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H. Melrose · SciRah

Researcher profile · Semantic Scholar

H. Melrose

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H. Melrose — researcher profile on SciRah

h-index: 34
Works: 54
Citations: 6,304

Most-cited papers

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
Jada Lewis, E. McGowan, Julia M. Rockwood, H. Melrose +14 more
2000Nature Genetics1,333 citations
Semantic Scholar
VPS35 mutations in Parkinson disease.
C. Vilariño-Güell, C. Wider, O. Ross, J. Dachsel +29 more
2011American Journal of Human Genetics903 citations Open access
Semantic Scholar
Identification of the (cid:1) 2 - (cid:2) -1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
M. J. Field, P. J. Cox, Emma Stott, H. Melrose +11 more
2006367 citations Open access
Semantic Scholar
Translation initiator EIF4G1 mutations in familial Parkinson disease.
M. Chartier-Harlin, J. Dachsel, C. Vilariño-Güell, S. Lincoln +46 more
2011American Journal of Human Genetics326 citations Open access
Semantic Scholar
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
M. J. Field, P. J. Cox, Emma Stott, H. Melrose +11 more
2006Proceedings of the National Academy of Sciences of the United States of America314 citations
Semantic Scholar
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
H. Melrose, J. Dachsel, B. Behrouz, S. Lincoln +23 more
2010Neurobiology of Disease275 citations Open access
Semantic Scholar
Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice
M. Yue, K. Hinkle, P. Davies, E. Trushina +16 more
2015Neurobiology of Disease260 citations Open access
Semantic Scholar
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
K. Hinkle, M. Yue, B. Behrouz, J. Dächsel +13 more
2012Molecular Neurodegeneration183 citations Open access
Semantic Scholar
Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain
Chia-Chen Liu, Jin Hu, Chih-Wei Tsai, M. Yue +3 more
2015Journal of Neuroscience133 citations Open access
Semantic Scholar
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress‐induced neuronal death
D. Angeles, Bong-Hwa Gan, L. Onstead, Yi Zhao +7 more
2011Human Mutation132 citations Open access
Semantic Scholar
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
J. Schapansky, Saurabh Khasnavis, M. Deandrade, Jonathan D Nardozzi +6 more
2017Neurobiology of Disease129 citations Open access
Semantic Scholar
Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents
A. West, R. Cowell, J. P. Daher, M. Moehle +4 more
2014The Journal of comparative neurology124 citations Open access
Semantic Scholar
Anatomical localization of leucine-rich repeat kinase 2 in mouse brain.
H. Melrose, S. Lincoln, G. Tyndall, Dennis W. Dickson +1 more
2006Neuroscience124 citations
Semantic Scholar
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
H. Melrose, C. Kent, J. P. Taylor, J. Dachsel +14 more
2007Neuroscience121 citations
Semantic Scholar
ER stress response plays an important role in aggregation of α-synuclein
Peizhou Jiang, Ming Gan, A. Ebrahim, Wen-Lang Lin +2 more
2010Molecular Neurodegeneration110 citations Open access
Semantic Scholar
LRRK2 phosphorylates novel tau epitopes and promotes tauopathy
Rachel M. Bailey, Jason P. Covy, H. Melrose, Linda Rousseau +7 more
2013Acta Neuropathologica100 citations Open access
Semantic Scholar
LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Dayne A Beccano-Kelly, Mattia Volta, Lise N. Munsie, Sarah A. Paschall +12 more
2015Human Molecular Genetics96 citations
Semantic Scholar
A comparative study of Lrrk2 function in primary neuronal cultures
J. Dächsel, B. Behrouz, M. Yue, Joel E. Beevers +2 more
2010Parkinsonism & Related Disorders95 citations Open access
Semantic Scholar
Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
Mattia Volta, Dayne A Beccano-Kelly, Sarah A. Paschall, Stefano Cataldi +11 more
2017eLife94 citations Open access
Semantic Scholar
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
P. Davies, K. Hinkle, N. Sukar, B. Sepulveda +10 more
2013Biochemical Journal90 citations Open access
Semantic Scholar
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits
A. J. Lara Ordóñez, B. Fernández, Elena Fdez, María Romo-Lozano +8 more
2019Human Molecular Genetics81 citations Open access
Semantic Scholar
Parkinson’s disease: a rethink of rodent models
H. Melrose, S. Lincoln, G. Tyndall, M. Farrer
2006Experimental Brain Research78 citations
Semantic Scholar
LINGO1 rs9652490 is associated with Essential Tremor and Parkinson Disease
C. Vilariño-Güell, O. Ross, C. Wider, B. Jasińska-Myga +12 more
2009Parkinsonism & Related Disorders76 citations Open access
Semantic Scholar
Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.
C. Napier, M. Stewart, H. Melrose, B. Hopkins +2 more
1999European Journal of Pharmacology75 citations
Semantic Scholar
Nigrostriatal dopaminergic activities in dementia with Lewy bodies in relation to neuroleptic sensitivity: comparisons with Parkinson's disease.
M. Piggott, E. K. Perry, Elizabeth F. Marshall, I. McKeith +8 more
1998Biological Psychiatry68 citations Open access
Semantic Scholar
Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology
Xu Hou, J. Watzlawik, C. Cook, Chia-Chen Liu +17 more
2020Alzheimer's & Dementia65 citations Open access
Semantic Scholar
Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity
Jillian H. Kluss, M. Conti, A. Kaganovich, A. Beilina +3 more
2018npj Parkinson's Disease62 citations Open access
Semantic Scholar
LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis.
Mattia Volta, H. Melrose
2017Biochemical Society Transactions61 citations Open access
Semantic Scholar
LRRK2 deficiency impacts ceramide metabolism in brain.
R. Ferrazza, S. Cogo, H. Melrose, L. Bubacco +4 more
2016Biochemical and Biophysical Research Communications - BBRC59 citations Open access
Semantic Scholar
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
L. Pellegrini, D. Hauser, Yan Li, A. Mamais +11 more
2018Human Molecular Genetics55 citations Open access
Semantic Scholar
Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia
Tatsunori Maekawa, T. Sasaoka, S. Azuma, T. Ichikawa +3 more
2016BMC Neuroscience52 citations Open access
Semantic Scholar
LRRK2 contributes to monocyte dysregulation in Parkinson’s disease
Corinna Bliederhaeuser, L. Zondler, Veselin Grozdanov, W. Ruf +8 more
2016Acta Neuropathologica Communications40 citations Open access
Semantic Scholar
Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson’s disease
Julie P. Taylor, M. Hulihan, J. Kachergus, H. Melrose +10 more
2007Neurogenetics40 citations
Semantic Scholar
Update on the functional biology of Lrrk2.
H. Melrose
2008Future Neurology38 citations Open access
Semantic Scholar
Transgenic mice expressing human glucocerebrosidase variants: utility for the study of Gaucher disease.
Angela L. Sanders, Harmony Hemmelgarn, H. Melrose, L. Hein +2 more
2013Blood Cells, Molecules & Diseases28 citations
Semantic Scholar
Gait deficits and loss of striatal tyrosine hydroxlase/trk-b are restored following 7,8-dihydroxyflavone treatment in a progressive mptp mouse model of parkinson's disease.
Michelle S. Massaquoi, William A. Liguore, Madeline J. Churchill, C. Moore +2 more
2020Neuroscience27 citations
Semantic Scholar
Lrrk2 Localization in the Primate Basal ganglia and Thalamus: A Light and Electron Microscopic Analysis in Monkeys
H. Lee, H. Melrose, M. Yu, J. Paré +2 more
2010Experimental Neurology22 citations Open access
Semantic Scholar
[3H] pregabalin binding is increased in ipsilateral dorsal horn following chronic constriction injury.
H. Melrose, R. Kinloch, P. J. Cox, M. J. Field +2 more
2007Neuroscience Letters21 citations
Semantic Scholar
Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses.
M. Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa +9 more
2016Journal of Neuroimmunology19 citations
Semantic Scholar
Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice
S. Adeosun, Xu Hou, B. Zheng, H. Melrose +2 more
2017Neurobiology of Learning and Memory14 citations Open access
Semantic Scholar
LRRK2 and ubiquitination: implications for kinase inhibitor therapy
H. Melrose
2015Biochemical Journal8 citations Open access
Semantic Scholar
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
K. Hinkle, M. Yue, B. Behrouz, J. Dächsel +13 more
2012Molecular Neurodegeneration7 citations Open access
Semantic Scholar
Erratum: VPS35 mutations in Parkinson disease (American Journal of Human Genetics (2011) 89 (162-167))
C. Vilariño-Güell, C. Wider, O. Ross, J. Dachsel +29 more
20114 citations Open access
Semantic Scholar
Transgenic Animal Models of Proteinopathies
N. Sahara, H. Melrose, Simon V. D'Alton, Jada Lewis
20112 citations
Semantic Scholar
Novel therapeutic agents: The analgesic actions of pregabalin are mediated through its binding to the α2-δ-1 subunit of voltage-gated calcium channels
M. J. Field, S. Bramwell, P. J. Cox, H. Melrose +4 more
20042 citations Open access
Semantic Scholar
Author response: Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
Mattia Volta, Dayne A Beccano-Kelly, Sarah A. Paschall, Stefano Cataldi +11 more
20171 citations Open access
Semantic Scholar
LRRK2 knockout mice display alterations in emotional and motor co-ordination behaviours
K. Hinkle, M. Yue, B. Behrouz, J. Dachsel +13 more
20121 citations
Semantic Scholar
4 Modeling LRRK 2 Parkinsonism
K. Hinkle, H. Melrose
20180 citations
Semantic Scholar
Modeling LRRK2 Parkinsonism
K. Hinkle, H. Melrose
20110 citations Open access
Semantic Scholar
EFFECTS OF WILD-TYPE AND G 2019 S MUTANT LRRK 2 ON THE PROGRESSION OF TAU PATHOLOGY
R. Watkinson, C. Wuertzer, S. Miles, M. Farrer +5 more
20110 citations
Semantic Scholar

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