations Open access
Semantic Scholar
Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
Andrés De la Rosa, N. Metzendorf, Jonathan Efverström, Ana Godec +3 more
2024Neurotherapeutics11 citations Open access
Semantic Scholar
A brain-penetrant bispecific antibody lowers oligomeric alpha-synuclein and activates microglia in a mouse model of alpha-synuclein pathology
D. Sehlin, Sahar Roshanbin, O. Zachrisson, M. Ingelsson +1 more
2024Neurotherapeutics11 citations Open access
Semantic Scholar
Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
E. Schlein, S. Syvänen, Johanna Rokka, T. Gustavsson +4 more
2022Molecular Pharmaceutics11 citations Open access
Semantic Scholar

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