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K. Tomaselli · SciRah

Researcher profile · Semantic Scholar

K. Tomaselli

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K. Tomaselli — researcher profile on SciRah

h-index: 48
Works: 73
Citations: 20K

Most-cited papers

An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T. Oltersdorf, S. Elmore, Alexander R. Shoemaker, R. Armstrong +29 more
2005Nature3,453 citations
Semantic Scholar
Two CD95 (APO‐1/Fas) signaling pathways
C. Scaffidi, S. Fulda, A. Srinivasan, C. Friesen +5 more
1998EMBO Journal3,343 citations Open access
Semantic Scholar
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
S. Namura, Jin-Min Zhu, K. Fink, M. Endres +4 more
1998Journal of Neuroscience942 citations Open access
Semantic Scholar
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
T. Fernandes-Alnemri, Robert C. Armstrong, Joseph F. Krebs, S. Srinivasula +7 more
1996Proceedings of the National Academy of Sciences of the United States of America795 citations Open access
Semantic Scholar
Extracellular matrix molecules and their receptors: functions in neural development.
L. Reichardt, K. Tomaselli
1991Annual Review of Neuroscience795 citations Open access
Semantic Scholar
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
V. Marsden, L. O'Connor, L. O'Reilly, J. Silke +12 more
2002Nature600 citations
Semantic Scholar
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.
J. Bertin, R. Armstrong, Sabine Ottilie, David A. Martin +9 more
1997Proceedings of the National Academy of Sciences of the United States of America468 citations Open access
Semantic Scholar
Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
T. Fernandes-Alnemri, Atsushi Takahashi, R. Armstrong, J. Krebs +9 more
1995Cancer Research417 citations
Semantic Scholar
Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.
M. Buerke, T. Murohara, C. Skurk, Charles Nuss +2 more
1995Proceedings of the National Academy of Sciences of the United States of America415 citations Open access
Semantic Scholar
Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.
M. Mattson, K. Tomaselli, R. Rydel
1993Brain Research395 citations
Semantic Scholar
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.
L. K. Simmons, P. May, K. Tomaselli, R. Rydel +6 more
1994Molecular Pharmacology392 citations
Semantic Scholar
In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
A. Srinivasan, K. Roth, Robert O. Sayers, K. Shindler +3 more
1998Cell Death and Differentiation390 citations
Semantic Scholar
Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c
Feng Li, A. Srinivasan, Yu Wang, R. Armstrong +2 more
1997Journal of Biological Chemistry378 citations Open access
Semantic Scholar
FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis*
S. Srinivasula, Manzoor Ahmad, Sabine Ottilie, F. Bullrich +8 more
1997Journal of Biological Chemistry378 citations Open access
Semantic Scholar
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
T. Oost, Chao-Hong Sun, R. Armstrong, A. Al-Assaad +13 more
2004Journal of Medicinal Chemistry374 citations Open access
Semantic Scholar
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors*
R. Armstrong, Teresa Aja, J. Xiang, S. Gaur +7 more
1996Journal of Biological Chemistry344 citations Open access
Semantic Scholar
N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro
K. Neugebauer, K. Tomaselli, J. Lilien, Louis E. Reichardt
1988Journal of Cell Biology338 citations Open access
Semantic Scholar
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
Shin-Jung Kang, Su-Yue Wang, H. Hara, E. Peterson +8 more
2000Journal of Cell Biology336 citations Open access
Semantic Scholar
The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32*
S. Srinivasula, T. Fernandes-Alnemri, J. Zangrilli, N. M. Robertson +6 more
1996Journal of Biological Chemistry335 citations Open access
Semantic Scholar
N-cadherin and integrins: two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces.
K. Tomaselli, K. Neugebauer, J. Bixby, J. Lilien +1 more
1988Neuron323 citations Open access
Semantic Scholar
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro.
C. Milligan, D. Prevette, H. Yaginuma, Shunsaku Homma +5 more
1995Neuron322 citations Open access
Semantic Scholar
Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis
R. Armstrong, Teresa Aja, K. Hoang, S. Gaur +6 more
1997Journal of Neuroscience288 citations Open access
Semantic Scholar
Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.
M. Pinkoski, M. Hobman, Jeffrey A. Heibein, K. Tomaselli +4 more
1998Blood246 citations
Semantic Scholar
Regulation of the Apaf-1/Caspase-9 Apoptosome by Caspase-3 and XIAP*
H. Zou, Ruo-Mei Yang, Jun-Shan Hao, Jean Y. J. Wang +5 more
2003Journal of Biological Chemistry241 citations Open access
Semantic Scholar
Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone*
P. Mittl, S. Di Marco, J. Krebs, Xu Bai +4 more
1997Journal of Biological Chemistry239 citations Open access
Semantic Scholar
Human IAP-Like Protein Regulates Programmed Cell Death Downstream of Bcl-xL and Cytochrome c
C. Duckett, Feng Li, Yu Wang, K. Tomaselli +2 more
1998Molecular and Cellular Biology234 citations Open access
Semantic Scholar
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Qiao Zhou, J. Krebs, Scott Snipas, Ann Price +3 more
1998Biochemistry219 citations
Semantic Scholar
Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth
K. Tomaselli, C. Damsky, L. Reichardt
1987Journal of Cell Biology212 citations Open access
Semantic Scholar
ATP-dependent steps in apoptotic signal transduction.
Y. Eguchi, A. Srinivasan, K. Tomaselli, S. Shimizu +1 more
1999Cancer Research182 citations
Semantic Scholar
Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease
J. Bertin, Susan M. Mendrysa, Douglas J. LaCount, S. Gaur +4 more
1996Journal of Virology182 citations Open access
Semantic Scholar
Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells*
A. Srinivasan, Feng Li, A. Wong, L. Kodandapani +5 more
1998Journal of Biological Chemistry169 citations Open access
Semantic Scholar
A neuronal cell line (PC12) expresses two β1-class integrins—α1β1, and α3β1—that recognize different neurite outgrowth-promoting domains in laminin
K. Tomaselli, D. E. Hall, L. A. Flier, K. Gehlsen +3 more
1990167 citations
Semantic Scholar
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
H. Blanchard, L. Kodandapani, P. Mittl, S. Di Marco +4 more
1999Structure145 citations Open access
Semantic Scholar
Channel formation in planar lipid bilayers by a neurotoxic fragment of the beta-amyloid peptide.
T. Mirzabekov, Meng-chin A. Lin, Weining Yuan, P. J. Marshall +4 more
1994Biochemical and Biophysical Research Communications - BBRC127 citations
Semantic Scholar
Activation of Caspase‐3 in Developmental Models of Programmed Cell Death in Neurons of the Substantia Nigra
B. Jeon, N. Kholodilov, T. Oo, Sang-yun Kim +4 more
1999Journal of Neurochemistry121 citations
Semantic Scholar
Acidosis induces necrosis and apoptosis of cultured hippocampal neurons.
Ding-Wu Ding, Shaye I. Moskowitz, Rong Li, S. B. Lee +4 more
2000Experimental Neurology119 citations
Semantic Scholar
Glucagon‐like peptide‐1 in the rat brain: Distribution of expression and functional implication
G. Gu, Barbara L. Roland, K. Tomaselli, C. Dolman +2 more
2013The Journal of comparative neurology115 citations
Semantic Scholar
DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia.
Joseph H. Su, Kathryn E. Nichol, Tom Sitch, P. Sheu +5 more
2000Experimental Neurology111 citations
Semantic Scholar
Identification of the MDM2 Oncoprotein as a Substrate for CPP32-like Apoptotic Proteases*
P. Erhardt, K. Tomaselli, G. Cooper
1997Journal of Biological Chemistry107 citations Open access
Semantic Scholar
Drug discovery opportunities from apoptosis research.
John Calvin Reed, K. Tomaselli
2000Current Opinion in Biotechnology106 citations
Semantic Scholar
First-in-class pan caspase inhibitor developed for the treatment of liver disease.
Steven D. Linton, Teresa Aja, R. Armstrong, Xu Bai +34 more
2005Journal of Medicinal Chemistry100 citations
Semantic Scholar
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
Guanghui Wang, J. Bertin, Yu Wang, David A. Martin +4 more
1997Journal of Virology70 citations Open access
Semantic Scholar
Activation of Membrane-associated Procaspase-3 Is Regulated by Bcl-2
J. Krebs, R. Armstrong, A. Srinivasan, Teresa Aja +12 more
1999Journal of Cell Biology68 citations Open access
Semantic Scholar
Differentiation of Brain Endothelial Cells in Cell Culture
Ru-Bin L. Lee, K. Barbu, F. Bard, C. Cannon +10 more
1991Annals of the New York Academy of Sciences68 citations
Semantic Scholar
Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region
L. Nadler, P. Stashenko, R. Hardy, K. Tomaselli +3 more
1981Nature64 citations
Semantic Scholar
Distribution and modulation of a human leukemia-associated antigen (CALLA).
J. Pesando, K. Tomaselli, Herbert Lazarus, S. Schlossman
1983Journal of Immunology61 citations Open access
Semantic Scholar
Fate of a common acute lymphoblastic leukemia antigen during modulation by monoclonal antibody.
J. Pesando, J. Ritz, Herbert Lazarus, K. Tomaselli +1 more
1981Journal of Immunology59 citations
Semantic Scholar
Structural and functional analysis of caspase active sites.
D. Chéreau, L. Kodandapani, K. Tomaselli, A. Spada +1 more
2003Biochemistry51 citations
Semantic Scholar
Peripheral motoneuron interactions with laminin and schwann cell‐derived neurite‐promoting molecules: Developmental regulation of laminin receptor function
K. Tomaselli, L. Reichardt
1988Journal of Neuroscience Research44 citations
Semantic Scholar
Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.
N. Hoglen, B. Hirakawa, C. Fisher, Suzanne Weeks +7 more
2001Journal of Pharmacology and Experimental Therapeutics38 citations
Semantic Scholar

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Feng Li — researcher profile on SciRah

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Yu Wang — researcher profile on SciRah

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Xu Bai — researcher profile on SciRah

T. Fernandes-Alnemri×4

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T. Fernandes-Alnemri — researcher profile on SciRah